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GRIN2B: Art & Measurement

Glutamate Receptor Ionotropic subunit epsilon-2, also known as N-methyl D-aspartate receptor subtype 2B (NMDAR2B or NR2B), is a protein that in humans is encoded by the GRIN2B gene.

Language: English [EN]
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GRIN2B topic overview

The analysis highlights Art and Measurement as prominent areas in the source structure around GRIN2B.

Related topics
36
Source areas
5
Connected nodes
41
Extracted relationships
137
Concept neighborhoods
12
Bridge connections
41

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Ligands · 14 topics
Interactions · 8 topics
NMDA receptors · 8 topics
Function · 4 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
GRIN2B, GluN2B, MRD6, NMDAR2B, NR2B, hNR3, EIEE27, glutamate ionotropic receptor NMDA type subunit 2B, NR3, DEE27
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5EWM, 5EWL, 5EWJ
Band
12p13.1 · 6 G1|6 66.38 cM
Bgee
buccal mucosa cell · Brodmann area 23 · sural nerve · middle temporal gyrus · primary visual cortex
BioGPS
More reference expression data
Chr.
Chromosome 12 (human) · Chromosome 6 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

NMDA receptors

Function

Ligands

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How GRIN2B connects Entity context

The extracted context around GRIN2B shows recurring relationship patterns in the source. For example, GRIN2B → amyloid-beta binding, brain development, calcium ion transmembrane import into cytosol, calcium-mediated signaling, cell junction, cell surface, chemical synaptic transmission, cytoplasm, ephrin receptor signaling pathway, excitatory chemical synaptic transmission, excitatory postsynaptic potential, extracellularly glutamate-gated ion channel activity, glutamate binding, glutamate receptor signaling pathway, glutamate-gated calcium ion channel activity, glycine binding, integral component of membrane, integral component of plasma membrane, intracellular anatomical structure, ion channel activity Another extracted example is GRIN2B → anterior amygdaloid area, Brodmann area 23, buccal mucosa cell, corpus callosum, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, endothelial cell, lateral geniculate nucleus, lateral septal nucleus, middle temporal gyrus, nucleus accumbens, olfactory tubercle, prefrontal cortex, primary visual cortex, seminiferous tubule, subiculum, superior frontal gyrus, sural nerve. Use these groups to spot repeated connection types before inspecting the individual relationships.

GRIN2B

Top relations

Gene ontology · 51
GRIN2B → amyloid-beta binding, brain development, calcium ion transmembrane import into cytosol, calcium-mediated signaling, cell junction, cell surface, chemical synaptic transmission, cytoplasm, ephrin receptor signaling pathway, excitatory chemical synaptic transmission, excitatory postsynaptic potential, extracellularly glutamate-gated ion channel activity, glutamate binding, glutamate receptor signaling pathway, glutamate-gated calcium ion channel activity, glycine binding, integral component of membrane, integral component of plasma membrane, intracellular anatomical structure, ion channel activity
Bgee · 18
GRIN2B → anterior amygdaloid area, Brodmann area 23, buccal mucosa cell, corpus callosum, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, endothelial cell, lateral geniculate nucleus, lateral septal nucleus, middle temporal gyrus, nucleus accumbens, olfactory tubercle, prefrontal cortex, primary visual cortex, seminiferous tubule, subiculum, superior frontal gyrus, sural nerve
RNA expression pattern · 18
GRIN2B → anterior amygdaloid area, Brodmann area 23, buccal mucosa cell, corpus callosum, dentate gyrus of hippocampal formation granule cell, dorsolateral prefrontal cortex, endothelial cell, lateral geniculate nucleus, lateral septal nucleus, middle temporal gyrus, nucleus accumbens, olfactory tubercle, prefrontal cortex, primary visual cortex, seminiferous tubule, subiculum, superior frontal gyrus, sural nerve
related to NMDA receptors · 14
GRIN2B → GRIN1, GRIN2A, GRIN2C, GRIN2D, N-Methyl-D-aspartate, NMDA, NMDAR1, NMDAR2, NMDAR2A, NMDAR2B, NMDAR2C, NMDAR2D, The NMDA, The NR2
related to Function · 7
GRIN2B → Doogie, Engineered, LTP, NR2B, NR2B/NR2A, The, This
related to Interactions · 6
GRIN2B → Actinin, DLG2, DLG3, DLG4, EXOC4, LIN7B
Band · 2
GRIN2B → 12p13.1, 6 G1|6 66.38 cM
Chr. · 2
GRIN2B → Chromosome 12 (human), Chromosome 6 (mouse)
End · 2
GRIN2B → 13,982,002 bp, 136,150,509 bp
Aliases · 1
GRIN2B → GRIN2B, GluN2B, MRD6, NMDAR2B, NR2B, hNR3, EIEE27, glutamate ionotropic receptor NMDA type subunit 2B, NR3, DEE27

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

nmda receptor glutamate bp chr human band gene nr2b ionotropic chromosome 12 subunit function also mouse nmdar2b location protein receptors

