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ROCK1 is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1. Other common names are ROKβ and P160ROCK. ROCK1 is a major downstream effector of the small GTPase RhoA and is a regulator of the actomyosin cytoskeleton which promotes contractile force generation. ROCK1 plays a role in cancer and in…
Structure and regulation, Clinical significance & Function
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rhoa kinase cell bp gene phosphorylation also angiogenesis human activity protein 18 role motility chr band function cytoskeleton tumor chromosome
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| ROCK1 | 2.7.11.39 | ↗ | 1.00 | infobox |
| ROCK1 | Aliases | ROCK1, P160ROCK, ROCK-I, Rho associated coiled-coil containing protein kinase 1 | 1.00 | infobox |
| ROCK1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1S1C, 2ESM, 2ETK, 2ETR, 2V55, 3D9V, 3NCZ, 3NDM, 3O0Z, 3TV7, 3TWJ, 3V8S, 4L2W, 4W7P, 4YVC, 4YVE, 5BML | 1.00 | infobox |
| ROCK1 | Band | 18q11.1 | 1.00 | infobox |
| ROCK1 | Band | 18|18 A1 | 1.00 | infobox |
| ROCK1 | Bgee | Achilles tendon | 1.00 | infobox |
| ROCK1 | Bgee | popliteal artery | 1.00 | infobox |
| ROCK1 | Bgee | tibial arteries | 1.00 | infobox |
| ROCK1 | Bgee | monocyte | 1.00 | infobox |
| ROCK1 | Bgee | right coronary artery | 1.00 | infobox |
| ROCK1 | Bgee | bone marrow cell | 1.00 | infobox |
| ROCK1 | Bgee | left coronary artery | 1.00 | infobox |
| ROCK1 | Bgee | Descending thoracic aorta | 1.00 | infobox |
| ROCK1 | Bgee | ascending aorta | 1.00 | infobox |
| ROCK1 | Bgee | epithelium of colon | 1.00 | infobox |
| ROCK1 | Bgee | tunica media of zone of aorta | 1.00 | infobox |
| ROCK1 | Bgee | Rostral migratory stream | 1.00 | infobox |
| ROCK1 | Bgee | zygote | 1.00 | infobox |
| ROCK1 | Bgee | secondary oocyte | 1.00 | infobox |
| ROCK1 | Bgee | ciliary body | 1.00 | infobox |
| ROCK1 | Bgee | primary oocyte | 1.00 | infobox |
| ROCK1 | Bgee | lacrimal gland | 1.00 | infobox |
| ROCK1 | Bgee | aortic valve | 1.00 | infobox |
| ROCK1 | Bgee | left lung lobe | 1.00 | infobox |
| ROCK1 | BioGPS | n/a | 1.00 | infobox |
| ROCK1 | Chr. | Chromosome 18 (human) | 1.00 | infobox |
| ROCK1 | Chr. | Chromosome 18 (mouse) | 1.00 | infobox |
| ROCK1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| ROCK1 | End | 21,111,813 bp | 1.00 | infobox |
| ROCK1 | End | 10,182,045 bp | 1.00 | infobox |
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