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Spironolactone: History, Community, Culture & Applications

Spironolactone, sold under the brand name Aldactone among others, is classed as a diuretic medication. It can be used to treat fluid build-up due to liver disease or kidney disease. It is also used to reduce risk of disease progression, hospitalization, and death due to some types of heart failure. Other uses include acne and excessive hair growth in…

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Spironolactone topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Spironolactone.

Related topics
374
Source areas
11
Connected nodes
385
Extracted relationships
345
Concept neighborhoods
43
Bridge connections
385

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Side effects · 80 topics
Overview · 79 topics
Medical uses · 77 topics
Pharmacology · 47 topics
Chemistry · 24 topics
Overdose · 17 topics
Society and culture · 16 topics
Interactions · 14 topics
Contraindications · 8 topics
Research · 7 topics
History · 5 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
C03DA01 (WHO)
Bioavailability
60–90%
CAS Number
52-01-7 Y
ChEBI
CHEBI:9241 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Contraindications

Side effects

Overdose

Interactions

Pharmacology

Chemistry

History

Society and culture

Research

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Spironolactone connects Entity context

The extracted context around Spironolactone shows recurring relationship patterns in the source. For example, Spironolactone → Aldactacine, Aldactazide, Aldactazine, Aldactide, Aldactone, Aldactone-A, Berlactone, Cardalis, CaroSpir, Dytor Plus, Espironolactona, Espironolactona Genfar, Fruselac, Lasilacton, Lasilactone, Metolactone, Novo-Spiroton, Other, Prilactone, Sali-Aldopur Another extracted example is Spironolactone → BANTooltip British Approved Name, DCFTooltip Dénomination Commune Française, DCITTooltip Denominazione Comune Italiana, French, German, INNTooltip International Nonproprietary Name, Italian, Its, JANTooltip Japanese Accepted Name, Latin, Name, NSC-150339, Portuguese, SC-9420, Spanish, Spironolacton, The English, USANTooltip United States Adopted, USPTooltip United States Pharmacopeia. Use these groups to spot repeated connection types before inspecting the individual relationships.

Spironolactone

Top relations

related to Brand names · 43
Spironolactone → Aldactacine, Aldactazide, Aldactazine, Aldactide, Aldactone, Aldactone-A, Berlactone, Cardalis, CaroSpir, Dytor Plus, Espironolactona, Espironolactona Genfar, Fruselac, Lasilacton, Lasilactone, Metolactone, Novo-Spiroton, Other, Prilactone, Sali-Aldopur
related to Generic names · 19
Spironolactone → BANTooltip British Approved Name, DCFTooltip Dénomination Commune Française, DCITTooltip Denominazione Comune Italiana, French, German, INNTooltip International Nonproprietary Name, Italian, Its, JANTooltip Japanese Accepted Name, Latin, Name, NSC-150339, Portuguese, SC-9420, Spanish, Spironolacton, The English, USANTooltip United States Adopted, USPTooltip United States Pharmacopeia
related to High potassium levels · 19
Spironolactone → ACE, Although, An, At, However, II, July, Notably, Occasional, Of, Other, RALES, Randomized Aldactone Evaluation Study, Rarely, Scotland, Side, The, These, This
related to Skin and hair conditions · 13
Spironolactone → Androgens, Because, Conversely, DHT, II, In, Moreover, Oftentimes, Ongoing, Positive, Response, There, Though
related to Chemistry · 10
Spironolactone → AR, C17α, C17β, C7α, In, It, SC-5233, SC-8365, The C7α, These
related to Interactions · 10
Spironolactone → CYP3A4, Doctors, However, In, Physicians, Recent, The, Therefore, UDP-glucuronosyltransferases, UGT2B7
has effect · 9
Spironolactone → Also, Aside, At, Because, Hyperkalemia, In, One, Other, The
related to Breast changes · 9
Spironolactone → As, At, Breast, Conversely, In, RALES, Some, The, This
related to Menstrual disturbances · 9
Spironolactone → An, CYP17A1, For, Indeed, It, Most, Regardless, The, They
related to Overdose · 9
Spironolactone → Hyperkalemia, In, Its, LD50, No, Symptoms, The, These, Treatment

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

effects women treatment acne also used levels hyperkalemia high side found due may potassium doses medication breast antiandrogen antiandrogenic well

