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NPAS3: Function, Clinical significance & Overview

NPAS3 or Neuronal PAS domain protein 3 is a brain-enriched transcription factor belonging to the bHLH-PAS superfamily of transcription factors, the members of which carry out diverse functions, including circadian oscillations, neurogenesis, toxin metabolism, hypoxia, and tracheal development. NPAS3 contains a basic helix-loop-helix structural motif and…

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NPAS3 topic overview

The analysis highlights Function, Clinical significance and Overview as prominent areas in the source structure around NPAS3.

Related topics
25
Source areas
3
Connected nodes
28
Extracted relationships
86
Concept neighborhoods
14
Bridge connections
28

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 12 topics
Overview · 10 topics
Clinical significance · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
NPAS3, neuronal PAS domain protein 3, MOP6, PASD6, bHLHe12
Band
14q13.1 · 12|12 C1
Bgee
endothelial cell · ventricular zone · corpus callosum · buccal mucosa cell · globus pallidus
BioGPS
n/a
Chr.
Chromosome 14 (human) · Chromosome 12 (mouse)
Databases
NCBI: entry; OMA: entry

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Clinical significance

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How NPAS3 connects Entity context

The extracted context around NPAS3 shows recurring relationship patterns in the source. For example, NPAS3 → buccal mucosa cell, condyle, corpus callosum, deep cerebellar nuclei, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, endothelial cell, entorhinal cortex, external globus pallidus, fossa, globus pallidus, inferior ganglion of vagus nerve, internal globus pallidus, lateral hypothalamus, lumbar subsegment of spinal cord, optic nerve, substantia nigra, ventral tegmental area, ventricular zone Another extracted example is NPAS3 → cytosol, developmental process, DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, nucleoplasm, nucleus, positive regulation of transcription by RNA polymerase II, positive regulation of transcription, DNA-templated, protein dimerization activity, protein heterodimerization activity, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, transcription, DNA-templated. Use these groups to spot repeated connection types before inspecting the individual relationships.

NPAS3

Top relations

Bgee · 19
NPAS3 → buccal mucosa cell, condyle, corpus callosum, deep cerebellar nuclei, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, endothelial cell, entorhinal cortex, external globus pallidus, fossa, globus pallidus, inferior ganglion of vagus nerve, internal globus pallidus, lateral hypothalamus, lumbar subsegment of spinal cord, optic nerve, substantia nigra, ventral tegmental area, ventricular zone
RNA expression pattern · 19
NPAS3 → buccal mucosa cell, condyle, corpus callosum, deep cerebellar nuclei, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, endothelial cell, entorhinal cortex, external globus pallidus, fossa, globus pallidus, inferior ganglion of vagus nerve, internal globus pallidus, lateral hypothalamus, lumbar subsegment of spinal cord, optic nerve, substantia nigra, ventral tegmental area, ventricular zone
Gene ontology · 13
NPAS3 → cytosol, developmental process, DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, nucleoplasm, nucleus, positive regulation of transcription by RNA polymerase II, positive regulation of transcription, DNA-templated, protein dimerization activity, protein heterodimerization activity, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, transcription, DNA-templated
related to Function · 4
NPAS3 → Among, From, HAR202, HAR21
Band · 2
NPAS3 → 12|12 C1, 14q13.1
Chr. · 2
NPAS3 → Chromosome 12 (mouse), Chromosome 14 (human)
End · 2
NPAS3 → 33,820,863 bp, 54,072,175 bp
related to Clinical significance · 2
NPAS3 → Disruption, In
Aliases · 1
NPAS3 → NPAS3, neuronal PAS domain protein 3, MOP6, PASD6, bHLHe12
BioGPS · 1
NPAS3 → n/a

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

human bp gene chr band chromosome 14 superfamily pas domain schizophrenia protein mouse location function bhlh-pas functions neuronal transcription factor

