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PHLPP

The PHLPP isoforms (PH domain and Leucine rich repeat Protein Phosphatases) are a pair of protein phosphatases, PHLPP1 and PHLPP2, that are important regulators of Akt serine-threonine kinases (Akt1, Akt2, Akt3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to…

Standards, Dephosphorylation of Akt & Domain structure

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Dephosphorylation of Akt

EnzymesSerine/threonine-specific protein kinaseECApoptoticProtein synthesis
13 related topics

Domain structure

MagnesiumManganeseRasPleckstrin homology domainLeucine-rich repeats
7 related topics

Role in cancer

LOHBcr-AblCMLGleevec
4 related topics

Dephosphorylation of protein kinase C

Phospho-mimeticDiacylglycerolG protein-coupled receptor
3 related topics

Key facts & relationships

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Alt. symbols
PHLPP1, PLEKHE1
Domains
InterPro
EC number
3.1.3.16
HGNC
20610
Locus
Chr. 18 q21.32
NCBI gene
23239

Topics to explore

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Overview

Domain structure

Dephosphorylation of Akt

Dephosphorylation of protein kinase C

Role in cancer

Advanced semantic analysis

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Map overview Semantic statistics

PHLPP

Nodes42
Edges41
Triples66
Avg. degree1.95
Density0.047619
Components1

How this topic connects Entity context

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PHLPP

Top relations

related to Role in cancer · 15
PHLPP → Akt, Bcr-Abl, CML, Finally, First, Gleevec, Investigators, LOH, PHLPP1, PHLPP2, PKC, Recent, Second, The, Wilms
related to Domain structure · 14
PHLPP → Akt, C-terminal PDZ, N-terminal, PDZ, PH, PHLPP's, PHLPP1, PHLPP1α, PHLPP1β, PHLPP2, PKC, PP2C, PPM, Ras
related to Dephosphorylation of Akt · 11
PHLPP → Akt, AKT1, AKT2, AKT3, Lack, PHLPP1, PHLPP2, Serine473, The, Threonine308, When
related to Phosphorylation of Akt by PDK1 and PDK2 · 9
PHLPP → Activated Akt, Akt, Once, PDK1, PDK2, PIP3, Serine473, The PHLPPs, Threonine308
related to Dephosphorylation of protein kinase C · 5
PHLPP → PHLPP1, PKC, PKCs, The, The PKC
Alt. symbols · 1
PHLPP → PHLPP1, PLEKHE1
Domains · 1
PHLPP → InterPro
EC number · 1
PHLPP → 3.1.3.16
HGNC · 1
PHLPP → 20610
Locus · 1
PHLPP → Chr. 18 q21.32

Important terminology Word statistics

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Important terminology

akt akt1 phlpp1 pkc kinase family protein akt2 domain cancer phlpp2 hydrophobic phosphorylation akt3 growth novel isoforms signaling conventional kinases

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PHLPPAlt. symbolsPHLPP1, PLEKHE11.00infobox
PHLPPDomainsInterPro1.00infobox
PHLPPEC number3.1.3.161.00infobox
PHLPPHGNC206101.00infobox
PHLPPLocusChr. 18 q21.321.00infobox
PHLPPNCBI gene232391.00infobox
PHLPPOMIM6093961.00infobox
PHLPPRefSeqXM_1662901.00infobox
PHLPPSearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
PHLPPStructuresSwiss-model1.00infobox
PHLPPSymbolPHLPP1.00infobox
PHLPPUniProtO603461.00infobox

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