| Major depressive disorder | Causes | Environmental (e.g. adverse life experiences), genetic predisposition, psychological factors such as stress | 1.00 | infobox |
| Major depressive disorder | Complications | Self-harm, suicide | 1.00 | infobox |
| Major depressive disorder | Differential diagnosis | Bipolar disorder, ADHD, autism spectrum disorder, sadness | 1.00 | infobox |
| Major depressive disorder | Duration | > 2 weeks | 1.00 | infobox |
| Major depressive disorder | Frequency | 163 million (2017) | 1.00 | infobox |
| Major depressive disorder | Medication | Antidepressants | 1.00 | infobox |
| Major depressive disorder | Other names | Clinical depression, major depression, unipolar depression, unipolar disorder, recurrent depression | 1.00 | infobox |
| Major depressive disorder | Risk factors | Family history, major life changes, living alone, certain medications, chronic health problems, substance use disorder | 1.00 | infobox |
| Major depressive disorder | Specialty | Psychiatry, clinical psychology | 1.00 | infobox |
| Major depressive disorder | Symptoms | Low mood, low self-esteem, loss of interest in normally enjoyable activities, low energy, pain without a clear cause, disturbed sleep pattern (insomnia or hypersomnia) | 1.00 | infobox |
| Major depressive disorder | Treatment | Psychotherapy, antidepressant medication, electroconvulsive therapy, transcranial magnetic stimulation, exercise | 1.00 | infobox |
| Major depressive disorder | Usual onset | Age 20s | 1.00 | infobox |
