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PLD2: Interactions, Function & Mechanism of activation

Phospholipase D2 is an enzyme that in humans is encoded by the PLD2 gene.

Language: English [EN]
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PLD2 topic overview

The analysis highlights Interactions, Function and Mechanism of activation as prominent areas in the source structure around PLD2.

Related topics
22
Source areas
5
Connected nodes
27
Extracted relationships
97
Concept neighborhoods
11
Bridge connections
27

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Interactions · 11 topics
Function · 6 topics
Mechanism of activation · 2 topics
Overview · 2 topics
Inhibitors · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

3.1.4.4
Aliases
PLD2, phospholipase D2, PLD1C
Band
17p13.2 · 11 B3|11 42.99 cM
Bgee
skin of leg · right hemisphere of cerebellum · ectocervix · right ovary · skin of abdomen
BioGPS
More reference expression data
Chr.
Chromosome 17 (human) · Chromosome 11 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Function

Mechanism of activation

Interactions

Inhibitors

  • PLD1 Phospholipase D1

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How PLD2 connects Entity context

The extracted context around PLD2 shows recurring relationship patterns in the source. For example, PLD2 → ankle, apex of heart, choroid plexus of fourth ventricle, dentate gyrus of hippocampal formation granule cell, ectocervix, esophagus, left ovary, lip, minor salivary glands, primary oocyte, right hemisphere of cerebellum, right ovary, secondary oocyte, skeletal muscle tissue, skin of abdomen, skin of leg, tibial nerve, ventricular zone, vestibular membrane of cochlear duct, zygote Another extracted example is PLD2 → catalytic activity, cell motility, cytoskeleton organization, endoplasmic reticulum membrane, Fc-gamma receptor signaling pathway involved in phagocytosis, Golgi apparatus, hydrolase activity, inositol lipid-mediated signaling, lipid catabolic process, lipid metabolism, membrane, N-acylphosphatidylethanolamine-specific phospholipase D activity, phosphatidic acid biosynthetic process, phosphatidylinositol binding, phospholipase D activity, plasma membrane, presynapse, protein binding, small GTPase mediated signal transduction, synaptic vesicle recycling. Use these groups to spot repeated connection types before inspecting the individual relationships.

PLD2

Top relations

Bgee · 20
PLD2 → ankle, apex of heart, choroid plexus of fourth ventricle, dentate gyrus of hippocampal formation granule cell, ectocervix, esophagus, left ovary, lip, minor salivary glands, primary oocyte, right hemisphere of cerebellum, right ovary, secondary oocyte, skeletal muscle tissue, skin of abdomen, skin of leg, tibial nerve, ventricular zone, vestibular membrane of cochlear duct, zygote
Gene ontology · 20
PLD2 → catalytic activity, cell motility, cytoskeleton organization, endoplasmic reticulum membrane, Fc-gamma receptor signaling pathway involved in phagocytosis, Golgi apparatus, hydrolase activity, inositol lipid-mediated signaling, lipid catabolic process, lipid metabolism, membrane, N-acylphosphatidylethanolamine-specific phospholipase D activity, phosphatidic acid biosynthetic process, phosphatidylinositol binding, phospholipase D activity, plasma membrane, presynapse, protein binding, small GTPase mediated signal transduction, synaptic vesicle recycling
RNA expression pattern · 20
PLD2 → ankle, apex of heart, choroid plexus of fourth ventricle, dentate gyrus of hippocampal formation granule cell, ectocervix, esophagus, left ovary, lip, minor salivary glands, primary oocyte, right hemisphere of cerebellum, right ovary, secondary oocyte, skeletal muscle tissue, skin of abdomen, skin of leg, tibial nerve, ventricular zone, vestibular membrane of cochlear duct, zygote
related to Interactions · 10
PLD2 → Aldolase, Aldrich, Amphiphysin, ARF1, BIN1, Caveolin, Glyceraldehyde, PLCG1, PRKCD, Src
related to Mechanism of activation · 5
PLD2 → PC, PIP2, Scaffolding, The, When PIP2
Band · 2
PLD2 → 11 B3|11 42.99 cM, 17p13.2
Chr. · 2
PLD2 → Chromosome 11 (mouse), Chromosome 17 (human)
End · 2
PLD2 → 4,823,434 bp, 70,448,936 bp
3.1.4.4 · 1
PLD2 → ↗
Aliases · 1
PLD2 → PLD2, phospholipase D2, PLD1C

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

bp chr human band gene chromosome 17 phospholipase enzyme lipid location function mouse d2 pc plds substrate rafts pip2 activity

PLD2 relationships Subject–Predicate–Object triples

TTTA extracted 97 structured relationships around PLD2. Examples in this analysis include PLD2 → 3.1.4.4 → ↗ and PLD2 → Aliases → PLD2, phospholipase D2, PLD1C. The table shows each extracted connection, where it came from and its confidence.

