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Dizocilpine: Applications & Products

Dizocilpine (INN), also known as MK-801, is a pore blocker of the NMDA receptor, a glutamate receptor, discovered by a team at Merck in 1982. Glutamate is the brain's primary excitatory neurotransmitter. The channel is normally blocked with a magnesium ion and requires depolarization of the neuron to remove the magnesium and allow the glutamate to open…

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Dizocilpine topic overview

The analysis highlights Applications and Products as prominent areas in the source structure around Dizocilpine. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.

Related topics
63
Source areas
5
Connected nodes
69
Extracted relationships
57
Concept neighborhoods
25
Bridge connections
69

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Possible future medical uses · 26 topics
Overview · 23 topics
Recreational use · 6 topics
Olney's lesions · 5 topics
An animal model of schizophrenia · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3D model (JSmol)
Interactive image
ATC code
None
CAS Number
77086-21-6 Y
ChEBI
CHEBI:34725
ChEMBL
ChEMBL284237 Y
ChemSpider
156718 Y

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

An animal model of schizophrenia

Possible future medical uses

Olney's lesions

Recreational use

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Dizocilpine connects Entity context

The extracted context around Dizocilpine shows recurring relationship patterns in the source. For example, Dizocilpine → Alzheimer's, Behavioural, Excitatory, However, Huntington's, It, NMDA, NR2B, The, The ED50, This, Thus NMDA Another extracted example is Dizocilpine → Additionally, As, Intraperitoneal, It, Little, None, PCP, Rats, Rhesus, Several, The, Users. Use these groups to spot repeated connection types before inspecting the individual relationships.

Dizocilpine

Top relations

related to Possible future medical uses · 12
Dizocilpine → Alzheimer's, Behavioural, Excitatory, However, Huntington's, It, NMDA, NR2B, The, The ED50, This, Thus NMDA
related to Recreational use · 12
Dizocilpine → Additionally, As, Intraperitoneal, It, Little, None, PCP, Rats, Rhesus, Several, The, Users
related to Olney's lesions · 6
Dizocilpine → John, Neurons, NMDA, Olney, Other, Vacuoles
related to An animal model of schizophrenia · 3
Dizocilpine → Another, Not, Unlike
is a · 2
Dizocilpine → most frequently used uncompetitive NMDA receptor antagonist in animal models to mimic psychosis for experimental purposes.Dizocilpine has also been found to act as a nicotinic a…, particularly strong NMDA antagonist
3D model (JSmol) · 1
Dizocilpine → Interactive image
ATC code · 1
Dizocilpine → None
CAS Number · 1
Dizocilpine → 77086-21-6 Y
ChEBI · 1
Dizocilpine → CHEBI:34725
ChEMBL · 1
Dizocilpine → ChEMBL284237 Y

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

nmda receptor also drug glutamate shown effects animal antagonist dissociative found used administration brain antagonists receptors rats models channel ketamine

Dizocilpine relationships Subject–Predicate–Object triples

TTTA extracted 57 structured relationships around Dizocilpine. Examples in this analysis include Dizocilpine → 3D model (JSmol) → Interactive image and Dizocilpine → ATC code → None. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Dizocilpine3D model (JSmol)Interactive image1.00infobox
DizocilpineATC codeNone1.00infobox
DizocilpineCAS Number77086-21-6 Y1.00infobox
DizocilpineChEBICHEBI:347251.00infobox
DizocilpineChEMBLChEMBL284237 Y1.00infobox
DizocilpineChemSpider156718 Y1.00infobox
DizocilpineCompTox Dashboard (EPA)DTXSID30484471.00infobox
DizocilpineDrugBank? N1.00infobox
DizocilpineFormulaC16H15N1.00infobox
DizocilpineIUPHAR/BPS24031.00infobox
DizocilpineMelting point68.75 °C (155.75 °F)1.00infobox
DizocilpineMolar mass221.303 g·mol−11.00infobox
DizocilpinePubChem CID1800811.00infobox
DizocilpineRoutes of administrationBy mouth, IM1.00infobox
DizocilpineUNII7PY8KH681I1.00infobox
Dizocilpineis amost frequently used uncompetitive NMDA receptor antagonist in animal models to mimic psychosis for experimental purposes.Dizocilpine has also been found to act as a nicotinic a…0.90text
Dizocilpineis aparticularly strong NMDA antagonist0.90text

Related concept clusters Concept neighborhoods

The concept neighborhoods around Dizocilpine bring nearby vocabulary together. In this analysis, examples include Nmda, Drug and Animal. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Dizocilpine
    • Nmda
    • Drug
    • Animal
    • Receptor
    • Administration
    • Effects
    • Shown
    • Models
    • Found
    • Antagonists
    • Development
    • Potential
  • dizocilpine
    • Nmda
    • Drug
    • Animal
    • Receptor
    • Administration
    • Effects
    • Shown
    • Models
    • Found
    • Antagonists
    • Development
    • Potential
  • nmda receptor
    • Antagonists
    • Receptors
    • Receptor
    • Effects
    • Inhibition
    • Used
    • Antagonist
    • Brain
    • Shown
    • However
    • Mimic
    • Neurons
  • nmda antagonists
    • Antagonists
    • Nmda
    • Inhibition
    • Receptors
    • Brain
    • Receptor
    • Effects
    • Shown
    • Antagonist
    • Discovered
    • Including
    • Dizocilpine
  • animal models of schizophrenia
    • Models
    • Potential
    • Model
    • Used
    • Schizophrenia
    • Studies
    • Shown
    • Dizocilpine
    • Psychosis
    • Drugs
    • Mimic
    • Neurons
  • animal models
    • Models
    • Potential
    • Model
    • Used
    • Schizophrenia
    • Studies
    • Shown
    • Dizocilpine
    • Psychosis
    • Drugs
    • Mimic
    • Neurons
  • animal models of depression
    • Models
    • Potential
    • Model
    • Used
    • Schizophrenia
    • Studies
    • Shown
    • Dizocilpine
    • Psychosis
    • Drugs
    • Mimic
    • Neurons
  • an animal model of schizophrenia
    • Models
    • Schizophrenia
    • Potential
    • Model
    • Studies
    • Olney's
    • Used
    • Recreational
    • Dizocilpine
    • Shown
    • Psychosis
    • Drugs

Connections between topic areas Semantic bridges

For Dizocilpine, one of the stronger structural bridges in this analysis connects Dizocilpine with Possible future medical uses. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Dizocilpine — Possible future medical uses · splits 43 ⟂ 27
Dizocilpine — Overview · splits 46 ⟂ 24
Dizocilpine — Recreational use · splits 63 ⟂ 7
Dizocilpine — Olney's lesions · splits 64 ⟂ 6
Dizocilpine — An animal model of schizophrenia · splits 65 ⟂ 5

Map overview Semantic statistics

Dizocilpine

Nodes70
Edges69
Triples57
Avg. degree1.97
Density0.028571
Components1

Source & methodology

TTTA analyzes the structure around Dizocilpine to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Applications & Products, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Dizocilpine · EN edition · Analysis: TopicsToTalkAbout

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