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Roxindole: History & Standards

Roxindole (INNTooltip International Nonproprietary Name; developmental code name EMD-49980) is a dopaminergic and serotonergic drug which was under development for the treatment of major depressive disorder, obsessive–compulsive disorder (OCD), panic disorder, and psychotic disorders like schizophrenia but was never marketed.

Language: English [EN]
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Roxindole topic overview

The analysis highlights History and Standards as prominent areas in the source structure around Roxindole.

Related topics
33
Source areas
3
Connected nodes
36
Extracted relationships
28
Concept neighborhoods
23
Bridge connections
36

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Pharmacology · 15 topics
History and development · 9 topics
Overview · 9 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
ATC code
None
CAS Number
112192-04-8
ChEBI
CHEBI:48558
ChEMBL
ChEMBL431367
ChemSpider
189880

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Pharmacology

History and development

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Roxindole connects Entity context

The extracted context around Roxindole shows recurring relationship patterns in the source. For example, Roxindole → As, However, In, It, Merck KGaA, Parkinson's, The Another extracted example is Roxindole → D2, D3, D4, HT1A, Ki. Use these groups to spot repeated connection types before inspecting the individual relationships.

Roxindole

Top relations

related to history · 7
Roxindole → As, However, In, It, Merck KGaA, Parkinson's, The
related to Pharmacodynamics · 5
Roxindole → D2, D3, D4, HT1A, Ki
3D model (JSmol) · 1
Roxindole → Interactive image
ATC code · 1
Roxindole → None
CAS Number · 1
Roxindole → 112192-04-8
ChEBI · 1
Roxindole → CHEBI:48558
ChEMBL · 1
Roxindole → ChEMBL431367
ChemSpider · 1
Roxindole → 189880
CompTox Dashboard (EPA) · 1
Roxindole → DTXSID5043895
Drug class · 1
Roxindole → Dopamine D2-like receptor agonist; Serotonin 5-HT1A receptor agonist; Serotonin reuptake inhibitor

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

drug development agonist treatment serotonin also schizophrenia receptor name code emd-49980 disorder obsessive compulsive panic never marketed receptors antipsychotic 5-ht1a

Roxindole relationships Subject–Predicate–Object triples

TTTA extracted 28 structured relationships around Roxindole. Examples in this analysis include Roxindole → 3D model (JSmol) → Interactive image and Roxindole → ATC code → None. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Roxindole3D model (JSmol)Interactive image1.00infobox
RoxindoleATC codeNone1.00infobox
RoxindoleCAS Number112192-04-81.00infobox
RoxindoleChEBICHEBI:485581.00infobox
RoxindoleChEMBLChEMBL4313671.00infobox
RoxindoleChemSpider1898801.00infobox
RoxindoleCompTox Dashboard (EPA)DTXSID50438951.00infobox
RoxindoleDrug classDopamine D2-like receptor agonist; Serotonin 5-HT1A receptor agonist; Serotonin reuptake inhibitor1.00infobox
RoxindoleDrugBankDB198831.00infobox
RoxindoleFormulaC23H26N2O1.00infobox
RoxindoleIUPHAR/BPS521.00infobox
RoxindoleMolar mass346.474 g·mol−11.00infobox
RoxindoleOther namesEMD-49980; EMD499801.00infobox
RoxindolePubChem CID2190501.00infobox
RoxindoleUNII43227SMS0O1.00infobox
Roxindoleis apartial agonist with preferential actions at autoreceptors and has been touted as a 'selective' autoreceptor agonist0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Roxindole bring nearby vocabulary together. In this analysis, examples include Treatment, Schizophrenia and Development. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Roxindole
    • Treatment
    • Schizophrenia
    • Development
    • Drug
    • 5-ht1a
    • Depressive
    • Disorders
    • Like
    • Major
    • Ocd
    • Psychotic
    • Serotonergic
  • roxindole
    • Treatment
    • Schizophrenia
    • Development
    • Drug
    • 5-ht1a
    • Depressive
    • Disorders
    • Like
    • Major
    • Ocd
    • Psychotic
    • Serotonergic
  • drug
    • Development
    • Emd-49980
    • Name
    • Roxindole
    • 5-ht1a
    • Depressive
    • Disorders
    • Inntooltip
    • International
    • Like
    • Major
    • Nonproprietary
  • major depressive disorder
    • Compulsive
    • Depressive
    • Developmental
    • Disorders
    • Dopaminergic
    • Inntooltip
    • International
    • Like
    • Major
    • Nonproprietary
    • Obsessive
    • Ocd
  • obsessive–compulsive disorder
    • Compulsive
    • Disorder
    • Obsessive
    • Panic
    • Depressive
    • Developmental
    • Disorders
    • Dopaminergic
    • Inntooltip
    • International
    • Like
    • Major
  • history and development
    • Drug
    • Emd-49980
    • Name
    • Roxindole
    • 5-ht1a
    • Depressive
    • Developmental
    • Disorders
    • Dopaminergic
    • Inntooltip
    • International
    • Like
  • dopaminergic
    • Depressive
    • Disorders
    • Inntooltip
    • International
    • Like
    • Major
    • Nonproprietary
    • Ocd
    • Psychotic
    • Serotonergic
    • Compulsive
    • Disorder
  • panic disorder
    • Compulsive
    • Obsessive
    • Panic
    • Disorders
    • Dopaminergic
    • Inntooltip
    • International
    • Like
    • Major
    • Nonproprietary
    • Ocd
    • Psychotic

Connections between topic areas Semantic bridges

For Roxindole, one of the stronger structural bridges in this analysis connects Roxindole with Pharmacology. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Roxindole — Pharmacology · splits 21 ⟂ 16
Roxindole — Overview · splits 27 ⟂ 10
Roxindole — History and development · splits 27 ⟂ 10

Map overview Semantic statistics

Roxindole

Nodes37
Edges36
Triples28
Avg. degree1.95
Density0.054054
Components1

Source & methodology

TTTA analyzes the structure around Roxindole to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as History & Standards, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Roxindole · EN edition · Analysis: TopicsToTalkAbout

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