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Restriction point

The restriction point (R), also known as the Start or G1/S checkpoint, is a cell cycle checkpoint in the G1 phase of the animal cell cycle at which the cell becomes "committed" to the cell cycle, and after which extracellular signals are no longer required to stimulate proliferation. The defining biochemical feature of the restriction point is the…

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Overview

History

Extracellular signals

Mechanism

Dynamics

In cancer

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Map overview Semantic statistics

Restriction point

Nodes63
Edges62
Triples80
Avg. degree1.97
Density0.031746
Components1

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Restriction point

Top relations

related to history · 16
Restriction point → About, Arthur Pardee, DNA, G0, G1, He, Howard Martin Temin, In, Larsson, No, Only, Originally, Pardee, Previously, R-point, Zetterberg
related to overview · 16
Restriction point → Accumulation, As, Ca2, Cdk, Cdk-activating, CKI, Cyclin, Cyclin D-bound Cdks, D's, Extracellular, Growth, In, Ink4, It, Phosphoprotein, Ultimately
related to Extracellular signals · 14
Restriction point → After, Before, DNA, Except, For, Further, G0, G1, G1a, G1b, R-point, Removal, S-phase, Under
related to In cancer · 11
Restriction point → By, Cancer, Cdks, Chemotherapy, CKIs, G0, Mutations, Some, The, This, Under
related to Mitogen Signaling · 11
Restriction point → After, Cdk4/6, D1-3, EGF, FGF, G1, Growth, MAPK, PDGF, PI3K, Sustained
related to Dynamics · 10
Restriction point → Duke University, E2F, Further, GFP, GFP-system, Joe Nevins, Lingchong You, Serum-starved, The, They
is a · 2
Restriction point → activation of G1/S- and S-phase cyclin-CDK complexes, important consideration in the development of new drug therapies

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Important terminology

cell g1 cyclin point restriction cycle cells p27 activity also extracellular p21 progression phosphorylation signals e2f factor phase early dna

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Restriction pointis aactivation of G1/S- and S-phase cyclin-CDK complexes0.90text
Restriction pointis aimportant consideration in the development of new drug therapies0.90text
Restriction pointrelated to DynamicsLingchong You0.60section
Restriction pointrelated to DynamicsJoe Nevins0.60section
Restriction pointrelated to DynamicsDuke University0.60section
Restriction pointrelated to DynamicsE2F0.60section
Restriction pointrelated to DynamicsThe0.60section
Restriction pointrelated to DynamicsGFP-system0.60section
Restriction pointrelated to DynamicsSerum-starved0.60section
Restriction pointrelated to DynamicsGFP0.60section
Restriction pointrelated to DynamicsThey0.60section
Restriction pointrelated to DynamicsFurther0.60section

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    Min side: 3
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