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S1PR1: Evolution, Function & Overview

Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1PR1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belongs to a sphingosine-1-phosphate receptor subfamily…

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S1PR1 topic overview

The analysis highlights Evolution, Function and Overview as prominent areas in the source structure around S1PR1.

Related topics
80
Source areas
6
Connected nodes
86
Extracted relationships
161
Concept neighborhoods
24
Bridge connections
86

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 29 topics
Evolution · 19 topics
Function · 13 topics
Clinical significance · 10 topics
Structure · 5 topics
Interactions · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
S1PR1, CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1, sphingosine-1-phosphate receptor 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3V2W, 3V2Y
Band
1p21.2 · 3|3 G1
Bgee
right lung · upper lobe of left lung · ventricular zone · granulocyte · subcutaneous adipose tissue
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 3 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Clinical significance

Evolution

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How S1PR1 connects Entity context

The extracted context around S1PR1 shows recurring relationship patterns in the source. For example, S1PR1 → actin cytoskeleton reorganization, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, angiogenesis, blood vessel maturation, brain development, cardiac muscle tissue growth involved in heart morphogenesis, cell adhesion, cell migration, chemotaxis, cytokine-mediated signaling pathway, endosome, endothelial cell differentiation, external side of plasma membrane, G protein-coupled receptor activity, G protein-coupled receptor binding, G protein-coupled receptor signaling pathway, heart trabecula morphogenesis, integral component of membrane, intracellular membrane-bounded organelle, intrinsic component of plasma membrane Another extracted example is S1PR1 → apex of heart, atrium, caudate nucleus, cerebellar cortex, dentate gyrus of hippocampal formation granule cell, globus pallidus, granulocyte, inferior colliculi, left lung, left ventricle, mesenteric lymph nodes, primary visual cortex, right auricle of heart, right lobe of thyroid gland, right lung, right lung lobe, subcutaneous adipose tissue, superior frontal gyrus, upper lobe of left lung, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

S1PR1

Top relations

Gene ontology · 46
S1PR1 → actin cytoskeleton reorganization, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, angiogenesis, blood vessel maturation, brain development, cardiac muscle tissue growth involved in heart morphogenesis, cell adhesion, cell migration, chemotaxis, cytokine-mediated signaling pathway, endosome, endothelial cell differentiation, external side of plasma membrane, G protein-coupled receptor activity, G protein-coupled receptor binding, G protein-coupled receptor signaling pathway, heart trabecula morphogenesis, integral component of membrane, intracellular membrane-bounded organelle, intrinsic component of plasma membrane
Bgee · 20
S1PR1 → apex of heart, atrium, caudate nucleus, cerebellar cortex, dentate gyrus of hippocampal formation granule cell, globus pallidus, granulocyte, inferior colliculi, left lung, left ventricle, mesenteric lymph nodes, primary visual cortex, right auricle of heart, right lobe of thyroid gland, right lung, right lung lobe, subcutaneous adipose tissue, superior frontal gyrus, upper lobe of left lung, ventricular zone
RNA expression pattern · 20
S1PR1 → apex of heart, atrium, caudate nucleus, cerebellar cortex, dentate gyrus of hippocampal formation granule cell, globus pallidus, granulocyte, inferior colliculi, left lung, left ventricle, mesenteric lymph nodes, primary visual cortex, right auricle of heart, right lobe of thyroid gland, right lung, right lung lobe, subcutaneous adipose tissue, superior frontal gyrus, upper lobe of left lung, ventricular zone
related to Structure · 17
S1PR1 → Compared, ECL1, ECL2, ECL3, GPCR, GPCRs, II, III, In, IV, Like, N-terminal, S1P, The, This, VI, VII
related to Cancer · 10
S1PR1 → CDC42, ERK, ERK1, ERK2, RAC-CDC42, RAC1, S1P, S1PR3, The, The RAC-CDC42
related to Vasculogenesis · 8
S1PR1 → FGF-2, In, It, Liu, Moreover, S1P, S1PR1-KO, VEGF
related to Multiple sclerosis · 6
S1PR1 → Fingolimod, Multiple, S1PR3, Sphingosine-1-phosphate, There, Van Doorn
related to Function · 3
S1PR1 → GPCR, Like, The
related to Interactions · 3
S1PR1 → GNAI1, GNAI3, HT1A
Band · 2
S1PR1 → 1p21.2, 3|3 G1

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

receptor s1p cell cells endothelial vascular migration sphingosine-1-phosphate bp gene immune signaling protein also binding chr human band lymph proliferation

