Phosphoinositide 3-kinase

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Phosphoinositide 3-kinase topic overview

The analysis highlights Classes, Function and Mechanism as prominent areas in the source structure around Phosphoinositide 3-kinase.

Related topics: 89
Source areas: 6
Connected nodes: 95
Extracted relationships: 24
Concept neighborhoods: 29
Bridge connections: 95

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Classes · 30 topics

Function · 22 topics

Mechanism · 15 topics

Overview · 12 topics

Inhibition · 7 topics

Discovery · 3 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

AlphaFold: IPR000403 · PF00454
Available protein structures:: IPR000403 · PF00454
InterPro: IPR000403
OPM protein: 3ml9
OPM superfamily: 265
PDB: IPR000403 PF00454 (ECOD; PDBsum)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Discovery

Lewis Cantley Lewis C. Cantley
Polyoma
PtdIns(3,4,5)P3 Phosphatidylinositol (3,4,5)-trisphosphate

Classes

Class I Class I PI 3-kinases
Class II Class II PI 3-kinases
III Class III PI 3-kinase
Phosphatidylinositol (4,5)-bisphosphate
Phosphatidylinositol 3-phosphate
Phosphatidylinositol 4-phosphate
Phosphatidylinositol (3,4)-bisphosphate
G protein-coupled receptors
Tyrosine kinase receptors
Heterodimeric
Subunit Protein subunit
Splice variants p85α, p55α, and p50α PIK3R1
P85β PIK3R2
P55γ PIK3R3
P110α
P110β
P110δ
Leukocytes
P110γ
SH2 SH2 domain
SH3 SH3 domain
Online Mendelian Inheritance in Man
Asp Aspartic acid
Hepatocytes
Vps34
Phagocytosis
Ataxia telangiectasia mutated
Ataxia telangiectasia and Rad3 related
DNA-dependent protein kinase DNA-dependent protein kinase?action=edit&redlink=1
Mammalian target of rapamycin

Mechanism

Function

Protein kinase B
PI3K-mTOR pathway PI3K/AKT/mTOR pathway
Insulin signaling pathway Insulin signal transduction pathway and regulation of blood glucose
Diabetes mellitus
Class IA PI3K Class IA PI 3-kinase?action=edit&redlink=1
Glioblastoma
EGFR Epidermal growth factor receptor
Cellular transformation
Cancer
Long-term potentiation
Hippocampal CA1 Hippocampal ca1 region
AMPA receptors AMPA receptor
Postsynaptic density
Glutamatergic
NMDA receptor
CaMKII
AMPA-R
GluR1
GSK3β
PSD-95
P70S6K
Insulin receptor substrate

Inhibition

Wortmannin
LY294002
Inhibitors of PI3Ks Phosphoinositide 3-kinase inhibitor
FDA Food and Drug Administration
Idelalisib
Copanlisib
Duvelisib

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How Phosphoinositide 3-kinase connects Entity context

The extracted context around Phosphoinositide 3-kinase shows recurring relationship patterns in the source. For example, Phosphoinositide 3-kinase → IPR000403, PF00454 Another extracted example is Phosphoinositide 3-kinase → IPR000403. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

AlphaFold · 2

Phosphoinositide 3-kinase → IPR000403, PF00454

Available protein structures: · 2

Phosphoinositide 3-kinase → IPR000403, PF00454

InterPro · 1

Phosphoinositide 3-kinase → IPR000403

OPM protein · 1

Phosphoinositide 3-kinase → 3ml9

OPM superfamily · 1

Phosphoinositide 3-kinase → 265

PDB · 1

Phosphoinositide 3-kinase → IPR000403 PF00454 (ECOD; PDBsum)

Pfam · 1

Phosphoinositide 3-kinase → PF00454

PROSITE · 1

Phosphoinositide 3-kinase → PDOC00710

SCOP2 · 1

Phosphoinositide 3-kinase → 3gmm / SCOPe / SUPFAM

SMART · 1

Phosphoinositide 3-kinase → SM00146

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

pi3ks pi3k class also kinase akt ptdins pathway protein p2 p3 ii iii regulatory subunit phosphatidylinositol cancer catalytic many ltp

