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MECP2

MECP2 (methyl CpG binding protein 2) is a gene that encodes the protein MECP2. MECP2 appears to be essential for the normal function of nerve cells. The protein seems to be particularly important for mature nerve cells, where it is present in high levels. The MECP2 protein is likely to be involved in turning off ("repressing" or "silencing") several…

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Aliases
MECP2, AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT, methyl-CpG binding protein 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1QK9, 3C2I
Band
Xq28 · X A7.3|X 37.63 cM
Bgee
paraflocculus of cerebellum · Brodmann area 10 · sural nerve · frontal pole · epithelium of colon
BioGPS
More reference expression data
Chr.
X chromosome (human) · X chromosome (mouse)

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Overview

Function

Mechanism of action

Structure

Role in disease

Interactions

Hormones

Early life stress

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Map overview Semantic statistics

MECP2

Nodes68
Edges67
Triples234
Avg. degree1.97
Density0.029412
Components1

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MECP2

Top relations

Gene ontology · 93
MECP2 → adult locomotory behavior, behavioral fear response, brain development, cardiolipin metabolic process, catecholamine secretion, cellular biogenic amine metabolic process, centrosome, cerebellum development, chemical synaptic transmission, chromatin, chromatin binding, cytoplasm, cytosol, dendrite development, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, double-stranded methylated DNA binding, excitatory postsynaptic potential, extracellular space
Bgee · 20
MECP2 → Achilles tendon, anterior amygdaloid area, blood, Brodmann area 10, cerebellar vermis, ciliary body, dorsal striatum, epithelium of colon, frontal pole, habenula, lateral septal nucleus, middle frontal gyrus, paraflocculus of cerebellum, pineal gland, postcentral gyrus, Region I of hippocampus proper, Rostral migratory stream, substantia nigra, superior colliculus, sural nerve
RNA expression pattern · 20
MECP2 → Achilles tendon, anterior amygdaloid area, blood, Brodmann area 10, cerebellar vermis, ciliary body, dorsal striatum, epithelium of colon, frontal pole, habenula, lateral septal nucleus, middle frontal gyrus, paraflocculus of cerebellum, pineal gland, postcentral gyrus, Region I of hippocampus proper, Rostral migratory stream, substantia nigra, superior colliculus, sural nerve
related to Role in disease · 19
MECP2 → As, DNA, Due, Genes, Males, Many, MECP-2, Mutations, Other, Patients, Rett, RNA, SNP, The, The MECP2, These, This, X-linked, Xq28
related to Mechanism of action · 18
MECP2 → CpG, CREB1, DLX5, DNA, Further, HDAC, However, In, Many, MECP2's, MECP2-bound, More, Once, Researchers, The, The MeCP2, This, UBE3A
related to External links · 12
MECP2 → Archived, Families Affected, International Rett Syndrome FoundationRett, IRSA MECP2 Variation Database, MECP2 Duplication SyndromeUK Site, MECP2-Related DisordersGeneReviews/NCBI/NIH/UW, Registry UKRett Syndrome Research, Research CharityReverse Rett UKRett, Site, TrustEnsemblGenerefProteinrefGeneCardRettBASE, UK Support, Wayback MachineGeneReview/NIH/UW
related to Hormones · 8
MECP2 → AR, AVP, Male, Reductions, RNA, Specifically, Vasopressin, While
related to Early life stress · 6
MECP2 → AVP, Decreased, Early, Hypothalmic-Pituitary-Adrenal Axis, This, Vasopressin
related to Interactions · 6
MECP2 → BDNF, In, MSK1, Nuclear, SKI, This
related to Structure · 4
MECP2 → CpG-binding, It, MBD, TRD

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Important terminology

gene protein dna genes brain cells mutations expression function rett syndrome band also chromosome bp cpg levels chr human stress

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MECP2AliasesMECP2, AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT, methyl-CpG binding protein 21.00infobox
MECP2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1QK9, 3C2I1.00infobox
MECP2BandXq281.00infobox
MECP2BandX A7.3|X 37.63 cM1.00infobox
MECP2Bgeeparaflocculus of cerebellum1.00infobox
MECP2BgeeBrodmann area 101.00infobox
MECP2Bgeesural nerve1.00infobox
MECP2Bgeefrontal pole1.00infobox
MECP2Bgeeepithelium of colon1.00infobox
MECP2Bgeemiddle frontal gyrus1.00infobox
MECP2Bgeecerebellar vermis1.00infobox
MECP2BgeeAchilles tendon1.00infobox
MECP2Bgeepostcentral gyrus1.00infobox
MECP2Bgeeblood1.00infobox
MECP2Bgeesubstantia nigra1.00infobox
MECP2BgeeRostral migratory stream1.00infobox
MECP2Bgeepineal gland1.00infobox
MECP2Bgeehabenula1.00infobox
MECP2Bgeedorsal striatum1.00infobox
MECP2BgeeRegion I of hippocampus proper1.00infobox
MECP2Bgeeanterior amygdaloid area1.00infobox
MECP2Bgeesuperior colliculus1.00infobox
MECP2Bgeeciliary body1.00infobox
MECP2Bgeelateral septal nucleus1.00infobox
MECP2BioGPSMore reference expression data1.00infobox
MECP2Chr.X chromosome (human)1.00infobox
MECP2Chr.X chromosome (mouse)1.00infobox
MECP2DatabasesNCBI: entry; OMA: entry1.00infobox
MECP2End154,137,103 bp1.00infobox
MECP2End73,178,969 bp1.00infobox

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