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Integrin

Integrins are transmembrane receptors that help cell–cell and cell–extracellular matrix (ECM) adhesion. Upon ligand binding, integrins activate signal transduction pathways that mediate cellular signals such as regulation of the cell cycle, organization of the intracellular cytoskeleton, and movement of new receptors to the cell membrane. The presence of…

Structure, Function & Overview

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Key facts & relationships

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AlphaFold
IPR013649 · PF08441
Available protein structures:
IPR013649 · PF08441
InterPro
IPR013649
Membranome
13
OPM protein
2knc
OPM superfamily
176

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Overview

Structure

Function

Integrins and nerve repair

Advanced semantic analysis

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Map overview Semantic statistics

Integrin

Nodes93
Edges92
Triples114
Avg. degree1.98
Density0.021505
Components1

How this topic connects Entity context

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Integrin

Top relations

related to Structure · 21
Integrin → A-domains, As, Caenorhabditis, Despite, Drosophila, ECM, GPIIbIIIa, In, Integrins, Low-resolution, NMR, Perhaps, RGD-ligand, RGD-sequence, RNA, Several, The, The X-ray, Through, V-shape
related to Attachment of cell to the ECM · 14
Integrin → Among, Cell, CRK, ECM, EGF, FAK, Integrins, Src, The, These, Thus, Together, VEGF, Which
related to Activation · 13
Integrin → ECM, EM, In, Kindlin-1, Kindlin-2, Moreover, One, Recently, Talin, The, Therefore, Unfortunately, When
related to Signal transduction · 11
Integrin → Clustering, ECM, For, Gab1/Shp2, IGF1R, In, Integrins, RTK, Shp2, The, While
related to External links · 8
Integrin → Integrins, Media, Medicine Medical Subject Headings, MeSH, National Library, PMAP The Proteolysis Map, Wikimedia Commons Talin, Wiktionary-logo-en-v2
related to Function · 8
Integrin → ECM, GpIIb/IIIa, Integrins, Recently, These, They, This, Upon
related to Integrins and nerve repair · 6
Integrin → CNS, ECM, Integrins, It, PNS, There
related to Vertebrate integrins · 6
Integrin → Beta-1, Gene, Integrins, Once, Some, The
see also · 3
Integrin → D-dimerDisintegrinExopolymerExtracellular, EPS, XPS
AlphaFold · 2
Integrin → IPR013649, PF08441

Important terminology Word statistics

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Important terminology

integrins cell ecm membrane binding subunits ligands adhesion also ligand structure proteins extracellular signaling one surface interaction receptors signal transmembrane

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
IntegrinAlphaFoldIPR0136491.00infobox
IntegrinAlphaFoldPF084411.00infobox
IntegrinAvailable protein structures:IPR0136491.00infobox
IntegrinAvailable protein structures:PF084411.00infobox
IntegrinInterProIPR0136491.00infobox
IntegrinMembranome131.00infobox
IntegrinOPM protein2knc1.00infobox
IntegrinOPM superfamily1761.00infobox
IntegrinPDBIPR013649 PF08441 (ECOD; PDBsum)1.00infobox
IntegrinPfamPF084411.00infobox
IntegrinPfam clanCL01591.00infobox
IntegrinSCOP21jv2 / SCOPe / SUPFAM1.00infobox
IntegrinSymbolIntegrin_alphaVbeta31.00infobox

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    Min side: 3
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