BCL3

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Clinical significance

Late-onset Alzheimer's disease (LOAD)Chronic lymphocytic leukemia Β-amyloid Solid tumors Metastasis

22 related topics

Interactions

Interact BARD1 C-Fos C-jun C22orf25

11 related topics

Role in cancer therapy

Chemotherapy Gliomas Immune checkpoint PD-L1 Drug design

10 related topics

Overview

Protein Gene Oncogene Immunoglobulin Locus

16 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: BCL3, BCL4, D19S37, B-cell CLL/lymphoma 3, B cell CLL/lymphoma 3, transcription coactivator, BCL3 transcription coactivator
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1K1A, 1K1B
Band: 19q13.32 · 7 A3|7 9.95 cM
Bgee: left uterine tube · right lobe of liver · upper lobe of left lung · gastric mucosa · mucosa of transverse colon
BioGPS: More reference expression data
Chr.: Chromosome 19 (human) · Chromosome 7 (mouse)

Topics to explore

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Overview

Protein
Gene
Oncogene
Immunoglobulin
Locus Locus (genetics)
B-cell leukemia
Ankyrin repeats Ankyrin repeat
I kappa B IκBα
Coactivator Coactivator (genetics)
NF-kappa B NF-κB
P50 NFKB1
BCL2
BCL6
BCL9
BCL10
Lymphoma

Interactions

Interact Protein-protein interaction
BARD1
C-Fos
C-jun
C22orf25
COPS5 COP9 constitutive photomorphogenic homolog subunit 5
EP300
HTATIP
NFKB2
PIR PIR (gene)
NR2B1 Retinoid X receptor alpha

Clinical significance

Late-onset Alzheimer's disease (LOAD) Alzheimer's disease
Chronic lymphocytic leukemia
Β-amyloid Amyloid beta
Solid tumors
Metastasis
ErbB2 HER2
Breast cancer
Colorectal cancer
AKT signalling Akt/PKB signaling pathway
Cancer stem cell
Beta-catenin Catenin beta-1
COX-2 Prostaglandin-endoperoxide synthase 2
Inflammatory cytokines Inflammatory cytokine
DNA damage
Hallmarks Hallmarks of cancer
Cell signalling Cell signaling
Wnt Wnt signaling pathway
Smad3 SMAD (protein)
Transcriptional regulation
Stat3 STAT protein
Phosphorylation
AKT

Role in cancer therapy

Chemotherapy
Gliomas Glioma
Immune checkpoint
PD-L1
Drug design
Protein-protein interaction Protein–protein interaction
Virtual screening
Cellular models Cellular model
Invasive breast cancer
Toxicity

Advanced semantic analysis

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Map overview Semantic statistics

Nodes64

Edges63

Triples143

Avg. degree1.97

Density0.03125

Components1

How this topic connects Entity context

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BCL3

Top relations

Gene ontology · 46

BCL3 → antimicrobial humoral response, Bcl3-Bcl10 complex, Bcl3/NF-kappaB2 complex, cellular response to DNA damage stimulus, cytoplasm, cytosol, defense response to bacterium, defense response to protozoan, DNA binding, DNA damage response, signal transduction by p53 class mediator, DNA-binding transcription factor activity, extracellular matrix organization, follicular dendritic cell differentiation, germinal center formation, humoral immune response mediated by circulating immunoglobulin, I-kappaB kinase/NF-kappaB signaling, intracellular membrane-bounded organelle, intrinsic apoptotic signaling pathway in response to DNA damage by p53 class mediator, maintenance of protein location in nucleus, marginal zone B cell differentiation

Bgee · 20

BCL3 → ankle joint, apex of heart, colon, duodenum, gastric mucosa, granulocyte, ileum, intestinal villus, jejunum, left adrenal cortex, left lobe of liver, left uterine tube, lumbar spinal ganglion, mesenteric lymph nodes, mucosa of transverse colon, olfactory zone of nasal mucosa, right lobe of liver, right lung, spleen, upper lobe of left lung

RNA expression pattern · 20

related to Clinical significance · 12

BCL3 → AKT, Alzheimer's, COX-2, DNA, ErbB2-positive, For, Further, Genetic, Increased, LOAD, NF-κB, The

related to Interactions · 10

BCL3 → BARD1, C-Fos, C-jun, C22orf25, COPS5, EP300, HTATIP, NFKB1, NFKB2, PIR

related to Role in cancer therapy · 6

BCL3 → Bcl3-inhibitory, DNA, In, NF-κB, PD-L1, The

related to Development · 3

BCL3 → It, TNA Therapeutics, TNAT-101

Band · 2

BCL3 → 19q13.32, 7 A3|7 9.95 cM

Chr. · 2

BCL3 → Chromosome 19 (human), Chromosome 7 (mouse)

End · 2

BCL3 → 19,556,695 bp, 44,760,044 bp

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene cancer protein bp human expression chr band cell role lymphoma tumor chromosome 19 location b-cell activity models colorectal transcriptional

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
BCL3	Aliases	BCL3, BCL4, D19S37, B-cell CLL/lymphoma 3, B cell CLL/lymphoma 3, transcription coactivator, BCL3 transcription coactivator	1.00	infobox
BCL3	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1K1A, 1K1B	1.00	infobox
BCL3	Band	19q13.32	1.00	infobox
BCL3	Band	7 A3\|7 9.95 cM	1.00	infobox
BCL3	Bgee	left uterine tube	1.00	infobox
BCL3	Bgee	right lobe of liver	1.00	infobox
BCL3	Bgee	upper lobe of left lung	1.00	infobox
BCL3	Bgee	gastric mucosa	1.00	infobox
BCL3	Bgee	mucosa of transverse colon	1.00	infobox
BCL3	Bgee	spleen	1.00	infobox
BCL3	Bgee	apex of heart	1.00	infobox
BCL3	Bgee	olfactory zone of nasal mucosa	1.00	infobox
BCL3	Bgee	left adrenal cortex	1.00	infobox
BCL3	Bgee	right lung	1.00	infobox
BCL3	Bgee	lumbar spinal ganglion	1.00	infobox
BCL3	Bgee	granulocyte	1.00	infobox
BCL3	Bgee	mesenteric lymph nodes	1.00	infobox
BCL3	Bgee	intestinal villus	1.00	infobox
BCL3	Bgee	jejunum	1.00	infobox
BCL3	Bgee	left lobe of liver	1.00	infobox
BCL3	Bgee	duodenum	1.00	infobox
BCL3	Bgee	colon	1.00	infobox
BCL3	Bgee	ileum	1.00	infobox
BCL3	Bgee	ankle joint	1.00	infobox
BCL3	BioGPS	More reference expression data	1.00	infobox
BCL3	Chr.	Chromosome 19 (human)	1.00	infobox
BCL3	Chr.	Chromosome 7 (mouse)	1.00	infobox
BCL3	Databases	NCBI: entry; OMA: entry	1.00	infobox
BCL3	End	44,760,044 bp	1.00	infobox
BCL3	End	19,556,695 bp	1.00	infobox

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