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Synaptic plasticity

In neuroscience, synaptic plasticity is the ability of synapses to strengthen or weaken over time, in response to increases or decreases in their activity. Since memories are postulated to be represented by vastly interconnected neural circuits in the brain, synaptic plasticity is one of the important neurochemical foundations of learning and memory (see…

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Overview

Historical discoveries

Biochemical mechanisms

Theoretical mechanisms

Short-term plasticity

Long-term plasticity

Synaptic strength

Computational use of plasticity

Synaptic plasticity in disease

Synaptic plasticity and aging

Videos, podcasts

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Synaptic plasticity

Nodes94
Edges93
Triples112
Avg. degree1.98
Density0.021277
Components1

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Synaptic plasticity

Top relations

related to Synaptic depression · 13
Synaptic plasticity → Akt, ATP, CaMK, Depression, ERK, G-protein, In, LTP, Many, Several, Synaptic, The, These
related to Biochemical mechanisms · 11
Synaptic plasticity → Also, AMPA, Ca2, LTD, LTP, Mg2, NMDA, Opening, These, This, Two
related to External links · 9
Synaptic plasticity → LondonBrain Basics Synaptic Plasticity, MRC Centre, Neurodegeneration Research, Neuroscience Online, Overview Archived, Plasticity, Synaptic, UT Houston Medical School, Wayback MachineFinnerty
related to Long-term plasticity · 8
Synaptic plasticity → D-serine, Long-term, LTD, LTP, NMDA, NMDA-dependent LTD, Recently, The
related to Synaptic plasticity and aging · 8
Synaptic plasticity → Although, As, CRISPR-based, DNA, In, One, The, This
related to Synaptic plasticity in disease · 8
Synaptic plasticity → Alzheimer's, Biomarkers, Furthermore, Individuals, Neuronal Pentraxin, NPTX2, Recent, Synaptic
related to Spike-timing-dependent plasticity (STDP) · 7
Synaptic plasticity → Additionally, Generally, Hebbian, In, It, Spike-timing-dependent, STDP
related to Theoretical mechanisms · 7
Synaptic plasticity → AMPA, Change, Insertion, LTD, LTP, Phosphorylation, Three
related to Videos, podcasts · 6
Synaptic plasticity → Multiple, Ph, Robert Malenka, Stanford University, Synaptic, Video
related to Computational use of plasticity · 5
Synaptic plasticity → Every, Forward, Long-term, Short-term, The

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Important terminology

synaptic plasticity receptors ltp synapse changes ltd long-term synapses depression nmda ampa also memory strength activity calcium increase brain d-serine

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Synaptic plasticityis aability of synapses to strengthen or weaken over time0.90text
CaMKIIinstance ofwhich act to dephosphorylate these cation channels.The second mechanism depends on a second messenger cascade regulating gene transcription and changes in the levels of key prot…0.80text
PKAIIinstance ofwhich act to dephosphorylate these cation channels.The second mechanism depends on a second messenger cascade regulating gene transcription and changes in the levels of key prot…0.80text
the addition of AMPA receptors to the plasma membraneinstance ofThese protein kinases have been linked to growth in dendritic spine volume and LTP processes0.80text
phosphorylation of ion channels for enhanced permeabilityinstance ofThese protein kinases have been linked to growth in dendritic spine volume and LTP processes0.80text
activin ß-Ainstance ofGenes0.80text
which encodes a subunit of activin Ainstance ofGenes0.80text
are up-regulated during early stage LTPinstance ofGenes0.80text
long-term potentiation occur effectively.Disruption to astrocytic release of D-serine reduces the ability of synapses to strengtheninstance ofbut important modulatory components of neuronal communication that ensure NMDA receptor-dependent processes0.80text
thereby demonstrating the close relationship between cognitive functioninstance ofbut important modulatory components of neuronal communication that ensure NMDA receptor-dependent processes0.80text
glial regulationinstance ofbut important modulatory components of neuronal communication that ensure NMDA receptor-dependent processes0.80text
axonal boutoninstance ofThe long-term stabilization of synaptic changes is determined by a parallel increase of pre- and postsynaptic structures0.80text

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