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NFAT

Nuclear factor of activated T-cells (NFAT) is a family of transcription factors shown to be important in immune response. One or more members of the NFAT family is expressed in most cells of the immune system. NFAT is also involved in the development of immune, cardiac, skeletal muscle, and nervous systems. NFAT was first discovered as an activator for…

Members, Signalling and binding & NFAT function in different cell types

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Signalling and binding

26 related topics

NFAT function in different cell types

40 related topics

Family members

15 related topics

As a drug target

7 related topics

Topics to explore

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Overview

Family members

Signalling and binding

NFAT function in different cell types

NFAT signalling in neural development

Clinical significance

As a drug target

Advanced semantic analysis

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Map overview Semantic statistics

NFAT

Nodes111
Edges110
Triples149
Avg. degree1.98
Density0.018018
Components1

How this topic connects Entity context

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NFAT

Top relations

related to T cells · 23
NFAT → AP-1, BATF, C-terminal, For Th1, GATA3, However, IFN-γ, NFAT2/αA, NFAT3, NFATc1, NFATc2, RORγ, T-bet, T-cell, TCR, Tfh, Th1, Th17, Th2, The TCR
related to Canonical signalling · 22
NFAT → Although, B-cell, BCR, CaM/CN, CRAC, DAG, ER, However, IP3, Only, ORAI1, PLC, PLCG1, PLCG2, SOCE, STIM, T-cell, TCR, The, The IP3
related to Family members · 16
NFAT → Activated CN, Calcium, CaM, CN, N-terminal, N-terminus, NFAT5, NFATc1, NFATc1-4, NFATc2, NFATc3, NFATc4, SP-repeats, SRR, The NFAT, This
related to T cell anergy and exhaustion · 16
NFAT → AP-1, Because, Cbl-b, Conversaly, DGKα, E3, GRAIL, In, ITCH, NFAT2/αA, NFATc1, NFATc2, Similar, T-cell, TCR, This
related to DNA binding · 15
NFAT → CK1, DNA, DNA-binding, EST, GSK-3β, If, In, MAPK, NFATn, NRON, Nuclear, PKA, PKC, Therefore, This
related to Alternative signalling · 11
NFAT → Although SOCE, CN, CsA, IL7R, In, Jnk3, MAPK, NFATc2, SOCE, The, This
related to Inflammation · 11
NFAT → Additionally, IBD, In, LRRK2, NFAT-dependent, NFATc2, RA, Rheumatoid Arthritis, The, This, TNF-α
related to B cells · 10
NFAT → Although, However, If, IL-10, In, NFAT2/αA, NFATc1, NFATc2, SOCE, STIM
related to As a drug target · 9
NFAT → Because, CN, Crohn's, CsA, Due, FK506, However, IL-2, There
related to Structure · 7
NFAT → AP-1, C-terminal, DNA, DNA-binding, N-terminus, Rel, SP-repeats

Important terminology Word statistics

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Important terminology

cells complex transcription also cell nfatc2 calcium important signalling proteins ap-1 activation role response family nfatc1 th2 immune cn tfh

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
NFATis aknown important player in both the developing and adult nervous system0.90text
PKAinstance ofthe exporting kinases in a nucleus0.80text
CK1 or GSK-3β rephosphorylate NFATinstance ofthe exporting kinases in a nucleus0.80text
ras-MAPK or PKCinstance ofThis important feature of NFAT transcription factors enables integration and coincidence detection of calcium signals with other signalling pathways0.80text
netrin to facilitate the formation of new synapsesinstance ofNFAT transcription complexes integrate neuronal growth with guidance cues0.80text
helping to build neural circuits in the braininstance ofNFAT transcription complexes integrate neuronal growth with guidance cues0.80text
NFATrelated to Alternative signallingAlthough SOCE0.60section
NFATrelated to Alternative signallingThis0.60section
NFATrelated to Alternative signallingNFATc20.60section
NFATrelated to Alternative signallingIn0.60section
NFATrelated to Alternative signallingSOCE0.60section
NFATrelated to Alternative signallingCsA0.60section

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