Research any topic before you write.

Find related topics.Discover entities.See connections.Build a topical map.

PROX1

Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene. The Prox1 gene is critical for the development of multiple tissues. Prox1 activity is necessary and sufficient to specify a lymphatic endothelial cell fate in endothelial progenitors located in the embryonic veins.

Clinical significance, Production & Interactions

Interactive map loads when it comes into view.
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Topic orientation

PROX1 at a glance

The strongest research directions include Clinical significance and Production. Use the connected concepts below as starting points, not as a keyword checklist.

Research this topic

Explore the main themes, entities and connections around PROX1. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Clinical significance

5 related topics

Production

3 related topics

Interactions

2 related topics

Homologous gene

1 related topic

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PROX1, prospero homeobox 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LMD
Band
1q32.3 · 1 H6|1 95.85 cM
Bgee
sural nerve · liver · right lobe of liver · right ventricle · buccal mucosa cell
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)

Topics to explore

A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Interactions

Production

Clinical significance

Homologous gene

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How this topic connects Entity context

Quick relationship hints grouped by predicate. Useful for spotting recurring semantic connections around the current entity.

See the strongest relationship patterns around the current topic before diving into the raw triples.

PROX1

Top relations

Gene ontology · 80
PROX1 → acinar cell differentiation, aorta smooth muscle tissue morphogenesis, atrial cardiac muscle tissue morphogenesis, brain development, branching involved in pancreas morphogenesis, cardiac muscle cell differentiation, cell fate determination, cerebellar granule cell differentiation, circadian rhythm, core promoter sequence-specific DNA binding, cytoplasm, dentate gyrus development, DNA binding, DNA binding domain binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, dorsal spinal cord development, embryonic retina morphogenesis in camera-type eye, endocardium formation
Bgee · 20
PROX1 → aortic valve, atrioventricular valve, biceps brachii, body of pancreas, buccal mucosa cell, corpus callosum, dentate gyrus of hippocampal formation granule cell, islet of Langerhans, lens, liver, lumbar subsegment of spinal cord, neural layer of retina, nucleus reuniens, right lobe of liver, right ventricle, Rostral migratory stream, Skeletal muscle tissue of biceps brachii, subthalamus, sural nerve, white matter
RNA expression pattern · 20
PROX1 → aortic valve, atrioventricular valve, biceps brachii, body of pancreas, buccal mucosa cell, corpus callosum, dentate gyrus of hippocampal formation granule cell, islet of Langerhans, lens, liver, lumbar subsegment of spinal cord, neural layer of retina, nucleus reuniens, right lobe of liver, right ventricle, Rostral migratory stream, Skeletal muscle tissue of biceps brachii, subthalamus, sural nerve, white matter
related to External links · 12
PROX1 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, Overview, PDB, PDBe-KB, Prospero, Q92786, This, UniProt, United States National Library
related to Clinical significance · 3
PROX1 → It, MG, Müller
Band · 2
PROX1 → 1 H6|1 95.85 cM, 1q32.3
Chr. · 2
PROX1 → Chromosome 1 (human), Chromosome 1 (mouse)
End · 2
PROX1 → 189,902,911 bp, 214,041,510 bp
related to Production · 2
PROX1 → Allen Brain Atlases, Gene
Aliases · 1
PROX1 → PROX1, prospero homeobox 1

Important terminology Word statistics

Frequent words and multi-word phrases across the lead, headings, infobox and body. Useful for terminology coverage.

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene human bp chr band chromosome protein mouse lymphatic prospero homeobox location development activity endothelial cell fate embryonic external pdb

Entity relationships Subject–Predicate–Object triples

Extracted RDF-like relationships with confidence and source. The table includes structured facts and lower-confidence contextual relations.
SubjectPredicateObjectConfidenceSrc
PROX1AliasesPROX1, prospero homeobox 11.00infobox
PROX1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LMD1.00infobox
PROX1Band1q32.31.00infobox
PROX1Band1 H6|1 95.85 cM1.00infobox
PROX1Bgeesural nerve1.00infobox
PROX1Bgeeliver1.00infobox
PROX1Bgeeright lobe of liver1.00infobox
PROX1Bgeeright ventricle1.00infobox
PROX1Bgeebuccal mucosa cell1.00infobox
PROX1Bgeecorpus callosum1.00infobox
PROX1Bgeebiceps brachii1.00infobox
PROX1Bgeeislet of Langerhans1.00infobox
PROX1BgeeSkeletal muscle tissue of biceps brachii1.00infobox
PROX1Bgeebody of pancreas1.00infobox
PROX1Bgeelens1.00infobox
PROX1Bgeeneural layer of retina1.00infobox
PROX1Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
PROX1Bgeesubthalamus1.00infobox
PROX1Bgeeatrioventricular valve1.00infobox
PROX1Bgeenucleus reuniens1.00infobox
PROX1Bgeelumbar subsegment of spinal cord1.00infobox
PROX1BgeeRostral migratory stream1.00infobox
PROX1Bgeewhite matter1.00infobox
PROX1Bgeeaortic valve1.00infobox
PROX1BioGPSMore reference expression data1.00infobox
PROX1Chr.Chromosome 1 (human)1.00infobox
PROX1Chr.Chromosome 1 (mouse)1.00infobox
PROX1DatabasesNCBI: entry; OMA: entry1.00infobox
PROX1End214,041,510 bp1.00infobox
PROX1End189,902,911 bp1.00infobox

Related concept clusters Concept neighborhoods

Clusters of nearby vocabulary surrounding the topic. Scan them for adjacent concepts and language you may have missed.

These clusters group vocabulary that occurs around closely connected concepts in the source material.

    Connections between topic areas Semantic bridges

    Bridge nodes connect otherwise separate parts of the map. Expand a row to inspect the topic groups on each side.

    Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

    Map overview Semantic statistics

    Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.

    PROX1

    Nodes19
    Edges18
    Triples161
    Avg. degree1.89
    Density0.105263
    Components1
    For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.