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Research this topic
Explore the main themes, entities and connections around Hsp27. Start with the topic map, then use the sections below for research and deeper semantic analysis.
Explore this topic
Start with a few of the strongest sections from the source topic. These are research directions, not a list of keywords you must use.
Function
21 related topics
Oligomerization
16 related topics
Cellular localization
12 related topics
Interactions
11 related topics
Key facts & relationships
High-confidence facts extracted from structured source data. Use them as anchors for further research.
- Aliases
- HSPB1, CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27, heat shock protein family B (small) member 1
- Available structures
- Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4MJH, 3Q9P, 3Q9Q, 2N3J
- Band
- 7q11.23 · 5 G2|5 75.51 cM
- Bgee
- ascending aorta · right coronary artery · mucosa of pharynx · gums · Descending thoracic aorta
- BioGPS
- n/a
- Chr.
- Chromosome 7 (human) · Chromosome 5 (mouse)
Topics to explore
A structured outline of related entities, concepts and subtopics. Open any item to build a new map centered on it.Browse the full topic structure. Each item opens a new analysis centered on that subject.
Overview
- Protein
- Gene
- Chaperone Chaperone (protein)
- SHsp
- Heat shock protein
- Crystallin
- Hsp20
- Apoptosis
- Cell differentiation Cellular differentiation
- Signal transduction
Structure
Oligomerization
- Dimers Protein dimer
- Monomers
- Methanocaldococcus jannaschii Methanocaldococcus
- Metazoans
- KDa Kilodalton
- Phosphorylation
- Expression Gene expression
- MAP kinase
- Mitogens
- Inflammatory Inflammation
- Cytokines
- TNFα TNF alpha
- IL-1β Interleukin 1
- Hydrogen peroxide
- Oxidants
- Tumor
Cellular localization
- Cell types Cell type
- Muscle
- Cytosol
- Endoplasmatic reticulum
- Nucleus Cell nucleus
- Muscle Muscle diseases
- Neurodegenerative diseases
- Cancers
- Cell proliferation
- Metastasis
- Chemotherapy
- Breast cancer
Function
- ATP Adenosine triphosphate
- Hsp70
- Mitochondrial Mitochondrion
- Cytochrome c
- Apaf-1
- Procaspase-9 Caspase
- Daxx Death associated protein 6
- Actin
- Cell membrane
- Proteasome
- Ubiquitinated Ubiquitin
- NF-κB
- Reactive oxygen species
- Glutathione
- Ehrlich ascite
- Embryonic stem cells Embryonic stem cell
- B-cells
- Lymphoma
- Osteoblasts Osteoblast
- Keratinocytes Keratinocyte
- Neurons Neuron
Clinical significance
Interactions
Advanced semantic analysis
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
Map overview Semantic statistics
Number of nodes, edges, triples, density and central hubs. Use it to gauge the size and connectivity of the map.Hsp27
Nodes89
Edges88
Triples204
Avg. degree1.98
Density0.022472
Components1
How this topic connects Entity context
Quick relationship hints grouped by predicate. Useful for spotting recurring semantic connections around the current entity.See the strongest relationship patterns around the current topic before diving into the raw triples.
Hsp27
Top relations
Gene ontology · 48
Hsp27 → anterograde axonal protein transport, axon cytoplasm, cellular response to vascular endothelial growth factor stimulus, chaperone-mediated protein folding, contractile fiber, cytoplasm, cytoskeleton, cytosol, extracellular exosome, extracellular matrix, extracellular space, focal adhesion, identical protein binding, intracellular anatomical structure, intracellular signal transduction, negative regulation of apoptotic process, negative regulation of apoptotic signaling pathway, negative regulation of oxidative stress-induced intrinsic apoptotic signaling pathway, negative regulation of protein kinase activity, negative regulation of protein serine/threonine kinase activity
Bgee · 20
Hsp27 → adrenal gland, ascending aorta, Descending thoracic aorta, esophagus, gingival epithelium, gums, heart, left coronary artery, lip, mucosa of pharynx, muscle of thigh, muscle tissue, placenta, popliteal artery, quadriceps femoris muscle, right coronary artery, Skeletal muscle tissue of rectus abdominis, tibial arteries, urinary bladder, zone of skin
RNA expression pattern · 20
