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Dizocilpine

Dizocilpine (INN), also known as MK-801, is a pore blocker of the NMDA receptor, a glutamate receptor, discovered by a team at Merck in 1982. Glutamate is the brain's primary excitatory neurotransmitter. The channel is normally blocked with a magnesium ion and requires depolarization of the neuron to remove the magnesium and allow the glutamate to open…

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3D model (JSmol)
Interactive image
ATC code
None
CAS Number
77086-21-6 Y
ChEBI
CHEBI:34725
ChEMBL
ChEMBL284237 Y
ChemSpider
156718 Y

Topics to explore

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Overview

An animal model of schizophrenia

Possible future medical uses

Olney's lesions

Recreational use

Advanced semantic analysis

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Map overview Semantic statistics

Dizocilpine

Nodes70
Edges69
Triples57
Avg. degree1.97
Density0.028571
Components1

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Dizocilpine

Top relations

related to Possible future medical uses · 12
Dizocilpine → Alzheimer's, Behavioural, Excitatory, However, Huntington's, It, NMDA, NR2B, The, The ED50, This, Thus NMDA
related to Recreational use · 12
Dizocilpine → Additionally, As, Intraperitoneal, It, Little, None, PCP, Rats, Rhesus, Several, The, Users
related to Olney's lesions · 6
Dizocilpine → John, Neurons, NMDA, Olney, Other, Vacuoles
related to An animal model of schizophrenia · 3
Dizocilpine → Another, Not, Unlike
is a · 2
Dizocilpine → most frequently used uncompetitive NMDA receptor antagonist in animal models to mimic psychosis for experimental purposes.Dizocilpine has also been found to act as a nicotinic a…, particularly strong NMDA antagonist
3D model (JSmol) · 1
Dizocilpine → Interactive image
ATC code · 1
Dizocilpine → None
CAS Number · 1
Dizocilpine → 77086-21-6 Y
ChEBI · 1
Dizocilpine → CHEBI:34725
ChEMBL · 1
Dizocilpine → ChEMBL284237 Y

Important terminology Word statistics

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Important terminology

nmda receptor also drug glutamate shown effects animal antagonist dissociative found used administration brain antagonists receptors rats models channel ketamine

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Dizocilpine3D model (JSmol)Interactive image1.00infobox
DizocilpineATC codeNone1.00infobox
DizocilpineCAS Number77086-21-6 Y1.00infobox
DizocilpineChEBICHEBI:347251.00infobox
DizocilpineChEMBLChEMBL284237 Y1.00infobox
DizocilpineChemSpider156718 Y1.00infobox
DizocilpineCompTox Dashboard (EPA)DTXSID30484471.00infobox
DizocilpineDrugBank? N1.00infobox
DizocilpineFormulaC16H15N1.00infobox
DizocilpineIUPHAR/BPS24031.00infobox
DizocilpineMelting point68.75 °C (155.75 °F)1.00infobox
DizocilpineMolar mass221.303 g·mol−11.00infobox
DizocilpinePubChem CID1800811.00infobox
DizocilpineRoutes of administrationBy mouth, IM1.00infobox
DizocilpineUNII7PY8KH681I1.00infobox
Dizocilpineis amost frequently used uncompetitive NMDA receptor antagonist in animal models to mimic psychosis for experimental purposes.Dizocilpine has also been found to act as a nicotinic a…0.90text
Dizocilpineis aparticularly strong NMDA antagonist0.90text

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