Low-density lipoprotein receptor-related protein 8

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Low-density lipoprotein receptor-related protein 8 topic overview

The analysis highlights Art, Clinical significance and Structure as prominent areas in the source structure around Low-density lipoprotein receptor-related protein 8.

Related topics: 83
Source areas: 5
Connected nodes: 88
Extracted relationships: 101
Concept neighborhoods: 23
Bridge connections: 88

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Clinical significance · 34 topics

Overview · 23 topics

Other interacting proteins · 12 topics

Structure · 12 topics

Function · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: LRP8, APOER2, HSZ75190, LRP-8, MCI1, low density lipoprotein receptor-related protein 8, LDL receptor related protein 8
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3A7Q
Band: 1p32.3 · 4|4 C7
Bgee: ganglionic eminence · retinal pigment epithelium · ventricular zone · right testis · left testis
BioGPS: More reference expression data
Chr.: Chromosome 1 (human) · Chromosome 4 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Protein
Gene
Cell surface receptor
Low-density lipoprotein receptor family Low-density lipoprotein receptor gene family
Reelin
Long-term potentiation
VLDLR VLDL receptor
Cajal-Retzius cells Cajal-Retzius cell
DAB1
Tyrosine kinases Tyrosine kinase
Fyn
Src Src (gene)
Phosphatidylinositol-3-kinase Phosphoinositide 3-kinase
GSK3B
Cortical plate
Reeler
Neuronal migration
Cortex Cerebral cortex
Hippocampus
NMDA receptor
Synaptic plasticity
PSD-95
Src family kinases Src family kinase

Structure

Function

Other interacting proteins

Clinical significance

Alzheimer's disease
Alleles Allele
Ps2 Presenilin
Tau protein
Amyloid beta Beta amyloid
Splice variants Alternative splicing
Alpha-2-macroglobulin
Proteases Protease
Neuritic plaques Senile plaques
CDNA Complementary DNA
Phosphorylation
Microtubule
Central Nervous System
Neurofibrillary tangles
Antiphospholipid syndrome
Autoimmune disease
Thrombosis
Fetal death Perinatal mortality
Antibodies Antibody
Phospholipids Phospholipid
Β2-glycoprotein I Apolipoprotein H
Symptoms Symptom
Monocytes Monocyte
Endothelial cells Endothelium
Platelets Platelet
P38MAPkinase P38 mitogen-activated protein kinases
Thromboxane A2
Blood clots Thrombus
Ferroptosis
Cancer
GPX4
Peripheral blood lymphocytes
Major depressive disorder
MRNA Messenger RNA

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Low-density lipoprotein receptor-related protein 8 connects Entity context

The extracted context around Low-density lipoprotein receptor-related protein 8 shows recurring relationship patterns in the source. For example, Low-density lipoprotein receptor-related protein 8 → ammon gyrus development, apolipoprotein binding, axon, calcium ion binding, caveola, cellular response to cholesterol, cellular response to growth factor stimulus, cerebral cortex development, cytokine-mediated signaling pathway, dendrite, endocytosis, extracellular region, high-density lipoprotein particle binding, integral component of membrane, kinesin binding, lipid metabolism, low-density lipoprotein particle receptor activity, membrane, microtubule associated complex, modulation of chemical synaptic transmission Another extracted example is Low-density lipoprotein receptor-related protein 8 → Brodmann area 46, cerebellar cortex, ganglionic eminence, habenula, lateral nuclear group of thalamus, left lobe of thyroid gland, left testis, neural layer of retina, olfactory bulb, pons, primary visual cortex, retinal pigment epithelium, right lobe of thyroid gland, right testis, Rostral migratory stream, superior frontal gyrus, tail of embryo, ventricular zone. Use these groups to spot repeated connection types before inspecting the individual relationships.

Low-density lipoprotein receptor-related protein 8

Top relations

Gene ontology · 41

Low-density lipoprotein receptor-related protein 8 → ammon gyrus development, apolipoprotein binding, axon, calcium ion binding, caveola, cellular response to cholesterol, cellular response to growth factor stimulus, cerebral cortex development, cytokine-mediated signaling pathway, dendrite, endocytosis, extracellular region, high-density lipoprotein particle binding, integral component of membrane, kinesin binding, lipid metabolism, low-density lipoprotein particle receptor activity, membrane, microtubule associated complex, modulation of chemical synaptic transmission

Bgee · 18

Low-density lipoprotein receptor-related protein 8 → Brodmann area 46, cerebellar cortex, ganglionic eminence, habenula, lateral nuclear group of thalamus, left lobe of thyroid gland, left testis, neural layer of retina, olfactory bulb, pons, primary visual cortex, retinal pigment epithelium, right lobe of thyroid gland, right testis, Rostral migratory stream, superior frontal gyrus, tail of embryo, ventricular zone

RNA expression pattern · 18

Band · 2

Low-density lipoprotein receptor-related protein 8 → 1p32.3, 4|4 C7

Chr. · 2

Low-density lipoprotein receptor-related protein 8 → Chromosome 1 (human), Chromosome 4 (mouse)

End · 2

Low-density lipoprotein receptor-related protein 8 → 107,876,840 bp, 53,328,469 bp

Aliases · 1

Low-density lipoprotein receptor-related protein 8 → LRP8, APOER2, HSZ75190, LRP-8, MCI1, low density lipoprotein receptor-related protein 8, LDL receptor related protein 8

