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TEC (gene): Clinical Significance, Overview & Structure

Tyrosine-protein kinase Tec is a tyrosine kinase that in humans is encoded by the TEC gene. Tec kinase is expressed in hematopoietic, liver, and kidney cells and plays an important role in T-helper cell processes. Tec kinase is the name-giving member of the Tec kinase family, a family of non-receptor protein-tyrosine kinases.

Language: English [EN]
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TEC (gene) topic overview

The analysis highlights Clinical Significance, Overview and Structure as prominent areas in the source structure around TEC (gene).

Related topics
88
Source areas
6
Connected nodes
94
Extracted relationships
108
Concept neighborhoods
22
Bridge connections
94

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Overview · 41 topics
Clinical Significance · 19 topics
Structure · 10 topics
Activation · 7 topics
Interactions · 7 topics
Function · 4 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

2.7.10.2
Aliases
TEC, PSCTK4, tec protein tyrosine kinase
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LUL
Band
4p12-p11 · 5 C3.2|5 38.44 cM
Bgee
gonad · bone marrow cell · testicle · skin of leg · skin of abdomen
BioGPS
More reference expression data

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Structure

Function

Activation

Clinical Significance

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How TEC (gene) connects Entity context

The extracted context around TEC (gene) shows recurring relationship patterns in the source. For example, TEC (gene) → adaptive immune response, ATP binding, B cell receptor signaling pathway, cell differentiation, cytokine-mediated signaling pathway, cytoplasm, cytoskeleton, cytosol, extrinsic component of cytoplasmic side of plasma membrane, Fc-epsilon receptor signaling pathway, immune system process, innate immune response, integrin-mediated signaling pathway, intracellular signal transduction, kinase activity, lipid binding, membrane, metal ion binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding Another extracted example is TEC (gene) → blood, bone marrow, bone marrow cell, gonad, granulocyte, iris, left lobe of liver, mesenteric lymph nodes, monocyte, proximal tubule, rectum, right adrenal cortex, right kidney, right lung, right uterine tube, sciatic nerve, skin of abdomen, skin of leg, spleen, testicle. Use these groups to spot repeated connection types before inspecting the individual relationships.

TEC (gene)

Top relations

Gene ontology · 37
TEC (gene) → adaptive immune response, ATP binding, B cell receptor signaling pathway, cell differentiation, cytokine-mediated signaling pathway, cytoplasm, cytoskeleton, cytosol, extrinsic component of cytoplasmic side of plasma membrane, Fc-epsilon receptor signaling pathway, immune system process, innate immune response, integrin-mediated signaling pathway, intracellular signal transduction, kinase activity, lipid binding, membrane, metal ion binding, non-membrane spanning protein tyrosine kinase activity, nucleotide binding
Bgee · 20
TEC (gene) → blood, bone marrow, bone marrow cell, gonad, granulocyte, iris, left lobe of liver, mesenteric lymph nodes, monocyte, proximal tubule, rectum, right adrenal cortex, right kidney, right lung, right uterine tube, sciatic nerve, skin of abdomen, skin of leg, spleen, testicle
RNA expression pattern · 20
TEC (gene) → blood, bone marrow, bone marrow cell, gonad, granulocyte, iris, left lobe of liver, mesenteric lymph nodes, monocyte, proximal tubule, rectum, right adrenal cortex, right kidney, right lung, right uterine tube, sciatic nerve, skin of abdomen, skin of leg, spleen, testicle
related to Interactions · 6
TEC (gene) → ARHGEF12, CD117, DOK1, GNA12, Janus, TEC
Band · 2
TEC (gene) → 4p12-p11, 5 C3.2|5 38.44 cM
Chr. · 2
TEC (gene) → Chromosome 4 (human), Chromosome 5 (mouse)
End · 2
TEC (gene) → 48,269,838 bp, 73,025,826 bp
2.7.10.2 · 1
TEC (gene) → ↗
Aliases · 1
TEC (gene) → TEC, PSCTK4, tec protein tyrosine kinase
Available structures · 1
TEC (gene) → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LUL

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

kinase tec cells btk family tyrosine function domain bp gene kinases human role sh3 signaling expressed chr chromosome band activation

