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Spironolactone, sold under the brand name Aldactone among others, is classed as a diuretic medication. It can be used to treat fluid build-up due to liver disease or kidney disease. It is also used to reduce risk of disease progression, hospitalization, and death due to some types of heart failure. Other uses include acne and excessive hair growth in…
The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Spironolactone.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Spironolactone shows recurring relationship patterns in the source. For example, Spironolactone → Aldactacine, Aldactazide, Aldactazine, Aldactide, Aldactone, Aldactone-A, Berlactone, Cardalis, CaroSpir, Dytor Plus, Espironolactona, Espironolactona Genfar, Fruselac, Lasilacton, Lasilactone, Metolactone, Novo-Spiroton, Other, Prilactone, Sali-Aldopur Another extracted example is Spironolactone → BANTooltip British Approved Name, DCFTooltip Dénomination Commune Française, DCITTooltip Denominazione Comune Italiana, French, German, INNTooltip International Nonproprietary Name, Italian, Its, JANTooltip Japanese Accepted Name, Latin, Name, NSC-150339, Portuguese, SC-9420, Spanish, Spironolacton, The English, USANTooltip United States Adopted, USPTooltip United States Pharmacopeia. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
effects women treatment acne also used levels hyperkalemia high side found due may potassium doses medication breast antiandrogen antiandrogenic well
TTTA extracted 345 structured relationships around Spironolactone. Examples in this analysis include Spironolactone → 3D model (JSmol) → Interactive image and Spironolactone → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Spironolactone | 3D model (JSmol) | Interactive image | 1.00 | infobox |
| Spironolactone | AHFS/Drugs.com | Monograph | 1.00 | infobox |
| Spironolactone | ATC code | C03DA01 (WHO) | 1.00 | infobox |
| Spironolactone | Bioavailability | 60–90% | 1.00 | infobox |
| Spironolactone | CAS Number | 52-01-7 Y | 1.00 | infobox |
| Spironolactone | ChEBI | CHEBI:9241 Y | 1.00 | infobox |
| Spironolactone | ChEMBL | ChEMBL1393 Y | 1.00 | infobox |
| Spironolactone | ChemSpider | 5628 Y | 1.00 | infobox |
| Spironolactone | CompTox Dashboard (EPA) | DTXSID6034186 | 1.00 | infobox |
| Spironolactone | Drug class | Antimineralocorticoid; Steroidal antiandrogen | 1.00 | infobox |
| Spironolactone | DrugBank | DB00421 Y | 1.00 | infobox |
| Spironolactone | ECHA InfoCard | 100.000.122 | 1.00 | infobox |
| Spironolactone | Elimination half-life | Spironolactone: 1.4 hrs 7α-TMSTooltip 7α-thiomethylspironolactone: 13.8 hours 6β-OH-7α-TMSTooltip 6β-hydroxy-7α-thiomethylspironolactone: 15.0 hrs Canrenone: 16.5 hours | 1.00 | infobox |
| Spironolactone | Excretion | Urine, bile | 1.00 | infobox |
| Spironolactone | Formula | C24H32O4S | 1.00 | infobox |
| Spironolactone | IUPHAR/BPS | 2875 | 1.00 | infobox |
| Spironolactone | KEGG | D00443 Y | 1.00 | infobox |
| Spironolactone | Legal status | UK: POM (Prescription only) | 1.00 | infobox |
| Spironolactone | Legal status | US: ℞-only | 1.00 | infobox |
| Spironolactone | Legal status | EU: Rx-only | 1.00 | infobox |
| Spironolactone | License data | US DailyMed: Spironolactone | 1.00 | infobox |
| Spironolactone | MedlinePlus | a682627 | 1.00 | infobox |
| Spironolactone | Melting point | 134 to 135 °C (273 to 275 °F) | 1.00 | infobox |
| Spironolactone | Metabolism | Liver, others: • Deacetylation via CESTooltip carboxylesterase • S-Oxygenation via FOMTooltip flavin-containing monooxygenase • S-Methylation via TMTTooltip thiol S-methyltransf… | 1.00 | infobox |
| Spironolactone | Metabolites | 7α-TSTooltip 7α-Thiospironolactone, 7α-TMSTooltip 7α-thiomethylspironolactone, 6β-OH-7α-TMSTooltip 6β-hydroxy-7α-thiomethylspironolactone, canrenone, others (All three active) | 1.00 | infobox |
| Spironolactone | Molar mass | 416.58 g·mol−1 | 1.00 | infobox |
| Spironolactone | Other names | SC-9420; NSC-150339; 7α-Acetylthiospirolactone; 7α-Acetylthio-17α-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone | 1.00 | infobox |
| Spironolactone | Pregnancy category | AU: B3 | 1.00 | infobox |
| Spironolactone | Pronunciation | /ˌspaɪroʊnoʊˈlæktoʊn/ SPY-roh-noh-LAK-tone, /ˌspɪəroʊnoʊˈlæktoʊn/ ⓘ SPEER-oh-noh-LAK-tone | 1.00 | infobox |
| Spironolactone | Protein binding | Spironolactone: 88% (to albumin and AGPTooltip alpha-1-acid glycoprotein) Canrenone: 99.2% (to albumin) | 1.00 | infobox |
The concept neighborhoods around Spironolactone bring nearby vocabulary together. In this analysis, examples include Women, Treatment and Levels. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Spironolactone, one of the stronger structural bridges in this analysis connects Spironolactone with Side effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Spironolactone to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Spironolactone · EN edition · Analysis: TopicsToTalkAbout