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PLCG2

1-Phosphatidylinositol-4,5-bisphosphate phosphodiesterase gamma-2 is an enzyme that in humans is encoded by the PLCG2 gene.

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6 related topics

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3.1.4.11
Aliases
PLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2, phospholipase C gamma 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2K2J, 2W2W, 2W2X
Band
16q23.3 · 8 E1|8 64.26 cM
Bgee
glomerulus · bone marrow cell · blood · metanephric glomerulus · epithelium of nasopharynx
BioGPS
More reference expression data

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Map overview Semantic statistics

PLCG2

Nodes13
Edges12
Triples99
Avg. degree1.85
Density0.153846
Components1

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PLCG2

Top relations

Gene ontology · 36
PLCG2 → activation of store-operated calcium channel activity, B cell differentiation, B cell receptor signaling pathway, calcium-mediated signaling, cytosol, extracellular exosome, Fc-epsilon receptor signaling pathway, Fc-gamma receptor signaling pathway involved in phagocytosis, follicular B cell differentiation, hydrolase activity, inositol phosphate metabolic process, inositol trisphosphate biosynthetic process, intracellular signal transduction, lipid catabolic process, lipid metabolism, negative regulation of programmed cell death, phosphatidylinositol biosynthetic process, phosphatidylinositol phospholipase C activity, phosphatidylinositol-mediated signaling, phospholipase C activity
Bgee · 17
PLCG2 → appendix, basilar part of occipital bone, blood, bone marrow, bone marrow cell, endothelial cell, epithelium of nasopharynx, external carotid artery, glomerulus, granulocyte, internal carotid artery, kidney tubule, mesenteric lymph nodes, metanephric glomerulus, sphenoid bone, spleen, tibiofemoral joint
RNA expression pattern · 17
PLCG2 → appendix, basilar part of occipital bone, blood, bone marrow, bone marrow cell, endothelial cell, epithelium of nasopharynx, external carotid artery, glomerulus, granulocyte, internal carotid artery, kidney tubule, mesenteric lymph nodes, metanephric glomerulus, sphenoid bone, spleen, tibiofemoral joint
related to Interactions · 4
PLCG2 → Bruton's, GAB2, LYN, PTPN11
Band · 2
PLCG2 → 16q23.3, 8 E1|8 64.26 cM
Chr. · 2
PLCG2 → Chromosome 16 (human), Chromosome 8 (mouse)
End · 2
PLCG2 → 118,361,881 bp, 81,962,685 bp
3.1.4.11 · 1
PLCG2 → ↗
Aliases · 1
PLCG2 → PLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2, phospholipase C gamma 2
Available structures · 1
PLCG2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2K2J, 2W2W, 2W2X

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Important terminology

bp chr human band gene phospholipase chromosome 16 location enzymes enzyme mouse function omim external search activity 962 685 end

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
PLCG23.1.4.111.00infobox
PLCG2AliasesPLCG2, APLAID, FCAS3, PLC-IV, PLC-gamma-2, phospholipase C gamma 21.00infobox
PLCG2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2K2J, 2W2W, 2W2X1.00infobox
PLCG2Band16q23.31.00infobox
PLCG2Band8 E1|8 64.26 cM1.00infobox
PLCG2Bgeeglomerulus1.00infobox
PLCG2Bgeebone marrow cell1.00infobox
PLCG2Bgeeblood1.00infobox
PLCG2Bgeemetanephric glomerulus1.00infobox
PLCG2Bgeeepithelium of nasopharynx1.00infobox
PLCG2Bgeespleen1.00infobox
PLCG2Bgeegranulocyte1.00infobox
PLCG2Bgeeendothelial cell1.00infobox
PLCG2Bgeeappendix1.00infobox
PLCG2Bgeekidney tubule1.00infobox
PLCG2Bgeebasilar part of occipital bone1.00infobox
PLCG2Bgeetibiofemoral joint1.00infobox
PLCG2Bgeemesenteric lymph nodes1.00infobox
PLCG2Bgeebone marrow1.00infobox
PLCG2Bgeesphenoid bone1.00infobox
PLCG2Bgeeexternal carotid artery1.00infobox
PLCG2Bgeeinternal carotid artery1.00infobox
PLCG2BioGPSMore reference expression data1.00infobox
PLCG2Chr.Chromosome 16 (human)1.00infobox
PLCG2Chr.Chromosome 8 (mouse)1.00infobox
PLCG2DatabasesNCBI: entry; OMA: entry1.00infobox
PLCG2End81,962,685 bp1.00infobox
PLCG2End118,361,881 bp1.00infobox
PLCG2EnsemblENSG000001979431.00infobox
PLCG2Entrez53361.00infobox

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