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Proteasomes are essential protein complexes responsible for the degradation of proteins by proteolysis, a chemical reaction that breaks peptide bonds. Enzymes that help such reactions are called proteases. Proteasomes are found inside all eukaryotes and archaea, and in some bacteria. In eukaryotes, proteasomes are located both in the nucleus and in the…
Discovery, Structure and organization & Protein degradation process
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ubiquitin degradation protein proteins substrate 20s also subunits complex particle 19s proteasomes yeast cell 26s core regulatory proteolysis rpn11 cells
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Proteasome | is a | complex process due to the number of subunits that must associate to form an active complex | 0.90 | text |
| those produced after infection by a virus | instance of | the 11S may play a role in degradation of foreign peptides | 0.80 | text |
| Thermoplasma acidophilum | instance of | suggesting that substrate proteins must be at least partially unfolded to enter.In archaea | 0.80 | text |
| all the α | instance of | suggesting that substrate proteins must be at least partially unfolded to enter.In archaea | 0.80 | text |
| all the β subunits are identical | instance of | suggesting that substrate proteins must be at least partially unfolded to enter.In archaea | 0.80 | text |
| whereas eukaryotic proteasomes such as those in yeast contain seven distinct types of each subunit | instance of | suggesting that substrate proteins must be at least partially unfolded to enter.In archaea | 0.80 | text |
| cytokines | instance of | and β5i can be expressed in hematopoietic cells in response to exposure to pro-inflammatory signals | 0.80 | text |
| in particular | instance of | and β5i can be expressed in hematopoietic cells in response to exposure to pro-inflammatory signals | 0.80 | text |
| interferon gamma | instance of | and β5i can be expressed in hematopoietic cells in response to exposure to pro-inflammatory signals | 0.80 | text |
| cadmium.The peptides that are formed by the 20S core have recently been shown to act as important metabolites for both programmed cell death | instance of | cells expressing these proteasomes show enhanced resistance to toxicity induced by metallic ions | 0.80 | text |
| for immunity | instance of | cells expressing these proteasomes show enhanced resistance to toxicity induced by metallic ions | 0.80 | text |
| disulfide bonds | instance of | and in particular nonlocal interactions | 0.80 | text |
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