S1PR1 relationships Subject–Predicate–Object triples

TTTA extracted 161 structured relationships around S1PR1. Examples in this analysis include S1PR1 → Aliases → S1PR1, CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1, sphingosine-1-phosphate receptor 1 and S1PR1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3V2W, 3V2Y. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
S1PR1AliasesS1PR1, CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1, sphingosine-1-phosphate receptor 11.00infobox
S1PR1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3V2W, 3V2Y1.00infobox
S1PR1Band1p21.21.00infobox
S1PR1Band3|3 G11.00infobox
S1PR1Bgeeright lung1.00infobox
S1PR1Bgeeupper lobe of left lung1.00infobox
S1PR1Bgeeventricular zone1.00infobox
S1PR1Bgeegranulocyte1.00infobox
S1PR1Bgeesubcutaneous adipose tissue1.00infobox
S1PR1Bgeeapex of heart1.00infobox
S1PR1Bgeeleft ventricle1.00infobox
S1PR1Bgeeright auricle of heart1.00infobox
S1PR1Bgeecaudate nucleus1.00infobox
S1PR1Bgeeright lobe of thyroid gland1.00infobox
S1PR1Bgeeright lung lobe1.00infobox
S1PR1Bgeeglobus pallidus1.00infobox
S1PR1Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
S1PR1Bgeeatrium1.00infobox
S1PR1Bgeeleft lung1.00infobox
S1PR1Bgeesuperior frontal gyrus1.00infobox
S1PR1Bgeeinferior colliculi1.00infobox
S1PR1Bgeemesenteric lymph nodes1.00infobox
S1PR1Bgeecerebellar cortex1.00infobox
S1PR1Bgeeprimary visual cortex1.00infobox
S1PR1BioGPSMore reference expression data1.00infobox
S1PR1Chr.Chromosome 1 (human)1.00infobox
S1PR1Chr.Chromosome 3 (mouse)1.00infobox
S1PR1DatabasesNCBI: entry; OMA: entry1.00infobox
S1PR1End101,243,713 bp1.00infobox
S1PR1End115,508,721 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around S1PR1 bring nearby vocabulary together. In this analysis, examples include Cell, Endothelial and Lymphoid. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • S1PR1
    • Cell
    • Endothelial
    • Lymphoid
    • Migration
    • Cells
    • Like
    • Involved
    • Signaling
    • Tissues
    • Vascular
    • Maturation
    • Members
  • s1pr1
    • Cell
    • Endothelial
    • Lymphoid
    • Migration
    • Cells
    • Like
    • Involved
    • Signaling
    • Tissues
    • Vascular
    • Maturation
    • Members
  • protein
    • Signaling
    • Receptor
    • Pathway
    • Proliferation
    • Sphingosine-1-phosphate
    • Binding
    • S1pr1
    • Band
    • Chromosome
    • Human
    • Lymphocytes
    • Maturation
  • gene
    • Chromosome
    • Human
    • Bp
    • Chr
    • Sphingosine-1-phosphate
    • Band
    • Regulation
    • Protein
    • Receptor
    • Maturation
    • Members
    • Multiple
  • g-protein-coupled receptor
    • Sphingosine-1-phosphate
    • Also
    • Protein
    • Gene
    • S1pr1
    • Signaling
    • Binding
    • Chromosome
    • Human
    • Members
    • Multiple
    • Regulation
  • sphingosine-1-phosphate receptor
    • Gene
    • Receptor
    • Sphingosine-1-phosphate
    • Also
    • Chromosome
    • Human
    • Members
    • Regulation
    • Protein
    • Bp
    • Chr
    • Involved
  • t-cell receptor
    • Sphingosine-1-phosphate
    • Also
    • Protein
    • Gene
    • S1pr1
    • Signaling
    • Binding
    • Chromosome
    • Human
    • Members
    • Multiple
    • Regulation
  • endothelial junctional contacts
    • Migration
    • Cell
    • Proliferation
    • S1pr1
    • Gene
    • Maturation
    • S1p
    • Like
    • Lymph
    • Pathway
    • Cells
    • Lymphoid

Connections between topic areas Semantic bridges

For S1PR1, one of the stronger structural bridges in this analysis connects S1PR1 with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
S1PR1Overview · splits 57 ⟂ 30
S1PR1Evolution · splits 67 ⟂ 20
S1PR1Function · splits 73 ⟂ 14
S1PR1Clinical significance · splits 76 ⟂ 11
S1PR1Structure · splits 81 ⟂ 6
S1PR1Interactions · splits 82 ⟂ 5

Map overview Semantic statistics

S1PR1

Nodes87
Edges86
Triples161
Avg. degree1.98
Density0.022989
Components1

Source & methodology

TTTA analyzes the structure around S1PR1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Evolution, Function & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — S1PR1 · EN edition · Analysis: TopicsToTalkAbout

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