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Ubiquitin-protein ligase E3A (UBE3A) also known as E6AP ubiquitin-protein ligase (E6AP) is an enzyme that in humans is encoded by the UBE3A gene. This enzyme is involved in targeting proteins for degradation within cells.
The analysis highlights Interactions, Clinical significance and Function as prominent areas in the source structure around UBE3A.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around UBE3A shows recurring relationship patterns in the source. For example, UBE3A → androgen receptor signaling pathway, brain development, cellular response to brain-derived neurotrophic factor stimulus, cytoplasm, cytosol, metal ion binding, negative regulation of dendritic spine morphogenesis, nucleus, ovarian follicle development, positive regulation of phosphatidylinositol 3-kinase signaling, positive regulation of protein ubiquitination, positive regulation of transcription by RNA polymerase II, progesterone receptor signaling pathway, prostate gland growth, proteasome complex, proteasome-mediated ubiquitin-dependent protein catabolic process, protein autoubiquitination, protein binding, protein K48-linked ubiquitination, protein polyubiquitination Another extracted example is UBE3A → Achilles tendon, arcuate nucleus, cardia, efferent ductule, Epithelium of choroid plexus, lateral septal nucleus, medial ganglionic eminence, median eminence, mucosa of paranasal sinus, nipple, paraventricular nucleus of hypothalamus, pineal gland, pylorus, Rostral migratory stream, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, sperm, vas deferens, vastus lateralis muscle, ventromedial nucleus. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
gene ligase enzyme protein bp ubiquitin human chromosome 15 chr band function e3a also known degradation within expression brain location
TTTA extracted 145 structured relationships around UBE3A. Examples in this analysis include UBE3A → 2.3.2.26 → ↗ and UBE3A → Aliases → UBE3A, ANCR, AS, E6-AP, EPVE6AP, HPVE6A, ubiquitin protein ligase E3A, PIX1. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| UBE3A | 2.3.2.26 | ↗ | 1.00 | infobox |
| UBE3A | Aliases | UBE3A, ANCR, AS, E6-AP, EPVE6AP, HPVE6A, ubiquitin protein ligase E3A, PIX1 | 1.00 | infobox |
| UBE3A | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4GIZ, 1C4Z, 1D5F, 1EQX, 2KR1 | 1.00 | infobox |
| UBE3A | Band | 15q11.2 | 1.00 | infobox |
| UBE3A | Band | 7 B5|7 33.95 cM | 1.00 | infobox |
| UBE3A | Bgee | sperm | 1.00 | infobox |
| UBE3A | Bgee | Skeletal muscle tissue of rectus abdominis | 1.00 | infobox |
| UBE3A | Bgee | Achilles tendon | 1.00 | infobox |
| UBE3A | Bgee | Skeletal muscle tissue of biceps brachii | 1.00 | infobox |
| UBE3A | Bgee | mucosa of paranasal sinus | 1.00 | infobox |
| UBE3A | Bgee | nipple | 1.00 | infobox |
| UBE3A | Bgee | Epithelium of choroid plexus | 1.00 | infobox |
| UBE3A | Bgee | vastus lateralis muscle | 1.00 | infobox |
| UBE3A | Bgee | pylorus | 1.00 | infobox |
| UBE3A | Bgee | cardia | 1.00 | infobox |
| UBE3A | Bgee | Rostral migratory stream | 1.00 | infobox |
| UBE3A | Bgee | vas deferens | 1.00 | infobox |
| UBE3A | Bgee | pineal gland | 1.00 | infobox |
| UBE3A | Bgee | ventromedial nucleus | 1.00 | infobox |
| UBE3A | Bgee | medial ganglionic eminence | 1.00 | infobox |
| UBE3A | Bgee | arcuate nucleus | 1.00 | infobox |
| UBE3A | Bgee | efferent ductule | 1.00 | infobox |
| UBE3A | Bgee | median eminence | 1.00 | infobox |
| UBE3A | Bgee | paraventricular nucleus of hypothalamus | 1.00 | infobox |
| UBE3A | Bgee | lateral septal nucleus | 1.00 | infobox |
| UBE3A | BioGPS | More reference expression data | 1.00 | infobox |
| UBE3A | Chr. | Chromosome 15 (human) | 1.00 | infobox |
| UBE3A | Chr. | Chromosome 7 (mouse) | 1.00 | infobox |
| UBE3A | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| UBE3A | End | 25,439,051 bp | 1.00 | infobox |
The concept neighborhoods around UBE3A bring nearby vocabulary together. In this analysis, examples include Gene, Protein and Expression. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For UBE3A, one of the stronger structural bridges in this analysis connects UBE3A with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around UBE3A to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — UBE3A · EN edition · Analysis: TopicsToTalkAbout