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S1PR1

Sphingosine-1-phosphate receptor 1 (S1P receptor 1 or S1PR1), also known as endothelial differentiation gene 1 (EDG1) is a protein that in humans is encoded by the S1PR1 gene. S1PR1 is a G-protein-coupled receptor which binds the bioactive signaling molecule sphingosine 1-phosphate (S1P). S1PR1 belongs to a sphingosine-1-phosphate receptor subfamily…

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Aliases
S1PR1, CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1, sphingosine-1-phosphate receptor 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3V2W, 3V2Y
Band
1p21.2 · 3|3 G1
Bgee
right lung · upper lobe of left lung · ventricular zone · granulocyte · subcutaneous adipose tissue
BioGPS
More reference expression data
Chr.
Chromosome 1 (human) · Chromosome 3 (mouse)

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Function

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Map overview Semantic statistics

S1PR1

Nodes87
Edges86
Triples161
Avg. degree1.98
Density0.022989
Components1

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S1PR1

Top relations

Gene ontology · 46
S1PR1 → actin cytoskeleton reorganization, adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway, angiogenesis, blood vessel maturation, brain development, cardiac muscle tissue growth involved in heart morphogenesis, cell adhesion, cell migration, chemotaxis, cytokine-mediated signaling pathway, endosome, endothelial cell differentiation, external side of plasma membrane, G protein-coupled receptor activity, G protein-coupled receptor binding, G protein-coupled receptor signaling pathway, heart trabecula morphogenesis, integral component of membrane, intracellular membrane-bounded organelle, intrinsic component of plasma membrane
Bgee · 20
S1PR1 → apex of heart, atrium, caudate nucleus, cerebellar cortex, dentate gyrus of hippocampal formation granule cell, globus pallidus, granulocyte, inferior colliculi, left lung, left ventricle, mesenteric lymph nodes, primary visual cortex, right auricle of heart, right lobe of thyroid gland, right lung, right lung lobe, subcutaneous adipose tissue, superior frontal gyrus, upper lobe of left lung, ventricular zone
RNA expression pattern · 20
S1PR1 → apex of heart, atrium, caudate nucleus, cerebellar cortex, dentate gyrus of hippocampal formation granule cell, globus pallidus, granulocyte, inferior colliculi, left lung, left ventricle, mesenteric lymph nodes, primary visual cortex, right auricle of heart, right lobe of thyroid gland, right lung, right lung lobe, subcutaneous adipose tissue, superior frontal gyrus, upper lobe of left lung, ventricular zone
related to Structure · 17
S1PR1 → Compared, ECL1, ECL2, ECL3, GPCR, GPCRs, II, III, In, IV, Like, N-terminal, S1P, The, This, VI, VII
related to Cancer · 10
S1PR1 → CDC42, ERK, ERK1, ERK2, RAC-CDC42, RAC1, S1P, S1PR3, The, The RAC-CDC42
related to Vasculogenesis · 8
S1PR1 → FGF-2, In, It, Liu, Moreover, S1P, S1PR1-KO, VEGF
related to Multiple sclerosis · 6
S1PR1 → Fingolimod, Multiple, S1PR3, Sphingosine-1-phosphate, There, Van Doorn
related to Function · 3
S1PR1 → GPCR, Like, The
related to Interactions · 3
S1PR1 → GNAI1, GNAI3, HT1A
Band · 2
S1PR1 → 1p21.2, 3|3 G1

Important terminology Word statistics

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Important terminology

receptor s1p cell cells endothelial vascular migration sphingosine-1-phosphate bp gene immune signaling protein also binding chr human band lymph proliferation

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
S1PR1AliasesS1PR1, CD363, CHEDG1, D1S3362, ECGF1, EDG-1, EDG1, S1P1, sphingosine-1-phosphate receptor 11.00infobox
S1PR1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3V2W, 3V2Y1.00infobox
S1PR1Band1p21.21.00infobox
S1PR1Band3|3 G11.00infobox
S1PR1Bgeeright lung1.00infobox
S1PR1Bgeeupper lobe of left lung1.00infobox
S1PR1Bgeeventricular zone1.00infobox
S1PR1Bgeegranulocyte1.00infobox
S1PR1Bgeesubcutaneous adipose tissue1.00infobox
S1PR1Bgeeapex of heart1.00infobox
S1PR1Bgeeleft ventricle1.00infobox
S1PR1Bgeeright auricle of heart1.00infobox
S1PR1Bgeecaudate nucleus1.00infobox
S1PR1Bgeeright lobe of thyroid gland1.00infobox
S1PR1Bgeeright lung lobe1.00infobox
S1PR1Bgeeglobus pallidus1.00infobox
S1PR1Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
S1PR1Bgeeatrium1.00infobox
S1PR1Bgeeleft lung1.00infobox
S1PR1Bgeesuperior frontal gyrus1.00infobox
S1PR1Bgeeinferior colliculi1.00infobox
S1PR1Bgeemesenteric lymph nodes1.00infobox
S1PR1Bgeecerebellar cortex1.00infobox
S1PR1Bgeeprimary visual cortex1.00infobox
S1PR1BioGPSMore reference expression data1.00infobox
S1PR1Chr.Chromosome 1 (human)1.00infobox
S1PR1Chr.Chromosome 3 (mouse)1.00infobox
S1PR1DatabasesNCBI: entry; OMA: entry1.00infobox
S1PR1End101,243,713 bp1.00infobox
S1PR1End115,508,721 bp1.00infobox

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