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Desipramine: History, Community, Culture & Applications

Desipramine, sold under the brand name Norpramin among others, is a tricyclic antidepressant (TCA) used in the treatment of depression. It acts as a relatively selective norepinephrine reuptake inhibitor, though it does also have other activities such as weak serotonin reuptake inhibitory, α1-blocking, antihistamine, and anticholinergic effects. The drug…

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Desipramine topic overview

The analysis highlights History, Community, Culture and Applications as prominent areas in the source structure around Desipramine.

Related topics
71
Source areas
7
Connected nodes
78
Extracted relationships
88
Concept neighborhoods
24
Bridge connections
78

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Chemistry · 22 topics
Pharmacology · 13 topics
Society and culture · 13 topics
Overview · 11 topics
Side effects · 7 topics
Medical uses · 4 topics
History · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N06AA01 (WHO)
Bioavailability
60–70%
CAS Number
50-47-5 Y 58-28-6 (hydrochloride) 62265-06-9 (dibudinate)
ChEBI
CHEBI:47781 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Medical uses

Side effects

Pharmacology

Chemistry

History

Society and culture

  • Generic name Generic term
  • INN International Nonproprietary Name
  • BAN British Approved Name
  • USAN United States Adopted Name
  • USP United States Pharmacopeia
  • JAN Japanese Accepted Name
  • French French language
  • DCF Dénomination Commune Française
  • Spanish Spanish language
  • Italian Italian language
  • DCIT Denominazione Comune Italiana
  • German German language
  • Latin Latin language

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Desipramine connects Entity context

The extracted context around Desipramine shows recurring relationship patterns in the source. For example, Desipramine → BANTooltip British Approved Name, DCFTooltip Dénomination Commune Française, DCITTooltip Denominazione Comune Italiana, French, German, INNTooltip International Nonproprietary Name, Italian, Its, JANTooltip Japanese Accepted Name, Latin, Name, Spanish, USANTooltip United States Adopted, USPTooltip United States Pharmacopeia Another extracted example is Desipramine → Argentina, C18H22N2, N-methylated, N-methyldesipramine, N-methylpropan-1-amine, Nebril, Other, TCA, TCAs, The, The CAS Registry Number. Use these groups to spot repeated connection types before inspecting the individual relationships.

Desipramine

Top relations

related to Generic names · 14
Desipramine → BANTooltip British Approved Name, DCFTooltip Dénomination Commune Française, DCITTooltip Denominazione Comune Italiana, French, German, INNTooltip International Nonproprietary Name, Italian, Its, JANTooltip Japanese Accepted Name, Latin, Name, Spanish, USANTooltip United States Adopted, USPTooltip United States Pharmacopeia
related to Chemistry · 11
Desipramine → Argentina, C18H22N2, N-methylated, N-methyldesipramine, N-methylpropan-1-amine, Nebril, Other, TCA, TCAs, The, The CAS Registry Number
related to Pharmacodynamics · 10
Desipramine → ADHD, Based, It, NET, NRI, Secondary, TCA, TCAs, The, Whereas
related to Brand names · 7
Desipramine → Irene, Nebril, Norpramin, Pertofran, Pertofrane, Pertrofran, Petylyl
related to history · 3
Desipramine → Geigy, It, The
related to Medical uses · 3
Desipramine → ADHD, Evidence, It
Legal status · 2
Desipramine → BR: Class C1 (Other controlled substances), US: ℞-only
3D model (JSmol) · 1
Desipramine → Interactive image
AHFS/Drugs.com · 1
Desipramine → Monograph
ATC code · 1
Desipramine → N06AA01 (WHO)

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

tcas effects treatment name also selective side depression drug overdose hydrochloride brand others used reuptake inhibitor anticholinergic norpramin dibudinate names

