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Coactivator (genetics)

A coactivator is a type of transcriptional coregulator that binds to an activator (a transcription factor) to increase the rate of transcription of a gene or set of genes. The activator contains a DNA binding domain that binds either to a DNA promoter site or a specific DNA regulatory sequence called an enhancer. Binding of the activator-coactivator…

Significance, Known coactivators & Mechanism

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Known coactivators

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Coactivator (genetics)

Nodes65
Edges64
Triples6
Avg. degree1.97
Density0.030769
Components1

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Important terminology

transcription coactivators gene expression dna promoter coactivator histone histones machinery activator many hat proteins targets function regulation binds specific complex

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TAF1instance ofCofactors0.80text
BTAF1 can initiate transcription in the presence of an activatorinstance ofCofactors0.80text
birth defectsinstance ofThis enables each cell to be able to quickly respond to environmental or physiological changes and helps to mitigate any damage that may occur if it were otherwise unregulated.A…0.80text
cancerinstance ofThis enables each cell to be able to quickly respond to environmental or physiological changes and helps to mitigate any damage that may occur if it were otherwise unregulated.A…0.80text
birth defectsinstance ofAssociated disordersMutations to coactivator genes leading to loss or gain of protein function have been linked to diseases and disorders0.80text
cancerinstance ofAssociated disordersMutations to coactivator genes leading to loss or gain of protein function have been linked to diseases and disorders0.80text

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