SubjectPredicateObjectConfidenceSrc
PLD23.1.4.41.00infobox
PLD2AliasesPLD2, phospholipase D2, PLD1C1.00infobox
PLD2Band17p13.21.00infobox
PLD2Band11 B3|11 42.99 cM1.00infobox
PLD2Bgeeskin of leg1.00infobox
PLD2Bgeeright hemisphere of cerebellum1.00infobox
PLD2Bgeeectocervix1.00infobox
PLD2Bgeeright ovary1.00infobox
PLD2Bgeeskin of abdomen1.00infobox
PLD2Bgeeminor salivary glands1.00infobox
PLD2Bgeeleft ovary1.00infobox
PLD2Bgeetibial nerve1.00infobox
PLD2Bgeeapex of heart1.00infobox
PLD2Bgeeventricular zone1.00infobox
PLD2Bgeelip1.00infobox
PLD2Bgeeesophagus1.00infobox
PLD2Bgeezygote1.00infobox
PLD2Bgeesecondary oocyte1.00infobox
PLD2Bgeeankle1.00infobox
PLD2Bgeeprimary oocyte1.00infobox
PLD2Bgeevestibular membrane of cochlear duct1.00infobox
PLD2Bgeechoroid plexus of fourth ventricle1.00infobox
PLD2Bgeedentate gyrus of hippocampal formation granule cell1.00infobox
PLD2Bgeeskeletal muscle tissue1.00infobox
PLD2BioGPSMore reference expression data1.00infobox
PLD2Chr.Chromosome 17 (human)1.00infobox
PLD2Chr.Chromosome 11 (mouse)1.00infobox
PLD2DatabasesNCBI: entry; OMA: entry1.00infobox
PLD2End4,823,434 bp1.00infobox
PLD2End70,448,936 bp1.00infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around PLD2 bring nearby vocabulary together. In this analysis, examples include Interact, Protein and Pip2. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

  • gene
    • Location
    • Phospholipase
    • Chromosome
    • Human
    • Activity
    • B3
    • Bp
    • Chr
    • End
    • Mouse
    • Function
    • Band
  • wiskott–aldrich syndrome protein
    • Acid
    • Phosphatidic
    • Activity
    • B3
    • Cell
    • End
    • Interact
    • Membrane
    • Mouse
    • Nm
    • Phosphatidylinositol
    • Function
  • function
    • Activity
    • Cell
    • Omim
    • Location
    • Phospholipase
    • Plds
    • Chromosome
    • Gene
    • Human
    • Pld2
    • Acid
    • Bp
  • phosphatidic acid
    • Phosphatidic
    • Activity
    • B3
    • Cell
    • End
    • Membrane
    • Mouse
    • Nm
    • Phosphatidylinositol
    • Protein
    • Function
    • Location
  • enzyme
    • Phospholipase
    • Gene
    • Pld2
    • Activation
    • Activity
    • Omim
    • Function
    • Location
    • Rafts
    • Chromosome
    • Human
    • Lipid
  • mechanism of activation
    • Activity
    • D2
    • Omim
    • Enzyme
    • Function
    • Location
    • Phospholipase
    • Plds
    • Chromosome
    • Gene
    • Human
    • Bp
  • substrate presentation
    • Pc
    • Pip2
    • Cell
    • Membrane
    • Omim
    • Phosphatidylinositol
    • Pld2
    • Function
    • Plds
    • Rafts
    • Lipid
  • phosphatidylinositol 4,5-bisphosphate
    • Pc
    • Phosphatidic
    • Nm
    • Protein
    • Phospholipase
    • Pip2
    • Plds
    • Rafts
    • Substrate
    • Pld2

Connections between topic areas Semantic bridges

For PLD2, one of the stronger structural bridges in this analysis connects PLD2 with Interactions. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3
PLD2Interactions · splits 16 ⟂ 12
PLD2Function · splits 21 ⟂ 7
PLD2Overview · splits 25 ⟂ 3
PLD2Mechanism of activation · splits 25 ⟂ 3

Map overview Semantic statistics

PLD2

Nodes28
Edges27
Triples97
Avg. degree1.93
Density0.071429
Components1

Source & methodology

TTTA analyzes the structure around PLD2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Interactions, Function & Mechanism of activation, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — PLD2 · EN edition · Analysis: TopicsToTalkAbout

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