Research any topic before you write.

Find related topics. | Discover entities. | See connections. | Build a topical map.

TBR1: Functions, Non-human orthologs & Gene regulation

T-box, brain, 1 is a transcription factor protein important in vertebrate embryo development. It is encoded by the TBR1 gene. This gene is also known by several other names: T-Brain 1, TBR-1, TES-56, and MGC141978. TBR1 is a member of the TBR1 subfamily of T-box family transcription factors, which share a common DNA-binding domain. Other members of the…

Language: English [EN]
Use the mouse wheel or two fingers (on touchscreens) to zoom in and out of the map.
100%
More settings
100% 100% 100% 100% 100%

TBR1 topic overview

The analysis highlights Functions, Non-human orthologs and Gene regulation as prominent areas in the source structure around TBR1.

Related topics
76
Source areas
8
Connected nodes
84
Extracted relationships
216
Concept neighborhoods
24
Bridge connections
84

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Functions · 18 topics
Overview · 14 topics
Non-human orthologs · 13 topics
Gene regulation · 12 topics
Clinical significance · 10 topics
Discovery · 5 topics
Human TBR1 gene and encoded protein · 3 topics
Tissue and cellular distribution · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
TBR1, TBR-1, TES-56, T-box, brain 1, IDDAS, T-box brain transcription factor 1
Band
2q24.2 · 2 C1.3|2 35.56 cM
Bgee
ganglionic eminence · Brodmann area 10 · frontal pole · Brodmann area 9 · right frontal lobe
BioGPS
n/a
Chr.
Chromosome 2 (human) · Chromosome 2 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Human TBR1 gene and encoded protein

Functions

Tissue and cellular distribution

Non-human orthologs

Gene regulation

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How TBR1 connects Entity context

The extracted context around TBR1 shows recurring relationship patterns in the source. For example, TBR1 → amygdala development, brain development, cerebral cortex development, commitment of neuronal cell to specific neuron type in forebrain, conditioned taste aversion, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, hindbrain development, identical protein binding, neuron differentiation, nucleus, positive regulation of transcription by RNA polymerase II, protein binding, protein kinase binding, regulation of axon guidance, regulation of gene expression, regulation of neuron projection development, regulation of transcription, DNA-templated, RNA polymerase II cis-regulatory region sequence-specific DNA binding Another extracted example is TBR1 → anterior cingulate cortex, Brodmann area 10, Brodmann area 9, CA3 field, cingulate gyrus, entorhinal cortex, frontal pole, ganglionic eminence, perirhinal cortex, piriform cortex, postcentral gyrus, prefrontal cortex, primary motor cortex, primary visual cortex, right frontal lobe, superior frontal gyrus, testicle, visual cortex. Use these groups to spot repeated connection types before inspecting the individual relationships.

TBR1

Top relations

Gene ontology · 22
TBR1 → amygdala development, brain development, cerebral cortex development, commitment of neuronal cell to specific neuron type in forebrain, conditioned taste aversion, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, hindbrain development, identical protein binding, neuron differentiation, nucleus, positive regulation of transcription by RNA polymerase II, protein binding, protein kinase binding, regulation of axon guidance, regulation of gene expression, regulation of neuron projection development, regulation of transcription, DNA-templated, RNA polymerase II cis-regulatory region sequence-specific DNA binding
Bgee · 18
TBR1 → anterior cingulate cortex, Brodmann area 10, Brodmann area 9, CA3 field, cingulate gyrus, entorhinal cortex, frontal pole, ganglionic eminence, perirhinal cortex, piriform cortex, postcentral gyrus, prefrontal cortex, primary motor cortex, primary visual cortex, right frontal lobe, superior frontal gyrus, testicle, visual cortex
RNA expression pattern · 18
TBR1 → anterior cingulate cortex, Brodmann area 10, Brodmann area 9, CA3 field, cingulate gyrus, entorhinal cortex, frontal pole, ganglionic eminence, perirhinal cortex, piriform cortex, postcentral gyrus, prefrontal cortex, primary motor cortex, primary visual cortex, right frontal lobe, superior frontal gyrus, testicle, visual cortex
related to Co-regulatory proteins · 15
TBR1 → C-terminal, CASK, CASK-interacting, CINAP, GK, IL-7R, It, NMDAR, NMDAR2b, One, OX-2, RELN, Tbr1/CASK, The Tbr1/CASK/CINAP, Through
related to Clinical significance · 14
TBR1 → AD, Alzheimer's, APP, ChBF, CINAP, However, In, It, NMDA, NR2b, Parkinson's, PD, Reduced, This
related to Discovery · 13
TBR1 → Brachyury, California, Developmental Neurobiology Center, Nina Ireland Laboratory, San Francisco, T-box, Tbx-1, Tbx-2, Tbx-3, TES-56, The, Thus, University
related to Genes regulated by TBR1 · 11
TBR1 → Abnormal, Bhlhb5, Fezf2, In, It, Mutation, Recent, The, This, Using, VI
related to Human TBR1 gene and encoded protein · 11
TBR1 → Da, EOMES, It, T-BET, T-box, T-box Brain Protein, T-Brain, TBR2, TBX21, TES-56, The
related to Tissue and cellular distribution · 11
TBR1 → Being, DNA, GABAergic, High, I-VI, Layers II-VI, No Tbr1, Successive, The, These, VI
related to Transcription factors that regulate the expression of Tbr1 · 11
TBR1 → Af9, DOT1L, H3, H3K79, II, Mutants, RNA, RNAPolII, Studies, This, VI

