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Topologically associating domain

A topologically associating domain (TAD) is a self-interacting genomic region, meaning that DNA sequences within a TAD physically interact with each other more frequently than with sequences outside the TAD. The average size of a topologically associating domain (TAD) is 1000 kb in humans, 880 kb in mouse cells, and 140 kb in fruit flies. Boundaries at…

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Topologically associating domain

Nodes40
Edges39
Triples13
Avg. degree1.95
Density0.05
Components1

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Important terminology

tad boundaries tads ctcf cohesin formation shown chromatin expression boundary dna types associated gene domains genes however interactions domain genome

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
cancerinstance ofDisruption of TAD boundaries are found to be associated with wide range of diseases0.80text
variety of limb malformations such as synpolydactylyinstance ofDisruption of TAD boundaries are found to be associated with wide range of diseases0.80text
Cooks syndromeinstance ofDisruption of TAD boundaries are found to be associated with wide range of diseases0.80text
and F-syndromeinstance ofDisruption of TAD boundaries are found to be associated with wide range of diseases0.80text
and number of brain disorders like Hypoplastic corpus callosuminstance ofDisruption of TAD boundaries are found to be associated with wide range of diseases0.80text
Adult-onset demyelinating leukodystrophyinstance ofDisruption of TAD boundaries are found to be associated with wide range of diseases0.80text
Juiceboxinstance ofthe directionality index is a signed chi-square statistic.The development of specialized genome browsers and visualization tools0.80text
HiGlass/HiPilerinstance ofthe directionality index is a signed chi-square statistic.The development of specialized genome browsers and visualization tools0.80text
The 3D Genome Browserinstance ofthe directionality index is a signed chi-square statistic.The development of specialized genome browsers and visualization tools0.80text
3DIVinstance ofthe directionality index is a signed chi-square statistic.The development of specialized genome browsers and visualization tools0.80text
3D-GNOMEinstance ofthe directionality index is a signed chi-square statistic.The development of specialized genome browsers and visualization tools0.80text
and TADKB have enabled us to visualize the TAD organization of regions of interest in different cell typesinstance ofthe directionality index is a signed chi-square statistic.The development of specialized genome browsers and visualization tools0.80text

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