MECP2

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MECP2 topic overview

The analysis highlights Art and Regions as prominent areas in the source structure around MECP2.

Related topics: 59
Source areas: 8
Connected nodes: 67
Extracted relationships: 234
Concept neighborhoods: 23
Bridge connections: 67

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Mechanism of action · 17 topics

Role in disease · 14 topics

Overview · 9 topics

Hormones · 6 topics

Interactions · 6 topics

Function · 5 topics

Early life stress · 1 topics

Structure · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: MECP2, AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT, methyl-CpG binding protein 2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1QK9, 3C2I
Band: Xq28 · X A7.3|X 37.63 cM
Bgee: paraflocculus of cerebellum · Brodmann area 10 · sural nerve · frontal pole · epithelium of colon
BioGPS: More reference expression data
Chr.: X chromosome (human) · X chromosome (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Role in disease

Interactions

Interact Protein-protein interaction
SKI protein
Nuclear receptor co-repressor 1
MiR-132 Mir-132 microRNA
MSK1 MSK1?action=edit&redlink=1
BDNF Brain-derived neurotrophic factor

Hormones

Early life stress

Paraventricular nucleus

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How MECP2 connects Entity context

The extracted context around MECP2 shows recurring relationship patterns in the source. For example, MECP2 → adult locomotory behavior, behavioral fear response, brain development, cardiolipin metabolic process, catecholamine secretion, cellular biogenic amine metabolic process, centrosome, cerebellum development, chemical synaptic transmission, chromatin, chromatin binding, cytoplasm, cytosol, dendrite development, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, double-stranded methylated DNA binding, excitatory postsynaptic potential, extracellular space Another extracted example is MECP2 → Achilles tendon, anterior amygdaloid area, blood, Brodmann area 10, cerebellar vermis, ciliary body, dorsal striatum, epithelium of colon, frontal pole, habenula, lateral septal nucleus, middle frontal gyrus, paraflocculus of cerebellum, pineal gland, postcentral gyrus, Region I of hippocampus proper, Rostral migratory stream, substantia nigra, superior colliculus, sural nerve. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Gene ontology · 93

MECP2 → adult locomotory behavior, behavioral fear response, brain development, cardiolipin metabolic process, catecholamine secretion, cellular biogenic amine metabolic process, centrosome, cerebellum development, chemical synaptic transmission, chromatin, chromatin binding, cytoplasm, cytosol, dendrite development, DNA binding, DNA-binding transcription factor activity, DNA-binding transcription repressor activity, RNA polymerase II-specific, double-stranded methylated DNA binding, excitatory postsynaptic potential, extracellular space

Bgee · 20

MECP2 → Achilles tendon, anterior amygdaloid area, blood, Brodmann area 10, cerebellar vermis, ciliary body, dorsal striatum, epithelium of colon, frontal pole, habenula, lateral septal nucleus, middle frontal gyrus, paraflocculus of cerebellum, pineal gland, postcentral gyrus, Region I of hippocampus proper, Rostral migratory stream, substantia nigra, superior colliculus, sural nerve

RNA expression pattern · 20

related to Role in disease · 19

MECP2 → As, DNA, Due, Genes, Males, Many, MECP-2, Mutations, Other, Patients, Rett, RNA, SNP, The, The MECP2, These, This, X-linked, Xq28

related to Mechanism of action · 18

MECP2 → CpG, CREB1, DLX5, DNA, Further, HDAC, However, In, Many, MECP2's, MECP2-bound, More, Once, Researchers, The, The MeCP2, This, UBE3A

related to External links · 12

MECP2 → Archived, Families Affected, International Rett Syndrome FoundationRett, IRSA MECP2 Variation Database, MECP2 Duplication SyndromeUK Site, MECP2-Related DisordersGeneReviews/NCBI/NIH/UW, Registry UKRett Syndrome Research, Research CharityReverse Rett UKRett, Site, TrustEnsemblGenerefProteinrefGeneCardRettBASE, UK Support, Wayback MachineGeneReview/NIH/UW

related to Hormones · 8

MECP2 → AR, AVP, Male, Reductions, RNA, Specifically, Vasopressin, While

related to Early life stress · 6

MECP2 → AVP, Decreased, Early, Hypothalmic-Pituitary-Adrenal Axis, This, Vasopressin

related to Interactions · 6

MECP2 → BDNF, In, MSK1, Nuclear, SKI, This

related to Structure · 4

MECP2 → CpG-binding, It, MBD, TRD

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

gene protein dna genes brain cells mutations expression function rett syndrome band also chromosome bp cpg levels chr human stress

