PHLPP

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PHLPP topic overview

The analysis highlights Standards, Dephosphorylation of Akt and Domain structure as prominent areas in the source structure around PHLPP.

Related topics: 36
Source areas: 5
Connected nodes: 41
Extracted relationships: 66
Concept neighborhoods: 19
Bridge connections: 41

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Dephosphorylation of Akt · 13 topics

Overview · 9 topics

Domain structure · 7 topics

Role in cancer · 4 topics

Dephosphorylation of protein kinase C · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Alt. symbols: PHLPP1, PLEKHE1
Domains: InterPro
EC number: 3.1.3.16
HGNC: 20610
Locus: Chr. 18 q21.32
NCBI gene: 23239

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Dephosphorylation of protein kinase C

Role in cancer

LOH Loss of heterozygosity
Bcr-Abl Bcr-abl fusion protein
CML Chronic myelogenous leukemia
Gleevec

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PHLPP connects Entity context

The extracted context around PHLPP shows recurring relationship patterns in the source. For example, PHLPP → Akt, Bcr-Abl, CML, Finally, First, Gleevec, Investigators, LOH, PHLPP1, PHLPP2, PKC, Recent, Second, The, Wilms Another extracted example is PHLPP → Akt, C-terminal PDZ, N-terminal, PDZ, PH, PHLPP's, PHLPP1, PHLPP1α, PHLPP1β, PHLPP2, PKC, PP2C, PPM, Ras. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

related to Role in cancer · 15

PHLPP → Akt, Bcr-Abl, CML, Finally, First, Gleevec, Investigators, LOH, PHLPP1, PHLPP2, PKC, Recent, Second, The, Wilms

related to Domain structure · 14

PHLPP → Akt, C-terminal PDZ, N-terminal, PDZ, PH, PHLPP's, PHLPP1, PHLPP1α, PHLPP1β, PHLPP2, PKC, PP2C, PPM, Ras

related to Dephosphorylation of Akt · 11

PHLPP → Akt, AKT1, AKT2, AKT3, Lack, PHLPP1, PHLPP2, Serine473, The, Threonine308, When

related to Phosphorylation of Akt by PDK1 and PDK2 · 9

PHLPP → Activated Akt, Akt, Once, PDK1, PDK2, PIP3, Serine473, The PHLPPs, Threonine308

related to Dephosphorylation of protein kinase C · 5

PHLPP → PHLPP1, PKC, PKCs, The, The PKC

Alt. symbols · 1

PHLPP → PHLPP1, PLEKHE1

Domains · 1

PHLPP → InterPro

EC number · 1

PHLPP → 3.1.3.16

HGNC · 1

PHLPP → 20610

Locus · 1

PHLPP → Chr. 18 q21.32

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

akt akt1 phlpp1 pkc kinase family protein akt2 domain cancer phlpp2 hydrophobic phosphorylation akt3 growth novel isoforms signaling conventional kinases

PHLPP relationships Subject–Predicate–Object triples

TTTA extracted 66 structured relationships around PHLPP. Examples in this analysis include PHLPP → Alt. symbols → PHLPP1, PLEKHE1 and PHLPP → Domains → InterPro. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
PHLPP	Alt. symbols	PHLPP1, PLEKHE1	1.00	infobox
PHLPP	Domains	InterPro	1.00	infobox
PHLPP	EC number	3.1.3.16	1.00	infobox
PHLPP	HGNC	20610	1.00	infobox
PHLPP	Locus	Chr. 18 q21.32	1.00	infobox
PHLPP	NCBI gene	23239	1.00	infobox
PHLPP	OMIM	609396	1.00	infobox
PHLPP	RefSeq	XM_166290	1.00	infobox
PHLPP	Search for	Search forStructuresSwiss-modelDomainsInterPro	1.00	infobox
PHLPP	Structures	Swiss-model	1.00	infobox
PHLPP	Symbol	PHLPP	1.00	infobox
PHLPP	UniProt	O60346	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PHLPP bring nearby vocabulary together. In this analysis, examples include Protein, Akt and Pkc. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

PHLPP
- Protein
- Akt
- Pkc
- Phosphorylation
- Phlpp1
- Family
- Kinase
- Hydrophobic
- Cancer
- May
- Phosphatases
- Tumor
phlpp
- Protein
- Akt
- Pkc
- Phosphorylation
- Phlpp1
- Family
- Kinase
- Hydrophobic
- Cancer
- May
- Phosphatases
- Tumor
akt
- Phosphorylation
- Phlpp
- Kinase
- Pkc
- Family
- Activation
- Kinases
- Pdk1
- Phlpp1
- Domain
- Phlpp2
- Akt1
protein kinase c
- Kinases
- Protein
- Also
- Family
- Hydrophobic
- Novel
- Phlpp
- Dephosphorylates
- Including
- Motif
- Pdk1
- Pdk2
pleckstrin homology domain
- Structure
- Kinases
- Protein
- Phlpp1
- Phlpp
- Kinase
- Conventional
- Dephosphorylate
- Isoforms
- Novel
- Pkc
- Phlpp2
serine/threonine-specific protein kinase
- Kinases
- Protein
- Also
- Family
- Hydrophobic
- Novel
- Phlpp
- Dephosphorylates
- Including
- Motif
- Pdk1
- Pdk2
domain structure
- Structure
- Kinases
- Protein
- Phlpp1
- Phlpp
- Kinase
- Conventional
- Dephosphorylate
- Isoforms
- Novel
- Pkc
- Phlpp2
dephosphorylation of akt
- Phosphorylation
- Phlpp
- Kinase
- Pkc
- Family
- Activation
- Kinases
- Pdk1
- Phlpp1
- Domain
- Phlpp2
- Akt1

Connections between topic areas Semantic bridges

For PHLPP, one of the stronger structural bridges in this analysis connects PHLPP with Dephosphorylation of Akt. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

PHLPP — Dephosphorylation of Akt · splits 28 ⟂ 14

PHLPP — Overview · splits 32 ⟂ 10

PHLPP — Domain structure · splits 34 ⟂ 8

PHLPP — Role in cancer · splits 37 ⟂ 5

PHLPP — Dephosphorylation of protein kinase C · splits 38 ⟂ 4

Map overview Semantic statistics

PHLPP

Nodes42

Edges41

Triples66

Avg. degree1.95

Density0.047619

Components1

Source & methodology

TTTA analyzes the structure around PHLPP to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Dephosphorylation of Akt & Domain structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PHLPP · EN edition · Analysis: TopicsToTalkAbout