Research any topic before you write.
Find related topics. | Discover entities. | See connections. | Build a topical map.
Alpha-synuclein (aSyn) is a protein that in humans is encoded by the SNCA gene. It is a neuronal protein involved in the regulation of synaptic vesicle trafficking and the release of neurotransmitters.
The analysis highlights Tissue expression, Structure and Clinical significance as prominent areas in the source structure around Alpha-synuclein.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around Alpha-synuclein shows recurring relationship patterns in the source. For example, Alpha-synuclein → actin binding, actin cytoskeleton, activation of cysteine-type endopeptidase activity involved in apoptotic process, adult locomotory behavior, ageing, alpha-tubulin binding, apoptotic process, axon, axon terminus, behavioral response to cocaine, beta-tubulin binding, calcium ion binding, calcium ion homeostasis, cell cortex, cell junction, cellular response to copper ion, cellular response to epinephrine stimulus, cellular response to fibroblast growth factor stimulus, cellular response to oxidative stress, chemical synaptic transmission Another extracted example is Alpha-synuclein → Additionally, Alpha, Alzheimer's, Among, Calcium, However, In, It, Lewy, Mutations, Nevertheless, NMR, Occasionally, One, Parkinson's, Proponents, SAA, The, The Epstein-Barr, There. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
protein aggregation disease synuclein human gene neurons also snca lipid structure shown cells brain synaptic amyloid membrane parkinson's synucleinopathies vesicles
TTTA extracted 331 structured relationships around Alpha-synuclein. Examples in this analysis include Alpha-synuclein → Aliases → SNCA, NACP, PARK1, PARK4, PD1, synuclein alpha and Alpha-synuclein → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1XQ8, 2JN5, 2KKW, 2M55, 2X6M, 3Q25, 3Q26, 3Q27, 3Q28, 3Q29, 4BXL, 4R0U, 4R0W, 4RIK, 4RIL, 4ZNN, 5CRW, 2N0A. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Alpha-synuclein | Aliases | SNCA, NACP, PARK1, PARK4, PD1, synuclein alpha | 1.00 | infobox |
| Alpha-synuclein | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1XQ8, 2JN5, 2KKW, 2M55, 2X6M, 3Q25, 3Q26, 3Q27, 3Q28, 3Q29, 4BXL, 4R0U, 4R0W, 4RIK, 4RIL, 4ZNN, 5CRW, 2N0A | 1.00 | infobox |
| Alpha-synuclein | Band | 4q22.1 | 1.00 | infobox |
| Alpha-synuclein | Band | 6 B3|6 29.15 cM | 1.00 | infobox |
| Alpha-synuclein | Bgee | trabecular bone | 1.00 | infobox |
| Alpha-synuclein | Bgee | orbitofrontal cortex | 1.00 | infobox |
| Alpha-synuclein | Bgee | pons | 1.00 | infobox |
| Alpha-synuclein | Bgee | Brodmann area 46 | 1.00 | infobox |
| Alpha-synuclein | Bgee | endothelial cell | 1.00 | infobox |
| Alpha-synuclein | Bgee | Brodmann area 23 | 1.00 | infobox |
| Alpha-synuclein | Bgee | tendon of biceps brachii | 1.00 | infobox |
| Alpha-synuclein | Bgee | postcentral gyrus | 1.00 | infobox |
| Alpha-synuclein | Bgee | middle temporal gyrus | 1.00 | infobox |
| Alpha-synuclein | Bgee | monocyte | 1.00 | infobox |
| Alpha-synuclein | Bgee | dentate gyrus of hippocampal formation granule cell | 1.00 | infobox |
| Alpha-synuclein | Bgee | subiculum | 1.00 | infobox |
| Alpha-synuclein | Bgee | fetal liver hematopoietic progenitor cell | 1.00 | infobox |
| Alpha-synuclein | Bgee | nucleus accumbens | 1.00 | infobox |
| Alpha-synuclein | Bgee | dorsal striatum | 1.00 | infobox |
| Alpha-synuclein | Bgee | barrel cortex | 1.00 | infobox |
| Alpha-synuclein | Bgee | anterior amygdaloid area | 1.00 | infobox |
| Alpha-synuclein | Bgee | ventral tegmental area | 1.00 | infobox |
| Alpha-synuclein | Bgee | hippocampus proper | 1.00 | infobox |
| Alpha-synuclein | Bgee | habenula | 1.00 | infobox |
| Alpha-synuclein | BioGPS | More reference expression data | 1.00 | infobox |
| Alpha-synuclein | Chr. | Chromosome 4 (human) | 1.00 | infobox |
| Alpha-synuclein | Chr. | Chromosome 6 (mouse) | 1.00 | infobox |
| Alpha-synuclein | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Alpha-synuclein | End | 89,838,315 bp | 1.00 | infobox |
| Alpha-synuclein | End | 60,806,839 bp | 1.00 | infobox |
The concept neighborhoods around Alpha-synuclein bring nearby vocabulary together. In this analysis, examples include Lipid, Disease and Protein. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For Alpha-synuclein, one of the stronger structural bridges in this analysis connects Alpha-synuclein with Tissue expression. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around Alpha-synuclein to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Tissue expression, Structure & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — Alpha-synuclein · EN edition · Analysis: TopicsToTalkAbout