NFATC2

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Explore the main themes, entities and connections around NFATC2. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Interactions

Interact MEF2D EP300 IRF4 Protein kinase Mζ

7 related topics

Function

NFAT DNA-binding protein REL-homology region Cytosol Translocates to the nucleus

6 related topics

Clinical significance

Translocation EWSR1 gene Bone tumor Ewing sarcoma N terminal

5 related topics

Overview

Protein Gene

2 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: NFATC2, NFAT1, NFATP, nuclear factor of activated T-cells 2, nuclear factor of activated T cells 2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A02, 1OWR, 1P7H, 1PZU, 2AS5, 2O93, 3QRF
Band: 20q13.2 · 2 H3|2 88.91 cM
Bgee: vena cava · synovial joint · synovial membrane · nipple · buccal mucosa cell
BioGPS: n/a
Chr.: Chromosome 20 (human) · Chromosome 2 (mouse)

Topics to explore

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Overview

Function

NFAT
DNA-binding protein
REL-homology region
Cytosol
Translocates to the nucleus Nuclear import
T cell receptor

Clinical significance

Translocation Chromosomal translocation
EWSR1 gene Ewing sarcoma breakpoint region 1
Bone tumor
Ewing sarcoma
N terminal

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

Nodes25

Edges24

Triples116

Avg. degree1.92

Density0.08

Components1

How this topic connects Entity context

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NFATC2

Top relations

Gene ontology · 36

NFATC2 → B cell receptor signaling pathway, calcineurin-NFAT signaling cascade, cell migration, cellular response to DNA damage stimulus, chromatin binding, cytokine production, cytoplasm, cytosol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, Fc-epsilon receptor signaling pathway, myotube cell development, negative regulation of transcription by RNA polymerase II, negative regulation of vascular associated smooth muscle cell differentiation, nucleoplasm, nucleus, phosphatase binding

Bgee · 20

NFATC2 → ankle, buccal mucosa cell, cartilage tissue, condyle, Epithelium of choroid plexus, facial motor nucleus, lumbar subsegment of spinal cord, mesenteric lymph nodes, motor neuron, nipple, pylorus, saphenous vein, skin of arm, soleus muscle, stroma of bone marrow, substantia nigra, synovial joint, synovial membrane, tendon of biceps brachii, vena cava

RNA expression pattern · 20

related to Interactions · 7

NFATC2 → EP300, IRF4, MEF2D, Mζ, NFCT2, Prostaglandin F2alpha, Protein

related to External links · 6

NFATC2 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library

related to Clinical significance · 4

NFATC2 → Ewing, EWSR1, The, Translocation

Band · 2

NFATC2 → 2 H3|2 88.91 cM, 20q13.2

Chr. · 2

NFATC2 → Chromosome 2 (mouse), Chromosome 20 (human)

End · 2

NFATC2 → 168,443,577 bp, 51,562,831 bp

Aliases · 1

NFATC2 → NFATC2, NFAT1, NFATP, nuclear factor of activated T-cells 2, nuclear factor of activated T cells 2

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene bp protein human chr band factor chromosome 20 nuclear activated cells location mouse transcription region complex t-cells function external

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
NFATC2	Aliases	NFATC2, NFAT1, NFATP, nuclear factor of activated T-cells 2, nuclear factor of activated T cells 2	1.00	infobox
NFATC2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A02, 1OWR, 1P7H, 1PZU, 2AS5, 2O93, 3QRF	1.00	infobox
NFATC2	Band	20q13.2	1.00	infobox
NFATC2	Band	2 H3\|2 88.91 cM	1.00	infobox
NFATC2	Bgee	vena cava	1.00	infobox
NFATC2	Bgee	synovial joint	1.00	infobox
NFATC2	Bgee	synovial membrane	1.00	infobox
NFATC2	Bgee	nipple	1.00	infobox
NFATC2	Bgee	buccal mucosa cell	1.00	infobox
NFATC2	Bgee	pylorus	1.00	infobox
NFATC2	Bgee	tendon of biceps brachii	1.00	infobox
NFATC2	Bgee	cartilage tissue	1.00	infobox
NFATC2	Bgee	saphenous vein	1.00	infobox
NFATC2	Bgee	skin of arm	1.00	infobox
NFATC2	Bgee	lumbar subsegment of spinal cord	1.00	infobox
NFATC2	Bgee	motor neuron	1.00	infobox
NFATC2	Bgee	substantia nigra	1.00	infobox
NFATC2	Bgee	ankle	1.00	infobox
NFATC2	Bgee	condyle	1.00	infobox
NFATC2	Bgee	facial motor nucleus	1.00	infobox
NFATC2	Bgee	stroma of bone marrow	1.00	infobox
NFATC2	Bgee	soleus muscle	1.00	infobox
NFATC2	Bgee	mesenteric lymph nodes	1.00	infobox
NFATC2	Bgee	Epithelium of choroid plexus	1.00	infobox
NFATC2	BioGPS	n/a	1.00	infobox
NFATC2	Chr.	Chromosome 20 (human)	1.00	infobox
NFATC2	Chr.	Chromosome 2 (mouse)	1.00	infobox
NFATC2	Databases	NCBI: entry; OMA: entry	1.00	infobox
NFATC2	End	51,562,831 bp	1.00	infobox
NFATC2	End	168,443,577 bp	1.00	infobox

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