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SH2B2: Interactions & Overview

SH2B adapter protein 2 is a protein that in humans is encoded by the SH2B2 gene.

Language: English [EN]
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SH2B2 topic overview

The analysis highlights Interactions and Overview as prominent areas in the source structure around SH2B2.

Related topics
5
Source areas
2
Connected nodes
7
Extracted relationships
92
Concept neighborhoods
6
Bridge connections
7

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 3 topics
Overview · 2 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases
SH2B2, APS, SH2B adaptor protein 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1Q2H
Band
7q22.1 · 5|5 G2
Bgee
triceps brachii muscle · Skeletal muscle tissue of biceps brachii · muscle of thigh · vastus lateralis muscle · renal medulla
BioGPS
n/a
Chr.
Chromosome 7 (human) · Chromosome 5 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Interactions

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How SH2B2 connects Entity context

The extracted context around SH2B2 shows recurring relationship patterns in the source. For example, SH2B2 → actin cytoskeleton organization, actin filament, antigen receptor-mediated signaling pathway, B-1 B cell homeostasis, blood coagulation, brown fat cell differentiation, cytokine-mediated signaling pathway, cytoplasm, cytosol, identical protein binding, insulin receptor signaling pathway, intracellular signal transduction, JAK pathway signal transduction adaptor activity, membrane, nervous system development, plasma membrane, positive regulation of signal transduction, protein binding, regulation of immune response, regulation of metabolic process Another extracted example is SH2B2 → body of tongue, brown adipose tissue, ganglionic eminence, gastrula, granulocyte, internal carotid artery, muscle of thigh, muscle of trunk, placenta, renal medulla, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, spermatocyte, tail of embryo, thoracic diaphragm, tibialis anterior muscle, triceps brachii muscle, tunica adventitia of aorta, vastus lateralis muscle, white adipose tissue. Use these groups to spot repeated connection types before inspecting the individual relationships.

SH2B2

Top relations

Gene ontology · 27
SH2B2 → actin cytoskeleton organization, actin filament, antigen receptor-mediated signaling pathway, B-1 B cell homeostasis, blood coagulation, brown fat cell differentiation, cytokine-mediated signaling pathway, cytoplasm, cytosol, identical protein binding, insulin receptor signaling pathway, intracellular signal transduction, JAK pathway signal transduction adaptor activity, membrane, nervous system development, plasma membrane, positive regulation of signal transduction, protein binding, regulation of immune response, regulation of metabolic process
Bgee · 20
SH2B2 → body of tongue, brown adipose tissue, ganglionic eminence, gastrula, granulocyte, internal carotid artery, muscle of thigh, muscle of trunk, placenta, renal medulla, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, spermatocyte, tail of embryo, thoracic diaphragm, tibialis anterior muscle, triceps brachii muscle, tunica adventitia of aorta, vastus lateralis muscle, white adipose tissue
RNA expression pattern · 20
SH2B2 → body of tongue, brown adipose tissue, ganglionic eminence, gastrula, granulocyte, internal carotid artery, muscle of thigh, muscle of trunk, placenta, renal medulla, Skeletal muscle tissue of biceps brachii, Skeletal muscle tissue of rectus abdominis, spermatocyte, tail of embryo, thoracic diaphragm, tibialis anterior muscle, triceps brachii muscle, tunica adventitia of aorta, vastus lateralis muscle, white adipose tissue
Band · 2
SH2B2 → 5|5 G2, 7q22.1
Chr. · 2
SH2B2 → Chromosome 5 (mouse), Chromosome 7 (human)
End · 2
SH2B2 → 102,321,711 bp, 136,275,410 bp
related to Interactions · 2
SH2B2 → Cbl, TrkA
Aliases · 1
SH2B2 → SH2B2, APS, SH2B adaptor protein 2
Available structures · 1
SH2B2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1Q2H
BioGPS · 1
SH2B2 → n/a

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp gene chr human band protein chromosome location mouse receptor sh2b function encoded adaptor search 321 711 end 102 275

SH2B2 relationships Subject–Predicate–Object triples

TTTA extracted 92 structured relationships around SH2B2. Examples in this analysis include SH2B2 → Aliases → SH2B2, APS, SH2B adaptor protein 2 and SH2B2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1Q2H. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
SH2B2AliasesSH2B2, APS, SH2B adaptor protein 21.00infobox
SH2B2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes1Q2H1.00infobox
SH2B2Band7q22.11.00infobox
SH2B2Band5|5 G21.00infobox
SH2B2Bgeetriceps brachii muscle1.00infobox
SH2B2BgeeSkeletal muscle tissue of biceps brachii1.00infobox
SH2B2Bgeemuscle of thigh1.00infobox
SH2B2Bgeevastus lateralis muscle1.00infobox
SH2B2Bgeerenal medulla1.00infobox
SH2B2Bgeemuscle of trunk1.00infobox
SH2B2BgeeSkeletal muscle tissue of rectus abdominis1.00infobox
SH2B2Bgeethoracic diaphragm1.00infobox
SH2B2Bgeetibialis anterior muscle1.00infobox
SH2B2Bgeebody of tongue1.00infobox
SH2B2Bgeebrown adipose tissue1.00infobox
SH2B2Bgeegranulocyte1.00infobox
SH2B2Bgeewhite adipose tissue1.00infobox
SH2B2Bgeetunica adventitia of aorta1.00infobox
SH2B2Bgeespermatocyte1.00infobox
SH2B2Bgeeganglionic eminence1.00infobox
SH2B2Bgeeinternal carotid artery1.00infobox
SH2B2Bgeegastrula1.00infobox
SH2B2Bgeetail of embryo1.00infobox
SH2B2Bgeeplacenta1.00infobox
SH2B2BioGPSn/a1.00infobox
SH2B2Chr.Chromosome 7 (human)1.00infobox
SH2B2Chr.Chromosome 5 (mouse)1.00infobox
SH2B2DatabasesNCBI: entry; OMA: entry1.00infobox
SH2B2End102,321,711 bp1.00infobox
SH2B2End136,275,410 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around SH2B2 bring nearby vocabulary together. In this analysis, examples include Signal, Transduction and Tyrosine. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • protein
    • Sh2b2
    • Adaptor
    • Encoded
    • Function
    • Search
    • Sh2b
    • Gene
    • Location
    • Chromosome
    • Human
    • Bp
    • Chr
  • gene
    • Sh2b2
    • Location
    • Protein
    • Chromosome
    • Human
    • Bp
    • Chr
    • Adaptor
    • End
    • Function
    • Mouse
    • Search
  • cbl gene
    • Sh2b2
    • Location
    • Protein
    • Chromosome
    • Human
    • Bp
    • Chr
    • Adaptor
    • End
    • Function
    • Mouse
    • Search
  • interactions
    • Reading
    • References
    • Search
    • Sh2b
    • Location
    • Protein
    • Human
    • Sh2b2
  • SH2B2
    • Signal
    • Transduction
    • Tyrosine
  • sh2b2
    • Signal
    • Transduction
    • Tyrosine

Connections between topic areas Semantic bridges

For SH2B2, one of the stronger structural bridges in this analysis connects SH2B2 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
SH2B2Interactions · splits 4 ⟂ 4
SH2B2Overview · splits 5 ⟂ 3

Map overview Semantic statistics

SH2B2

Nodes8
Edges7
Triples92
Avg. degree1.75
Density0.25
Components1

Source & methodology

TTTA analyzes the structure around SH2B2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions & Overview, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — SH2B2 · EN edition · Analysis: TopicsToTalkAbout

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