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Peroxisome proliferator-activated receptor gamma: Research & Standards

Peroxisome proliferator-activated receptor gamma (PPAR-γ or PPARG), also known as the glitazone reverse insulin resistance receptor, or NR1C3 (nuclear receptor subfamily 1, group C, member 3) is a type II nuclear receptor functioning as a transcription factor that in humans is encoded by the PPARG gene.

Language: English [EN]

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Peroxisome proliferator-activated receptor gamma topic overview

The analysis highlights Research and Standards as prominent areas in the source structure around Peroxisome proliferator-activated receptor gamma.

Related topics: 53
Source areas: 6
Connected nodes: 59
Extracted relationships: 195
Concept neighborhoods: 20
Bridge connections: 59

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 22 topics

Interactions · 13 topics

Gene expression · 7 topics

Research · 7 topics

Overview · 3 topics

Tissue distribution · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma, peroxisome proliferator activated receptor gamma, PPARG5
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1FM6, 1FM9, 1I7I, 1K74, 1KNU, 1NYX, 1PRG, 1RDT, 1WM0, 1ZEO, 1ZGY, 2ATH, 2F4B, 2FVJ, 2G0G, 2G0H, 2GTK, 2HFP,…
Band: 3p25.2 · 6 E3|6 53.41 cM
Bgee: mucosa of transverse colon · subcutaneous adipose tissue · rectum · epithelium of colon · mucosa of sigmoid colon
BioGPS: More reference expression data
Chr.: Chromosome 3 (human) · Chromosome 6 (mouse)

Suggested research paths

A focused starting point derived from the topic graph, ranked independently of the source article order.

Start with these areas

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Tissue distribution

Adipose tissue

Gene expression

Peroxisome proliferator-activated receptor
Retinoid X receptors Retinoid X receptor
PPAR-alpha Peroxisome proliferator-activated receptor alpha
PPAR-delta Peroxisome proliferator-activated receptor delta
Adipocyte
Alternatively spliced Alternative splicing
Isoforms Protein isoform

Function

Adipogenesis
Knockout mice Knockout mouse
Lipotoxicity
Adiponectin
FGF21
Nicotinic acid adenine dinucleotide phosphate
Upregulation Downregulation and upregulation
CD38
M2 macrophage Macrophage polarization
ABCA1
Reverse cholesterol transport
LXRα/β Liver X receptor
Polyunsaturated fatty acids
Arachidonic acid
5-hydroxyicosatetraenoic acid
5-oxo-eicosatetraenoic acid
15-hydroxyicosatetraenoic acid
Phytocannabinoid Cannabinoid
Tetrahydrocannabinol
THC-COOH 11-Nor-9-carboxy-THC
Synthetic Synthetic cannabinoids
Ajulemic acid

Interactions

Interact Protein-protein interaction
Tetrahydrocannabivarin
Cannabidiol
Anandamide
CD36
EDF1
EP300
HDAC3
NCOA4
NR0B2 Small heterodimer partner
PPARGC1A
RB1 Retinoblastoma protein
MiR3666 MiR3666?action=edit&redlink=1

Research

Agonists Agonist
Hyperlipidaemia
Hyperglycemia
Insulin sensitizing drugs Anti-diabetic drug
Thiazolidinediones
Diabetes
Insulin resistance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Peroxisome proliferator-activated receptor gamma connects Entity context

The extracted context around Peroxisome proliferator-activated receptor gamma shows recurring relationship patterns in the source. For example, Peroxisome proliferator-activated receptor gamma → activation of cysteine-type endopeptidase activity involved in apoptotic process, alpha-actinin binding, animal organ regeneration, arachidonic acid binding, cell differentiation, cell fate commitment, cell maturation, cellular response to hyperoxia, cellular response to insulin stimulus, cellular response to low-density lipoprotein particle stimulus, cellular response to prostaglandin E stimulus, cellular response to prostaglandin stimulus, cellular response to retinoic acid, cellular response to vitamin E, chromatin binding, core promoter sequence-specific DNA binding, cytoplasm, cytosol, development of the heart, DNA binding Another extracted example is Peroxisome proliferator-activated receptor gamma → Achilles tendon, brown adipose tissue, epithelium of colon, epithelium of stomach, gonad, mammary gland, mucosa of sigmoid colon, mucosa of transverse colon, mucous cell of stomach, pyloric antrum, rectum, right lung, secondary oocyte, subcutaneous adipose tissue, testicle, transitional epithelium of urinary bladder, tunica adventitia of aorta, urinary bladder, white adipose tissue. Use these groups to spot repeated connection types before inspecting the individual relationships.

