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NFAT: Members, Signalling and binding & NFAT function in different cell types

Nuclear factor of activated T-cells (NFAT) is a family of transcription factors shown to be important in immune response. One or more members of the NFAT family is expressed in most cells of the immune system. NFAT is also involved in the development of immune, cardiac, skeletal muscle, and nervous systems. NFAT was first discovered as an activator for…

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NFAT topic overview

The analysis highlights Members, Signalling and binding and NFAT function in different cell types as prominent areas in the source structure around NFAT.

Related topics
103
Source areas
7
Connected nodes
110
Extracted relationships
149
Concept neighborhoods
25
Bridge connections
110

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

NFAT function in different cell types · 40 topics
Signalling and binding · 26 topics
Family members · 15 topics
As a drug target · 7 topics
Clinical significance · 6 topics
Overview · 6 topics
NFAT signalling in neural development · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Family members

Signalling and binding

NFAT function in different cell types

NFAT signalling in neural development

Clinical significance

As a drug target

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How NFAT connects Entity context

The extracted context around NFAT shows recurring relationship patterns in the source. For example, NFAT → AP-1, BATF, C-terminal, For Th1, GATA3, However, IFN-γ, NFAT2/αA, NFAT3, NFATc1, NFATc2, RORγ, T-bet, T-cell, TCR, Tfh, Th1, Th17, Th2, The TCR Another extracted example is NFAT → Although, B-cell, BCR, CaM/CN, CRAC, DAG, ER, However, IP3, Only, ORAI1, PLC, PLCG1, PLCG2, SOCE, STIM, T-cell, TCR, The, The IP3. Use these groups to spot repeated connection types before inspecting the individual relationships.

NFAT

Top relations

related to T cells · 23
NFAT → AP-1, BATF, C-terminal, For Th1, GATA3, However, IFN-γ, NFAT2/αA, NFAT3, NFATc1, NFATc2, RORγ, T-bet, T-cell, TCR, Tfh, Th1, Th17, Th2, The TCR
related to Canonical signalling · 22
NFAT → Although, B-cell, BCR, CaM/CN, CRAC, DAG, ER, However, IP3, Only, ORAI1, PLC, PLCG1, PLCG2, SOCE, STIM, T-cell, TCR, The, The IP3
related to Family members · 16
NFAT → Activated CN, Calcium, CaM, CN, N-terminal, N-terminus, NFAT5, NFATc1, NFATc1-4, NFATc2, NFATc3, NFATc4, SP-repeats, SRR, The NFAT, This
related to T cell anergy and exhaustion · 16
NFAT → AP-1, Because, Cbl-b, Conversaly, DGKα, E3, GRAIL, In, ITCH, NFAT2/αA, NFATc1, NFATc2, Similar, T-cell, TCR, This
related to DNA binding · 15
NFAT → CK1, DNA, DNA-binding, EST, GSK-3β, If, In, MAPK, NFATn, NRON, Nuclear, PKA, PKC, Therefore, This
related to Alternative signalling · 11
NFAT → Although SOCE, CN, CsA, IL7R, In, Jnk3, MAPK, NFATc2, SOCE, The, This
related to Inflammation · 11
NFAT → Additionally, IBD, In, LRRK2, NFAT-dependent, NFATc2, RA, Rheumatoid Arthritis, The, This, TNF-α
related to B cells · 10
NFAT → Although, However, If, IL-10, In, NFAT2/αA, NFATc1, NFATc2, SOCE, STIM
related to As a drug target · 9
NFAT → Because, CN, Crohn's, CsA, Due, FK506, However, IL-2, There
related to Structure · 7
NFAT → AP-1, C-terminal, DNA, DNA-binding, N-terminus, Rel, SP-repeats

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

cells complex transcription also cell nfatc2 calcium important signalling proteins ap-1 activation role response family nfatc1 th2 immune cn tfh

