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Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1PR1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belongs to a sphingosine-1-phosphate receptor subfamily…
The analysis highlights Evolution, Function and Overview as prominent areas in the source structure around S1PR1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around S1PR1 shows recurring relationship patterns in the source. For example, S1PR1 → actin cytoskeleton reorganization, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, angiogenesis, blood vessel maturation, brain development, cardiac muscle tissue growth involved in heart morphogenesis, cell adhesion, cell migration, chemotaxis, cytokine-mediated signaling pathway, endosome, endothelial cell differentiation, external side of plasma membrane, G protein-coupled receptor activity, G protein-coupled receptor binding, G protein-coupled receptor signaling pathway, heart trabecula morphogenesis, integral component of membrane, intracellular membrane-bounded organelle, intrinsic component of plasma membrane Another extracted example is S1PR1 → apex of heart, atrium, caudate nucleus, cerebellar cortex, dentate gyrus of hippocampal formation granule cell, globus pallidus, granulocyte, inferior colliculi, left lung, left ventricle, mesenteric lymph nodes, primary visual cortex, right auricle of heart, right lobe of thyroid gland, right lung, right lung lobe, subcutaneous adipose tissue, superior frontal gyrus, upper lobe of left lung, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
receptor s1p cell cells endothelial vascular migration sphingosine-1-phosphate bp gene immune signaling protein also binding chr human band lymph proliferation
TTTA extracted 161 structured relationships around S1PR1. Examples in this analysis include S1PR1 → Aliases → S1PR1, CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1, sphingosine-1-phosphate receptor 1 and S1PR1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3V2W, 3V2Y. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| S1PR1 | Aliases | S1PR1, CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1, sphingosine-1-phosphate receptor 1 | 1.00 | infobox |
| S1PR1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3V2W, 3V2Y | 1.00 | infobox |
| S1PR1 | Band | 1p21.2 | 1.00 | infobox |
| S1PR1 | Band | 3|3 G1 | 1.00 | infobox |
| S1PR1 | Bgee | right lung | 1.00 | infobox |
| S1PR1 | Bgee | upper lobe of left lung | 1.00 | infobox |
| S1PR1 | Bgee | ventricular zone | 1.00 | infobox |
| S1PR1 | Bgee | granulocyte | 1.00 | infobox |
| S1PR1 | Bgee | subcutaneous adipose tissue | 1.00 | infobox |
| S1PR1 | Bgee | apex of heart | 1.00 | infobox |
| S1PR1 | Bgee | left ventricle | 1.00 | infobox |
| S1PR1 | Bgee | right auricle of heart | 1.00 | infobox |
| S1PR1 | Bgee | caudate nucleus | 1.00 | infobox |
| S1PR1 | Bgee | right lobe of thyroid gland | 1.00 | infobox |
| S1PR1 | Bgee | right lung lobe | 1.00 | infobox |
| S1PR1 | Bgee | globus pallidus | 1.00 | infobox |
| S1PR1 | Bgee | dentate gyrus of hippocampal formation granule cell | 1.00 | infobox |
| S1PR1 | Bgee | atrium | 1.00 | infobox |
| S1PR1 | Bgee | left lung | 1.00 | infobox |
| S1PR1 | Bgee | superior frontal gyrus | 1.00 | infobox |
| S1PR1 | Bgee | inferior colliculi | 1.00 | infobox |
| S1PR1 | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| S1PR1 | Bgee | cerebellar cortex | 1.00 | infobox |
| S1PR1 | Bgee | primary visual cortex | 1.00 | infobox |
| S1PR1 | BioGPS | More reference expression data | 1.00 | infobox |
| S1PR1 | Chr. | Chromosome 1 (human) | 1.00 | infobox |
| S1PR1 | Chr. | Chromosome 3 (mouse) | 1.00 | infobox |
| S1PR1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| S1PR1 | End | 101,243,713 bp | 1.00 | infobox |
| S1PR1 | End | 115,508,721 bp | 1.00 | infobox |
The concept neighborhoods around S1PR1 bring nearby vocabulary together. In this analysis, examples include Cell, Endothelial and Lymphoid. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For S1PR1, one of the stronger structural bridges in this analysis connects S1PR1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around S1PR1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Evolution, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — S1PR1 · EN edition · Analysis: TopicsToTalkAbout