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Transcription factor PU.1 is a protein that in humans is encoded by the SPI1 gene.
The analysis highlights Function, Interactions and Overview as prominent areas in the source structure around SPI1.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around SPI1 shows recurring relationship patterns in the source. For example, SPI1 → anatomical structure regression, apoptotic process involved in blood vessel morphogenesis, cell differentiation, cellular response to ethanol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, erythrocyte differentiation, granulocyte differentiation, histone H3 acetylation, hypermethylation of CpG island, interleukin-6-mediated signaling pathway, lymphocyte differentiation, lymphoid progenitor cell differentiation, macrophage differentiation, myeloid dendritic cell differentiation, myeloid leukocyte differentiation, negative regulation of gene expression, epigenetic Another extracted example is SPI1 → ankle joint, appendix, blood, bone marrow cell, embryo, granulocyte, lip, lymph node, medulla of thymus, mesenteric lymph nodes, monocyte, right coronary artery, right lung, spleen, stroma of bone marrow, tibiofemoral joint, upper lobe of left lung. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
pu bp gene transcription chr human band fibroblasts chromosome 11 protein expression factor mouse cell location genes factors pro-fibrotic expressed
TTTA extracted 105 structured relationships around SPI1. Examples in this analysis include SPI1 → Aliases → SPI1, OF, PU.1, SFPI1, SPI-1, SPI-A, Spi-1 proto-oncogene, AGM10 and SPI1 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PUE. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| SPI1 | Aliases | SPI1, OF, PU.1, SFPI1, SPI-1, SPI-A, Spi-1 proto-oncogene, AGM10 | 1.00 | infobox |
| SPI1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PUE | 1.00 | infobox |
| SPI1 | Band | 11p11.2 | 1.00 | infobox |
| SPI1 | Band | 2 E1|2 50.44 cM | 1.00 | infobox |
| SPI1 | Bgee | granulocyte | 1.00 | infobox |
| SPI1 | Bgee | monocyte | 1.00 | infobox |
| SPI1 | Bgee | right lung | 1.00 | infobox |
| SPI1 | Bgee | upper lobe of left lung | 1.00 | infobox |
| SPI1 | Bgee | spleen | 1.00 | infobox |
| SPI1 | Bgee | blood | 1.00 | infobox |
| SPI1 | Bgee | bone marrow cell | 1.00 | infobox |
| SPI1 | Bgee | appendix | 1.00 | infobox |
| SPI1 | Bgee | right coronary artery | 1.00 | infobox |
| SPI1 | Bgee | lymph node | 1.00 | infobox |
| SPI1 | Bgee | tibiofemoral joint | 1.00 | infobox |
| SPI1 | Bgee | mesenteric lymph nodes | 1.00 | infobox |
| SPI1 | Bgee | stroma of bone marrow | 1.00 | infobox |
| SPI1 | Bgee | medulla of thymus | 1.00 | infobox |
| SPI1 | Bgee | embryo | 1.00 | infobox |
| SPI1 | Bgee | lip | 1.00 | infobox |
| SPI1 | Bgee | ankle joint | 1.00 | infobox |
| SPI1 | BioGPS | More reference expression data | 1.00 | infobox |
| SPI1 | Chr. | Chromosome 11 (human) | 1.00 | infobox |
| SPI1 | Chr. | Chromosome 2 (mouse) | 1.00 | infobox |
| SPI1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| SPI1 | End | 47,378,547 bp | 1.00 | infobox |
| SPI1 | End | 90,946,101 bp | 1.00 | infobox |
| SPI1 | Ensembl | ENSG00000066336 | 1.00 | infobox |
| SPI1 | Entrez | 6688 | 1.00 | infobox |
| SPI1 | External IDs | OMIM: 165170; MGI: 98282; GeneCards: SPI1 | 1.00 | infobox |
The concept neighborhoods around SPI1 bring nearby vocabulary together. In this analysis, examples include Function, Gene and Search. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For SPI1, one of the stronger structural bridges in this analysis connects SPI1 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around SPI1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — SPI1 · EN edition · Analysis: TopicsToTalkAbout