KCNH2

Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.

Export map as:

Research this topic

Explore the main themes, entities and connections around KCNH2. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Explore this topic

Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.

Structure

X-ray crystallography Plasma membrane Α-helices N-C-termini

9 related topics

Naming

University of Wisconsin–Madison Drosophila City of Hope Duarte, California Ether

7 related topics

Inhibitors

Astemizole Domperidone Sertindole Terfenadine Vanoxerine

6 related topics

Function

Cardiac myocytes Isoforms Heterologous

3 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: KCNH2, ERG-1, ERG1, H-ERG, HERG, HERG1, Kv11.1, LQT2, SQT1, potassium voltage-gated channel subfamily H member 2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BYW, 1UJL, 2L0W, 2L1M, 2L4R, 2LE7, 4HP9, 4HQA, 2N7G
Band: 7q36.1 · 5 A3|5 10.94 cM
Bgee: apex of heart · right auricle of heart · left ventricle · muscle layer of sigmoid colon · right hemisphere of cerebellum
BioGPS: More reference expression data
Chr.: Chromosome 7 (human) · Chromosome 5 (mouse)

Topics to explore

Browse the full topic structure. Each item opens a new analysis centered on that subject.

Overview

Subunit Protein subunit
Potassium ion channel Potassium channel
Electrical activity of the heart Electrical conduction system of the heart
Cardiac action potential
Long QT syndrome
Short QT syndrome
Irregularity of the heartbeat Heart arrhythmia
Ventricular tachyarrhythmia
Torsades de pointes
Antitarget

Function

Cardiac myocytes Cardiac muscle
Isoforms Isoform
Heterologous

Structure

X-ray crystallography Crystallography
Plasma membrane Cell membrane
Α-helices Alpha helix
N- N-terminus
C-termini C-terminus
Arginine
Lysine
KcsA channels KcsA potassium channel
PAS domain

Genetics

Channelopathies Channelopathy

Drug interactions

Drug development considerations

GLP Good Laboratory Practice

Naming

University of Wisconsin–Madison
Drosophila
City of Hope City of Hope National Medical Center
Duarte, California
Ether Diethyl ether
Whisky a Go Go
West Hollywood, California

Interactions

Interact Protein-protein interaction
YWHAE

Inhibitors

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes51

Edges50

Triples113

Avg. degree1.96

Density0.039216

Components1

How this topic connects Entity context

See the strongest relationship patterns around the current topic before diving into the raw triples.

KCNH2

Top relations

Gene ontology · 50

KCNH2 → C3HC4-type RING finger domain binding, cardiac conduction, cardiac muscle contraction, cell surface, delayed rectifier potassium channel activity, identical protein binding, integral component of membrane, integral component of plasma membrane, inward rectifier potassium channel activity, inward rectifier potassium channel complex, ion channel activity, ion transport, membrane, membrane depolarization during action potential, membrane repolarization, membrane repolarization during action potential, membrane repolarization during cardiac muscle cell action potential, membrane repolarization during ventricular cardiac muscle cell action potential, negative regulation of potassium ion export across plasma membrane, negative regulation of potassium ion transmembrane transport

Bgee · 20

KCNH2 → anterior pituitary, apex of heart, atrium, central gray substance of midbrain, cerebellar cortex, choroid plexus of fourth ventricle, epithelium of lens, interventricular septum, left testis, left ventricle, lens, medulla oblongata, muscle layer of sigmoid colon, myocardium of left ventricle, neural layer of retina, pituitary gland, right auricle of heart, right hemisphere of cerebellum, right testis, right ventricle

RNA expression pattern · 20

Band · 2

KCNH2 → 5 A3|5 10.94 cM, 7q36.1

Chr. · 2

KCNH2 → Chromosome 5 (mouse), Chromosome 7 (human)

End · 2

KCNH2 → 150,978,321 bp, 24,556,602 bp

Aliases · 1

KCNH2 → KCNH2, ERG-1, ERG1, H-ERG, HERG, HERG1, Kv11.1, LQT2, SQT1, potassium voltage-gated channel subfamily H member 2

Available structures · 1

KCNH2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BYW, 1UJL, 2L0W, 2L1M, 2L4R, 2LE7, 4HP9, 4HQA, 2N7G

BioGPS · 1

KCNH2 → More reference expression data

Databases · 1

KCNH2 → NCBI: entry; OMA: entry

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

herg channel qt potassium human gene current bp cardiac potential ion drugs syndrome membrane heart chr band mutations repolarization drug

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
KCNH2	Aliases	KCNH2, ERG-1, ERG1, H-ERG, HERG, HERG1, Kv11.1, LQT2, SQT1, potassium voltage-gated channel subfamily H member 2	1.00	infobox
KCNH2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1BYW, 1UJL, 2L0W, 2L1M, 2L4R, 2LE7, 4HP9, 4HQA, 2N7G	1.00	infobox
KCNH2	Band	7q36.1	1.00	infobox
KCNH2	Band	5 A3\|5 10.94 cM	1.00	infobox
KCNH2	Bgee	apex of heart	1.00	infobox
KCNH2	Bgee	right auricle of heart	1.00	infobox
KCNH2	Bgee	left ventricle	1.00	infobox
KCNH2	Bgee	muscle layer of sigmoid colon	1.00	infobox
KCNH2	Bgee	right hemisphere of cerebellum	1.00	infobox
KCNH2	Bgee	pituitary gland	1.00	infobox
KCNH2	Bgee	myocardium of left ventricle	1.00	infobox
KCNH2	Bgee	anterior pituitary	1.00	infobox
KCNH2	Bgee	right testis	1.00	infobox
KCNH2	Bgee	left testis	1.00	infobox
KCNH2	Bgee	choroid plexus of fourth ventricle	1.00	infobox
KCNH2	Bgee	neural layer of retina	1.00	infobox
KCNH2	Bgee	right ventricle	1.00	infobox
KCNH2	Bgee	lens	1.00	infobox
KCNH2	Bgee	central gray substance of midbrain	1.00	infobox
KCNH2	Bgee	epithelium of lens	1.00	infobox
KCNH2	Bgee	medulla oblongata	1.00	infobox
KCNH2	Bgee	atrium	1.00	infobox
KCNH2	Bgee	interventricular septum	1.00	infobox
KCNH2	Bgee	cerebellar cortex	1.00	infobox
KCNH2	BioGPS	More reference expression data	1.00	infobox
KCNH2	Chr.	Chromosome 7 (human)	1.00	infobox
KCNH2	Chr.	Chromosome 5 (mouse)	1.00	infobox
KCNH2	Databases	NCBI: entry; OMA: entry	1.00	infobox
KCNH2	End	150,978,321 bp	1.00	infobox
KCNH2	End	24,556,602 bp	1.00	infobox

Related concept clusters Concept neighborhoods

These clusters group vocabulary that occurs around closely connected concepts in the source material.

Connections between topic areas Semantic bridges

Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.

Min side: 3