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PROX1: Clinical significance, Production & Interactions

Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene. The Prox1 gene is critical for the development of multiple tissues. Prox1 activity is necessary and sufficient to specify a lymphatic endothelial cell fate in endothelial progenitors located in the embryonic veins.

Language: English [EN]
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PROX1 topic overview

The analysis highlights Clinical significance, Production and Interactions as prominent areas in the source structure around PROX1.

Related topics
13
Source areas
5
Connected nodes
18
Extracted relationships
161
Concept neighborhoods
8
Bridge connections
18

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 5 topics
Production · 3 topics
Interactions · 2 topics
Overview · 2 topics
Homologous gene · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
PROX1, prospero homeobox 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LMD
Band
1q32.3 · 1 H6|1 95.85 cM
Bgee
sural nerve · liver · right lobe of liver · right ventricle · buccal mucosa cell
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 1 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Interactions

Production

Clinical significance

Homologous gene

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PROX1 connects Entity context

The extracted context around PROX1 shows recurring relationship patterns in the source. For example, PROX1 → acinar cell differentiation, aorta smooth muscle tissue morphogenesis, atrial cardiac muscle tissue morphogenesis, brain development, branching involved in pancreas morphogenesis, cardiac muscle cell differentiation, cell fate determination, cerebellar granule cell differentiation, circadian rhythm, core promoter sequence-specific DNA binding, cytoplasm, dentate gyrus development, DNA binding, DNA binding domain binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, dorsal spinal cord development, embryonic retina morphogenesis in camera-type eye, endocardium formation Another extracted example is PROX1 → aortic valve, atrioventricular valve, biceps brachii, body of pancreas, buccal mucosa cell, corpus callosum, dentate gyrus of hippocampal formation granule cell, islet of Langerhans, lens, liver, lumbar subsegment of spinal cord, neural layer of retina, nucleus reuniens, right lobe of liver, right ventricle, Rostral migratory stream, Skeletal muscle tissue of biceps brachii, subthalamus, sural nerve, white matter. Use these groups to spot repeated connection types before inspecting the individual relationships.

PROX1

Top relations

Gene ontology · 80
PROX1 → acinar cell differentiation, aorta smooth muscle tissue morphogenesis, atrial cardiac muscle tissue morphogenesis, brain development, branching involved in pancreas morphogenesis, cardiac muscle cell differentiation, cell fate determination, cerebellar granule cell differentiation, circadian rhythm, core promoter sequence-specific DNA binding, cytoplasm, dentate gyrus development, DNA binding, DNA binding domain binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, dorsal spinal cord development, embryonic retina morphogenesis in camera-type eye, endocardium formation
Bgee · 20
PROX1 → aortic valve, atrioventricular valve, biceps brachii, body of pancreas, buccal mucosa cell, corpus callosum, dentate gyrus of hippocampal formation granule cell, islet of Langerhans, lens, liver, lumbar subsegment of spinal cord, neural layer of retina, nucleus reuniens, right lobe of liver, right ventricle, Rostral migratory stream, Skeletal muscle tissue of biceps brachii, subthalamus, sural nerve, white matter
RNA expression pattern · 20
PROX1 → aortic valve, atrioventricular valve, biceps brachii, body of pancreas, buccal mucosa cell, corpus callosum, dentate gyrus of hippocampal formation granule cell, islet of Langerhans, lens, liver, lumbar subsegment of spinal cord, neural layer of retina, nucleus reuniens, right lobe of liver, right ventricle, Rostral migratory stream, Skeletal muscle tissue of biceps brachii, subthalamus, sural nerve, white matter
related to External links · 12
PROX1 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, Overview, PDB, PDBe-KB, Prospero, Q92786, This, UniProt, United States National Library
related to Clinical significance · 3
PROX1 → It, MG, Müller
Band · 2
PROX1 → 1 H6|1 95.85 cM, 1q32.3
Chr. · 2
PROX1 → Chromosome 1 (human), Chromosome 1 (mouse)
End · 2
PROX1 → 189,902,911 bp, 214,041,510 bp
related to Production · 2
PROX1 → Allen Brain Atlases, Gene
Aliases · 1
PROX1 → PROX1, prospero homeobox 1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene human bp chr band chromosome protein mouse lymphatic prospero homeobox location development activity endothelial cell fate embryonic external pdb

