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MYF5

Myogenic factor 5 is a protein that in humans is encoded by the MYF5 gene. It is a protein with a key role in regulating muscle differentiation or myogenesis, specifically the development of skeletal muscle. Myf5 belongs to a family of proteins known as myogenic regulatory factors (MRFs). These basic helix loop helix transcription factors act…

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Aliases
MYF5, bHLHc2, myogenic factor 5, EORVA
Band
12q21.31 · 10 D1|10 55.95 cM
Bgee
biceps brachii · muscle of thigh · gastrocnemius muscle · skeletal muscle tissue · deltoid muscle
BioGPS
n/a
Chr.
Chromosome 12 (human) · Chromosome 10 (mouse)
Databases
NCBI: entry; OMA: entry

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Expression

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MYF5

Nodes13
Edges12
Triples129
Avg. degree1.85
Density0.153846
Components1

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MYF5

Top relations

Gene ontology · 37
MYF5 → camera-type eye development, cartilage condensation, cell differentiation, DNA binding, DNA-binding transcription activator activity, RNA polymerase II-specific, DNA-binding transcription factor activity, RNA polymerase II-specific, E-box binding, embryonic skeletal system morphogenesis, extracellular matrix organization, multicellular organism development, muscle cell fate commitment, muscle organ development, muscle organ morphogenesis, muscle tissue morphogenesis, nucleoplasm, nucleus, ossification, positive regulation of muscle cell differentiation, positive regulation of myoblast differentiation, positive regulation of myoblast fusion
Bgee · 20
MYF5 → biceps brachii, body of tongue, deltoid muscle, exocrine gland, extraocular muscle, gastrocnemius muscle, human fetus, internal carotid artery, male reproductive gland, male urethra, muscle layer of urethra, muscle of thigh, muscle of upper limb, myotome, salivary gland, skeletal muscle tissue, soleus muscle, temporal muscle, tibialis anterior muscle, urethra
RNA expression pattern · 20
MYF5 → biceps brachii, body of tongue, deltoid muscle, exocrine gland, extraocular muscle, gastrocnemius muscle, human fetus, internal carotid artery, male reproductive gland, male urethra, muscle layer of urethra, muscle of thigh, muscle of upper limb, myotome, salivary gland, skeletal muscle tissue, soleus muscle, temporal muscle, tibialis anterior muscle, urethra
related to Expression · 17
MYF5 → Although, Most, MRF4, MRFs, Myf5-dependent, MyoD, MyoD-dependent, Numerous, Pax3, Some, Sonic, Specifically, Still, The, These, This, While
related to Regulation · 8
MYF5 → After, Although, Following, It, Sonic, Termed, The, This
related to Clinical significance · 5
MYF5 → Although, As, Hypoxia, MRFs, This
Band · 2
MYF5 → 10 D1|10 55.95 cM, 12q21.31
Chr. · 2
MYF5 → Chromosome 10 (mouse), Chromosome 12 (human)
End · 2
MYF5 → 107,321,995 bp, 80,719,671 bp
is a · 2
MYF5 → first MRF expressed in embryonic myogenesis and is required for adult viability, master regulator of muscle development

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Important terminology

muscle expression expressed myogenic development skeletal cells factor differentiation bp mrfs gene transcription chr myogenesis human band specifically chromosome enhancer

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MYF5AliasesMYF5, bHLHc2, myogenic factor 5, EORVA1.00infobox
MYF5Band12q21.311.00infobox
MYF5Band10 D1|10 55.95 cM1.00infobox
MYF5Bgeebiceps brachii1.00infobox
MYF5Bgeemuscle of thigh1.00infobox
MYF5Bgeegastrocnemius muscle1.00infobox
MYF5Bgeeskeletal muscle tissue1.00infobox
MYF5Bgeedeltoid muscle1.00infobox
MYF5Bgeetibialis anterior muscle1.00infobox
MYF5Bgeebody of tongue1.00infobox
MYF5Bgeeexocrine gland1.00infobox
MYF5Bgeesalivary gland1.00infobox
MYF5Bgeemale reproductive gland1.00infobox
MYF5Bgeemyotome1.00infobox
MYF5Bgeeurethra1.00infobox
MYF5Bgeemale urethra1.00infobox
MYF5Bgeehuman fetus1.00infobox
MYF5Bgeeextraocular muscle1.00infobox
MYF5Bgeemuscle layer of urethra1.00infobox
MYF5Bgeesoleus muscle1.00infobox
MYF5Bgeemuscle of upper limb1.00infobox
MYF5Bgeeinternal carotid artery1.00infobox
MYF5Bgeetemporal muscle1.00infobox
MYF5BioGPSn/a1.00infobox
MYF5Chr.Chromosome 12 (human)1.00infobox
MYF5Chr.Chromosome 10 (mouse)1.00infobox
MYF5DatabasesNCBI: entry; OMA: entry1.00infobox
MYF5End80,719,671 bp1.00infobox
MYF5End107,321,995 bp1.00infobox
MYF5EnsemblENSG000001110491.00infobox

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