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Vortioxetine

Vortioxetine, sold under the brand names Trintellix (in the US) and Brintellix (in Europe) among others, is an antidepressant medication of the serotonin modulator and stimulator (SMS) class used in the treatment of major depressive disorder. Its effectiveness is viewed as similar to that of other antidepressants. It is taken orally.

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3D model (JSmol)
Interactive image
AHFS/Drugs.com
Monograph
ATC code
N06AX26 (WHO)
Bioavailability
75% (peak at 7–11 hours)
CAS Number
508233-74-7 Y
ChEBI
CHEBI:76016 Y

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Overview

Medical uses

Contraindications

Adverse effects

Interactions

Pharmacology

Chemistry

History

Society and culture

Research

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Map overview Semantic statistics

Vortioxetine

Nodes170
Edges169
Triples135
Avg. degree1.99
Density0.011765
Components1

How this topic connects Entity context

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Vortioxetine

Top relations

related to Names · 18
Vortioxetine → Brilinta, Brintellix, Drug Administration, FDA, May, Other, Torvox, Trintellix, Trivoxetin, United States, US Food, Vantaxa, Vatoin, Vipca, Vortica, Vortidif, Voxigain, Xomat
has effect · 15
Vortioxetine → Arizona Sexual Experience Scale, ASEX, Discontinuation, However, In, Incidence, Sexual, Significant, SNRI, SNRIs, SSRI, SSRIs, The, These, With
related to Pharmacodynamics · 15
Vortioxetine → EC50, HT1A, HT1B, HT1D, HT3, HT7, IC50, In, More, Occupancy, REM, SERT, The, This, Whereas
related to Pharmacogenomics · 11
Vortioxetine → Area-under-the-curve, CYP2C19, CYP2D6, Depending, Dosage, Genetic, However, In, L/h, P450, The
related to history · 9
Vortioxetine → In, Japan, Lu AA21004, Lu AA24530, Lundbeck, Phase II, Takeda, The, US
Legal status · 7
Vortioxetine → AU: S4 (Prescription only), BR: Class C1 (Other controlled substances), CA: ℞-only, EU: Rx-only, In general: ℞ (Prescription only), UK: POM (Prescription only), US: ℞-only
related to Interactions · 7
Vortioxetine → Bupropion, CYP2D6, Inhibitors, Lesser, Other, P450, The
related to Pharmacokinetics · 5
Vortioxetine → Food, It, Peak, Steady-state, The
related to Research · 5
Vortioxetine → As, August, II, It, There
related to Medical uses · 3
Vortioxetine → Cochrane, However, SSRIs

Important terminology Word statistics

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Important terminology

serotonin may cyp2d6 effects 5-ht3 mg receptor sexual dysfunction levels anxiety found day nausea disorder side pharmacokinetics receptors ssris also

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Vortioxetine3D model (JSmol)Interactive image1.00infobox
VortioxetineAHFS/Drugs.comMonograph1.00infobox
VortioxetineATC codeN06AX26 (WHO)1.00infobox
VortioxetineBioavailability75% (peak at 7–11 hours)1.00infobox
VortioxetineCAS Number508233-74-7 Y1.00infobox
VortioxetineChEBICHEBI:76016 Y1.00infobox
VortioxetineChEMBLChEMBL2204360 Y1.00infobox
VortioxetineChemSpider8141643 Y1.00infobox
VortioxetineCompTox Dashboard (EPA)DTXSID809650621.00infobox
VortioxetineDrug classSerotonin modulator and stimulator (SMS)1.00infobox
VortioxetineDrugBankDB09068 Y1.00infobox
VortioxetineECHA InfoCard100.258.7481.00infobox
VortioxetineElimination half-life66 hours1.00infobox
VortioxetineExcretion59% in urine, 26% in feces1.00infobox
VortioxetineFormulaC18H22N2S1.00infobox
VortioxetineIUPHAR/BPS73511.00infobox
VortioxetineKEGGD10184 Y1.00infobox
VortioxetineKEGGas salt: D10185 Y1.00infobox
VortioxetineLegal statusAU: S4 (Prescription only)1.00infobox
VortioxetineLegal statusBR: Class C1 (Other controlled substances)1.00infobox
VortioxetineLegal statusCA: ℞-only1.00infobox
VortioxetineLegal statusUK: POM (Prescription only)1.00infobox
VortioxetineLegal statusUS: ℞-only1.00infobox
VortioxetineLegal statusEU: Rx-only1.00infobox
VortioxetineLegal statusIn general: ℞ (Prescription only)1.00infobox
VortioxetineLicense dataUS DailyMed: Vortioxetine1.00infobox
VortioxetineMedlinePlusa6140031.00infobox
VortioxetineMetabolismLiver, primarily CYP2D6-mediated oxidation1.00infobox
VortioxetineMolar mass298.45 g·mol−11.00infobox
VortioxetineOther namesLu AA21004, Vortioxetine hydrobromide (JAN JP), Vortioxetine hydrobromide (USAN US)1.00infobox

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