MECP2 relationships Subject–Predicate–Object triples

TTTA extracted 234 structured relationships around MECP2. Examples in this analysis include MECP2 → Aliases → MECP2, AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT, methyl-CpG binding protein 2 and MECP2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1QK9, 3C2I. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
MECP2	Aliases	MECP2, AUTSX3, MRX16, MRX79, MRXS13, MRXSL, PPMX, RS, RTS, RTT, methyl-CpG binding protein 2	1.00	infobox
MECP2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1QK9, 3C2I	1.00	infobox
MECP2	Band	Xq28	1.00	infobox
MECP2	Band	X A7.3\|X 37.63 cM	1.00	infobox
MECP2	Bgee	paraflocculus of cerebellum	1.00	infobox
MECP2	Bgee	Brodmann area 10	1.00	infobox
MECP2	Bgee	sural nerve	1.00	infobox
MECP2	Bgee	frontal pole	1.00	infobox
MECP2	Bgee	epithelium of colon	1.00	infobox
MECP2	Bgee	middle frontal gyrus	1.00	infobox
MECP2	Bgee	cerebellar vermis	1.00	infobox
MECP2	Bgee	Achilles tendon	1.00	infobox
MECP2	Bgee	postcentral gyrus	1.00	infobox
MECP2	Bgee	blood	1.00	infobox
MECP2	Bgee	substantia nigra	1.00	infobox
MECP2	Bgee	Rostral migratory stream	1.00	infobox
MECP2	Bgee	pineal gland	1.00	infobox
MECP2	Bgee	habenula	1.00	infobox
MECP2	Bgee	dorsal striatum	1.00	infobox
MECP2	Bgee	Region I of hippocampus proper	1.00	infobox
MECP2	Bgee	anterior amygdaloid area	1.00	infobox
MECP2	Bgee	superior colliculus	1.00	infobox
MECP2	Bgee	ciliary body	1.00	infobox
MECP2	Bgee	lateral septal nucleus	1.00	infobox
MECP2	BioGPS	More reference expression data	1.00	infobox
MECP2	Chr.	X chromosome (human)	1.00	infobox
MECP2	Chr.	X chromosome (mouse)	1.00	infobox
MECP2	Databases	NCBI: entry; OMA: entry	1.00	infobox
MECP2	End	154,137,103 bp	1.00	infobox
MECP2	End	73,178,969 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around MECP2 bring nearby vocabulary together. In this analysis, examples include Gene, Protein and Genes. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

MECP2
- Gene
- Protein
- Genes
- Dna
- Expression
- Mutations
- Function
- Levels
- Cells
- Brain
- Rett
- Syndrome
mecp2
- Gene
- Protein
- Genes
- Dna
- Expression
- Mutations
- Function
- Levels
- Cells
- Brain
- Rett
- Syndrome
gene
- Mutations
- Mecp2
- Protein
- Chromosome
- Expression
- Rett
- Syndrome
- Human
- Band
- Bp
- Chr
- Also
nerve cells
- Nerve
- Normal
- Expression
- Dna
- Protein
- Domain
- Function
- Human
- Involved
- Methylation
- Band
- Bp
x chromosome
- Human
- Band
- Bp
- Chr
- Stress
- Gene
- Function
- Domain
- Involved
- Methylation
- Nerve
- Protein
cells
- Nerve
- Expression
- Normal
- Dna
- Protein
- Function
- Mecp2
- Domain
- Human
- Involved
- Methylation
- Band
brain
- Males
- Found
- Levels
- Involved
- Females
- Region
- Social
- Stress
- Mecp2
- Domain
- Human
- Methylation
neural stem cells
- Nerve
- Expression
- Normal
- Dna
- Protein
- Function
- Mecp2
- Domain
- Human
- Involved
- Methylation
- Band

Connections between topic areas Semantic bridges

For MECP2, one of the stronger structural bridges in this analysis connects MECP2 with Mechanism of action. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

MECP2 — Mechanism of action · splits 50 ⟂ 18

MECP2 — Role in disease · splits 53 ⟂ 15

MECP2 — Overview · splits 58 ⟂ 10

MECP2 — Interactions · splits 61 ⟂ 7

MECP2 — Hormones · splits 61 ⟂ 7

MECP2 — Function · splits 62 ⟂ 6

Map overview Semantic statistics

MECP2

Nodes68

Edges67

Triples234

Avg. degree1.97

Density0.029412

Components1

Source & methodology

TTTA analyzes the structure around MECP2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Art & Regions, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — MECP2 · EN edition · Analysis: TopicsToTalkAbout