SPI1

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Explore the main themes, entities and connections around SPI1. Start with the topic map, then use the sections below for research and deeper semantic analysis.

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Function

Hematopoiesis Cell fate SWI/SNF TFIID GATA-2

19 related topics

Interactions

Interact FUS IRF4 NONO

4 related topics

Overview

Protein Gene

2 related topics

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: SPI1, OF, PU.1, SFPI1, SPI-1, SPI-A, Spi-1 proto-oncogene, AGM10
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PUE
Band: 11p11.2 · 2 E1|2 50.44 cM
Bgee: granulocyte · monocyte · right lung · upper lobe of left lung · spleen
BioGPS: More reference expression data
Chr.: Chromosome 11 (human) · Chromosome 2 (mouse)

Topics to explore

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Overview

Function

Hematopoiesis Haematopoiesis
Cell fate Cell fate determination
SWI/SNF
TFIID Transcription factor II D
GATA-2 GATA2
GATA-1 GATA1
C-Jun
Cytokines Cytokine
Monocytes Monocyte
Granulocytes Granulocyte
NK cells Natural killer cell
T cells T cell
Reticulocytes Reticulocyte
Megakaryocytes Megakaryocyte
Fibrotic conditions Fibrosis
Fibroblasts Fibroblast
Extracellular matrix
Inflammatory Inflammation
Lymphocytes Lymphocyte

Interactions

Interact Protein-protein interaction
FUS FUS (gene)
IRF4
NONO

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

Map overview Semantic statistics

Nodes29

Edges28

Triples105

Avg. degree1.93

Density0.068966

Components1

How this topic connects Entity context

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SPI1

Top relations

Gene ontology · 45

SPI1 → anatomical structure regression, apoptotic process involved in blood vessel morphogenesis, cell differentiation, cellular response to ethanol, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, DNA-binding transcription factor activity, RNA polymerase II-specific, DNA-binding transcription repressor activity, RNA polymerase II-specific, erythrocyte differentiation, granulocyte differentiation, histone H3 acetylation, hypermethylation of CpG island, interleukin-6-mediated signaling pathway, lymphocyte differentiation, lymphoid progenitor cell differentiation, macrophage differentiation, myeloid dendritic cell differentiation, myeloid leukocyte differentiation, negative regulation of gene expression, epigenetic

Bgee · 17

SPI1 → ankle joint, appendix, blood, bone marrow cell, embryo, granulocyte, lip, lymph node, medulla of thymus, mesenteric lymph nodes, monocyte, right coronary artery, right lung, spleen, stroma of bone marrow, tibiofemoral joint, upper lobe of left lung

RNA expression pattern · 17

related to Interactions · 3

SPI1 → FUS, GATA2, IRF4

Band · 2

SPI1 → 11p11.2, 2 E1|2 50.44 cM

Chr. · 2

SPI1 → Chromosome 11 (human), Chromosome 2 (mouse)

End · 2

SPI1 → 47,378,547 bp, 90,946,101 bp

Aliases · 1

SPI1 → SPI1, OF, PU.1, SFPI1, SPI-1, SPI-A, Spi-1 proto-oncogene, AGM10

Available structures · 1

SPI1 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PUE

BioGPS · 1

SPI1 → More reference expression data

Important terminology Word statistics

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pu bp gene transcription chr human band fibroblasts chromosome 11 protein expression factor mouse cell location genes factors pro-fibrotic expressed

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
SPI1	Aliases	SPI1, OF, PU.1, SFPI1, SPI-1, SPI-A, Spi-1 proto-oncogene, AGM10	1.00	infobox
SPI1	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1PUE	1.00	infobox
SPI1	Band	11p11.2	1.00	infobox
SPI1	Band	2 E1\|2 50.44 cM	1.00	infobox
SPI1	Bgee	granulocyte	1.00	infobox
SPI1	Bgee	monocyte	1.00	infobox
SPI1	Bgee	right lung	1.00	infobox
SPI1	Bgee	upper lobe of left lung	1.00	infobox
SPI1	Bgee	spleen	1.00	infobox
SPI1	Bgee	blood	1.00	infobox
SPI1	Bgee	bone marrow cell	1.00	infobox
SPI1	Bgee	appendix	1.00	infobox
SPI1	Bgee	right coronary artery	1.00	infobox
SPI1	Bgee	lymph node	1.00	infobox
SPI1	Bgee	tibiofemoral joint	1.00	infobox
SPI1	Bgee	mesenteric lymph nodes	1.00	infobox
SPI1	Bgee	stroma of bone marrow	1.00	infobox
SPI1	Bgee	medulla of thymus	1.00	infobox
SPI1	Bgee	embryo	1.00	infobox
SPI1	Bgee	lip	1.00	infobox
SPI1	Bgee	ankle joint	1.00	infobox
SPI1	BioGPS	More reference expression data	1.00	infobox
SPI1	Chr.	Chromosome 11 (human)	1.00	infobox
SPI1	Chr.	Chromosome 2 (mouse)	1.00	infobox
SPI1	Databases	NCBI: entry; OMA: entry	1.00	infobox
SPI1	End	47,378,547 bp	1.00	infobox
SPI1	End	90,946,101 bp	1.00	infobox
SPI1	Ensembl	ENSG00000066336	1.00	infobox
SPI1	Entrez	6688	1.00	infobox
SPI1	External IDs	OMIM: 165170; MGI: 98282; GeneCards: SPI1	1.00	infobox

Related concept clusters Concept neighborhoods

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Connections between topic areas Semantic bridges

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