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Proteasome

Proteasomes are essential protein complexes responsible for the degradation of proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases. Proteasomes are found inside all eukaryotes and archaea, and in some bacteria. In eukaryotes, proteasomes are located both in the nucleus and in the…

Discovery, Structure and organization & Protein degradation process

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Discovery

21 related topics

Structure and organization

30 related topics

Protein degradation process

39 related topics

Cell cycle control

36 related topics

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Overview

Discovery

Structure and organization

Assembly

Protein degradation process

Evolution

Cell cycle control

Response to cellular stress

Role in the immune system

Proteasome inhibitors

Clinical significance

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Map overview Semantic statistics

Proteasome

Nodes290
Edges289
Triples318
Avg. degree1.99
Density0.006897
Components1

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Proteasome

Top relations

related to 19S regulatory particle · 40
Proteasome → AAA, AAA Family, AAA-ATPase, AAA-ATPases, ATP, ATP-binding, ATPase, ATPases, ATPases Rpn1, COP9, EM, However, In, N-terminal, Note, PAN, PCI, Rpn10, Rpn11, Rpn12
related to Discovery · 24
Proteasome → Aaron Ciechanover, Alfred, APF-1, ATP-dependent, Avram Hershko, Before, C-terminal, Chemistry, Fox Chase Cancer Center, Goldberg, Hershko's, However, Irwin Rose, It, Joseph Etlinger, Later, Marion Orlowski, Much, Nobel Prize, Rose
related to Cell cycle control · 15
Proteasome → After, APC, CDK-cyclin, CDKs, Cell, E3, Earlier, G1, G1-S, In, Mitotic, SCF, Skp1/Cul1/F-box, Skp2, The APC
related to Response to cellular stress · 15
Proteasome → ATP, Both Hsp27, CHIP, E2, E3, However, Hsp70, Hsp70-interacting, Hsp90, In, Larger, Oxidized, PARP, Similar, The CHIP
related to Ubiquitin-independent degradation · 15
Proteasome → AAA, Although, Another, AZ, C-terminal, Finally, N-terminal, NF-κB, ODC, Ornithine, RP, Some, The, Thymidine, Ubiquitin-independent
related to Proteasomal chaperones · 14
Proteasome → Ddi1, Dsk2, DUBs, In, K48-Ubiquitin, Ligases, Proteasomal Chaperones, Rad23, These, UBA, Ubiquitin, Ubiquitin-like, UBL, UBLs
related to 20S core particle · 13
Proteasome → All, Alternative, Although, In, N-termini, PfamPF10584, PHGH, Recently, The, Thermoplasma, These, They, Three
related to Assembly · 13
Proteasome → AAA-ATPase, Assembly, Hsm3/S5b, In, N-terminal, Nas2/p27, Nas6/gankyrin, Only, Rpn14/PAAF1, The, These, To, Ubp6/Usp14
related to Proteolysis · 13
Proteasome → Although, Certain, Degradation, Each, It, NF-κB, PHGH, RUP, Similar, Such, The, These, This
related to Unfolding and translocation · 13
Proteasome → After, ATP, ATP-bound, ATP-dependent, Because, For, However, N-terminal, Passage, The, The ATP, Which, While

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Important terminology

ubiquitin degradation protein proteins substrate 20s also subunits complex particle 19s proteasomes yeast cell 26s core regulatory proteolysis rpn11 cells

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Proteasomeis acomplex process due to the number of subunits that must associate to form an active complex0.90text
those produced after infection by a virusinstance ofthe 11S may play a role in degradation of foreign peptides0.80text
Thermoplasma acidophiluminstance ofsuggesting that substrate proteins must be at least partially unfolded to enter.In archaea0.80text
all the αinstance ofsuggesting that substrate proteins must be at least partially unfolded to enter.In archaea0.80text
all the β subunits are identicalinstance ofsuggesting that substrate proteins must be at least partially unfolded to enter.In archaea0.80text
whereas eukaryotic proteasomes such as those in yeast contain seven distinct types of each subunitinstance ofsuggesting that substrate proteins must be at least partially unfolded to enter.In archaea0.80text
cytokinesinstance ofand β5i can be expressed in hematopoietic cells in response to exposure to pro-inflammatory signals0.80text
in particularinstance ofand β5i can be expressed in hematopoietic cells in response to exposure to pro-inflammatory signals0.80text
interferon gammainstance ofand β5i can be expressed in hematopoietic cells in response to exposure to pro-inflammatory signals0.80text
cadmium.The peptides that are formed by the 20S core have recently been shown to act as important metabolites for both programmed cell deathinstance ofcells expressing these proteasomes show enhanced resistance to toxicity induced by metallic ions0.80text
for immunityinstance ofcells expressing these proteasomes show enhanced resistance to toxicity induced by metallic ions0.80text
disulfide bondsinstance ofand in particular nonlocal interactions0.80text

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