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Tramadol: Community, Culture, Applications & Research

Tramadol, sold under the brand name Tramal among others, is an opioid pain medication and a serotonin–norepinephrine reuptake inhibitor (SNRI) used to treat moderate to severe pain. When taken by mouth in an immediate-release formulation, the onset of pain relief usually begins within an hour. It is also available by injection. It is available in…

Language: English [EN]
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Tramadol topic overview

The analysis highlights Community, Culture, Applications and Research as prominent areas in the source structure around Tramadol.

Related topics
219
Source areas
11
Connected nodes
230
Extracted relationships
178
Related term clusters
46
Bridge connections
230

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Pharmacology · 50 topics
Overview · 48 topics
Interactions · 22 topics
Veterinary medicine · 22 topics
Society and culture · 21 topics
Overdose · 16 topics
Chemistry · 14 topics
Medical uses · 10 topics
Side effects · 9 topics
Contraindications · 4 topics
Research · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N02AX02 (WHO) N02AJ13 (WHO)
Bioavailability
68% (by mouth), 77% (rectal), 100% (IM)
CAS Number
27203-92-5 Y
ChEBI
CHEBI:9648 N

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Side effects

Overdose

Interactions

Pharmacology

Chemistry

Society and culture

Research

Veterinary medicine

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Tramadol connects Entity context

The extracted context around Tramadol shows recurring relationship patterns in the source. For example, Tramadol → Appeals, August, Court, Delaware, District, Drug Administration, ER, ER Tramadol, FDA, Federal Circuit, Food, Manufacture, March, May, September, The FDA, Ultram ER, United States, US, US District Court Another extracted example is Tramadol → African, Angewandte Chemie, Cameroon, Grenoble, Grenoble Institute, La Tronche, Michael Spiteller, Michel, Nauclea, Neuroscience, Spiteller, Technische Universität Dortmund, Université Joseph Fourier, Waard. Use these groups to spot repeated connection types before inspecting the individual relationships.

Tramadol

Top relations

related to history · 20
Tramadol → Appeals, August, Court, Delaware, District, Drug Administration, ER, ER Tramadol, FDA, Federal Circuit, Food, Manufacture, March, May, September, The FDA, Ultram ER, United States, US, US District Court
related to Discrepant reports on natural agency · 14
Tramadol → African, Angewandte Chemie, Cameroon, Grenoble, Grenoble Institute, La Tronche, Michael Spiteller, Michel, Nauclea, Neuroscience, Spiteller, Technische Universität Dortmund, Université Joseph Fourier, Waard
related to In war · 13
Tramadol → Anti-balaka, Boko Haram, Central African Republic, China, Congo, Democratic Republic, Dubai, Gaza Strip, Illicit, India, One, Researchers, Shalina
Legal status · 9
Tramadol → AU: S4 (Prescription only), BR: Class A2 (Narcotic drugs), CA: Schedule I, EU: Rx-only, NZ: Class C2, SE: Förteckning III In general: Prescription only, UK: POM (Prescription only) / Class C, UN: Unscheduled, US: Schedule IV
related to Legal status · 8
Tramadol → Australia, Controlled Drug, Controlled Substances Act, Effective August, Schedule, Schedule IV, United States, US
related to Pharmacokinetics · 8
Tramadol → CYP2B6, CYP2D6, CYP3A4, N-demethylated, O-desmethyltramadol, P450, Phase II, Thus
related to Veterinary medicine · 7
Tramadol → American, Another, COX, O-desmethyltramadol, One, P450, Reported
related to In sport · 6
Tramadol → From March, January, Misuse, The WADA, UCI, Union Cycliste Internationale
related to Overdose · 6
Tramadol → Additionally, CNS, CYP2D6, Gastrointestinal, Patients, Seizures
related to Dependence and withdrawal · 4
Tramadol → Long-term, Psychiatric, Seven, SNRI

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

effects serotonin may desmetramadol found drug use also pain opioid due used analgesic plasma reuptake cyp2d6 receptor risk inhibitor seizures

