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NFATC2: Regions, Interactions & Function

Nuclear factor of activated T-cells, cytoplasmic 2 is a protein that in humans is encoded by the NFATC2 gene.

Language: English [EN]
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NFATC2 topic overview

The analysis highlights Regions, Interactions and Function as prominent areas in the source structure around NFATC2.

Related topics
20
Source areas
4
Connected nodes
24
Extracted relationships
116
Concept neighborhoods
16
Bridge connections
24

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 7 topics
Function · 6 topics
Clinical significance · 5 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
NFATC2, NFAT1, NFATP, nuclear factor of activated T-cells 2, nuclear factor of activated T cells 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A02, 1OWR, 1P7H, 1PZU, 2AS5, 2O93, 3QRF
Band
20q13.2 · 2 H3|2 88.91 cM
Bgee
vena cava · synovial joint · synovial membrane · nipple · buccal mucosa cell
BioGPS
n/a
Chr.
Chromosome 20 (human) · Chromosome 2 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How NFATC2 connects Entity context

The extracted context around NFATC2 shows recurring relationship patterns in the source. For example, NFATC2 → B cell receptor signaling pathway, calcineurin-NFAT signaling cascade, cell migration, cellular response to DNA damage stimulus, chromatin binding, cytokine production, cytoplasm, cytosol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, Fc-epsilon receptor signaling pathway, myotube cell development, negative regulation of transcription by RNA polymerase II, negative regulation of vascular associated smooth muscle cell differentiation, nucleoplasm, nucleus, phosphatase binding Another extracted example is NFATC2 → ankle, buccal mucosa cell, cartilage tissue, condyle, Epithelium of choroid plexus, facial motor nucleus, lumbar subsegment of spinal cord, mesenteric lymph nodes, motor neuron, nipple, pylorus, saphenous vein, skin of arm, soleus muscle, stroma of bone marrow, substantia nigra, synovial joint, synovial membrane, tendon of biceps brachii, vena cava. Use these groups to spot repeated connection types before inspecting the individual relationships.

NFATC2

Top relations

Gene ontology · 36
NFATC2 → B cell receptor signaling pathway, calcineurin-NFAT signaling cascade, cell migration, cellular response to DNA damage stimulus, chromatin binding, cytokine production, cytoplasm, cytosol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, Fc-epsilon receptor signaling pathway, myotube cell development, negative regulation of transcription by RNA polymerase II, negative regulation of vascular associated smooth muscle cell differentiation, nucleoplasm, nucleus, phosphatase binding
Bgee · 20
NFATC2 → ankle, buccal mucosa cell, cartilage tissue, condyle, Epithelium of choroid plexus, facial motor nucleus, lumbar subsegment of spinal cord, mesenteric lymph nodes, motor neuron, nipple, pylorus, saphenous vein, skin of arm, soleus muscle, stroma of bone marrow, substantia nigra, synovial joint, synovial membrane, tendon of biceps brachii, vena cava
RNA expression pattern · 20
NFATC2 → ankle, buccal mucosa cell, cartilage tissue, condyle, Epithelium of choroid plexus, facial motor nucleus, lumbar subsegment of spinal cord, mesenteric lymph nodes, motor neuron, nipple, pylorus, saphenous vein, skin of arm, soleus muscle, stroma of bone marrow, substantia nigra, synovial joint, synovial membrane, tendon of biceps brachii, vena cava
related to Interactions · 7
NFATC2 → EP300, IRF4, MEF2D, Mζ, NFCT2, Prostaglandin F2alpha, Protein
related to External links · 6
NFATC2 → Medicine, Medicine Medical Subject Headings, MeSH, National Library, This, United States National Library
related to Clinical significance · 4
NFATC2 → Ewing, EWSR1, The, Translocation
Band · 2
NFATC2 → 2 H3|2 88.91 cM, 20q13.2
Chr. · 2
NFATC2 → Chromosome 2 (mouse), Chromosome 20 (human)
End · 2
NFATC2 → 168,443,577 bp, 51,562,831 bp
Aliases · 1
NFATC2 → NFATC2, NFAT1, NFATP, nuclear factor of activated T-cells 2, nuclear factor of activated T cells 2

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene bp protein human chr band factor chromosome 20 nuclear activated cells location mouse transcription region complex t-cells function external

