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P53

p53, also known as tumor protein p53, TP53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory transcription factor protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer…

Function, Regulation & Role in disease

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Aliases
TP53, BCC7, LFS1, P53, TRP53, tumor protein p53, BMFS5, Genes, p53
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4QO1, 1A1U, 1AIE, 1C26, 1DT7, 1GZH, 1H26, 1HS5, 1KZY, 1MA3, 1OLG, 1OLH, 1PES, 1PET, 1SAE, 1SAF, 1SAK, 1SAL,…
Band
17p13.1 · 11 B3|11 42.83 cM
Bgee
ventricular zone · ganglionic eminence · tendon of biceps brachii · monocyte · stromal cell of endometrium
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

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Overview

Gene

Structure

Tetramerization

Function

Regulation

Role in disease

Discovery

Interactions

Advanced semantic analysis

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Map overview Semantic statistics

P53

Nodes283
Edges282
Triples598
Avg. degree1.99
Density0.007067
Components1

How this topic connects Entity context

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P53

Top relations

Gene ontology · 197
P53 → apoptotic process, ATP binding, autophagy, B cell lineage commitment, base-excision repair, bone marrow development, cardiac septum morphogenesis, cell cycle, cell differentiation, cell population proliferation, cellular response to actinomycin D, cellular response to DNA damage stimulus, cellular response to gamma radiation, cellular response to glucose starvation, cellular response to hypoxia, cellular response to ionizing radiation, cellular response to UV, cellular response to UV-C, central nervous system development, cerebellum development
related to Interactions · 108
P53 → AIMP2, ANKRD2, APTX, ATF3, ATM, ATR, AURKA, BAK1, BARD1, BLM, BRCA1, BRCA2, BRCC3, BRE, CCNG1, CDC14A, CDC14B, Cdk1, CDK7, CEBPZ
related to External links · 37
P53 → Archived, Cell Biology, Cytogenetics, DNA, DS, GeneCardsp53 News, GeneReviews/NCBI/NIH/UW, Genetics, George Pantziarka TP53 Trust, HaematologyTP53 Gene, Human P53, IARC, IMCB, Institute, Knowledgebase, Lane Group, Li-Fraumeni Syndrome, Li-Fraumeni SyndromeTUMOR PROTEIN, Living LFS, Lyon
related to Discovery · 25
P53 → Academy, Arnold Levine, Cancer Institute, Center, David, David Givol, Imperial Cancer Research Fund, It, Lane, Lionel Crawford, Lloyd Old, Memorial Sloan Kettering Cancer, Moshe Oren, New Jersey, Peter Chumakov, Princeton University/UMDNJ, Science, Sciences, SV40, The
related to Stress-responsive kinases · 20
P53 → Additional, ATM, ATR, CAK, CDK-activating, CDK7, CHK1, CHK2, DNA, DNA-PK, ERK1/2, JNK1, Kinases, MAPK, MAT1, One, PRPK, Ser15, Ser33, TP53RK
Bgee · 18
P53 → blastocyst, embryo, epiblast, ganglionic eminence, genital tubercle, granulocyte, lip, monocyte, rectum, skin of abdomen, skin of leg, smooth muscle tissue, somite, stromal cell of endometrium, tail of embryo, tendon of biceps brachii, ventricular zone, yolk sac
RNA expression pattern · 18
P53 → blastocyst, embryo, epiblast, ganglionic eminence, genital tubercle, granulocyte, lip, monocyte, rectum, skin of abdomen, skin of leg, smooth muscle tissue, somite, stromal cell of endometrium, tail of embryo, tendon of biceps brachii, ventricular zone, yolk sac
related to Structure · 14
P53 → AD1, AD2, An, C-terminal, DBD, DNA, DNA-binding, LMO3, MAPK, N-terminus, NLS, OD, TAD, The
related to Tetramerization · 14
P53 → Arg337, Asp352, Each, Gly334, Helix, Ile332, Leu330, Leu344, Phe328, Phe338, Phe341, The, This, V-shaped
related to Deubiquitination · 11
P53 → After DNA, DUB, DUBs, HAUSP, In, It, MDM2, Several, USP10, USP42, USP7

Important terminology Word statistics

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Important terminology

tp53 gene human dna cancer cell protein also mdm2 mutations isoforms cells damage p21 tumor activation stem apoptosis role repair

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
P53AliasesTP53, BCC7, LFS1, P53, TRP53, tumor protein p53, BMFS5, Genes, p531.00infobox
P53Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4QO1, 1A1U, 1AIE, 1C26, 1DT7, 1GZH, 1H26, 1HS5, 1KZY, 1MA3, 1OLG, 1OLH, 1PES, 1PET, 1SAE, 1SAF, 1SAK, 1SAL,…1.00infobox
P53Band17p13.11.00infobox
P53Band11 B3|11 42.83 cM1.00infobox
P53Bgeeventricular zone1.00infobox
P53Bgeeganglionic eminence1.00infobox
P53Bgeetendon of biceps brachii1.00infobox
P53Bgeemonocyte1.00infobox
P53Bgeestromal cell of endometrium1.00infobox
P53Bgeeskin of abdomen1.00infobox
P53Bgeerectum1.00infobox
P53Bgeegranulocyte1.00infobox
P53Bgeeskin of leg1.00infobox
P53Bgeesmooth muscle tissue1.00infobox
P53Bgeetail of embryo1.00infobox
P53Bgeegenital tubercle1.00infobox
P53Bgeeembryo1.00infobox
P53Bgeeepiblast1.00infobox
P53Bgeeyolk sac1.00infobox
P53Bgeelip1.00infobox
P53Bgeeblastocyst1.00infobox
P53Bgeesomite1.00infobox
P53BioGPSMore reference expression data1.00infobox
P53Chr.Chromosome 17 (human)1.00infobox
P53Chr.Chromosome 11 (mouse)1.00infobox
P53DatabasesNCBI: entry; OMA: entry1.00infobox
P53End7,687,538 bp1.00infobox
P53End69,482,699 bp1.00infobox
P53EnsemblENSG000001415101.00infobox
P53Entrez71571.00infobox

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