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Prospero homeobox protein 1 is a protein that in humans is encoded by the PROX1 gene. The Prox1 gene is critical for the development of multiple tissues. Prox1 activity is necessary and sufficient to specify a lymphatic endothelial cell fate in endothelial progenitors located in the embryonic veins.
The analysis highlights Clinical significance, Production and Interactions as prominent areas in the source structure around PROX1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around PROX1 shows recurring relationship patterns in the source. For example, PROX1 → acinar cell differentiation, aorta smooth muscle tissue morphogenesis, atrial cardiac muscle tissue morphogenesis, brain development, branching involved in pancreas morphogenesis, cardiac muscle cell differentiation, cell fate determination, cerebellar granule cell differentiation, circadian rhythm, core promoter sequence-specific DNA binding, cytoplasm, dentate gyrus development, DNA binding, DNA binding domain binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, dorsal spinal cord development, embryonic retina morphogenesis in camera-type eye, endocardium formation Another extracted example is PROX1 → aortic valve, atrioventricular valve, biceps brachii, body of pancreas, buccal mucosa cell, corpus callosum, dentate gyrus of hippocampal formation granule cell, islet of Langerhans, lens, liver, lumbar subsegment of spinal cord, neural layer of retina, nucleus reuniens, right lobe of liver, right ventricle, Rostral migratory stream, Skeletal muscle tissue of biceps brachii, subthalamus, sural nerve, white matter. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
gene human bp chr band chromosome protein mouse lymphatic prospero homeobox location development activity endothelial cell fate embryonic external pdb
TTTA extracted 161 structured relationships around PROX1. Examples in this analysis include PROX1 → Aliases → PROX1, prospero homeobox 1 and PROX1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LMD. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| PROX1 | Aliases | PROX1, prospero homeobox 1 | 1.00 | infobox |
| PROX1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LMD | 1.00 | infobox |
| PROX1 | Band | 1q32.3 | 1.00 | infobox |
| PROX1 | Band | 1 H6|1 95.85 cM | 1.00 | infobox |
| PROX1 | Bgee | sural nerve | 1.00 | infobox |
| PROX1 | Bgee | liver | 1.00 | infobox |
| PROX1 | Bgee | right lobe of liver | 1.00 | infobox |
| PROX1 | Bgee | right ventricle | 1.00 | infobox |
| PROX1 | Bgee | buccal mucosa cell | 1.00 | infobox |
| PROX1 | Bgee | corpus callosum | 1.00 | infobox |
| PROX1 | Bgee | biceps brachii | 1.00 | infobox |
| PROX1 | Bgee | islet of Langerhans | 1.00 | infobox |
| PROX1 | Bgee | Skeletal muscle tissue of biceps brachii | 1.00 | infobox |
| PROX1 | Bgee | body of pancreas | 1.00 | infobox |
| PROX1 | Bgee | lens | 1.00 | infobox |
| PROX1 | Bgee | neural layer of retina | 1.00 | infobox |
| PROX1 | Bgee | dentate gyrus of hippocampal formation granule cell | 1.00 | infobox |
| PROX1 | Bgee | subthalamus | 1.00 | infobox |
| PROX1 | Bgee | atrioventricular valve | 1.00 | infobox |
| PROX1 | Bgee | nucleus reuniens | 1.00 | infobox |
| PROX1 | Bgee | lumbar subsegment of spinal cord | 1.00 | infobox |
| PROX1 | Bgee | Rostral migratory stream | 1.00 | infobox |
| PROX1 | Bgee | white matter | 1.00 | infobox |
| PROX1 | Bgee | aortic valve | 1.00 | infobox |
| PROX1 | BioGPS | More reference expression data | 1.00 | infobox |
| PROX1 | Chr. | Chromosome 1 (human) | 1.00 | infobox |
| PROX1 | Chr. | Chromosome 1 (mouse) | 1.00 | infobox |
| PROX1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| PROX1 | End | 214,041,510 bp | 1.00 | infobox |
| PROX1 | End | 189,902,911 bp | 1.00 | infobox |
The concept neighborhoods around PROX1 bring nearby vocabulary together. In this analysis, examples include Human, Dentate and Gyrus. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For PROX1, one of the stronger structural bridges in this analysis connects PROX1 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around PROX1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical significance, Production & Interactions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — PROX1 · EN edition · Analysis: TopicsToTalkAbout