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ROCK1

ROCK1 is a protein serine/threonine kinase also known as rho-associated, coiled-coil-containing protein kinase 1. Other common names are ROKβ and P160ROCK. ROCK1 is a major downstream effector of the small GTPase RhoA and is a regulator of the actomyosin cytoskeleton which promotes contractile force generation. ROCK1 plays a role in cancer and in…

Structure and regulation, Clinical significance & Function

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2.7.11.39
Aliases
ROCK1, P160ROCK, ROCK-I, Rho associated coiled-coil containing protein kinase 1
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1S1C, 2ESM, 2ETK, 2ETR, 2V55, 3D9V, 3NCZ, 3NDM, 3O0Z, 3TV7, 3TWJ, 3V8S, 4L2W, 4W7P, 4YVC, 4YVE, 5BML
Band
18q11.1 · 18|18 A1
Bgee
Achilles tendon · popliteal artery · tibial arteries · monocyte · right coronary artery
BioGPS
n/a

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Overview

Gene and expression

Structure and regulation

Substrates and interactions

Function

Interactions

Clinical significance

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Map overview Semantic statistics

ROCK1

Nodes84
Edges83
Triples252
Avg. degree1.98
Density0.02381
Components1

How this topic connects Entity context

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ROCK1

Top relations

Gene ontology · 94
ROCK1 → actin cytoskeleton organization, actomyosin structure organization, amyloid-beta complex, aortic valve morphogenesis, apical constriction, apoptotic process, ATP binding, bleb, bleb assembly, blood vessel diameter maintenance, cell projection, centriole, cortical actin cytoskeleton organization, cytoplasm, cytoplasmic stress granule, cytoskeleton, cytosol, embryonic morphogenesis, ephrin receptor signaling pathway, execution phase of apoptosis
Bgee · 19
ROCK1 → Achilles tendon, aortic valve, ascending aorta, bone marrow cell, ciliary body, Descending thoracic aorta, epithelium of colon, lacrimal gland, left coronary artery, left lung lobe, monocyte, popliteal artery, primary oocyte, right coronary artery, Rostral migratory stream, secondary oocyte, tibial arteries, tunica media of zone of aorta, zygote
RNA expression pattern · 19
ROCK1 → Achilles tendon, aortic valve, ascending aorta, bone marrow cell, ciliary body, Descending thoracic aorta, epithelium of colon, lacrimal gland, left coronary artery, left lung lobe, monocyte, popliteal artery, primary oocyte, right coronary artery, Rostral migratory stream, secondary oocyte, tibial arteries, tunica media of zone of aorta, zygote
related to Substrates and interactions · 15
ROCK1 → Cardiac, F-actin, For, GTPase RhoA, LIM, MLC, More, MYPT-1, PTEN, RhoA, RXS/T, RXXS/T, This, VEGF, When ROCK1
related to Structure and regulation · 14
ROCK1 → According, C-terminal, C-terminus, Cleavage, Enzyme, GTP-bound RhoA, It, N-terminus, Rho-binding, RhoA, ROCK, The ROCK1, This, When
related to Function · 13
ROCK1 → Additionally, DAPK3, FHOD1, GFAP, It, LIMK1, LIMK2, MYL9/MLC2, Other, PFN1, PPP1R12A, SRC-dependent, These
related to Role in cancer · 6
ROCK1 → Recent, Rho GTPases, RhoA, Therefore, These, When
related to Gene and expression · 5
ROCK1 → GTP-bound, In, RhoA, The, This
related to Angiogenesis · 4
ROCK1 → By, Increased, It, RhoA
related to Clinical significance · 4
ROCK1 → As, Given, In, ROCK

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Important terminology

rhoa kinase cell bp gene phosphorylation also angiogenesis human activity protein 18 role motility chr band function cytoskeleton tumor chromosome

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
ROCK12.7.11.391.00infobox
ROCK1AliasesROCK1, P160ROCK, ROCK-I, Rho associated coiled-coil containing protein kinase 11.00infobox
ROCK1Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1S1C, 2ESM, 2ETK, 2ETR, 2V55, 3D9V, 3NCZ, 3NDM, 3O0Z, 3TV7, 3TWJ, 3V8S, 4L2W, 4W7P, 4YVC, 4YVE, 5BML1.00infobox
ROCK1Band18q11.11.00infobox
ROCK1Band18|18 A11.00infobox
ROCK1BgeeAchilles tendon1.00infobox
ROCK1Bgeepopliteal artery1.00infobox
ROCK1Bgeetibial arteries1.00infobox
ROCK1Bgeemonocyte1.00infobox
ROCK1Bgeeright coronary artery1.00infobox
ROCK1Bgeebone marrow cell1.00infobox
ROCK1Bgeeleft coronary artery1.00infobox
ROCK1BgeeDescending thoracic aorta1.00infobox
ROCK1Bgeeascending aorta1.00infobox
ROCK1Bgeeepithelium of colon1.00infobox
ROCK1Bgeetunica media of zone of aorta1.00infobox
ROCK1BgeeRostral migratory stream1.00infobox
ROCK1Bgeezygote1.00infobox
ROCK1Bgeesecondary oocyte1.00infobox
ROCK1Bgeeciliary body1.00infobox
ROCK1Bgeeprimary oocyte1.00infobox
ROCK1Bgeelacrimal gland1.00infobox
ROCK1Bgeeaortic valve1.00infobox
ROCK1Bgeeleft lung lobe1.00infobox
ROCK1BioGPSn/a1.00infobox
ROCK1Chr.Chromosome 18 (human)1.00infobox
ROCK1Chr.Chromosome 18 (mouse)1.00infobox
ROCK1DatabasesNCBI: entry; OMA: entry1.00infobox
ROCK1End21,111,813 bp1.00infobox
ROCK1End10,182,045 bp1.00infobox

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