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Tramadol

Tramadol, sold under the brand name Tramal among others, is an opioid pain medication and a serotonin–norepinephrine reuptake inhibitor (SNRI) used to treat moderate to severe pain. When taken by mouth in an immediate-release formulation, the onset of pain relief usually begins within an hour. It is also available by injection. It is available in…

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Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N02AX02 (WHO) N02AJ13 (WHO)
Bioavailability
68% (by mouth), 77% (rectal), 100% (IM)
CAS Number
27203-92-5 Y
ChEBI
CHEBI:9648 N

Topics to explore

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Overview

Medical uses

Contraindications

Side effects

Overdose

Interactions

Pharmacology

Chemistry

Society and culture

Research

Veterinary medicine

Advanced semantic analysis

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Map overview Semantic statistics

Tramadol

Nodes237
Edges236
Triples219
Avg. degree1.99
Density0.008439
Components1

How this topic connects Entity context

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Tramadol

Top relations

related to history · 22
Tramadol → Appeals, August, Court, Delaware, District, Drug Administration, ER, ER Tramadol, FDA, Federal Circuit, Food, However, Manufacture, March, May, September, The, The FDA, Ultram ER, United States
related to Discrepant reports on natural agency · 16
Tramadol → African, Angewandte Chemie, Cameroon, Grenoble, Grenoble Institute, In, La Tronche, Michael Spiteller, Michel, Nauclea, Neuroscience, Spiteller, Technische Universität Dortmund, They, Université Joseph Fourier, Waard
related to In war · 15
Tramadol → Anti-balaka, Boko Haram, Central African Republic, China, Congo, Democratic Republic, Dubai, Gaza Strip, Illicit, In, India, One, Researchers, Shalina, When
related to Pharmacokinetics · 11
Tramadol → As, CYP2B6, CYP2D6, CYP3A4, N-demethylated, O-desmethyltramadol, Of, P450, Phase II, Those, Thus
related to Veterinary medicine · 11
Tramadol → American, Another, As, COX, In, O-desmethyltramadol, One, P450, Reported, The, These
Legal status · 9
Tramadol → AU: S4 (Prescription only), BR: Class A2 (Narcotic drugs), CA: Schedule I, EU: Rx-only, NZ: Class C2, SE: Förteckning III In general: Prescription only, UK: POM (Prescription only) / Class C, UN: Unscheduled, US: Schedule IV
related to Legal status · 9
Tramadol → Australia, Before, Controlled Drug, Controlled Substances Act, Effective August, Schedule, Schedule IV, United States, US
related to Overdose · 8
Tramadol → Additionally, CNS, CYP2D6, Gastrointestinal, Patients, Seizures, The, While
related to In sport · 7
Tramadol → From March, January, Misuse, No, The WADA, UCI, Union Cycliste Internationale
related to Children · 6
Tramadol → FDA, Its, On, September, The, The FDA

Important terminology Word statistics

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Important terminology

effects serotonin may desmetramadol found drug use also pain opioid due used analgesic plasma reuptake cyp2d6 receptor risk inhibitor seizures

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Tramadol3D model (JSmol)Interactive image1.00infobox
TramadolAHFS/Drugs.comMonograph1.00infobox
TramadolATC codeN02AX02 (WHO) N02AJ13 (WHO)1.00infobox
TramadolBioavailability68% (by mouth), 77% (rectal), 100% (IM)1.00infobox
TramadolCAS Number27203-92-5 Y1.00infobox
TramadolChEBICHEBI:9648 N1.00infobox
TramadolChEMBLChEMBL1066 Y1.00infobox
TramadolChemSpider31105 Y1.00infobox
TramadolCompTox Dashboard (EPA)DTXSID401167150 DTXSID90858931, DTXSID4011671501.00infobox
TramadolDrug classOpioid;1.00infobox
TramadolDrug classSerotonin–norepinephrine reuptake inhibitor1.00infobox
TramadolDrugBankDB00193 Y1.00infobox
TramadolDuration of action6 hours1.00infobox
TramadolECHA InfoCard100.043.9121.00infobox
TramadolElimination half-life6.3 ± 1.4 h1.00infobox
TramadolExcretionUrine (95%)1.00infobox
TramadolFormulaC16H25NO21.00infobox
TramadolKEGGD08623 Y1.00infobox
TramadolKEGGas HCl: D01355 Y1.00infobox
TramadolLegal statusAU: S4 (Prescription only)1.00infobox
TramadolLegal statusBR: Class A2 (Narcotic drugs)1.00infobox
TramadolLegal statusCA: Schedule I1.00infobox
TramadolLegal statusNZ: Class C21.00infobox
TramadolLegal statusUK: POM (Prescription only) / Class C1.00infobox
TramadolLegal statusUS: Schedule IV1.00infobox
TramadolLegal statusUN: Unscheduled1.00infobox
TramadolLegal statusEU: Rx-only1.00infobox
TramadolLegal statusSE: Förteckning III In general: Prescription only1.00infobox
TramadolLicense dataUS DailyMed: Tramadol1.00infobox
TramadolMedlinePlusa6950111.00infobox

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