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UBE3A

Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene. This enzyme is involved in targeting proteins for degradation within cells.

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2.3.2.26
Aliases
UBE3A, ANCR, AS, E6-AP, EPVE6AP, HPVE6A, ubiquitin protein ligase E3A, PIX1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4GIZ, 1C4Z, 1D5F, 1EQX, 2KR1
Band
15q11.2 · 7 B5|7 33.95 cM
Bgee
sperm · Skeletal muscle tissue of rectus abdominis · Achilles tendon · Skeletal muscle tissue of biceps brachii · mucosa of paranasal sinus
BioGPS
More reference expression data

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Overview

Gene

Tissue distribution

Function

Clinical significance

Interactions

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Map overview Semantic statistics

UBE3A

Nodes45
Edges44
Triples145
Avg. degree1.96
Density0.044444
Components1

How this topic connects Entity context

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UBE3A

Top relations

Gene ontology · 35
UBE3A → androgen receptor signaling pathway, brain development, cellular response to brain-derived neurotrophic factor stimulus, cytoplasm, cytosol, metal ion binding, negative regulation of dendritic spine morphogenesis, nucleus, ovarian follicle development, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of protein ubiquitination, positive regulation of transcription by RNA polymerase II, progesterone receptor signaling pathway, prostate gland growth, proteasome complex, proteasome-mediated ubiquitin-dependent protein catabolic process, protein autoubiquitination, protein binding, protein K48-linked ubiquitination, protein polyubiquitination
Bgee · 20
UBE3A → Achilles tendon, arcuate nucleus, cardia, efferent ductule, Epithelium of choroid plexus, lateral septal nucleus, medial ganglionic eminence, median eminence, mucosa of paranasal sinus, nipple, paraventricular nucleus of hypothalamus, pineal gland, pylorus, Rostral migratory stream, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, sperm, vas deferens, vastus lateralis muscle, ventromedial nucleus
RNA expression pattern · 20
UBE3A → Achilles tendon, arcuate nucleus, cardia, efferent ductule, Epithelium of choroid plexus, lateral septal nucleus, medial ganglionic eminence, median eminence, mucosa of paranasal sinus, nipple, paraventricular nucleus of hypothalamus, pineal gland, pylorus, Rostral migratory stream, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, sperm, vas deferens, vastus lateralis muscle, ventromedial nucleus
related to Clinical significance · 13
UBE3A → Angelman, Because, Dup15q, E3A, Isodicentric, Like, Most, Mutations, Other, Prader-Willi, The UBE3A, These, This
related to Function · 10
UBE3A → Angelman, E3, E3A, E6AP, In, Its, Notably, The UBE3A, This, UBE3A's
related to Interactions · 10
UBE3A → BLK, Lck, MCM7, MECP2, Progesterone, TSC2, UBE2D1, UBE2D2, UBE2L3, UBQLN1
related to Gene · 5
UBE3A → Large Non-Coding Antisense Transcript, LNCAT, Silencing, The UBE3A, Ube3a-ATS
related to Tissue distribution · 4
UBE3A → Both, Further, In, Recent
Band · 2
UBE3A → 15q11.2, 7 B5|7 33.95 cM
Chr. · 2
UBE3A → Chromosome 15 (human), Chromosome 7 (mouse)

Important terminology Word statistics

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Important terminology

gene ligase enzyme protein bp ubiquitin human chromosome 15 chr band function e3a also known degradation within expression brain location

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
UBE3A2.3.2.261.00infobox
UBE3AAliasesUBE3A, ANCR, AS, E6-AP, EPVE6AP, HPVE6A, ubiquitin protein ligase E3A, PIX11.00infobox
UBE3AAvailable structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4GIZ, 1C4Z, 1D5F, 1EQX, 2KR11.00infobox
UBE3ABand15q11.21.00infobox
UBE3ABand7 B5|7 33.95 cM1.00infobox
UBE3ABgeesperm1.00infobox
UBE3ABgeeSkeletal muscle tissue of rectus abdominis1.00infobox
UBE3ABgeeAchilles tendon1.00infobox
UBE3ABgeeSkeletal muscle tissue of biceps brachii1.00infobox
UBE3ABgeemucosa of paranasal sinus1.00infobox
UBE3ABgeenipple1.00infobox
UBE3ABgeeEpithelium of choroid plexus1.00infobox
UBE3ABgeevastus lateralis muscle1.00infobox
UBE3ABgeepylorus1.00infobox
UBE3ABgeecardia1.00infobox
UBE3ABgeeRostral migratory stream1.00infobox
UBE3ABgeevas deferens1.00infobox
UBE3ABgeepineal gland1.00infobox
UBE3ABgeeventromedial nucleus1.00infobox
UBE3ABgeemedial ganglionic eminence1.00infobox
UBE3ABgeearcuate nucleus1.00infobox
UBE3ABgeeefferent ductule1.00infobox
UBE3ABgeemedian eminence1.00infobox
UBE3ABgeeparaventricular nucleus of hypothalamus1.00infobox
UBE3ABgeelateral septal nucleus1.00infobox
UBE3ABioGPSMore reference expression data1.00infobox
UBE3AChr.Chromosome 15 (human)1.00infobox
UBE3AChr.Chromosome 7 (mouse)1.00infobox
UBE3ADatabasesNCBI: entry; OMA: entry1.00infobox
UBE3AEnd25,439,051 bp1.00infobox

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