Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

Vascular endothelial growth factor: History, Clinical significance & Classification

Vascular endothelial growth factor (VEGF, /vɛdʒˈɛf/), originally known as vascular permeability factor (VPF), is a signal protein produced by many cells that stimulates the formation of blood vessels. To be specific, VEGF is a sub-family of growth factors, the platelet-derived growth factor family of cystine-knot growth factors. They are important…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

Vascular endothelial growth factor topic overview

The analysis highlights History, Clinical significance and Classification as prominent areas in the source structure around Vascular endothelial growth factor.

Related topics
75
Source areas
7
Connected nodes
82
Extracted relationships
31
Related term clusters
20
Bridge connections
82

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 21 topics
Overview · 17 topics
Classification · 10 topics
Mechanism · 10 topics
Isoforms · 8 topics
History · 5 topics
Expression · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Start with your topic. Discover where to go next.

Explore different angles and find fresh ideas to shape your next piece of content.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

History

Classification

Isoforms

Mechanism

Expression

Clinical significance

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How Vascular endothelial growth factor connects Entity context

The extracted context around Vascular endothelial growth factor shows recurring relationship patterns in the source. For example, Vascular endothelial growth factor → Another, CL, Class, Flt-1, KDR/Flk-1, Neuropilins, NRP, NRP/VEGFR, R3, The VEGF, Vascular, VEGF, VEGF-A, VEGF-C, VEGF-D, VEGF-mediated, VEGF165, VEGFC, VEGFD, VEGFR-1. Use these groups to spot repeated connection types before inspecting the individual relationships.

Vascular endothelial growth factor

Top relations

related to Mechanism · 25
Vascular endothelial growth factor → Another, CL, Class, Flt-1, KDR/Flk-1, Neuropilins, NRP, NRP/VEGFR, R3, The VEGF, Vascular, VEGF, VEGF-A, VEGF-C, VEGF-D, VEGF-mediated, VEGF165, VEGFC, VEGFD, VEGFR-1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

vegf vegf-a angiogenesis vascular cell endothelial blood factor growth cells disease receptor vessels expression receptors cause also oxygen shown although

Vascular endothelial growth factor relationships Subject–Predicate–Object triples

TTTA extracted 31 structured relationships around Vascular endothelial growth factor. Examples in this analysis include in hypoxic conditions → instance of → It is part of the system that restores the oxygen supply to tissues when blood circulation is inadequate and aflibercept → instance of → Drugs. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
in hypoxic conditionsinstance ofIt is part of the system that restores the oxygen supply to tissues when blood circulation is inadequate0.80text
afliberceptinstance ofDrugs0.80text
bevacizumabinstance ofDrugs0.80text
ranibizumabinstance ofDrugs0.80text
and pegaptanib can inhibit VEGFinstance ofDrugs0.80text
control or slow those diseasesinstance ofDrugs0.80text
Vascular endothelial growth factorrelated to MechanismVEGF0.60section
Vascular endothelial growth factorrelated to MechanismVEGFRs0.60section
Vascular endothelial growth factorrelated to MechanismThe VEGF0.60section
Vascular endothelial growth factorrelated to MechanismVEGF-A0.60section
Vascular endothelial growth factorrelated to MechanismVEGFR-10.60section
Vascular endothelial growth factorrelated to MechanismFlt-10.60section

Related concept clusters Related term clusters

The concept neighborhoods around Vascular endothelial growth factor bring nearby vocabulary together. In this analysis, examples include Vascular, Growth and Cells. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Vascular endothelial growth factor
    • Vascular
    • Growth
    • Cells
    • Permeability
    • Angiogenesis
    • Although
    • Cause
    • Disease
    • Factor
    • Cell
    • System
    • Proteins
  • vascular endothelial growth factor
    • Vascular
    • Growth
    • Factor
    • Permeability
    • Cells
    • Angiogenesis
    • Formation
    • Tumors
    • Vessels
    • Al
    • Et
    • Also
  • platelet-derived growth factor
    • Vascular
    • Factor
    • Growth
    • Permeability
    • Formation
    • Angiogenesis
    • Tumors
    • Vessels
    • Al
    • Et
    • Also
    • Blood
  • angiogenesis
    • Endothelial
    • Expression
    • Growth
    • Formation
    • Vascular
    • Proteins
    • Important
    • Also
    • Cells
    • Vegf-a
    • System
    • Vegf
  • vegf receptors
    • Cell
    • Receptors
    • Vegf
    • Receptor
    • Decreased
    • System
    • Addition
    • Binding
    • Al
    • Et
    • Shown
    • Although
  • blood vessels
    • Blood
    • Vessels
    • Formation
    • System
    • Growth
    • Cells
    • Endothelial
    • Retina
    • Function
    • Known
    • Permeability
    • Proteins
  • hypoxia-inducible factor
    • Growth
    • Permeability
    • Vascular
    • Tumors
    • Al
    • Et
    • Also
    • Cells
    • Vegf
    • Formation
    • Known
    • Oxygen
  • growth factors
    • Vascular
    • Factor
    • Formation
    • Angiogenesis
    • Vessels
    • Blood
    • Cells
    • System
    • Known
    • Permeability
    • Proteins
    • Vegf-d

Connections between topic areas Semantic bridges

For Vascular endothelial growth factor, one of the stronger structural bridges in this analysis connects Vascular endothelial growth factor with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Vascular endothelial growth factor — Clinical significance · splits 61 ⟂ 22
Vascular endothelial growth factor — Overview · splits 65 ⟂ 18
Vascular endothelial growth factor — Classification · splits 72 ⟂ 11
Vascular endothelial growth factor — Mechanism · splits 72 ⟂ 11
Vascular endothelial growth factor — Isoforms · splits 74 ⟂ 9
Vascular endothelial growth factor — History · splits 77 ⟂ 6
Vascular endothelial growth factor — Expression · splits 78 ⟂ 5

Map overview Semantic statistics

Vascular endothelial growth factor

Nodes83
Edges82
Triples31
Avg. degree1.98
Density0.024096
Components1

Source & methodology

TTTA analyzes the structure around Vascular endothelial growth factor to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Clinical significance & Classification, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Vascular endothelial growth factor · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.

Monitor your Domain Rating with FrogDR