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Endothelin

Endothelins are peptides with receptors and effects in many body organs. Endothelin constricts blood vessels and raises blood pressure. The endothelins are normally kept in balance by other mechanisms, but when overexpressed, they contribute to high blood pressure (hypertension), heart disease, and potentially other diseases.

Art, Clinical significance & Physiological effects

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Key facts & relationships

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AlphaFold
IPR001928 · PF00322
Available protein structures:
IPR001928 · PF00322
InterPro
IPR001928
OPM protein
3cmh
OPM superfamily
147
PDB
IPR001928 PF00322 (ECOD; PDBsum)

Topics to explore

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Overview

Etymology

Isoforms

Mechanism of action and function

Physiological effects

Clinical significance

Antagonists

Advanced semantic analysis

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Map overview Semantic statistics

Endothelin

Nodes70
Edges69
Triples44
Avg. degree1.97
Density0.028571
Components1

How this topic connects Entity context

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Endothelin

Top relations

related to Mechanism of action and function · 10
Endothelin → Clinically, Endothelin-1, ET, ET-1, ETA, ETB, Most, Secretion, The, These
related to Isoforms · 9
Endothelin → ET-1, ET-2, ET-3, ETA, ETB1, ETB2, ETC, The, There
related to Clinical significance · 4
Endothelin → Among, Hirschsprung, II, The
related to External links · 4
Endothelin → Endothelins, Medicine Medical Subject Headings, MeSH, National Library
has effect · 3
Endothelin → Endothelins, ET-1, Overproduction
AlphaFold · 2
Endothelin → IPR001928, PF00322
Available protein structures: · 2
Endothelin → IPR001928, PF00322
InterPro · 1
Endothelin → IPR001928
OPM protein · 1
Endothelin → 3cmh
OPM superfamily · 1
Endothelin → 147

Important terminology Word statistics

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Important terminology

endothelins hypertension receptors et-1 vascular endothelin-1 eta peptides etb blood heart diseases several organ systems effects cardiovascular receptor pressure two

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
EndothelinAlphaFoldIPR0019281.00infobox
EndothelinAlphaFoldPF003221.00infobox
EndothelinAvailable protein structures:IPR0019281.00infobox
EndothelinAvailable protein structures:PF003221.00infobox
EndothelinInterProIPR0019281.00infobox
EndothelinOPM protein3cmh1.00infobox
EndothelinOPM superfamily1471.00infobox
EndothelinPDBIPR001928 PF00322 (ECOD; PDBsum)1.00infobox
EndothelinPfamPF003221.00infobox
EndothelinPROSITEPDOC002431.00infobox
EndothelinSCOP21edp / SCOPe / SUPFAM1.00infobox
EndothelinSymbolEndothelin1.00infobox

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