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MG132

MG132 is a potent, reversible, and cell-permeable proteasome inhibitor (Ki = 4 nM). It belongs to the class of synthetic peptide aldehydes. It reduces the degradation of ubiquitin-conjugated proteins in mammalian cells and permeable strains of yeast by the 26S complex without affecting its ATPase or isopeptidase activities. MG132 activates c-Jun…

Standards, Molecular mechanism & Overview

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Overview

Molecular mechanism

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Map overview Semantic statistics

MG132

Nodes22
Edges21
Triples9
Avg. degree1.91
Density0.090909
Components1

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MG132

Top relations

related to Molecular mechanism · 8
MG132 → ALLN, Cbz-leu-leu-leucinal, Cbz-leu-leu-norvalinal, It, MG115, The, There, These
is a · 1
MG132 → potent

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Important terminology

peptide aldehydes proteasome references inhibitors potent inhibitor also standard state ki atpase isopeptidase apoptosis nf-κb ic50 β-secretase inhibit pathway reversible

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
MG132is apotent0.90text
MG132related to Molecular mechanismThere0.60section
MG132related to Molecular mechanismIt0.60section
MG132related to Molecular mechanismCbz-leu-leu-leucinal0.60section
MG132related to Molecular mechanismCbz-leu-leu-norvalinal0.60section
MG132related to Molecular mechanismMG1150.60section
MG132related to Molecular mechanismALLN0.60section
MG132related to Molecular mechanismThese0.60section
MG132related to Molecular mechanismThe0.60section

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    Min side: 3
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