TEC (gene) relationships Subject–Predicate–Object triples

TTTA extracted 108 structured relationships around TEC (gene). Examples in this analysis include TEC (gene) → 2.7.10.2 → ↗ and TEC (gene) → Aliases → TEC, PSCTK4, tec protein tyrosine kinase. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
TEC (gene)2.7.10.21.00infobox
TEC (gene)AliasesTEC, PSCTK4, tec protein tyrosine kinase1.00infobox
TEC (gene)Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2LUL1.00infobox
TEC (gene)Band4p12-p111.00infobox
TEC (gene)Band5 C3.2|5 38.44 cM1.00infobox
TEC (gene)Bgeegonad1.00infobox
TEC (gene)Bgeebone marrow cell1.00infobox
TEC (gene)Bgeetesticle1.00infobox
TEC (gene)Bgeeskin of leg1.00infobox
TEC (gene)Bgeeskin of abdomen1.00infobox
TEC (gene)Bgeemonocyte1.00infobox
TEC (gene)Bgeeright uterine tube1.00infobox
TEC (gene)Bgeerectum1.00infobox
TEC (gene)Bgeeright lung1.00infobox
TEC (gene)Bgeeright adrenal cortex1.00infobox
TEC (gene)Bgeesciatic nerve1.00infobox
TEC (gene)Bgeegranulocyte1.00infobox
TEC (gene)Bgeespleen1.00infobox
TEC (gene)Bgeeleft lobe of liver1.00infobox
TEC (gene)Bgeemesenteric lymph nodes1.00infobox
TEC (gene)Bgeeblood1.00infobox
TEC (gene)Bgeeproximal tubule1.00infobox
TEC (gene)Bgeebone marrow1.00infobox
TEC (gene)Bgeeright kidney1.00infobox
TEC (gene)Bgeeiris1.00infobox
TEC (gene)BioGPSMore reference expression data1.00infobox
TEC (gene)Chr.Chromosome 4 (human)1.00infobox
TEC (gene)Chr.Chromosome 5 (mouse)1.00infobox
TEC (gene)DatabasesNCBI: entry; OMA: entry1.00infobox
TEC (gene)End48,269,838 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around TEC (gene) bring nearby vocabulary together. In this analysis, examples include Bp, Chr and Chromosome. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • TEC (gene)
    • Bp
    • Chr
    • Chromosome
    • Human
    • Band
    • Mouse
    • Family
    • Cells
    • Btk
    • Domain
    • Activated
    • Kinases
  • tec (gene)
    • Bp
    • Chr
    • Chromosome
    • Human
    • Tyrosine
    • Activity
    • Band
    • Protein
    • Mouse
    • Family
    • Activation
    • Cells
  • tyrosine kinase
    • Tec
    • Gene
    • Activity
    • Cells
    • Protein
    • Bp
    • Chr
    • Chromosome
    • Human
    • Kinase
    • Tyrosine
    • Activation
  • gene
    • Bp
    • Chr
    • Chromosome
    • Human
    • Tyrosine
    • Activity
    • Band
    • Protein
    • Mouse
    • Activation
    • Signaling
    • Function
  • naïve t cells
    • Expressed
    • Function
    • Kinase
    • Tec
    • Activated
    • Cell
    • May
    • Plays
    • Response
    • Stimulation
    • Upon
    • Activation
  • b cells
    • Expressed
    • Function
    • Kinase
    • Tec
    • Activated
    • Cell
    • May
    • Plays
    • Response
    • Stimulation
    • Upon
    • Activation
  • mast cells
    • Expressed
    • Function
    • Kinase
    • Tec
    • Activated
    • Cell
    • May
    • Plays
    • Response
    • Stimulation
    • Upon
    • Activation
  • kinase
    • Tec
    • Cells
    • Tyrosine
    • Btk
    • Activated
    • Role
    • Function
    • Family
    • Activation
    • Domain
    • Likely
    • Plays

Connections between topic areas Semantic bridges

For TEC (gene), one of the stronger structural bridges in this analysis connects TEC (gene) with Overview. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
TEC (gene)Overview · splits 53 ⟂ 42
TEC (gene)Clinical Significance · splits 75 ⟂ 20
TEC (gene)Structure · splits 84 ⟂ 11
TEC (gene)Activation · splits 87 ⟂ 8
TEC (gene)Interactions · splits 87 ⟂ 8
TEC (gene)Function · splits 90 ⟂ 5

Map overview Semantic statistics

TEC (gene)

Nodes95
Edges94
Triples108
Avg. degree1.98
Density0.021053
Components1

Source & methodology

TTTA analyzes the structure around TEC (gene) to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Clinical Significance, Overview & Structure, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — TEC (gene) · EN edition · Analysis: TopicsToTalkAbout

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