Peroxisome proliferator-activated receptor gamma

Top relations

Gene ontology · 128

Peroxisome proliferator-activated receptor gamma → activation of cysteine-type endopeptidase activity involved in apoptotic process, alpha-actinin binding, animal organ regeneration, arachidonic acid binding, cell differentiation, cell fate commitment, cell maturation, cellular response to hyperoxia, cellular response to insulin stimulus, cellular response to low-density lipoprotein particle stimulus, cellular response to prostaglandin E stimulus, cellular response to prostaglandin stimulus, cellular response to retinoic acid, cellular response to vitamin E, chromatin binding, core promoter sequence-specific DNA binding, cytoplasm, cytosol, development of the heart, DNA binding

Bgee · 19

Peroxisome proliferator-activated receptor gamma → Achilles tendon, brown adipose tissue, epithelium of colon, epithelium of stomach, gonad, mammary gland, mucosa of sigmoid colon, mucosa of transverse colon, mucous cell of stomach, pyloric antrum, rectum, right lung, secondary oocyte, subcutaneous adipose tissue, testicle, transitional epithelium of urinary bladder, tunica adventitia of aorta, urinary bladder, white adipose tissue

RNA expression pattern · 19

Band · 2

Peroxisome proliferator-activated receptor gamma → 3p25.2, 6 E3|6 53.41 cM

Chr. · 2

Peroxisome proliferator-activated receptor gamma → Chromosome 3 (human), Chromosome 6 (mouse)

End · 2

Peroxisome proliferator-activated receptor gamma → 115,467,360 bp, 12,434,356 bp

related to Interactions · 2

Peroxisome proliferator-activated receptor gamma → Peroxisome, TetrahydrocannabivarinCannabidiolAnandamideCD36EDF1EP300HDAC3NCOA4NR0B2PPARGC1ARB1

Aliases · 1

Peroxisome proliferator-activated receptor gamma → PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma, peroxisome proliferator activated receptor gamma, PPARG5

Available structures · 1

Peroxisome proliferator-activated receptor gamma → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1FM6, 1FM9, 1I7I, 1K74, 1KNU, 1NYX, 1PRG, 1RDT, 1WM0, 1ZEO, 1ZGY, 2ATH, 2F4B, 2FVJ, 2G0G, 2G0H, 2GTK, 2HFP,…

BioGPS · 1

Peroxisome proliferator-activated receptor gamma → More reference expression data

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pparg gene human bp insulin chr band tissue mice peroxisome receptor gamma chromosome mouse activation placenta also adipose acid fatty

Peroxisome proliferator-activated receptor gamma relationships Subject–Predicate–Object triples