GRIN2B relationships Subject–Predicate–Object triples

TTTA extracted 137 structured relationships around GRIN2B. Examples in this analysis include GRIN2B → Aliases → GRIN2B, GluN2B, MRD6, NMDAR2B, NR2B, hNR3, EIEE27, glutamate ionotropic receptor NMDA type subunit 2B, NR3, DEE27 and GRIN2B → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5EWM, 5EWL, 5EWJ. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
GRIN2BAliasesGRIN2B, GluN2B, MRD6, NMDAR2B, NR2B, hNR3, EIEE27, glutamate ionotropic receptor NMDA type subunit 2B, NR3, DEE271.00infobox
GRIN2BAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes5EWM, 5EWL, 5EWJ1.00infobox
GRIN2BBand12p13.11.00infobox
GRIN2BBand6 G1|6 66.38 cM1.00infobox
GRIN2BBgeebuccal mucosa cell1.00infobox
GRIN2BBgeeBrodmann area 231.00infobox
GRIN2BBgeesural nerve1.00infobox
GRIN2BBgeemiddle temporal gyrus1.00infobox
GRIN2BBgeeprimary visual cortex1.00infobox
GRIN2BBgeecorpus callosum1.00infobox
GRIN2BBgeeprefrontal cortex1.00infobox
GRIN2BBgeenucleus accumbens1.00infobox
GRIN2BBgeeendothelial cell1.00infobox
GRIN2BBgeedorsolateral prefrontal cortex1.00infobox
GRIN2BBgeelateral septal nucleus1.00infobox
GRIN2BBgeeolfactory tubercle1.00infobox
GRIN2BBgeelateral geniculate nucleus1.00infobox
GRIN2BBgeedentate gyrus of hippocampal formation granule cell1.00infobox
GRIN2BBgeeanterior amygdaloid area1.00infobox
GRIN2BBgeesuperior frontal gyrus1.00infobox
GRIN2BBgeesubiculum1.00infobox
GRIN2BBgeeseminiferous tubule1.00infobox
GRIN2BBioGPSMore reference expression data1.00infobox
GRIN2BChr.Chromosome 12 (human)1.00infobox
GRIN2BChr.Chromosome 6 (mouse)1.00infobox
GRIN2BDatabasesNCBI: entry; OMA: entry1.00infobox
GRIN2BEnd13,982,002 bp1.00infobox
GRIN2BEnd136,150,509 bp1.00infobox
GRIN2BEnsemblENSG000002730791.00infobox
GRIN2BEntrez29041.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around GRIN2B bring nearby vocabulary together. In this analysis, examples include Receptor, Ionotropic and Nmda. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • GRIN2B
    • Receptor
    • Ionotropic
    • Nmda
    • Nmdar2b
    • Function
    • Subunit
    • Nr2b
    • Known
    • Protein
    • Search
    • Location
    • Receptors
  • grin2b
    • Receptor
    • Ionotropic
    • Nmda
    • Nmdar2b
    • Function
    • Subunit
    • Nr2b
    • Known
    • Protein
    • Search
    • Location
    • Receptors
  • gene
    • Ionotropic
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
    • End
    • G1
    • Glutamate
    • Protein
    • Search
    • Grin2b
  • nmda
    • Receptor
    • Grin2b
    • Nmdar2b
    • Subunit
    • Protein
    • Search
    • Learning
    • Location
    • Receptors
    • Chromosome
    • Function
    • Human
  • ionotropic glutamate receptors
    • Binding
    • Protein
    • Search
    • Ionotropic
    • Receptors
    • Nmda
    • Excitatory
    • Gene
    • Grin2b
    • Location
    • Nmdar2b
    • Subunit
  • glutamate
    • Ionotropic
    • Receptors
    • Nmda
    • Gene
    • Subunit
    • Receptor
    • 2b
    • Binding
    • Protein
    • Search
    • Grin2b
    • Also
  • gabaa receptor
    • Grin2b
    • Nr2b
    • Nmdar2b
    • Selective
    • Function
    • Subunit
    • Ethanol
    • Known
    • Protein
    • Search
    • Learning
    • Location
  • nmda receptors
    • Receptor
    • Binding
    • Search
    • Excitatory
    • Grin2b
    • Nmdar2b
    • Subunit
    • Protein
    • Learning
    • Location
    • Receptors
    • Chromosome

Connections between topic areas Semantic bridges

For GRIN2B, one of the stronger structural bridges in this analysis connects GRIN2B with Ligands. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
GRIN2BLigands · splits 27 ⟂ 15
GRIN2BNMDA receptors · splits 33 ⟂ 9
GRIN2BInteractions · splits 33 ⟂ 9
GRIN2BFunction · splits 37 ⟂ 5
GRIN2BOverview · splits 39 ⟂ 3

Map overview Semantic statistics

GRIN2B

Nodes42
Edges41
Triples137
Avg. degree1.95
Density0.047619
Components1

Source & methodology

TTTA analyzes the structure around GRIN2B to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art & Measurement, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — GRIN2B · EN edition · Analysis: TopicsToTalkAbout

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