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NPAS3

NPAS3 or Neuronal PAS domain protein 3 is a brain-enriched transcription factor belonging to the bHLH-PAS superfamily of transcription factors, the members of which carry out diverse functions, including circadian oscillations, neurogenesis, toxin metabolism, hypoxia, and tracheal development. NPAS3 contains a basic helix-loop-helix structural motif and…

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Aliases
NPAS3, neuronal PAS domain protein 3, MOP6, PASD6, bHLHe12
Band
14q13.1 · 12|12 C1
Bgee
endothelial cell · ventricular zone · corpus callosum · buccal mucosa cell · globus pallidus
BioGPS
n/a
Chr.
Chromosome 14 (human) · Chromosome 12 (mouse)
Databases
NCBI: entry; OMA: entry

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Function

Clinical significance

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Map overview Semantic statistics

NPAS3

Nodes29
Edges28
Triples86
Avg. degree1.93
Density0.068966
Components1

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NPAS3

Top relations

Bgee · 19
NPAS3 → buccal mucosa cell, condyle, corpus callosum, deep cerebellar nuclei, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, endothelial cell, entorhinal cortex, external globus pallidus, fossa, globus pallidus, inferior ganglion of vagus nerve, internal globus pallidus, lateral hypothalamus, lumbar subsegment of spinal cord, optic nerve, substantia nigra, ventral tegmental area, ventricular zone
RNA expression pattern · 19
NPAS3 → buccal mucosa cell, condyle, corpus callosum, deep cerebellar nuclei, dorsal tegmental nucleus, dorsomedial hypothalamic nucleus, endothelial cell, entorhinal cortex, external globus pallidus, fossa, globus pallidus, inferior ganglion of vagus nerve, internal globus pallidus, lateral hypothalamus, lumbar subsegment of spinal cord, optic nerve, substantia nigra, ventral tegmental area, ventricular zone
Gene ontology · 13
NPAS3 → cytosol, developmental process, DNA binding, DNA-binding transcription factor activity, RNA polymerase II-specific, nucleoplasm, nucleus, positive regulation of transcription by RNA polymerase II, positive regulation of transcription, DNA-templated, protein dimerization activity, protein heterodimerization activity, regulation of transcription by RNA polymerase II, regulation of transcription, DNA-templated, transcription, DNA-templated
related to Function · 4
NPAS3 → Among, From, HAR202, HAR21
Band · 2
NPAS3 → 12|12 C1, 14q13.1
Chr. · 2
NPAS3 → Chromosome 12 (mouse), Chromosome 14 (human)
End · 2
NPAS3 → 33,820,863 bp, 54,072,175 bp
related to Clinical significance · 2
NPAS3 → Disruption, In
Aliases · 1
NPAS3 → NPAS3, neuronal PAS domain protein 3, MOP6, PASD6, bHLHe12
BioGPS · 1
NPAS3 → n/a

Important terminology Word statistics

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Important terminology

human bp gene chr band chromosome 14 superfamily pas domain schizophrenia protein mouse location function bhlh-pas functions neuronal transcription factor

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
NPAS3AliasesNPAS3, neuronal PAS domain protein 3, MOP6, PASD6, bHLHe121.00infobox
NPAS3Band14q13.11.00infobox
NPAS3Band12|12 C11.00infobox
NPAS3Bgeeendothelial cell1.00infobox
NPAS3Bgeeventricular zone1.00infobox
NPAS3Bgeecorpus callosum1.00infobox
NPAS3Bgeebuccal mucosa cell1.00infobox
NPAS3Bgeeglobus pallidus1.00infobox
NPAS3Bgeeinternal globus pallidus1.00infobox
NPAS3Bgeeexternal globus pallidus1.00infobox
NPAS3Bgeeoptic nerve1.00infobox
NPAS3Bgeeinferior ganglion of vagus nerve1.00infobox
NPAS3Bgeeentorhinal cortex1.00infobox
NPAS3Bgeesubstantia nigra1.00infobox
NPAS3Bgeelumbar subsegment of spinal cord1.00infobox
NPAS3Bgeedeep cerebellar nuclei1.00infobox
NPAS3Bgeedorsal tegmental nucleus1.00infobox
NPAS3Bgeefossa1.00infobox
NPAS3Bgeedorsomedial hypothalamic nucleus1.00infobox
NPAS3Bgeeventral tegmental area1.00infobox
NPAS3Bgeecondyle1.00infobox
NPAS3Bgeelateral hypothalamus1.00infobox
NPAS3BioGPSn/a1.00infobox
NPAS3Chr.Chromosome 14 (human)1.00infobox
NPAS3Chr.Chromosome 12 (mouse)1.00infobox
NPAS3DatabasesNCBI: entry; OMA: entry1.00infobox
NPAS3End33,820,863 bp1.00infobox
NPAS3End54,072,175 bp1.00infobox
NPAS3EnsemblENSG000001513221.00infobox
NPAS3Entrez640671.00infobox

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