NFATC2 relationships Subject–Predicate–Object triples

TTTA extracted 116 structured relationships around NFATC2. Examples in this analysis include NFATC2 → Aliases → NFATC2, NFAT1, NFATP, nuclear factor of activated T-cells 2, nuclear factor of activated T cells 2 and NFATC2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A02, 1OWR, 1P7H, 1PZU, 2AS5, 2O93, 3QRF. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
NFATC2AliasesNFATC2, NFAT1, NFATP, nuclear factor of activated T-cells 2, nuclear factor of activated T cells 21.00infobox
NFATC2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1A02, 1OWR, 1P7H, 1PZU, 2AS5, 2O93, 3QRF1.00infobox
NFATC2Band20q13.21.00infobox
NFATC2Band2 H3|2 88.91 cM1.00infobox
NFATC2Bgeevena cava1.00infobox
NFATC2Bgeesynovial joint1.00infobox
NFATC2Bgeesynovial membrane1.00infobox
NFATC2Bgeenipple1.00infobox
NFATC2Bgeebuccal mucosa cell1.00infobox
NFATC2Bgeepylorus1.00infobox
NFATC2Bgeetendon of biceps brachii1.00infobox
NFATC2Bgeecartilage tissue1.00infobox
NFATC2Bgeesaphenous vein1.00infobox
NFATC2Bgeeskin of arm1.00infobox
NFATC2Bgeelumbar subsegment of spinal cord1.00infobox
NFATC2Bgeemotor neuron1.00infobox
NFATC2Bgeesubstantia nigra1.00infobox
NFATC2Bgeeankle1.00infobox
NFATC2Bgeecondyle1.00infobox
NFATC2Bgeefacial motor nucleus1.00infobox
NFATC2Bgeestroma of bone marrow1.00infobox
NFATC2Bgeesoleus muscle1.00infobox
NFATC2Bgeemesenteric lymph nodes1.00infobox
NFATC2BgeeEpithelium of choroid plexus1.00infobox
NFATC2BioGPSn/a1.00infobox
NFATC2Chr.Chromosome 20 (human)1.00infobox
NFATC2Chr.Chromosome 2 (mouse)1.00infobox
NFATC2DatabasesNCBI: entry; OMA: entry1.00infobox
NFATC2End51,562,831 bp1.00infobox
NFATC2End168,443,577 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around NFATC2 bring nearby vocabulary together. In this analysis, examples include Protein, Gene and Nuclear. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • NFATC2
    • Protein
    • Gene
    • Nuclear
    • Human
    • Bone
    • Clinical
    • Function
    • Search
    • T-cells
    • Translocation
    • Location
    • Region
  • nfatc2
    • Protein
    • Gene
    • Nuclear
    • Human
    • Bone
    • Clinical
    • Function
    • Search
    • T-cells
    • Translocation
    • Location
    • Region
  • protein
    • Region
    • Cell
    • Cytosol
    • Dna-binding
    • Nucleus
    • Receptor
    • Complex
    • Transcription
    • Cells
    • Human
    • Bone
    • End
  • gene
    • Nfatc2
    • Location
    • Region
    • Protein
    • Chromosome
    • Nuclear
    • Bp
    • Chr
    • Human
    • Bone
    • Clinical
    • Dna-binding
  • dna-binding protein
    • Region
    • Cytosol
    • End
    • Function
    • H3
    • Mouse
    • Muscle
    • Nucleus
    • Receptor
    • Search
    • Cell
    • Dna-binding
  • t cell receptor
    • Cytosol
    • Nucleus
    • Receptor
    • Complex
    • Transcription
    • Cells
    • Nuclear
    • Bone
    • Dna-binding
    • End
    • Function
    • H3
  • ewsr1 gene
    • Nfatc2
    • Location
    • Region
    • Protein
    • Chromosome
    • Nuclear
    • Bp
    • Chr
    • Human
    • Bone
    • Clinical
    • Dna-binding
  • bone tumor
    • Cell
    • Clinical
    • Cytosol
    • Dna-binding
    • End
    • Function
    • H3
    • Mouse
    • Muscle
    • Nucleus
    • Receptor
    • Search

Connections between topic areas Semantic bridges

For NFATC2, one of the stronger structural bridges in this analysis connects NFATC2 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
NFATC2Interactions · splits 17 ⟂ 8
NFATC2Function · splits 18 ⟂ 7
NFATC2Clinical significance · splits 19 ⟂ 6
NFATC2Overview · splits 22 ⟂ 3

Map overview Semantic statistics

NFATC2

Nodes25
Edges24
Triples116
Avg. degree1.92
Density0.08
Components1

Source & methodology

TTTA analyzes the structure around NFATC2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Regions, Interactions & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — NFATC2 · EN edition · Analysis: TopicsToTalkAbout

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