NPAS3 relationships Subject–Predicate–Object triples

TTTA extracted 86 structured relationships around NPAS3. Examples in this analysis include NPAS3 → Aliases → NPAS3, neuronal PAS domain protein 3, MOP6, PASD6, bHLHe12 and NPAS3 → Band → 14q13.1. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
NPAS3AliasesNPAS3, neuronal PAS domain protein 3, MOP6, PASD6, bHLHe121.00infobox
NPAS3Band14q13.11.00infobox
NPAS3Band12|12 C11.00infobox
NPAS3Bgeeendothelial cell1.00infobox
NPAS3Bgeeventricular zone1.00infobox
NPAS3Bgeecorpus callosum1.00infobox
NPAS3Bgeebuccal mucosa cell1.00infobox
NPAS3Bgeeglobus pallidus1.00infobox
NPAS3Bgeeinternal globus pallidus1.00infobox
NPAS3Bgeeexternal globus pallidus1.00infobox
NPAS3Bgeeoptic nerve1.00infobox
NPAS3Bgeeinferior ganglion of vagus nerve1.00infobox
NPAS3Bgeeentorhinal cortex1.00infobox
NPAS3Bgeesubstantia nigra1.00infobox
NPAS3Bgeelumbar subsegment of spinal cord1.00infobox
NPAS3Bgeedeep cerebellar nuclei1.00infobox
NPAS3Bgeedorsal tegmental nucleus1.00infobox
NPAS3Bgeefossa1.00infobox
NPAS3Bgeedorsomedial hypothalamic nucleus1.00infobox
NPAS3Bgeeventral tegmental area1.00infobox
NPAS3Bgeecondyle1.00infobox
NPAS3Bgeelateral hypothalamus1.00infobox
NPAS3BioGPSn/a1.00infobox
NPAS3Chr.Chromosome 14 (human)1.00infobox
NPAS3Chr.Chromosome 12 (mouse)1.00infobox
NPAS3DatabasesNCBI: entry; OMA: entry1.00infobox
NPAS3End33,820,863 bp1.00infobox
NPAS3End54,072,175 bp1.00infobox
NPAS3EnsemblENSG000001513221.00infobox
NPAS3Entrez640671.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around NPAS3 bring nearby vocabulary together. In this analysis, examples include Gene, Human and Domain. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • NPAS3
    • Gene
    • Human
    • Domain
    • Found
    • Function
    • Pas
    • Protein
    • Study
    • Schizophrenia
    • Expression
    • External
    • Factor
  • npas3
    • Gene
    • Human
    • Domain
    • Found
    • Function
    • Pas
    • Protein
    • Study
    • Schizophrenia
    • Expression
    • External
    • Factor
  • transcription factor
    • Factor
    • Transcription
    • Protein
    • Metabolism
    • Toxin
    • Activity
    • Bhlh-pas
    • Binding
    • End
    • Expression
    • External
    • Functions
  • human accelerated regions
    • Activity
    • Species
    • Location
    • Band
    • End
    • Expression
    • Npas3
    • Accelerated
    • Human
    • Mouse
    • Protein
    • Binding
  • pas domain
    • Pas
    • Neuronal
    • Protein
    • Superfamily
    • Metabolism
    • Toxin
    • Npas3
    • Bhlh-pas
    • External
    • Factor
    • Functions
    • Neurogenesis
  • function
    • External
    • Location
    • Mouse
    • Protein
    • Chromosome
    • Bp
    • Chr
    • Npas3
    • Gene
    • Human
    • Activity
    • End
  • human evolution
    • Location
    • Band
    • End
    • Expression
    • Npas3
    • Accelerated
    • Mouse
    • Protein
    • Activity
    • Neuronal
    • Npas1
    • Species
  • neurogenesis
    • Metabolism
    • Toxin
    • Neuronal
    • Transcription
    • Function
    • Mouse
    • Pas
    • Protein
    • Superfamily
    • Npas3

Connections between topic areas Semantic bridges

For NPAS3, one of the stronger structural bridges in this analysis connects NPAS3 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
NPAS3Function · splits 16 ⟂ 13
NPAS3Overview · splits 18 ⟂ 11
NPAS3Clinical significance · splits 25 ⟂ 4

Map overview Semantic statistics

NPAS3

Nodes29
Edges28
Triples86
Avg. degree1.93
Density0.068966
Components1

Source & methodology

TTTA analyzes the structure around NPAS3 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Clinical significance & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — NPAS3 · EN edition · Analysis: TopicsToTalkAbout

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