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MAPK3

Mitogen-activated protein kinase 3, also known as p44MAPK and ERK1, is an enzyme that in humans is encoded by the MAPK3 gene.

Interactions, Function & Clinical significance

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Interactions

10 related topics

Function

7 related topics

Clinical significance

3 related topics

Signaling pathways

2 related topics

Key facts & relationships

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2.7.11.24
Aliases
MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK, mitogen-activated protein kinase 3
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ZOQ, 4QTB
Band
16p11.2 · 7 F3|7 69.25 cM
Bgee
right frontal lobe · mucosa of transverse colon · amygdala · cingulate gyrus · anterior cingulate cortex
BioGPS
More reference expression data

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Overview

Function

Clinical significance

Signaling pathways

Interactions

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Map overview Semantic statistics

MAPK3

Nodes30
Edges29
Triples183
Avg. degree1.93
Density0.066667
Components1

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MAPK3

Top relations

Gene ontology · 106
MAPK3 → ageing, animal organ morphogenesis, apoptotic process, arachidonic acid metabolic process, ATP binding, axon guidance, Bergmann glial cell differentiation, BMP signaling pathway, cardiac neural crest cell development involved in heart development, cartilage development, caveola, caveolin-mediated endocytosis, cell cycle, cellular response to amino acid starvation, cellular response to cadmium ion, cellular response to DNA damage stimulus, cellular response to dopamine, cellular response to mechanical stimulus, cellular response to organic substance, cellular response to reactive oxygen species
Bgee · 20
MAPK3 → amygdala, anterior cingulate cortex, C1 segment, cingulate gyrus, colon, dentate gyrus of hippocampal formation granule cell, duodenum, ectocervix, entorhinal cortex, epithelium of stomach, gastric mucosa, granulocyte, large intestine, lip, mucosa of transverse colon, nucleus accumbens, pyloric antrum, rectum, right frontal lobe, yolk sac
RNA expression pattern · 20
MAPK3 → amygdala, anterior cingulate cortex, C1 segment, cingulate gyrus, colon, dentate gyrus of hippocampal formation granule cell, duodenum, ectocervix, entorhinal cortex, epithelium of stomach, gastric mucosa, granulocyte, large intestine, lip, mucosa of transverse colon, nucleus accumbens, pyloric antrum, rectum, right frontal lobe, yolk sac
related to Interactions · 7
MAPK3 → DUSP3, DUSP6GTF2I, HDAC4, MAP2K1, MAP2K2, PTPN7, RPS6KA2
Band · 2
MAPK3 → 16p11.2, 7 F3|7 69.25 cM
Chr. · 2
MAPK3 → Chromosome 16 (human), Chromosome 7 (mouse)
End · 2
MAPK3 → 126,364,991 bp, 30,123,506 bp
related to Clinical significance · 2
MAPK3 → IRAK1, It
2.7.11.24 · 1
MAPK3 → ↗
Aliases · 1
MAPK3 → MAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK, mitogen-activated protein kinase 3

Important terminology Word statistics

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Important terminology

bp gene human protein kinase chr band erk1 chromosome 16 map mitogen-activated location signaling activity enzyme mouse p44mapk function external

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MAPK32.7.11.241.00infobox
MAPK3AliasesMAPK3, ERK-1, ERK1, ERT2, HS44KDAP, HUMKER1A, P44ERK1, P44MAPK, PRKM3, p44-ERK1, p44-MAPK, mitogen-activated protein kinase 31.00infobox
MAPK3Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ZOQ, 4QTB1.00infobox
MAPK3Band16p11.21.00infobox
MAPK3Band7 F3|7 69.25 cM1.00infobox
MAPK3Bgeeright frontal lobe1.00infobox
MAPK3Bgeemucosa of transverse colon1.00infobox
MAPK3Bgeeamygdala1.00infobox
MAPK3Bgeecingulate gyrus1.00infobox
MAPK3Bgeeanterior cingulate cortex1.00infobox
MAPK3Bgeegastric mucosa1.00infobox
MAPK3Bgeenucleus accumbens1.00infobox
MAPK3Bgeeectocervix1.00infobox
MAPK3Bgeerectum1.00infobox
MAPK3BgeeC1 segment1.00infobox
MAPK3Bgeegranulocyte1.00infobox
MAPK3Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
MAPK3Bgeeyolk sac1.00infobox
MAPK3Bgeepyloric antrum1.00infobox
MAPK3Bgeelip1.00infobox
MAPK3Bgeeentorhinal cortex1.00infobox
MAPK3Bgeelarge intestine1.00infobox
MAPK3Bgeecolon1.00infobox
MAPK3Bgeeepithelium of stomach1.00infobox
MAPK3Bgeeduodenum1.00infobox
MAPK3BioGPSMore reference expression data1.00infobox
MAPK3Chr.Chromosome 16 (human)1.00infobox
MAPK3Chr.Chromosome 7 (mouse)1.00infobox
MAPK3DatabasesNCBI: entry; OMA: entry1.00infobox
MAPK3End30,123,506 bp1.00infobox

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