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Pleckstrin homology domain: Proteins containing PH domain, Examples & Lipid binding specificity

Pleckstrin homology domain (PH domain) or (PHIP) is a protein domain of approximately 120 amino acids that occurs in a wide range of proteins involved in intracellular signaling or as constituents of the cytoskeleton.

Language: English [EN]
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Pleckstrin homology domain topic overview

The analysis highlights Proteins containing PH domain, Examples and Lipid binding specificity as prominent areas in the source structure around Pleckstrin homology domain.

Related topics
288
Source areas
6
Connected nodes
294
Extracted relationships
21
Concept neighborhoods
32
Bridge connections
294

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Examples · 247 topics
Proteins containing PH domain · 20 topics
Overview · 12 topics
Lipid binding specificity · 4 topics
Structure · 4 topics
Subfamilies · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold
IPR001849 · PF00169
Available protein structures:
IPR001849 · PF00169
CDD
cd00821
ECOD
220.1.1
InterPro
IPR001849
OPM protein
1pls

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Lipid binding specificity

Structure

Proteins containing PH domain

Subfamilies

Examples

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Pleckstrin homology domain connects Entity context

The extracted context around Pleckstrin homology domain shows recurring relationship patterns in the source. For example, Pleckstrin homology domain → IPR001849, PF00169 Another extracted example is Pleckstrin homology domain → cd00821. Use these groups to spot repeated connection types before inspecting the individual relationships.

Pleckstrin homology domain

Top relations

AlphaFold · 2
Pleckstrin homology domain → IPR001849, PF00169
Available protein structures: · 2
Pleckstrin homology domain → IPR001849, PF00169
CDD · 1
Pleckstrin homology domain → cd00821
ECOD · 1
Pleckstrin homology domain → 220.1.1
InterPro · 1
Pleckstrin homology domain → IPR001849
OPM protein · 1
Pleckstrin homology domain → 1pls
OPM superfamily · 1
Pleckstrin homology domain → 49
PDB · 1
Pleckstrin homology domain → IPR001849 PF00169 (ECOD; PDBsum)
Pfam · 1
Pleckstrin homology domain → PF00169
Pfam clan · 1
Pleckstrin homology domain → CL0266

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

ph proteins domain domains protein kinase pleckstrin membranes different binding phosphatidylinositol btk interpro within osbp structure containing phosphoinositides function cerevisiae

Pleckstrin homology domain relationships Subject–Predicate–Object triples

TTTA extracted 21 structured relationships around Pleckstrin homology domain. Examples in this analysis include Pleckstrin homology domain → AlphaFold → IPR001849 and Pleckstrin homology domain → AlphaFold → PF00169. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
Pleckstrin homology domainAlphaFoldIPR0018491.00infobox
Pleckstrin homology domainAlphaFoldPF001691.00infobox
Pleckstrin homology domainAvailable protein structures:IPR0018491.00infobox
Pleckstrin homology domainAvailable protein structures:PF001691.00infobox
Pleckstrin homology domainCDDcd008211.00infobox
Pleckstrin homology domainECOD220.1.11.00infobox
Pleckstrin homology domainInterProIPR0018491.00infobox
Pleckstrin homology domainOPM protein1pls1.00infobox
Pleckstrin homology domainOPM superfamily491.00infobox
Pleckstrin homology domainPDBIPR001849 PF00169 (ECOD; PDBsum)1.00infobox
Pleckstrin homology domainPfamPF001691.00infobox
Pleckstrin homology domainPfam clanCL02661.00infobox
Pleckstrin homology domainPROSITEPDOC500031.00infobox
Pleckstrin homology domainSCOP21dyn / SCOPe / SUPFAM1.00infobox
Pleckstrin homology domainSMARTPH1.00infobox
Pleckstrin homology domainSymbolPH1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Pleckstrin homology domain bring nearby vocabulary together. In this analysis, examples include Ph, Within and Pleckstrin. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • Pleckstrin homology domain
    • Ph
    • Within
    • Pleckstrin
    • Cytoskeleton
    • -bisphosphate
    • -trisphosphate
    • Abr
    • Bind
    • Inositol
    • Itk
    • Proteins
    • Signaling
  • pleckstrin homology domain
    • Protein
    • Proteins
    • Ph
    • Containing
    • Phosphatidylinositol
    • Within
    • Pleckstrin
    • Cytoskeleton
    • Kinase
    • Domains
    • -bisphosphate
    • -trisphosphate
  • protein domain
    • Protein
    • Proteins
    • Ph
    • Kinase
    • Containing
    • Phosphatidylinositol
    • Within
    • Domains
    • Pleckstrin
    • -bisphosphate
    • -trisphosphate
    • Bind
  • phosphatidylinositol
    • Btk
    • Containing
    • Interpro
    • Within
    • Kinase
    • Βγ-subunits
    • Abr
    • Inositol
    • Itk
    • Lipid
    • Possess
    • See
  • phosphatidylinositol (3,4,5)-trisphosphate
    • -bisphosphate
    • Bind
    • Phosphatidylinositol
    • Within
    • Btk
    • Containing
    • Interpro
    • Βγ-subunits
    • Kinase
    • Inositol
    • Lipid
    • Possess
  • phosphatidylinositol (4,5)-bisphosphate
    • -trisphosphate
    • Bind
    • Phosphatidylinositol
    • Within
    • Btk
    • Containing
    • Interpro
    • Βγ-subunits
    • Kinase
    • Inositol
    • Lipid
    • Possess
  • heterotrimeric g proteins
    • Domains
    • Different
    • Containing
    • Interpro
    • Membranes
    • Osbp
    • Phosphatidylinositol
    • Kinase
    • -bisphosphate
    • -trisphosphate
    • Abr
    • Bind
  • protein kinase c
    • Lipid
    • Kinase
    • Protein
    • Phosphatidylinositol
    • Proteins
    • Within
    • Domains
    • -bisphosphate
    • -trisphosphate
    • Bind
    • See
    • Βγ-subunits

Connections between topic areas Semantic bridges

For Pleckstrin homology domain, one of the stronger structural bridges in this analysis connects Pleckstrin homology domain with Examples. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
Pleckstrin homology domain — Examples · splits 47 ⟂ 248
Pleckstrin homology domain — Proteins containing PH domain · splits 274 ⟂ 21
Pleckstrin homology domain — Overview · splits 282 ⟂ 13
Pleckstrin homology domain — Lipid binding specificity · splits 290 ⟂ 5
Pleckstrin homology domain — Structure · splits 290 ⟂ 5

Map overview Semantic statistics

Pleckstrin homology domain

Nodes295
Edges294
Triples21
Avg. degree1.99
Density0.00678
Components1

Source & methodology

TTTA analyzes the structure around Pleckstrin homology domain to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Proteins containing PH domain, Examples & Lipid binding specificity, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Pleckstrin homology domain · EN edition · Analysis: TopicsToTalkAbout

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