Available structures · 1

Low-density lipoprotein receptor-related protein 8 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3A7Q

BioGPS · 1

Low-density lipoprotein receptor-related protein 8 → More reference expression data

Databases · 1

Low-density lipoprotein receptor-related protein 8 → NCBI: entry; OMA: entry

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

apoer2 protein reelin role receptor disease binding receptors migration expression function endocytosis development lipoprotein pathway also gene alzheimer's phosphorylation apoe

Low-density lipoprotein receptor-related protein 8 relationships Subject–Predicate–Object triples

TTTA extracted 101 structured relationships around Low-density lipoprotein receptor-related protein 8. Examples in this analysis include Low-density lipoprotein receptor-related protein 8 → Aliases → LRP8, APOER2, HSZ75190, LRP-8, MCI1, low density lipoprotein receptor-related protein 8, LDL receptor related protein 8 and Low-density lipoprotein receptor-related protein 8 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3A7Q. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Low-density lipoprotein receptor-related protein 8	Aliases	LRP8, APOER2, HSZ75190, LRP-8, MCI1, low density lipoprotein receptor-related protein 8, LDL receptor related protein 8	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes3A7Q	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Band	1p32.3	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Band	4\|4 C7	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Bgee	ganglionic eminence	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Bgee	retinal pigment epithelium	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Bgee	ventricular zone	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Bgee	right testis	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Bgee	left testis	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Bgee	right lobe of thyroid gland	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Bgee	pons	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Bgee	left lobe of thyroid gland	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Bgee	lateral nuclear group of thalamus	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Bgee	Brodmann area 46	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Bgee	Rostral migratory stream	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Bgee	habenula	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Bgee	neural layer of retina	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Bgee	olfactory bulb	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Bgee	tail of embryo	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Bgee	cerebellar cortex	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Bgee	primary visual cortex	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Bgee	superior frontal gyrus	1.00	infobox
Low-density lipoprotein receptor-related protein 8	BioGPS	More reference expression data	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Chr.	Chromosome 1 (human)	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Chr.	Chromosome 4 (mouse)	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Databases	NCBI: entry; OMA: entry	1.00	infobox
Low-density lipoprotein receptor-related protein 8	End	53,328,469 bp	1.00	infobox
Low-density lipoprotein receptor-related protein 8	End	107,876,840 bp	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Ensembl	ENSG00000157193	1.00	infobox
Low-density lipoprotein receptor-related protein 8	Entrez	7804	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Low-density lipoprotein receptor-related protein 8 bring nearby vocabulary together. In this analysis, examples include Apolipoprotein, Lrp8 and Endocytosis. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

Low-density lipoprotein receptor-related protein 8
- Apolipoprotein
- Lrp8
- Endocytosis
- Gene
- Receptor
- Function
- Human
- Bp
- Chr
- Also
- Leads
- Pathway
low-density lipoprotein receptor-related protein 8
- Apolipoprotein
- Lrp8
- Endocytosis
- Gene
- Receptor
- Function
- Human
- Bp
- Chr
- Phosphorylation
- Also
- Leads
protein
- Phosphorylation
- Leads
- Receptors
- Dab1
- Process
- Reelin
- Alzheimer's
- Pathway
- Expression
- Receptor
- Disease
- Human
gene
- Human
- Bp
- Chr
- Lipoprotein
- Lrp8
- Band
- Receptor
- Dab1
- Protein
- Endocytosis
- Phosphorylation
- Function
low-density lipoprotein receptor family
- Ldl
- Apolipoprotein
- Lrp8
- Endocytosis
- Gene
- Receptor
- Function
- Human
- Receptors
- Bp
- Chr
- Reelin
reelin
- Binding
- Development
- Receptor
- Phosphorylation
- Alzheimer's
- Pathway
- Migration
- Disease
- Human
- Bp
- Chr
- Dab1
endocytosis
- Function
- Lipoprotein
- Human
- Bp
- Chr
- Receptor
- Lrp8
- Motif
- Gene
- Pathway
- Binding
- Band
lipoprotein
- Apolipoprotein
- Lrp8
- Endocytosis
- Gene
- Receptor
- Function
- Human
- Bp
- Chr
- Also
- Pathway
- Protein

Connections between topic areas Semantic bridges

For Low-density lipoprotein receptor-related protein 8, one of the stronger structural bridges in this analysis connects Low-density lipoprotein receptor-related protein 8 with Clinical significance. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Low-density lipoprotein receptor-related protein 8 — Clinical significance · splits 54 ⟂ 35

Low-density lipoprotein receptor-related protein 8 — Overview · splits 65 ⟂ 24

Low-density lipoprotein receptor-related protein 8 — Structure · splits 76 ⟂ 13

Low-density lipoprotein receptor-related protein 8 — Other interacting proteins · splits 76 ⟂ 13

Low-density lipoprotein receptor-related protein 8 — Function · splits 86 ⟂ 3

Map overview Semantic statistics

Low-density lipoprotein receptor-related protein 8

Nodes89

Edges88

Triples101

Avg. degree1.98

Density0.022472

Components1

Source & methodology

TTTA analyzes the structure around Low-density lipoprotein receptor-related protein 8 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art, Clinical significance & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Low-density lipoprotein receptor-related protein 8 · EN edition · Analysis: TopicsToTalkAbout