Spironolactone relationships Subject–Predicate–Object triples

TTTA extracted 345 structured relationships around Spironolactone. Examples in this analysis include Spironolactone → 3D model (JSmol) → Interactive image and Spironolactone → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Spironolactone3D model (JSmol)Interactive image1.00infobox
SpironolactoneAHFS/Drugs.comMonograph1.00infobox
SpironolactoneATC codeC03DA01 (WHO)1.00infobox
SpironolactoneBioavailability60–90%1.00infobox
SpironolactoneCAS Number52-01-7 Y1.00infobox
SpironolactoneChEBICHEBI:9241 Y1.00infobox
SpironolactoneChEMBLChEMBL1393 Y1.00infobox
SpironolactoneChemSpider5628 Y1.00infobox
SpironolactoneCompTox Dashboard (EPA)DTXSID60341861.00infobox
SpironolactoneDrug classAntimineralocorticoid; Steroidal antiandrogen1.00infobox
SpironolactoneDrugBankDB00421 Y1.00infobox
SpironolactoneECHA InfoCard100.000.1221.00infobox
SpironolactoneElimination half-lifeSpironolactone: 1.4 hrs 7α-TMSTooltip 7α-thiomethylspironolactone: 13.8 hours 6β-OH-7α-TMSTooltip 6β-hydroxy-7α-thiomethylspironolactone: 15.0 hrs Canrenone: 16.5 hours1.00infobox
SpironolactoneExcretionUrine, bile1.00infobox
SpironolactoneFormulaC24H32O4S1.00infobox
SpironolactoneIUPHAR/BPS28751.00infobox
SpironolactoneKEGGD00443 Y1.00infobox
SpironolactoneLegal statusUK: POM (Prescription only)1.00infobox
SpironolactoneLegal statusUS: ℞-only1.00infobox
SpironolactoneLegal statusEU: Rx-only1.00infobox
SpironolactoneLicense dataUS DailyMed: Spironolactone1.00infobox
SpironolactoneMedlinePlusa6826271.00infobox
SpironolactoneMelting point134 to 135 °C (273 to 275 °F)1.00infobox
SpironolactoneMetabolismLiver, others: • Deacetylation via CESTooltip carboxylesterase • S-Oxygenation via FOMTooltip flavin-containing monooxygenase • S-Methylation via TMTTooltip thiol S-methyltransf…1.00infobox
SpironolactoneMetabolites7α-TSTooltip 7α-Thiospironolactone, 7α-TMSTooltip 7α-thiomethylspironolactone, 6β-OH-7α-TMSTooltip 6β-hydroxy-7α-thiomethylspironolactone, canrenone, others (All three active)1.00infobox
SpironolactoneMolar mass416.58 g·mol−11.00infobox
SpironolactoneOther namesSC-9420; NSC-150339; 7α-Acetylthiospirolactone; 7α-Acetylthio-17α-hydroxy-3-oxopregn-4-ene-21-carboxylic acid γ-lactone1.00infobox
SpironolactonePregnancy categoryAU: B31.00infobox
SpironolactonePronunciation/ˌspaɪroʊnoʊˈlæktoʊn/ SPY-roh-noh-LAK-tone, /ˌspɪəroʊnoʊˈlæktoʊn/ ⓘ SPEER-oh-noh-LAK-tone1.00infobox
SpironolactoneProtein bindingSpironolactone: 88% (to albumin and AGPTooltip alpha-1-acid glycoprotein) Canrenone: 99.2% (to albumin)1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Spironolactone bring nearby vocabulary together. In this analysis, examples include Women, Treatment and Levels. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Spironolactone
    • Women
    • Treatment
    • Levels
    • Found
    • Used
    • Side
    • Hyperkalemia
    • Doses
    • Antiandrogenic
    • Cause
    • Well
    • Activity
  • spironolactone
    • Women
    • Treatment
    • Levels
    • Found
    • Used
    • Side
    • Hyperkalemia
    • Doses
    • Antiandrogenic
    • Cause
    • Well
    • Activity
  • liver disease
    • Aldosterone
    • Blood
    • Use
    • Failure
    • Antiandrogen
    • Heart
    • Used
    • Treatment
    • Potassium
    • Side
    • Oral
    • Levels
  • low blood potassium
    • Levels
    • Potassium
    • Hyperkalemia
    • High
    • Use
    • Risk
    • Blood
    • Low
    • Doses
    • Failure
    • Heart
    • People
  • block the effects
    • Side
    • Spironolactone
    • Antiandrogenic
    • Breast
    • High
    • Levels
    • Doses
    • Men
    • Testosterone
    • May
    • Low
    • Antimineralocorticoid
  • side effects
    • Side
    • Breast
    • Spironolactone
    • Antiandrogenic
    • Gynecomastia
    • Men
    • High
    • Doses
    • Levels
    • Feminization
    • Hyperkalemia
    • Testosterone
  • high blood potassium
    • Doses
    • Levels
    • Potassium
    • Hyperkalemia
    • Low
    • Women
    • High
    • Use
    • Risk
    • Effects
    • Side
    • Failure
  • aldosterone
    • Antimineralocorticoid
    • Levels
    • Liver
    • Blood
    • Activity
    • High
    • Risk
    • Potassium
    • Due
    • Effects
    • Side
    • Used

Connections between topic areas Semantic bridges

For Spironolactone, one of the stronger structural bridges in this analysis connects Spironolactone with Side effects. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SpironolactoneSide effects · splits 305 ⟂ 81
SpironolactoneOverview · splits 306 ⟂ 80
SpironolactoneMedical uses · splits 308 ⟂ 78
SpironolactonePharmacology · splits 338 ⟂ 48
SpironolactoneChemistry · splits 361 ⟂ 25
SpironolactoneOverdose · splits 368 ⟂ 18
SpironolactoneSociety and culture · splits 369 ⟂ 17
SpironolactoneInteractions · splits 371 ⟂ 15
SpironolactoneContraindications · splits 377 ⟂ 9
SpironolactoneResearch · splits 378 ⟂ 8
SpironolactoneHistory · splits 380 ⟂ 6

Map overview Semantic statistics

Spironolactone

Nodes386
Edges385
Triples345
Avg. degree1.99
Density0.005181
Components1

Source & methodology

TTTA analyzes the structure around Spironolactone to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Spironolactone · EN edition · Analysis: TopicsToTalkAbout

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