Transcription factor II B

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Structure

Polypeptide Amino acids C-terminal Amino terminal Protein-protein interactions

11 related topics

Phosphorylation

Phosphorylated Serine TFIIH Kinase Mammalian

8 related topics

Clinical significance

In vitro Herpes simplex virus Cyclin A Replication Cyclins

8 related topics

Mechanism of action

Phosphodiester bond Abortive transcripts Active site Dissociation NTPs

7 related topics

Key facts & relationships

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2.3.1.48: ↗
Aliases: GTF2B, TF2B, TFIIB, general transcription factor IIB
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1C9B, 1DL6, 1RLY, 1RO4, 1TFB, 1VOL, 2PHG, 5IY7, 5IYA, 5IY6, 5IY9, 5IYB, 5IYD, 5IY8, 5IYC
Band: 1p22.2 · 3|3 H1
Bgee: oocyte · secondary oocyte · Achilles tendon · gingival epithelium · epithelium of nasopharynx
BioGPS: More reference expression data

Topics to explore

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Overview

General transcription factor
RNA polymerase II
Preinitiation complex Transcription preinitiation complex
Transcription Transcription (genetics)
Nucleus Cell nucleus
TATA-binding protein
Archaeal transcription factor B
Sigma factors Sigma factor

Structure

Polypeptide Peptide
Amino acids
C-terminal C-terminus
Amino terminal N-terminus
Protein-protein interactions Protein-protein interaction
Transcription factor IID
RPB1 POLR2A
Protein-DNA interactions Protein-DNA interaction
B recognition element
Promoter element Response element
TATA element TATA box

Mechanism of action

Phosphodiester bond
Abortive transcripts Abortive initiation
Active site
Dissociation Dissociation (chemistry)
NTPs Nucleoside triphosphate
Magnesium ion Magnesium
Yeast

Phosphorylation

Phosphorylated Phosphorylation
Serine
TFIIH
Kinase
Mammalian Mammal
Cell cycle
Polyadenylation
CstF-64 Cleavage stimulation factor

Similarities in other transcription complexes

Clinical significance

In vitro
Herpes simplex virus
Cyclin A
Replication Viral replication
Cyclins Cyclin
Polyglutamine tract
Neurodegenerative diseases Neurodegeneration
Brain

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Map overview Semantic statistics

Nodes52

Edges51

Triples105

Avg. degree1.96

Density0.038462

Components1

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Transcription factor II B

Top relations

Gene ontology · 41

Transcription factor II B → acetyltransferase activity, acyltransferase activity, chromosome, DNA binding, DNA-templated transcription, initiation, histone acetylation, histone acetyltransferase activity, metal ion binding, nuclear body, nucleoplasm, nucleus, positive regulation by host of viral transcription, positive regulation of core promoter binding, positive regulation of transcription initiation from RNA polymerase II promoter, positive regulation of viral transcription, promoter-specific chromatin binding, protein acetylation, protein binding, protein-DNA complex, regulation of transcription, DNA-templated

Bgee · 19

Transcription factor II B → Achilles tendon, bone marrow, epithelium of nasopharynx, facial motor nucleus, gingival epithelium, islet of Langerhans, jejunum, medial ganglionic eminence, mucosa of sigmoid colon, olfactory zone of nasal mucosa, oocyte, palpebral conjunctiva, Paneth cell, primary oocyte, primitive streak, secondary oocyte, spermatid, spermatocyte, zygote

RNA expression pattern · 19

Band · 2

Transcription factor II B → 1p22.2, 3|3 H1

Chr. · 2

Transcription factor II B → Chromosome 1 (human), Chromosome 3 (mouse)

End · 2

Transcription factor II B → 142,489,367 bp, 88,891,944 bp

2.3.1.48 · 1

Transcription factor II B → ↗

Aliases · 1

Transcription factor II B → GTF2B, TF2B, TFIIB, general transcription factor IIB

Available structures · 1

Transcription factor II B → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1C9B, 1DL6, 1RLY, 1RO4, 1TFB, 1VOL, 2PHG, 5IY7, 5IYA, 5IY6, 5IY9, 5IYB, 5IYD, 5IY8, 5IYC

BioGPS · 1

Transcription factor II B → More reference expression data

Important terminology Word statistics

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Important terminology

tfiib rna transcription polymerase ii dna reader factor linker site complex gene bp found formation initiation binding chr human chromosome

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Transcription factor II B	2.3.1.48	↗	1.00	infobox
Transcription factor II B	Aliases	GTF2B, TF2B, TFIIB, general transcription factor IIB	1.00	infobox
Transcription factor II B	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1C9B, 1DL6, 1RLY, 1RO4, 1TFB, 1VOL, 2PHG, 5IY7, 5IYA, 5IY6, 5IY9, 5IYB, 5IYD, 5IY8, 5IYC	1.00	infobox
Transcription factor II B	Band	1p22.2	1.00	infobox
Transcription factor II B	Band	3\|3 H1	1.00	infobox
Transcription factor II B	Bgee	oocyte	1.00	infobox
Transcription factor II B	Bgee	secondary oocyte	1.00	infobox
Transcription factor II B	Bgee	Achilles tendon	1.00	infobox
Transcription factor II B	Bgee	gingival epithelium	1.00	infobox
Transcription factor II B	Bgee	epithelium of nasopharynx	1.00	infobox
Transcription factor II B	Bgee	bone marrow	1.00	infobox
Transcription factor II B	Bgee	islet of Langerhans	1.00	infobox
Transcription factor II B	Bgee	olfactory zone of nasal mucosa	1.00	infobox
Transcription factor II B	Bgee	mucosa of sigmoid colon	1.00	infobox
Transcription factor II B	Bgee	palpebral conjunctiva	1.00	infobox
Transcription factor II B	Bgee	primary oocyte	1.00	infobox
Transcription factor II B	Bgee	zygote	1.00	infobox
Transcription factor II B	Bgee	spermatocyte	1.00	infobox
Transcription factor II B	Bgee	spermatid	1.00	infobox
Transcription factor II B	Bgee	medial ganglionic eminence	1.00	infobox
Transcription factor II B	Bgee	primitive streak	1.00	infobox
Transcription factor II B	Bgee	Paneth cell	1.00	infobox
Transcription factor II B	Bgee	jejunum	1.00	infobox
Transcription factor II B	Bgee	facial motor nucleus	1.00	infobox
Transcription factor II B	BioGPS	More reference expression data	1.00	infobox
Transcription factor II B	Chr.	Chromosome 1 (human)	1.00	infobox
Transcription factor II B	Chr.	Chromosome 3 (mouse)	1.00	infobox
Transcription factor II B	Databases	NCBI: entry; OMA: entry	1.00	infobox
Transcription factor II B	End	88,891,944 bp	1.00	infobox
Transcription factor II B	End	142,489,367 bp	1.00	infobox

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