Desipramine relationships Subject–Predicate–Object triples

TTTA extracted 88 structured relationships around Desipramine. Examples in this analysis include Desipramine → 3D model (JSmol) → Interactive image and Desipramine → AHFS/Drugs.com → Monograph. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Desipramine3D model (JSmol)Interactive image1.00infobox
DesipramineAHFS/Drugs.comMonograph1.00infobox
DesipramineATC codeN06AA01 (WHO)1.00infobox
DesipramineBioavailability60–70%1.00infobox
DesipramineCAS Number50-47-5 Y 58-28-6 (hydrochloride) 62265-06-9 (dibudinate)1.00infobox
DesipramineChEBICHEBI:47781 Y1.00infobox
DesipramineChEMBLChEMBL72 Y1.00infobox
DesipramineChemSpider2888 Y1.00infobox
DesipramineCompTox Dashboard (EPA)DTXSID60228961.00infobox
DesipramineDrugBankDB01151 Y1.00infobox
DesipramineECHA InfoCard100.000.0371.00infobox
DesipramineElimination half-life12–30 hours1.00infobox
DesipramineExcretionUrine (70%), feces1.00infobox
DesipramineFormulaC18H22N21.00infobox
DesipramineIUPHAR/BPS23991.00infobox
DesipramineKEGGD07791 Y1.00infobox
DesipramineLegal statusBR: Class C1 (Other controlled substances)1.00infobox
DesipramineLegal statusUS: ℞-only1.00infobox
DesipramineMedlinePlusa6823871.00infobox
DesipramineMetabolismLiver (CYP2D6)1.00infobox
DesipramineMolar mass266.388 g·mol−11.00infobox
DesipramineOther namesDesmethylimipramine; Norimipramine; EX-4355; G-35020; JB-8181; NSC-1149011.00infobox
DesipramineProtein binding91%1.00infobox
DesipraminePubChem CID29951.00infobox
DesipramineRoutes of administrationOral, intramuscular injection1.00infobox
DesipramineTrade namesNorpramin, Pertofrane, others1.00infobox
DesipramineUNIITG537D343B1.00infobox
Desipramineis asecondary amine TCA0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Desipramine bring nearby vocabulary together. In this analysis, examples include Tcas, Name and Imipramine. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Desipramine
    • Tcas
    • Name
    • Imipramine
    • Norpramin
    • Others
    • Overdose
    • Used
    • Side
    • Effects
    • Treatment
    • Among
    • Medical
  • desipramine
    • Tcas
    • Name
    • Imipramine
    • Norpramin
    • Others
    • Overdose
    • Used
    • Side
    • Effects
    • Treatment
    • Among
    • Medical
  • depression
    • Treatment
    • Norpramin
    • Others
    • Overdose
    • Used
    • Drug
    • Side
    • Effects
    • Name
    • 50-47-5
    • Antidepressants
    • Considered
  • side effects
    • Side
    • Fewer
    • Serotonin
    • Inhibitor
    • Overdose
    • Reuptake
    • Selective
    • Treatment
    • 50-47-5
    • Medical
    • Names
    • Tricyclic
  • norepinephrine reuptake inhibitor
    • Reuptake
    • Relatively
    • Serotonin
    • Selective
    • Inhibitor
    • Norepinephrine
    • Effects
    • Antidepressants
    • Antihistamine
    • Considered
    • Fewer
    • Anticholinergic
  • generic name
    • Generic
    • Name
    • Hydrochloride
    • Used
    • Base
    • Dibudinate
    • Free
    • Norpramin
    • 50-47-5
    • Medical
    • Names
    • Others
  • selective serotonin reuptake inhibitor
    • Reuptake
    • Relatively
    • Serotonin
    • Selective
    • Norepinephrine
    • Fewer
    • Effects
    • Antidepressants
    • Antihistamine
    • Considered
    • Treatment
    • Anticholinergic
  • chemical name
    • Generic
    • Hydrochloride
    • Used
    • Base
    • Dibudinate
    • Free
    • Norpramin
    • Others
    • Drug
    • Treatment
    • 50-47-5
    • Medical

Connections between topic areas Semantic bridges

For Desipramine, one of the stronger structural bridges in this analysis connects Desipramine with Chemistry. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Desipramine — Chemistry · splits 56 ⟂ 23
Desipramine — Pharmacology · splits 65 ⟂ 14
Desipramine — Society and culture · splits 65 ⟂ 14
Desipramine — Overview · splits 67 ⟂ 12
Desipramine — Side effects · splits 71 ⟂ 8
Desipramine — Medical uses · splits 74 ⟂ 5

Map overview Semantic statistics

Desipramine

Nodes79
Edges78
Triples88
Avg. degree1.97
Density0.025316
Components1

Source & methodology

TTTA analyzes the structure around Desipramine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History, Community, Culture & Applications, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Desipramine · EN edition · Analysis: TopicsToTalkAbout

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