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Mitogen-activated protein kinase

A mitogen-activated protein kinase (MAPK or MAP kinase) is a type of serine/threonine-specific protein kinases involved in directing cellular responses to a diverse array of stimuli, such as mitogens, osmotic stress, heat shock and proinflammatory cytokines. They regulate cell functions including proliferation, gene expression, differentiation, mitosis…

Activation, Signaling cascades & As therapeutic targets

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Activation

Protein dynamicsConformational changeAllosteryActivation loopERK5
23 related topics

Signaling cascades

C-RafMEKK4MLK3RasGADD45
63 related topics

As therapeutic targets

AntineoplasticReceptor tyrosine kinasesRaf kinasesSorafenibCobimetinib
13 related topics

Evolutionary relationships

OpisthokontsMetazoansDrosophilaProtostomesCnidarians
9 related topics

Key facts & relationships

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BRENDA
enzyme data
CAS no.
142243-02-5
EC no.
2.7.11.24
ExPASy
NiceZyme view
Gene Ontology
AmiGO / QuickGO
KEGG
enzyme entry

Topics to explore

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Overview

Discovery

Types

Activation

Signaling cascades

Evolutionary relationships

Substrate and partner recognition

Scaffold proteins

As therapeutic targets

Advanced semantic analysis

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Map overview Semantic statistics

Mitogen-activated protein kinase

Nodes153
Edges152
Triples43
Avg. degree1.99
Density0.013072
Components1

How this topic connects Entity context

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Mitogen-activated protein kinase

Top relations

related to Activation · 14
Mitogen-activated protein kinase → ERK1, ERK2, ERK5, In, JNKs, MAP, Mitogen-activated, STE, TDY, TEY, TGY, This, TPY, TxY
related to Discovery · 13
Mitogen-activated protein kinase → Because, DNA, ERK1, ERK1/2, ERK2, MAPK, MAPK1, MAPK3, MAPKs, Since ERK1, The, Thus, With
BRENDA · 1
Mitogen-activated protein kinase → enzyme data
CAS no. · 1
Mitogen-activated protein kinase → 142243-02-5
EC no. · 1
Mitogen-activated protein kinase → 2.7.11.24
ExPASy · 1
Mitogen-activated protein kinase → NiceZyme view
Gene Ontology · 1
Mitogen-activated protein kinase → AmiGO / QuickGO
KEGG · 1
Mitogen-activated protein kinase → enzyme entry
MetaCyc · 1
Mitogen-activated protein kinase → metabolic pathway
NCBI · 1
Mitogen-activated protein kinase → proteins

Important terminology Word statistics

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Important terminology

kinases mapk also mapks pathway kinase activation erk1 map proteins needed p38 protein citation classical jnk involved phosphorylation erk5 substrates

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Mitogen-activated protein kinaseBRENDAenzyme data1.00infobox
Mitogen-activated protein kinaseCAS no.142243-02-51.00infobox
Mitogen-activated protein kinaseEC no.2.7.11.241.00infobox
Mitogen-activated protein kinaseExPASyNiceZyme view1.00infobox
Mitogen-activated protein kinaseGene OntologyAmiGO / QuickGO1.00infobox
Mitogen-activated protein kinaseKEGGenzyme entry1.00infobox
Mitogen-activated protein kinaseMetaCycmetabolic pathway1.00infobox
Mitogen-activated protein kinaseNCBIproteins1.00infobox
Mitogen-activated protein kinasePDB structuresRCSB PDB PDBe PDBsum1.00infobox
Mitogen-activated protein kinasePMCarticles1.00infobox
Mitogen-activated protein kinasePubMedarticles1.00infobox
Mitogen-activated protein kinaseRheareactions1.00infobox
Mitogen-activated protein kinaseSearchSearchPMCarticlesPubMedarticlesNCBIproteins1.00infobox

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