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Frizzled

Frizzled is a family of atypical G protein-coupled receptors that serve as receptors in the Wnt signaling pathway and other signaling pathways. There are 10 known Frizzled receptor family members in humans. When activated, Frizzled leads to activation of Dishevelled in the cytosol.

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Key facts & relationships

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AlphaFold
IPR000539 · PF01534
Available protein structures:
IPR000539 · PF01534
CDD
cd13951
InterPro
IPR000539
OPM protein
4jkv
OPM superfamily
6

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Overview

Structure

Function

Group members

As a drug target

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Map overview Semantic statistics

Frizzled

Nodes32
Edges31
Triples69
Avg. degree1.94
Density0.0625
Components1

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Frizzled

Top relations

related to Group members · 21
Frizzled → Frizzled-1, Frizzled-10, Frizzled-2, Frizzled-3, Frizzled-4, Frizzled-5, Frizzled-6, Frizzled-7, Frizzled-8, Frizzled-9, FZD1, FZD10, FZD2, FZD3, FZD4, FZD5, FZD6, FZD7, FZD8, FZD9
related to External links · 12
Frizzled → Archived, Basic, Clinical Pharmacology, Frizzled Receptors, International Union, Ion Channels, IUPHAR Database, Medicine Medical Subject Headings, MeSH, National Library, Receptors, Retrieved
related to Function · 8
Frizzled → In, Mutations, PCP, These, Wingless-Int, Wnt, Wnt/calcium, Wnt/β-catenin
related to Structure · 6
Frizzled → All Frizzled, CRD, Dishevelled, Intracellularly, PDZ, The
related to The cysteine-rich domain · 5
Frizzled → MuSK, NSK2, ROR1, ROR2, The
AlphaFold · 2
Frizzled → IPR000539, PF01534
Available protein structures: · 2
Frizzled → IPR000539, PF01534
CDD · 1
Frizzled → cd13951
InterPro · 1
Frizzled → IPR000539
OPM protein · 1
Frizzled → 4jkv

Important terminology Word statistics

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Important terminology

receptors family protein domain members structure fz receptor transmembrane proteins polarity wnt signaling pathway pathways known cysteine-rich human dishevelled cell

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
FrizzledAlphaFoldIPR0005391.00infobox
FrizzledAlphaFoldPF015341.00infobox
FrizzledAvailable protein structures:IPR0005391.00infobox
FrizzledAvailable protein structures:PF015341.00infobox
FrizzledCDDcd139511.00infobox
FrizzledInterProIPR0005391.00infobox
FrizzledOPM protein4jkv1.00infobox
FrizzledOPM superfamily61.00infobox
FrizzledPDBIPR000539 PF01534 (ECOD; PDBsum)1.00infobox
FrizzledPfamPF015341.00infobox
FrizzledPfam clanGPCR_A1.00infobox
FrizzledPROSITEPDOC500381.00infobox
FrizzledSymbolFrizzled1.00infobox
FrizzledTCDB9.A.141.00infobox
Frizzledis afamily of atypical G protein-coupled receptors that serve as receptors in the Wnt signaling pathway and other signaling pathways0.90text

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