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

expression gene neurons transcription brain protein development layer developing also cortex cortical t-box expressed found human vi genes factor mice

TBR1 relationships Subject–Predicate–Object triples

TTTA extracted 216 structured relationships around TBR1. Examples in this analysis include TBR1 → Aliases → TBR1, TBR-1, TES-56, T-box, brain 1, IDDAS, T-box brain transcription factor 1 and TBR1 → Band → 2q24.2. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TBR1AliasesTBR1, TBR-1, TES-56, T-box, brain 1, IDDAS, T-box brain transcription factor 11.00infobox
TBR1Band2q24.21.00infobox
TBR1Band2 C1.3|2 35.56 cM1.00infobox
TBR1Bgeeganglionic eminence1.00infobox
TBR1BgeeBrodmann area 101.00infobox
TBR1Bgeefrontal pole1.00infobox
TBR1BgeeBrodmann area 91.00infobox
TBR1Bgeeright frontal lobe1.00infobox
TBR1Bgeecingulate gyrus1.00infobox
TBR1Bgeeanterior cingulate cortex1.00infobox
TBR1Bgeepostcentral gyrus1.00infobox
TBR1Bgeesuperior frontal gyrus1.00infobox
TBR1Bgeetesticle1.00infobox
TBR1Bgeeperirhinal cortex1.00infobox
TBR1Bgeepiriform cortex1.00infobox
TBR1Bgeeprimary motor cortex1.00infobox
TBR1Bgeeentorhinal cortex1.00infobox
TBR1Bgeevisual cortex1.00infobox
TBR1Bgeeprimary visual cortex1.00infobox
TBR1Bgeeprefrontal cortex1.00infobox
TBR1BgeeCA3 field1.00infobox
TBR1BioGPSn/a1.00infobox
TBR1Chr.Chromosome 2 (human)1.00infobox
TBR1Chr.Chromosome 2 (mouse)1.00infobox
TBR1DatabasesNCBI: entry; OMA: entry1.00infobox
TBR1End161,425,870 bp1.00infobox
TBR1End61,644,458 bp1.00infobox
TBR1EnsemblENSG000001365351.00infobox
TBR1Entrez107161.00infobox
TBR1External IDsOMIM: 604616; MGI: 107404; GeneCards: TBR11.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around TBR1 bring nearby vocabulary together. In this analysis, examples include Expression, Transcription and Neurons. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • TBR1
    • Expression
    • Transcription
    • Neurons
    • Genes
    • Cortex
    • Found
    • Layer
    • Cask
    • Expressed
    • Developing
    • Zebrafish
    • Fezf2
  • tbr1
    • Expression
    • Transcription
    • Neurons
    • Genes
    • Cortex
    • Found
    • Layer
    • Cask
    • Expressed
    • Developing
    • Zebrafish
    • Fezf2
  • transcription factor
    • Transcription
    • Protein
    • Genes
    • T-box
    • Bp
    • Chr
    • Development
    • Tes-56
    • Differentiation
    • Human
    • Neuronal
    • Cells
  • protein
    • Transcription
    • T-box
    • Tes-56
    • Neuronal
    • Genes
    • Tbr1
    • Development
    • Bp
    • Chr
    • Expression
    • Cask
    • Differentiation
  • gene
    • Human
    • Mouse
    • Tbr1
    • Also
    • Bp
    • Chr
    • Tes-56
    • Differentiation
    • Expression
    • Expressed
    • Cortex
    • Transcription
  • differentiation
    • Neuronal
    • Involved
    • Mouse
    • Bp
    • Chr
    • Human
    • Developing
    • Factor
    • Gene
    • Neurons
    • Cortex
    • Transcription
  • brachyury protein
    • Transcription
    • T-box
    • Tes-56
    • Neuronal
    • Genes
    • Tbr1
    • Development
    • Bp
    • Chr
    • Expression
    • Cask
    • Differentiation
  • mouse brain
    • Differentiation
    • Development
    • Mouse
    • Neuronal
    • Forebrain
    • Gene
    • Involved
    • Protein
    • Factor
    • T-box
    • Tbr1
    • Also

Connections between topic areas Semantic bridges

For TBR1, one of the stronger structural bridges in this analysis connects TBR1 with Functions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TBR1Functions · splits 66 ⟂ 19
TBR1Overview · splits 70 ⟂ 15
TBR1Non-human orthologs · splits 71 ⟂ 14
TBR1Gene regulation · splits 72 ⟂ 13
TBR1Clinical significance · splits 74 ⟂ 11
TBR1Discovery · splits 79 ⟂ 6
TBR1Human TBR1 gene and encoded protein · splits 81 ⟂ 4

Map overview Semantic statistics

TBR1

Nodes85
Edges84
Triples216
Avg. degree1.98
Density0.023529
Components1

Source & methodology

TTTA analyzes the structure around TBR1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Functions, Non-human orthologs & Gene regulation, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TBR1 · EN edition · Analysis: TopicsToTalkAbout

For writers, content strategists, SEOs, marketers and creators — from quick topic research to advanced semantic analysis.