TTTA extracted 195 structured relationships around Peroxisome proliferator-activated receptor gamma. Examples in this analysis include Peroxisome proliferator-activated receptor gamma → Aliases → PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma, peroxisome proliferator activated receptor gamma, PPARG5 and Peroxisome proliferator-activated receptor gamma → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1FM6, 1FM9, 1I7I, 1K74, 1KNU, 1NYX, 1PRG, 1RDT, 1WM0, 1ZEO, 1ZGY, 2ATH, 2F4B, 2FVJ, 2G0G, 2G0H, 2GTK, 2HFP,…. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Peroxisome proliferator-activated receptor gamma	Aliases	PPARG, CIMT1, GLM1, NR1C3, PPARG1, PPARG2, PPARgamma, peroxisome proliferator activated receptor gamma, PPARG5	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1FM6, 1FM9, 1I7I, 1K74, 1KNU, 1NYX, 1PRG, 1RDT, 1WM0, 1ZEO, 1ZGY, 2ATH, 2F4B, 2FVJ, 2G0G, 2G0H, 2GTK, 2HFP,…	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Band	3p25.2	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Band	6 E3\|6 53.41 cM	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	mucosa of transverse colon	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	subcutaneous adipose tissue	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	rectum	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	epithelium of colon	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	mucosa of sigmoid colon	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	right lung	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	testicle	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	urinary bladder	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	gonad	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	Achilles tendon	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	brown adipose tissue	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	transitional epithelium of urinary bladder	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	white adipose tissue	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	mucous cell of stomach	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	tunica adventitia of aorta	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	epithelium of stomach	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	pyloric antrum	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	secondary oocyte	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Bgee	mammary gland	1.00	infobox
Peroxisome proliferator-activated receptor gamma	BioGPS	More reference expression data	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Chr.	Chromosome 3 (human)	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Chr.	Chromosome 6 (mouse)	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Databases	NCBI: entry; OMA: entry	1.00	infobox
Peroxisome proliferator-activated receptor gamma	End	12,434,356 bp	1.00	infobox
Peroxisome proliferator-activated receptor gamma	End	115,467,360 bp	1.00	infobox
Peroxisome proliferator-activated receptor gamma	Ensembl	ENSG00000132170	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Peroxisome proliferator-activated receptor gamma bring nearby vocabulary together. In this analysis, examples include Receptor, Nuclear and Proliferator-activated. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Peroxisome proliferator-activated receptor gamma
- Receptor
- Nuclear
- Proliferator-activated
- Gene
- Gamma
- Peroxisome
- Factor
- Ii
- Nr1c3
- Activated
- Also
- Expression
peroxisome proliferator-activated receptor gamma
- Receptor
- Nuclear
- Proliferator-activated
- Gene
- Gamma
- Peroxisome
- Factor
- Ii
- Nr1c3
- Activated
- Also
- Expression
nuclear receptor
- Factor
- Ii
- Peroxisome
- Receptor
- Proliferator-activated
- Transcription
- Gene
- Activated
- Expression
- Function
- Location
- Chromosome
transcription factor
- Ii
- Factor
- Nuclear
- Transcription
- Peroxisome
- Receptor
- Insulin
- Nr1c3
- Gene
- Activated
- Activity
- Adipose
gene
- Peroxisome
- Receptor
- Location
- Nuclear
- Chromosome
- Bp
- Chr
- Insulin
- Ii
- Nr1c3
- Human
- Activated
adipose tissue
- Tissue
- Muscle
- Regulator
- Differentiation
- Mouse
- Factor
- Human
- Ii
- Placenta
- Activity
- Cell
- Expression
peroxisome proliferator-activated receptor
- Receptor
- Nuclear
- Proliferator-activated
- Gene
- Gamma
- Factor
- Ii
- Nr1c3
- Activated
- Also
- Expression
- Function
nicotinic acid adenine dinucleotide phosphate
- Fatty
- Storage
- Glucose
- Fat
- Insulin
- Factor
- Ii
- Activated
- Activity
- Adipose
- Cell
- Expression

Connections between topic areas Semantic bridges

For Peroxisome proliferator-activated receptor gamma, one of the stronger structural bridges in this analysis connects Peroxisome proliferator-activated receptor gamma with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Peroxisome proliferator-activated receptor gamma — Function · splits 37 ⟂ 23

Peroxisome proliferator-activated receptor gamma — Interactions · splits 46 ⟂ 14

Peroxisome proliferator-activated receptor gamma — Gene expression · splits 52 ⟂ 8

Peroxisome proliferator-activated receptor gamma — Research · splits 52 ⟂ 8

Peroxisome proliferator-activated receptor gamma — Overview · splits 56 ⟂ 4

Map overview Semantic statistics

Peroxisome proliferator-activated receptor gamma

Nodes60

Edges59

Triples195

Avg. degree1.97

Density0.033333

Components1

Source & methodology

TTTA analyzes the structure around Peroxisome proliferator-activated receptor gamma to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Research & Standards, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Peroxisome proliferator-activated receptor gamma · EN edition · Analysis: TopicsToTalkAbout

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