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LPAR1

Lysophosphatidic acid receptor 1 also known as LPA1 is a protein that in humans is encoded by the LPAR1 gene. LPA1 is a G protein-coupled receptor that binds the lipid signaling molecule lysophosphatidic acid (LPA).

Evolution, Cancer & Function

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Aliases
LPAR1, receptor 1, lysophosphatidic acid receptor 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4Z34, 4Z35, 4Z36
Band
4 B3|4 32.2 cM
Bgee
maxillary prominence · calvaria · mandibular prominence · optic nerve · autopod region
BioGPS
More reference expression data
Chr.
Chromosome 4 (mouse)

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Overview

Function

Cancer

Evolution

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LPAR1

Nodes33
Edges32
Triples90
Avg. degree1.94
Density0.060606
Components1

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LPAR1

Top relations

Gene ontology · 49
LPAR1 → activation of phospholipase C activity, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, bleb assembly, brain development, cell chemotaxis, cell surface, cellular response to 1-oleoyl-sn-glycerol 3-phosphate, cellular response to oxygen levels, cerebellum development, corpus callosum development, cytoplasm, dendritic shaft, dendritic spine, endocytic vesicle, endosome, G protein-coupled receptor activity, G protein-coupled receptor signaling pathway, G-protein alpha-subunit binding, integral component of membrane, integral component of plasma membrane
Bgee · 10
LPAR1 → autopod region, calvaria, conjunctival fornix, decidua, foot, hand, mandibular prominence, maxillary prominence, optic nerve, utricle
RNA expression pattern · 10
LPAR1 → autopod region, calvaria, conjunctival fornix, decidua, foot, hand, mandibular prominence, maxillary prominence, optic nerve, utricle
related to Cancer · 2
LPAR1 → For, Human
Aliases · 1
LPAR1 → LPAR1, receptor 1, lysophosphatidic acid receptor 1
Available structures · 1
LPAR1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4Z34, 4Z35, 4Z36
Band · 1
LPAR1 → 4 B3|4 32.2 cM
BioGPS · 1
LPAR1 → More reference expression data
Chr. · 1
LPAR1 → Chromosome 4 (mouse)
Databases · 1
LPAR1 → NCBI: entry; OMA: entry

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Important terminology

receptor gene lysophosphatidic acid receptors bp lpa1 protein protein-coupled signaling chr lpa also mouse band lipid function external known encoded

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
LPAR1AliasesLPAR1, receptor 1, lysophosphatidic acid receptor 11.00infobox
LPAR1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4Z34, 4Z35, 4Z361.00infobox
LPAR1Band4 B3|4 32.2 cM1.00infobox
LPAR1Bgeemaxillary prominence1.00infobox
LPAR1Bgeecalvaria1.00infobox
LPAR1Bgeemandibular prominence1.00infobox
LPAR1Bgeeoptic nerve1.00infobox
LPAR1Bgeeautopod region1.00infobox
LPAR1Bgeehand1.00infobox
LPAR1Bgeefoot1.00infobox
LPAR1Bgeedecidua1.00infobox
LPAR1Bgeeconjunctival fornix1.00infobox
LPAR1Bgeeutricle1.00infobox
LPAR1BioGPSMore reference expression data1.00infobox
LPAR1Chr.Chromosome 4 (mouse)1.00infobox
LPAR1DatabasesNCBI: entry; OMA: entry1.00infobox
LPAR1End58,553,898 bp1.00infobox
LPAR1EnsemblENSG000001981211.00infobox
LPAR1Entrez19021.00infobox
LPAR1External IDsOMIM: 602282; MGI: 108429; GeneCards: LPAR11.00infobox
LPAR1Gene location (Mouse)Gene location (Mouse)Chr.Chromosome 4 (mouse)Band4 B3|4 32.2 cMStart58,435,255 bpEnd58,553,898 bp1.00infobox
LPAR1Gene ontologylysophosphatidic acid binding1.00infobox
LPAR1Gene ontologyPDZ domain binding1.00infobox
LPAR1Gene ontologyG protein-coupled receptor activity1.00infobox
LPAR1Gene ontologysignal transducer activity1.00infobox
LPAR1Gene ontologyprotein binding1.00infobox
LPAR1Gene ontologylysophosphatidic acid receptor activity1.00infobox
LPAR1Gene ontologyG-protein alpha-subunit binding1.00infobox
LPAR1Gene ontologyphospholipid binding1.00infobox
LPAR1Gene ontologylipid binding1.00infobox

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