Phosphoinositide 3-kinase relationships Subject–Predicate–Object triples

TTTA extracted 24 structured relationships around Phosphoinositide 3-kinase. Examples in this analysis include Phosphoinositide 3-kinase → AlphaFold → IPR000403 and Phosphoinositide 3-kinase → AlphaFold → PF00454. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
Phosphoinositide 3-kinase	AlphaFold	IPR000403	1.00	infobox
Phosphoinositide 3-kinase	AlphaFold	PF00454	1.00	infobox
Phosphoinositide 3-kinase	Available protein structures:	IPR000403	1.00	infobox
Phosphoinositide 3-kinase	Available protein structures:	PF00454	1.00	infobox
Phosphoinositide 3-kinase	InterPro	IPR000403	1.00	infobox
Phosphoinositide 3-kinase	OPM protein	3ml9	1.00	infobox
Phosphoinositide 3-kinase	OPM superfamily	265	1.00	infobox
Phosphoinositide 3-kinase	PDB	IPR000403 PF00454 (ECOD; PDBsum)	1.00	infobox
Phosphoinositide 3-kinase	Pfam	PF00454	1.00	infobox
Phosphoinositide 3-kinase	PROSITE	PDOC00710	1.00	infobox
Phosphoinositide 3-kinase	SCOP2	3gmm / SCOPe / SUPFAM	1.00	infobox
Phosphoinositide 3-kinase	SMART	SM00146	1.00	infobox
Phosphoinositide 3-kinase	Symbol	PI3K	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around Phosphoinositide 3-kinase bring nearby vocabulary together. In this analysis, examples include Kinase, Enzymes and Intracellular. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

class i
- Ii
- Iii
- Pi3ks
- Catalytic
- Regulatory
- Pi
- Pi3k
- Subunit
- Many
- Kinase
- Family
- However
class ii
- Ii
- Iii
- Pi3ks
- Catalytic
- Regulatory
- Pi
- However
- Pi3k
- Subunit
- Many
- Kinase
- Family
pi3k/akt pathway
- Akt
- Pathway
- Mtor
- Pi3k
- Protein
- Many
- Kinase
- Shown
- Activity
- P2
- P3
- Ptdins
class ia pi3k
- Ii
- Iii
- Pi3ks
- Catalytic
- Akt
- Regulatory
- Many
- Pi
- Pi3k
- Kinase
- Protein
- Subunit
inhibitors of pi3ks
- Class
- Pi3k
- Expression
- Ltp
- Protein
- Catalytic
- Ii
- Regulatory
- Pik3ca
- Kinase
- Activity
- Subunits
ptdins(3,4)p2
- P3
- P2
- Ptdins
- Pi
- Group
- Phosphatidylinositol
- Also
- However
- Shown
- Proteins
- Many
- Akt
ptdins(3,5)p2
- P3
- P2
- Ptdins
- Pi
- Group
- Phosphatidylinositol
- Also
- However
- Shown
- Proteins
- Many
- Akt
Phosphoinositide 3-kinase
- Kinase
- Enzymes
- Intracellular
- Cancer
- Family
- Functions
- Involved
- Phosphatidylinositol
- Cellular
- Mtor
- Protein
- Pi3k

Connections between topic areas Semantic bridges

For Phosphoinositide 3-kinase, one of the stronger structural bridges in this analysis connects Phosphoinositide 3-kinase with Classes. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

Phosphoinositide 3-kinase — Classes · splits 65 ⟂ 31

Phosphoinositide 3-kinase — Function · splits 73 ⟂ 23

Phosphoinositide 3-kinase — Mechanism · splits 80 ⟂ 16

Phosphoinositide 3-kinase — Overview · splits 83 ⟂ 13

Phosphoinositide 3-kinase — Inhibition · splits 88 ⟂ 8

Phosphoinositide 3-kinase — Discovery · splits 92 ⟂ 4

Map overview Semantic statistics

Phosphoinositide 3-kinase

Nodes96

Edges95

Triples24

Avg. degree1.98

Density0.020833

Components1

Source & methodology

TTTA analyzes the structure around Phosphoinositide 3-kinase to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Classes, Function & Mechanism, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — Phosphoinositide 3-kinase · EN edition · Analysis: TopicsToTalkAbout