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TBR1

T-box, brain, 1 is a transcription factor protein important in vertebrate embryo development. It is encoded by the TBR1 gene. This gene is also known by several other names: T-Brain 1, TBR-1, TES-56, and MGC141978. TBR1 is a member of the TBR1 subfamily of T-box family transcription factors, which share a common DNA-binding domain. Other members of the…

Functions, Non-human orthologs & Gene regulation

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Aliases
TBR1, TBR-1, TES-56, T-box, brain 1, IDDAS, T-box brain transcription factor 1
Band
2q24.2 · 2 C1.3|2 35.56 cM
Bgee
ganglionic eminence · Brodmann area 10 · frontal pole · Brodmann area 9 · right frontal lobe
BioGPS
n/a
Chr.
Chromosome 2 (human) · Chromosome 2 (mouse)
Databases
NCBI: entry; OMA: entry

Topics to explore

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Overview

Discovery

Human TBR1 gene and encoded protein

Functions

Tissue and cellular distribution

Non-human orthologs

Gene regulation

Clinical significance

Advanced semantic analysis

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Map overview Semantic statistics

TBR1

Nodes85
Edges84
Triples216
Avg. degree1.98
Density0.023529
Components1

How this topic connects Entity context

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TBR1

Top relations

Gene ontology · 22
TBR1 → amygdala development, brain development, cerebral cortex development, commitment of neuronal cell to specific neuron type in forebrain, conditioned taste aversion, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, hindbrain development, identical protein binding, neuron differentiation, nucleus, positive regulation of transcription by RNA polymerase II, protein binding, protein kinase binding, regulation of axon guidance, regulation of gene expression, regulation of neuron projection development, regulation of transcription, DNA-templated, RNA polymerase II cis-regulatory region sequence-specific DNA binding
Bgee · 18
TBR1 → anterior cingulate cortex, Brodmann area 10, Brodmann area 9, CA3 field, cingulate gyrus, entorhinal cortex, frontal pole, ganglionic eminence, perirhinal cortex, piriform cortex, postcentral gyrus, prefrontal cortex, primary motor cortex, primary visual cortex, right frontal lobe, superior frontal gyrus, testicle, visual cortex
RNA expression pattern · 18
TBR1 → anterior cingulate cortex, Brodmann area 10, Brodmann area 9, CA3 field, cingulate gyrus, entorhinal cortex, frontal pole, ganglionic eminence, perirhinal cortex, piriform cortex, postcentral gyrus, prefrontal cortex, primary motor cortex, primary visual cortex, right frontal lobe, superior frontal gyrus, testicle, visual cortex
related to Co-regulatory proteins · 15
TBR1 → C-terminal, CASK, CASK-interacting, CINAP, GK, IL-7R, It, NMDAR, NMDAR2b, One, OX-2, RELN, Tbr1/CASK, The Tbr1/CASK/CINAP, Through
related to Clinical significance · 14
TBR1 → AD, Alzheimer's, APP, ChBF, CINAP, However, In, It, NMDA, NR2b, Parkinson's, PD, Reduced, This
related to Discovery · 13
TBR1 → Brachyury, California, Developmental Neurobiology Center, Nina Ireland Laboratory, San Francisco, T-box, Tbx-1, Tbx-2, Tbx-3, TES-56, The, Thus, University
related to Genes regulated by TBR1 · 11
TBR1 → Abnormal, Bhlhb5, Fezf2, In, It, Mutation, Recent, The, This, Using, VI
related to Human TBR1 gene and encoded protein · 11
TBR1 → Da, EOMES, It, T-BET, T-box, T-box Brain Protein, T-Brain, TBR2, TBX21, TES-56, The
related to Tissue and cellular distribution · 11
TBR1 → Being, DNA, GABAergic, High, I-VI, Layers II-VI, No Tbr1, Successive, The, These, VI
related to Transcription factors that regulate the expression of Tbr1 · 11
TBR1 → Af9, DOT1L, H3, H3K79, II, Mutants, RNA, RNAPolII, Studies, This, VI

Important terminology Word statistics

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Important terminology

expression gene neurons transcription brain protein development layer developing also cortex cortical t-box expressed found human vi genes factor mice

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
TBR1AliasesTBR1, TBR-1, TES-56, T-box, brain 1, IDDAS, T-box brain transcription factor 11.00infobox
TBR1Band2q24.21.00infobox
TBR1Band2 C1.3|2 35.56 cM1.00infobox
TBR1Bgeeganglionic eminence1.00infobox
TBR1BgeeBrodmann area 101.00infobox
TBR1Bgeefrontal pole1.00infobox
TBR1BgeeBrodmann area 91.00infobox
TBR1Bgeeright frontal lobe1.00infobox
TBR1Bgeecingulate gyrus1.00infobox
TBR1Bgeeanterior cingulate cortex1.00infobox
TBR1Bgeepostcentral gyrus1.00infobox
TBR1Bgeesuperior frontal gyrus1.00infobox
TBR1Bgeetesticle1.00infobox
TBR1Bgeeperirhinal cortex1.00infobox
TBR1Bgeepiriform cortex1.00infobox
TBR1Bgeeprimary motor cortex1.00infobox
TBR1Bgeeentorhinal cortex1.00infobox
TBR1Bgeevisual cortex1.00infobox
TBR1Bgeeprimary visual cortex1.00infobox
TBR1Bgeeprefrontal cortex1.00infobox
TBR1BgeeCA3 field1.00infobox
TBR1BioGPSn/a1.00infobox
TBR1Chr.Chromosome 2 (human)1.00infobox
TBR1Chr.Chromosome 2 (mouse)1.00infobox
TBR1DatabasesNCBI: entry; OMA: entry1.00infobox
TBR1End161,425,870 bp1.00infobox
TBR1End61,644,458 bp1.00infobox
TBR1EnsemblENSG000001365351.00infobox
TBR1Entrez107161.00infobox
TBR1External IDsOMIM: 604616; MGI: 107404; GeneCards: TBR11.00infobox

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