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ROCK1 is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1. Other common names are ROKβ and P160ROCK. ROCK1 is a major downstream effector of the small GTPase RhoA and is a regulator of the actomyosin cytoskeleton which promotes contractile force generation. ROCK1 plays a role in cancer and in…
The analysis highlights Structure and regulation, Clinical significance and Function as prominent areas in the source structure around ROCK1. 1 topic appears in more than one source area, which can help identify connections that are less obvious in a linear reading.
Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.
Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.
High-confidence facts extracted from structured source data. Use them as anchors for further research.
Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.
Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.
The extracted context around ROCK1 shows recurring relationship patterns in the source. For example, ROCK1 → actin cytoskeleton organization, actomyosin structure organization, amyloid-beta complex, aortic valve morphogenesis, apical constriction, apoptotic process, ATP binding, bleb, bleb assembly, blood vessel diameter maintenance, cell projection, centriole, cortical actin cytoskeleton organization, cytoplasm, cytoplasmic stress granule, cytoskeleton, cytosol, embryonic morphogenesis, ephrin receptor signaling pathway, execution phase of apoptosis Another extracted example is ROCK1 → Achilles tendon, aortic valve, ascending aorta, bone marrow cell, ciliary body, Descending thoracic aorta, epithelium of colon, lacrimal gland, left coronary artery, left lung lobe, monocyte, popliteal artery, primary oocyte, right coronary artery, Rostral migratory stream, secondary oocyte, tibial arteries, tunica media of zone of aorta, zygote. Use these groups to spot repeated connection types before inspecting the individual relationships.
Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.
rhoa kinase cell bp gene phosphorylation also angiogenesis human activity protein 18 role motility chr band function cytoskeleton tumor chromosome
TTTA extracted 252 structured relationships around ROCK1. Examples in this analysis include ROCK1 → 2.7.11.39 → ↗ and ROCK1 → Aliases → ROCK1, P160ROCK, ROCK-I, Rho associated coiled-coil containing protein kinase 1. The table shows each extracted connection, where it came from and its confidence.
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| ROCK1 | 2.7.11.39 | ↗ | 1.00 | infobox |
| ROCK1 | Aliases | ROCK1, P160ROCK, ROCK-I, Rho associated coiled-coil containing protein kinase 1 | 1.00 | infobox |
| ROCK1 | Available structures | Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1S1C, 2ESM, 2ETK, 2ETR, 2V55, 3D9V, 3NCZ, 3NDM, 3O0Z, 3TV7, 3TWJ, 3V8S, 4L2W, 4W7P, 4YVC, 4YVE, 5BML | 1.00 | infobox |
| ROCK1 | Band | 18q11.1 | 1.00 | infobox |
| ROCK1 | Band | 18|18 A1 | 1.00 | infobox |
| ROCK1 | Bgee | Achilles tendon | 1.00 | infobox |
| ROCK1 | Bgee | popliteal artery | 1.00 | infobox |
| ROCK1 | Bgee | tibial arteries | 1.00 | infobox |
| ROCK1 | Bgee | monocyte | 1.00 | infobox |
| ROCK1 | Bgee | right coronary artery | 1.00 | infobox |
| ROCK1 | Bgee | bone marrow cell | 1.00 | infobox |
| ROCK1 | Bgee | left coronary artery | 1.00 | infobox |
| ROCK1 | Bgee | Descending thoracic aorta | 1.00 | infobox |
| ROCK1 | Bgee | ascending aorta | 1.00 | infobox |
| ROCK1 | Bgee | epithelium of colon | 1.00 | infobox |
| ROCK1 | Bgee | tunica media of zone of aorta | 1.00 | infobox |
| ROCK1 | Bgee | Rostral migratory stream | 1.00 | infobox |
| ROCK1 | Bgee | zygote | 1.00 | infobox |
| ROCK1 | Bgee | secondary oocyte | 1.00 | infobox |
| ROCK1 | Bgee | ciliary body | 1.00 | infobox |
| ROCK1 | Bgee | primary oocyte | 1.00 | infobox |
| ROCK1 | Bgee | lacrimal gland | 1.00 | infobox |
| ROCK1 | Bgee | aortic valve | 1.00 | infobox |
| ROCK1 | Bgee | left lung lobe | 1.00 | infobox |
| ROCK1 | BioGPS | n/a | 1.00 | infobox |
| ROCK1 | Chr. | Chromosome 18 (human) | 1.00 | infobox |
| ROCK1 | Chr. | Chromosome 18 (mouse) | 1.00 | infobox |
| ROCK1 | Databases | NCBI: entry; OMA: entry | 1.00 | infobox |
| ROCK1 | End | 21,111,813 bp | 1.00 | infobox |
| ROCK1 | End | 10,182,045 bp | 1.00 | infobox |
The concept neighborhoods around ROCK1 bring nearby vocabulary together. In this analysis, examples include Rhoa, Activity and Kinase. Use the clusters to find adjacent concepts and terminology that may deserve separate research.
For ROCK1, one of the stronger structural bridges in this analysis connects ROCK1 with Structure and regulation. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.
TTTA analyzes the structure around ROCK1 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Structure and regulation, Clinical significance & Function, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.
Source: Wikipedia — ROCK1 · EN edition · Analysis: TopicsToTalkAbout