NFAT relationships Subject–Predicate–Object triples

TTTA extracted 149 structured relationships around NFAT. Examples in this analysis include NFAT → is a → known important player in both the developing and adult nervous system and PKA → instance of → the exporting kinases in a nucleus. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
NFATis aknown important player in both the developing and adult nervous system0.90text
PKAinstance ofthe exporting kinases in a nucleus0.80text
CK1 or GSK-3β rephosphorylate NFATinstance ofthe exporting kinases in a nucleus0.80text
ras-MAPK or PKCinstance ofThis important feature of NFAT transcription factors enables integration and coincidence detection of calcium signals with other signalling pathways0.80text
netrin to facilitate the formation of new synapsesinstance ofNFAT transcription complexes integrate neuronal growth with guidance cues0.80text
helping to build neural circuits in the braininstance ofNFAT transcription complexes integrate neuronal growth with guidance cues0.80text
NFATrelated to Alternative signallingAlthough SOCE0.60section
NFATrelated to Alternative signallingThis0.60section
NFATrelated to Alternative signallingNFATc20.60section
NFATrelated to Alternative signallingIn0.60section
NFATrelated to Alternative signallingSOCE0.60section
NFATrelated to Alternative signallingCsA0.60section

Related concept clusters Concept neighborhoods

The concept neighborhoods around NFAT bring nearby vocabulary together. In this analysis, examples include Cells, Transcription and Complex. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • NFAT
    • Cells
    • Transcription
    • Complex
    • Also
    • Proteins
    • Ap-1
    • Cell
    • Signalling
    • Family
    • Production
    • Important
    • Immune
  • nfat
    • Cells
    • Transcription
    • Complex
    • Also
    • Proteins
    • Ap-1
    • Cell
    • Signalling
    • Family
    • Production
    • Important
    • Immune
  • transcription factors
    • Factors
    • Transcription
    • Nuclear
    • Complex
    • Activates
    • Nfat
    • Proteins
    • Cell
    • Immune
    • Important
    • Cells
    • Cytokine
  • immune response
    • Since
    • Th2
    • Nfatc2
    • Th1
    • Th17
    • Transcription
    • Cells
    • Response
    • Tfh
    • Important
    • Proteins
    • Cell
  • t cells
    • Nfat
    • Tfh
    • Nfatc2
    • Since
    • Nfatc1
    • Ap-1
    • Response
    • Role
    • Complex
    • Important
    • Members
    • Also
  • effector t cells
    • Nfat
    • Tfh
    • Nfatc2
    • Since
    • Nfatc1
    • Ap-1
    • Response
    • Role
    • Complex
    • Important
    • Members
    • Also
  • cd4+ t cells
    • Nfat
    • Tfh
    • Nfatc2
    • Since
    • Nfatc1
    • Ap-1
    • Response
    • Role
    • Complex
    • Important
    • Members
    • Also
  • t cell exhaustion
    • Anergy
    • Stimulation
    • Transcription
    • Nfat
    • Complex
    • Signalling
    • Cytokine
    • Different
    • Nfat5
    • Immune
    • Activates
    • Tcr

Connections between topic areas Semantic bridges

For NFAT, one of the stronger structural bridges in this analysis connects NFAT with NFAT function in different cell types. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
NFAT — NFAT function in different cell types · splits 70 ⟂ 41
NFAT — Signalling and binding · splits 84 ⟂ 27
NFAT — Family members · splits 95 ⟂ 16
NFAT — As a drug target · splits 103 ⟂ 8
NFAT — Overview · splits 104 ⟂ 7
NFAT — Clinical significance · splits 104 ⟂ 7
NFAT — NFAT signalling in neural development · splits 107 ⟂ 4

Map overview Semantic statistics

NFAT

Nodes111
Edges110
Triples149
Avg. degree1.98
Density0.018018
Components1

Source & methodology

TTTA analyzes the structure around NFAT to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Members, Signalling and binding & NFAT function in different cell types, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — NFAT · EN edition · Analysis: TopicsToTalkAbout

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