Tramadol relationships Subject–Predicate–Object triples

TTTA extracted 178 structured relationships around Tramadol. Examples in this analysis include Tramadol → 3D model (JSmol) → Interactive image and Tramadol → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Tramadol3D model (JSmol)Interactive image1.00infobox
TramadolAHFS/Drugs.comMonograph1.00infobox
TramadolATC codeN02AX02 (WHO) N02AJ13 (WHO)1.00infobox
TramadolBioavailability68% (by mouth), 77% (rectal), 100% (IM)1.00infobox
TramadolCAS Number27203-92-5 Y1.00infobox
TramadolChEBICHEBI:9648 N1.00infobox
TramadolChEMBLChEMBL1066 Y1.00infobox
TramadolChemSpider31105 Y1.00infobox
TramadolCompTox Dashboard (EPA)DTXSID401167150 DTXSID90858931, DTXSID4011671501.00infobox
TramadolDrug classOpioid;1.00infobox
TramadolDrug classSerotonin–norepinephrine reuptake inhibitor1.00infobox
TramadolDrugBankDB00193 Y1.00infobox
TramadolDuration of action6 hours1.00infobox
TramadolECHA InfoCard100.043.9121.00infobox
TramadolElimination half-life6.3 ± 1.4 h1.00infobox
TramadolExcretionUrine (95%)1.00infobox
TramadolFormulaC16H25NO21.00infobox
TramadolKEGGD08623 Y1.00infobox
TramadolKEGGas HCl: D01355 Y1.00infobox
TramadolLegal statusAU: S4 (Prescription only)1.00infobox
TramadolLegal statusBR: Class A2 (Narcotic drugs)1.00infobox
TramadolLegal statusCA: Schedule I1.00infobox
TramadolLegal statusNZ: Class C21.00infobox
TramadolLegal statusUK: POM (Prescription only) / Class C1.00infobox
TramadolLegal statusUS: Schedule IV1.00infobox
TramadolLegal statusUN: Unscheduled1.00infobox
TramadolLegal statusEU: Rx-only1.00infobox
TramadolLegal statusSE: Förteckning III In general: Prescription only1.00infobox
TramadolLicense dataUS DailyMed: Tramadol1.00infobox
TramadolMedlinePlusa6950111.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around Tramadol bring nearby vocabulary together. In this analysis, examples include Effects, Found and Desmetramadol. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Tramadol
    • Effects
    • Found
    • Desmetramadol
    • Also
    • Drug
    • Used
    • Due
    • Analgesia
    • Plasma
    • Effective
    • Receptor
    • Use
  • tramadol
    • Effects
    • Found
    • Desmetramadol
    • Also
    • Drug
    • Used
    • Due
    • Analgesia
    • Plasma
    • Effective
    • Receptor
    • Use
  • serotonin–norepinephrine reuptake inhibitor
    • Inhibitor
    • Reuptake
    • Serotonin
    • Norepinephrine
    • Syndrome
    • Opioid
    • Activity
    • Used
    • Also
    • Due
    • Cyp2d6
    • Pain
  • serotonin syndrome
    • Reuptake
    • Inhibitor
    • Norepinephrine
    • Syndrome
    • Used
    • Due
    • Activity
    • Tramadol
    • Effects
    • Also
    • Found
    • Include
  • drug addiction
    • Used
    • Liver
    • Metabolites
    • Tramadol
    • Syndrome
    • Risk
    • Effects
    • Also
    • Desmetramadol
    • Serotonin
    • Use
    • Generally
  • o-desmethyltramadol (desmetramadol)
    • Receptor
    • Plasma
    • Found
    • Opioid
    • Liver
    • Tramadol
    • Generally
    • Inhibitor
    • Levels
    • Cyp2d6
    • Drug
    • May
  • serotonin reuptake inhibitor
    • Inhibitor
    • Reuptake
    • Serotonin
    • Norepinephrine
    • Syndrome
    • Opioid
    • Activity
    • Used
    • Due
    • Cyp2d6
    • Also
    • Pain
  • cyp2d6
    • Analgesic
    • Pain
    • Liver
    • Metabolites
    • Effects
    • Activity
    • Inhibitor
    • Desmetramadol
    • Found
    • May
    • Dose
    • Levels

Connections between topic areas Semantic bridges

For Tramadol, one of the stronger structural bridges in this analysis connects Tramadol with Pharmacology. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Tramadol — Pharmacology · splits 180 ⟂ 51
Tramadol — Overview · splits 182 ⟂ 49
Tramadol — Interactions · splits 208 ⟂ 23
Tramadol — Veterinary medicine · splits 208 ⟂ 23
Tramadol — Society and culture · splits 209 ⟂ 22
Tramadol — Overdose · splits 214 ⟂ 17
Tramadol — Chemistry · splits 216 ⟂ 15
Tramadol — Medical uses · splits 220 ⟂ 11
Tramadol — Side effects · splits 221 ⟂ 10
Tramadol — Contraindications · splits 226 ⟂ 5
Tramadol — Research · splits 227 ⟂ 4

Map overview Semantic statistics

Tramadol

Nodes231
Edges230
Triples178
Avg. degree1.99
Density0.008658
Components1

Source & methodology

TTTA analyzes the structure around Tramadol to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Community, Culture, Applications & Research, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Tramadol · EN edition · Analysis: TopicsToTalkAbout

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