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PHLPP: Standards, Dephosphorylation of Akt & Domain structure

The PHLPP isoforms (PH domain and Leucine rich repeat Protein Phosphatases) are a pair of protein phosphatases, PHLPP1 and PHLPP2, that are important regulators of Akt serine-threonine kinases (Akt1, Akt2, Akt3) and conventional/novel protein kinase C (PKC) isoforms. PHLPP may act as a tumor suppressor in several types of cancer due to its ability to…

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PHLPP topic overview

The analysis highlights Standards, Dephosphorylation of Akt and Domain structure as prominent areas in the source structure around PHLPP.

Related topics
36
Source areas
5
Connected nodes
41
Extracted relationships
59
Related term clusters
19
Bridge connections
41

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Dephosphorylation of Akt · 13 topics
Overview · 9 topics
Domain structure · 7 topics
Role in cancer · 4 topics
Dephosphorylation of protein kinase C · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Alt. symbols
PHLPP1, PLEKHE1
Domains
InterPro
EC number
3.1.3.16
HGNC
20610
Locus
Chr. 18 q21.32
NCBI gene
23239

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Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Domain structure

Dephosphorylation of Akt

Dephosphorylation of protein kinase C

Role in cancer

For the semantics nerds

You can skip this section if you’re here for content ideas and keyword inspiration.

Advanced semantic analysis

How PHLPP connects Entity context

The extracted context around PHLPP shows recurring relationship patterns in the source. For example, PHLPP → Akt, C-terminal PDZ, N-terminal, PDZ, PH, PHLPP's, PHLPP1, PHLPP1α, PHLPP1β, PHLPP2, PKC, PP2C, PPM, Ras Another extracted example is PHLPP → Akt, Bcr-Abl, CML, Finally, Gleevec, Investigators, LOH, PHLPP1, PHLPP2, PKC, Recent, Wilms. Use these groups to spot repeated connection types before inspecting the individual relationships.

PHLPP

Top relations

related to Domain structure · 14
PHLPP → Akt, C-terminal PDZ, N-terminal, PDZ, PH, PHLPP's, PHLPP1, PHLPP1α, PHLPP1β, PHLPP2, PKC, PP2C, PPM, Ras
related to Role in cancer · 12
PHLPP → Akt, Bcr-Abl, CML, Finally, Gleevec, Investigators, LOH, PHLPP1, PHLPP2, PKC, Recent, Wilms
related to Dephosphorylation of Akt · 9
PHLPP → Akt, AKT1, AKT2, AKT3, Lack, PHLPP1, PHLPP2, Serine473, Threonine308
related to Phosphorylation of Akt by PDK1 and PDK2 · 8
PHLPP → Activated Akt, Akt, PDK1, PDK2, PIP3, Serine473, The PHLPPs, Threonine308
related to Dephosphorylation of protein kinase C · 4
PHLPP → PHLPP1, PKC, PKCs, The PKC
Alt. symbols · 1
PHLPP → PHLPP1, PLEKHE1
Domains · 1
PHLPP → InterPro
EC number · 1
PHLPP → 3.1.3.16
HGNC · 1
PHLPP → 20610
Locus · 1
PHLPP → Chr. 18 q21.32

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

akt akt1 phlpp1 pkc kinase family protein akt2 domain cancer phlpp2 hydrophobic phosphorylation akt3 growth novel isoforms signaling conventional kinases

PHLPP relationships Subject–Predicate–Object triples

TTTA extracted 59 structured relationships around PHLPP. Examples in this analysis include PHLPP → Alt. symbols → PHLPP1, PLEKHE1 and PHLPP → Domains → InterPro. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PHLPPAlt. symbolsPHLPP1, PLEKHE11.00infobox
PHLPPDomainsInterPro1.00infobox
PHLPPEC number3.1.3.161.00infobox
PHLPPHGNC206101.00infobox
PHLPPLocusChr. 18 q21.321.00infobox
PHLPPNCBI gene232391.00infobox
PHLPPOMIM6093961.00infobox
PHLPPRefSeqXM_1662901.00infobox
PHLPPSearch forSearch forStructuresSwiss-modelDomainsInterPro1.00infobox
PHLPPStructuresSwiss-model1.00infobox
PHLPPSymbolPHLPP1.00infobox
PHLPPUniProtO603461.00infobox

Related concept clusters Related term clusters

The concept neighborhoods around PHLPP bring nearby vocabulary together. In this analysis, examples include Protein, Akt and Pkc. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • PHLPP
    • Protein
    • Akt
    • Pkc
    • Phosphorylation
    • Phlpp1
    • Family
    • Kinase
    • Hydrophobic
    • Cancer
    • May
    • Phosphatases
    • Tumor
  • phlpp
    • Protein
    • Akt
    • Pkc
    • Phosphorylation
    • Phlpp1
    • Family
    • Kinase
    • Hydrophobic
    • Cancer
    • May
    • Phosphatases
    • Tumor
  • akt
    • Phosphorylation
    • Phlpp
    • Kinase
    • Pkc
    • Family
    • Activation
    • Kinases
    • Pdk1
    • Phlpp1
    • Domain
    • Phlpp2
    • Akt1
  • protein kinase c
    • Kinases
    • Protein
    • Also
    • Family
    • Hydrophobic
    • Novel
    • Phlpp
    • Dephosphorylates
    • Including
    • Motif
    • Pdk1
    • Pdk2
  • pleckstrin homology domain
    • Structure
    • Kinases
    • Protein
    • Phlpp1
    • Phlpp
    • Kinase
    • Conventional
    • Dephosphorylate
    • Isoforms
    • Novel
    • Pkc
    • Phlpp2
  • serine/threonine-specific protein kinase
    • Kinases
    • Protein
    • Also
    • Family
    • Hydrophobic
    • Novel
    • Phlpp
    • Dephosphorylates
    • Including
    • Motif
    • Pdk1
    • Pdk2
  • domain structure
    • Structure
    • Kinases
    • Protein
    • Phlpp1
    • Phlpp
    • Kinase
    • Conventional
    • Dephosphorylate
    • Isoforms
    • Novel
    • Pkc
    • Phlpp2
  • dephosphorylation of akt
    • Phosphorylation
    • Phlpp
    • Kinase
    • Pkc
    • Family
    • Activation
    • Kinases
    • Pdk1
    • Phlpp1
    • Domain
    • Phlpp2
    • Akt1

Connections between topic areas Semantic bridges

For PHLPP, one of the stronger structural bridges in this analysis connects PHLPP with Dephosphorylation of Akt. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PHLPP — Dephosphorylation of Akt · splits 28 ⟂ 14
PHLPP — Overview · splits 32 ⟂ 10
PHLPP — Domain structure · splits 34 ⟂ 8
PHLPP — Role in cancer · splits 37 ⟂ 5
PHLPP — Dephosphorylation of protein kinase C · splits 38 ⟂ 4

Map overview Semantic statistics

PHLPP

Nodes42
Edges41
Triples59
Avg. degree1.95
Density0.047619
Components1

Source & methodology

TTTA analyzes the structure around PHLPP to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Standards, Dephosphorylation of Akt & Domain structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PHLPP · EN edition · Analysis: TopicsToTalkAbout

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