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Reelin

Reelin, encoded by the RELN gene, is a large secreted extracellular matrix glycoprotein that helps regulate processes of neuronal migration and positioning in the developing brain by controlling cell–cell interactions. Besides this important role in early development, reelin continues to work in the adult brain. It modulates synaptic plasticity by…

Discovery, Tissue distribution and secretion & Mechanism of action

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Aliases
RELN, LIS2, PRO1598, RL, reelin, ETL7
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ddu, 2e26, 2DDU, 2E26, 3A7Q
Band
7q22.1 · 5 A3|5 9.98 cM
Bgee
olfactory bulb · cerebellar vermis · cerebellar hemisphere · paraflocculus of cerebellum · right hemisphere of cerebellum
BioGPS
More reference expression data
Chr.
Chromosome 7 (human) · Chromosome 5 (mouse)

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Overview

Discovery

Tissue distribution and secretion

Structure

Function

Evolutionary significance

Mechanism of action

Possible pathological role

Factors affecting reelin expression

Advanced semantic analysis

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Map overview Semantic statistics

Reelin

Nodes237
Edges236
Triples351
Avg. degree1.99
Density0.008439
Components1

How this topic connects Entity context

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Reelin

Top relations

Gene ontology · 63
Reelin → associative learning, axon guidance, brain development, cell adhesion, cell migration, cell morphogenesis involved in differentiation, central nervous system development, cerebral cortex development, cerebral cortex tangential migration, cytoplasm, dendrite, dendrite development, extracellular matrix, extracellular region, extracellular space, forebrain development, glial cell differentiation, hippocampus development, hydrolase activity, lateral motor column neuron migration
related to Alzheimer's disease · 24
Reelin → According, AD, All, Alzheimer's, AMPA, ApoE, ApoE4, ApoER2, Apolipoprotein, Aβ-induced, Cajal-Retzius, E2, E3, E4, In, LDL, NMDA, NMDA-receptor, RELN, The
Bgee · 18
Reelin → cerebellar hemisphere, cerebellar vermis, ciliary body, endothelial cell, endothelial cell of lymphatic vessel, iris, lobe of cerebellum, olfactory bulb, paraflocculus of cerebellum, paraventricular nucleus of hypothalamus, piriform cortex, pons, right hemisphere of cerebellum, sciatic nerve, spinal ganglia, superior colliculus, tibial nerve, trigeminal ganglion
RNA expression pattern · 18
Reelin → cerebellar hemisphere, cerebellar vermis, ciliary body, endothelial cell, endothelial cell of lymphatic vessel, iris, lobe of cerebellum, olfactory bulb, paraflocculus of cerebellum, paraventricular nucleus of hypothalamus, piriform cortex, pons, right hemisphere of cerebellum, sciatic nerve, spinal ganglia, superior colliculus, tibial nerve, trigeminal ganglion
related to External links · 18
Reelin → Archived, August, Brain Gene Expression Map, CS1, Gabriella D'Arcangelo, Jude Children's Research Hospital, July, Mouse Reelin, Overview, PDB, PDBe-KB, Q60841, RELN, Retrieved, Rutgers University, St, UniProt, WikiGenes
related to Schizophrenia · 16
Reelin → Blood, Costa, DNA, DNMT1, Epigenetic, GABA, GABAergic, GAD-67, Grayson, Guidotti, L-methionine, Methylation, Reduced, Stanley Foundation Neuropathology Consortium, The, There
related to Autism · 15
Reelin → Although, An, And, ATG, Autism, CGG, European, German, GGC/CGG, However, In, Italian, Longer, RELN, The
related to Signaling cascades · 15
Reelin → Activated, ApoER2, DAB1, FABP7, Fyn, In, It, Notch-1, NPxY, Phosphorylation, Some, Src, Such, The, VLDLR
related to Interaction with Cdk5 · 13
Reelin → ApoER2, ApoER2/VLDLR, Cdk5, Cyclin-dependent, DAB1, GSK3B, Lis1, LTP, NUDEL, P35, RELN, Tau, VLDLR
related to Receptors · 13
Reelin → After, ApoER2, As, CNR1, II/III, It, N-terminal, NPxY, Reelin's, The, This, VLDLR, VLDLR/ApoER2

Important terminology Word statistics

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Important terminology

gene expression reln study brain role cells protein schizophrenia one found neurons dab1 also mice apoer2 receptors migration reeler levels

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ReelinAliasesRELN, LIS2, PRO1598, RL, reelin, ETL71.00infobox
ReelinAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2ddu, 2e26, 2DDU, 2E26, 3A7Q1.00infobox
ReelinBand7q22.11.00infobox
ReelinBand5 A3|5 9.98 cM1.00infobox
ReelinBgeeolfactory bulb1.00infobox
ReelinBgeecerebellar vermis1.00infobox
ReelinBgeecerebellar hemisphere1.00infobox
ReelinBgeeparaflocculus of cerebellum1.00infobox
ReelinBgeeright hemisphere of cerebellum1.00infobox
ReelinBgeespinal ganglia1.00infobox
ReelinBgeetrigeminal ganglion1.00infobox
ReelinBgeeendothelial cell1.00infobox
ReelinBgeetibial nerve1.00infobox
ReelinBgeepons1.00infobox
ReelinBgeeciliary body1.00infobox
ReelinBgeelobe of cerebellum1.00infobox
ReelinBgeeiris1.00infobox
ReelinBgeesciatic nerve1.00infobox
ReelinBgeeendothelial cell of lymphatic vessel1.00infobox
ReelinBgeesuperior colliculus1.00infobox
ReelinBgeeparaventricular nucleus of hypothalamus1.00infobox
ReelinBgeepiriform cortex1.00infobox
ReelinBioGPSMore reference expression data1.00infobox
ReelinChr.Chromosome 7 (human)1.00infobox
ReelinChr.Chromosome 5 (mouse)1.00infobox
ReelinDatabasesNCBI: entry; OMA: entry1.00infobox
ReelinEnd103,989,658 bp1.00infobox
ReelinEnd22,549,700 bp1.00infobox
ReelinEnsemblENSG000001890561.00infobox
ReelinEntrez56491.00infobox

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