Hsp27 → adrenal gland, ascending aorta, Descending thoracic aorta, esophagus, gingival epithelium, gums, heart, left coronary artery, lip, mucosa of pharynx, muscle of thigh, muscle tissue, placenta, popliteal artery, quadriceps femoris muscle, right coronary artery, Skeletal muscle tissue of rectus abdominis, tibial arteries, urinary bladder, zone of skin
related to Oligomerization · 19
Hsp27 → Argpyrimidine, Furthermore, Hsp16, Hsp27-oligomers, IL-1β, In, Indeed, MAP, MAPKAP, Methanocaldococcus, MjHSP16, Stimulation, Stress, The, The N-terminus, There, Therefore, TNFα, WD/EPF-region
related to Structure · 19
Hsp27 → C-terminal, C-terminus, Charcot-Marie-Tooth, Despite, Hsp25Δ18, Hsp27Δ182-205, Ile-Pro-Val-183, Ile-Xxx-Ile/Val, In, It, IxI/V, Pro, Probably, The C-terminal, The N-terminus, These, This, Very, WD/EPF
related to Function · 14
Hsp27 → Apaf-1/dATP, Ask1, ATP-independent, Daxx, Fas, Hsp70-complex, In, It, More, Moreover, TAK1, TAK1-p38/ERK, The, TNF-α-induced
related to Interactions · 9
Hsp27 → ASK1, CIMIP6, CRYAA, CRYAB, CRYBB2, HNRPD, HSPB8, MK2, TAK1
related to Motor neuropathies · 9
Hsp27 → At, Charcot-Marie-Tooth, Heritable, HSPB1, One, Pro182Leu, Since, The, There
related to Roles in apoptosis · 5
Hsp27 → Fas-induced, Notably, OGX-427, PCa, Unphosphorylated Hsp27
is a · 4
Hsp27 → activation of the proteasome, chaperone of the sHsp, dynamic process, interaction with actin and intermediate filaments
Important terminology Word statistics
Frequent words and multi-word phrases across the lead, headings, infobox and body. Useful for terminology coverage.Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
Important terminology
protein cell hspb1 phosphorylation human oligomers also bp gene chaperone α-crystallin shsps chr band function sequence domain region high levels
Entity relationships Subject–Predicate–Object triples
Extracted RDF-like relationships with confidence and source. The table includes structured facts and lower-confidence contextual relations.| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Hsp27 | Aliases | HSPB1, CMT2F, HEL-S-102, HMN2B, HS.76067, HSP27, HSP28, Hsp25, SRP27, heat shock protein family B (small) member 1 | 1.00 | infobox |
| Hsp27 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes4MJH, 3Q9P, 3Q9Q, 2N3J | 1.00 | infobox |
| Hsp27 | Band | 7q11.23 | 1.00 | infobox |
| Hsp27 | Band | 5 G2|5 75.51 cM | 1.00 | infobox |
| Hsp27 | Bgee | ascending aorta | 1.00 | infobox |
| Hsp27 | Bgee | right coronary artery | 1.00 | infobox |
| Hsp27 | Bgee | mucosa of pharynx | 1.00 | infobox |
| Hsp27 | Bgee | gums | 1.00 | infobox |
| Hsp27 | Bgee | Descending thoracic aorta | 1.00 | infobox |
| Hsp27 | Bgee | Skeletal muscle tissue of rectus abdominis | 1.00 | infobox |
| Hsp27 | Bgee | gingival epithelium | 1.00 | infobox |
| Hsp27 | Bgee | popliteal artery | 1.00 | infobox |
| Hsp27 | Bgee | tibial arteries | 1.00 | infobox |
| Hsp27 | Bgee | left coronary artery | 1.00 | infobox |
| Hsp27 | Bgee | esophagus | 1.00 | infobox |
| Hsp27 | Bgee | lip | 1.00 | infobox |
| Hsp27 | Bgee | zone of skin | 1.00 | infobox |
| Hsp27 | Bgee | muscle of thigh | 1.00 | infobox |
| Hsp27 | Bgee | urinary bladder | 1.00 | infobox |
| Hsp27 | Bgee | placenta | 1.00 | infobox |
| Hsp27 | Bgee | heart | 1.00 | infobox |
| Hsp27 | Bgee | quadriceps femoris muscle | 1.00 | infobox |
| Hsp27 | Bgee | muscle tissue | 1.00 | infobox |
| Hsp27 | Bgee | adrenal gland | 1.00 | infobox |
| Hsp27 | BioGPS | n/a | 1.00 | infobox |
| Hsp27 | Chr. | Chromosome 7 (human) | 1.00 | infobox |
| Hsp27 | Chr. | Chromosome 5 (mouse) | 1.00 | infobox |
| Hsp27 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| Hsp27 | End | 76,304,295 bp | 1.00 | infobox |
| Hsp27 | End | 135,918,417 bp | 1.00 | infobox |
No triples extracted yet.
Related concept clusters Concept neighborhoods
Clusters of nearby vocabulary surrounding the topic. Scan them for adjacent concepts and language you may have missed.These clusters group vocabulary that occurs around closely connected concepts in the source material.
Connections between topic areas Semantic bridges
Bridge nodes connect otherwise separate parts of the map. Expand a row to inspect the topic groups on each side.Bridges can reveal useful research angles that are easy to miss in a flat list of related terms.
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