PROX1 relationships Subject–Predicate–Object triples

TTTA extracted 161 structured relationships around PROX1. Examples in this analysis include PROX1 → Aliases → PROX1, prospero homeobox 1 and PROX1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LMD. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PROX1AliasesPROX1, prospero homeobox 11.00infobox
PROX1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LMD1.00infobox
PROX1Band1q32.31.00infobox
PROX1Band1 H6|1 95.85 cM1.00infobox
PROX1Bgeesural nerve1.00infobox
PROX1Bgeeliver1.00infobox
PROX1Bgeeright lobe of liver1.00infobox
PROX1Bgeeright ventricle1.00infobox
PROX1Bgeebuccal mucosa cell1.00infobox
PROX1Bgeecorpus callosum1.00infobox
PROX1Bgeebiceps brachii1.00infobox
PROX1Bgeeislet of Langerhans1.00infobox
PROX1BgeeSkeletal muscle tissue of biceps brachii1.00infobox
PROX1Bgeebody of pancreas1.00infobox
PROX1Bgeelens1.00infobox
PROX1Bgeeneural layer of retina1.00infobox
PROX1Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
PROX1Bgeesubthalamus1.00infobox
PROX1Bgeeatrioventricular valve1.00infobox
PROX1Bgeenucleus reuniens1.00infobox
PROX1Bgeelumbar subsegment of spinal cord1.00infobox
PROX1BgeeRostral migratory stream1.00infobox
PROX1Bgeewhite matter1.00infobox
PROX1Bgeeaortic valve1.00infobox
PROX1BioGPSMore reference expression data1.00infobox
PROX1Chr.Chromosome 1 (human)1.00infobox
PROX1Chr.Chromosome 1 (mouse)1.00infobox
PROX1DatabasesNCBI: entry; OMA: entry1.00infobox
PROX1End214,041,510 bp1.00infobox
PROX1End189,902,911 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PROX1 bring nearby vocabulary together. In this analysis, examples include Human, Dentate and Gyrus. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • protein
    • Q92786
    • Uniprot
    • Prox1
    • Human
    • Activity
    • Available
    • Cell
    • Dentate
    • Development
    • Embryonic
    • End
    • Endothelial
  • gene
    • Human
    • Location
    • Chromosome
    • Mouse
    • Prox1
    • Bp
    • Chr
    • Development
    • End
    • Expression
    • H6
    • Search
  • white matter
    • Dentate
    • Gyrus
    • Matter
    • White
    • Mouse
    • Activity
    • Cell
    • Development
    • Embryonic
    • End
    • Endothelial
    • Expression
  • homologous gene
    • Human
    • Location
    • Chromosome
    • Mouse
    • Prox1
    • Bp
    • Chr
    • Development
    • End
    • Expression
    • H6
    • Search
  • lymphatic
    • Cell
    • Embryonic
    • Endothelial
    • Fate
    • Prox1
    • Dentate
    • End
    • Expression
    • Gyrus
    • H6
    • Matter
    • Q92786
  • dentate gyrus
    • Gyrus
    • Matter
    • White
    • Mouse
    • Development
    • Embryonic
    • End
    • Endothelial
    • Expression
    • Fate
    • H6
    • Humans
  • PROX1
    • Human
    • Dentate
    • Gyrus
    • Matter
    • Search
    • White
    • Location
    • Mouse
    • End
    • Expression
    • H6
    • Pdb
  • prox1
    • Human
    • Dentate
    • Gyrus
    • Matter
    • Search
    • White
    • Location
    • Mouse
    • End
    • Expression
    • H6
    • Pdb

Connections between topic areas Semantic bridges

For PROX1, one of the stronger structural bridges in this analysis connects PROX1 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PROX1Clinical significance · splits 13 ⟂ 6
PROX1Production · splits 15 ⟂ 4
PROX1Overview · splits 16 ⟂ 3
PROX1Interactions · splits 16 ⟂ 3

Map overview Semantic statistics

PROX1

Nodes19
Edges18
Triples161
Avg. degree1.89
Density0.105263
Components1

Source & methodology

TTTA analyzes the structure around PROX1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Production & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PROX1 · EN edition · Analysis: TopicsToTalkAbout

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