Phosphoinositide 3-kinase

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Explore the main themes, entities and connections around Phosphoinositide 3-kinase. Start with the topic map, then use the sections below for research and deeper semantic analysis.

Key facts & relationships

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AlphaFold: IPR000403 · PF00454
Available protein structures:: IPR000403 · PF00454
InterPro: IPR000403
OPM protein: 3ml9
OPM superfamily: 265
PDB: IPR000403 PF00454 (ECOD; PDBsum)

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Overview

Discovery

Lewis Cantley Lewis C. Cantley
Polyoma
PtdIns(3,4,5)P3 Phosphatidylinositol (3,4,5)-trisphosphate

Classes

Class I Class I PI 3-kinases
Class II Class II PI 3-kinases
III Class III PI 3-kinase
Phosphatidylinositol (4,5)-bisphosphate
Phosphatidylinositol 3-phosphate
Phosphatidylinositol 4-phosphate
Phosphatidylinositol (3,4)-bisphosphate
G protein-coupled receptors
Tyrosine kinase receptors
Heterodimeric
Subunit Protein subunit
Splice variants p85α, p55α, and p50α PIK3R1
P85β PIK3R2
P55γ PIK3R3
P110α
P110β
P110δ
Leukocytes
P110γ
SH2 SH2 domain
SH3 SH3 domain
Online Mendelian Inheritance in Man
Asp Aspartic acid
Hepatocytes
Vps34
Phagocytosis
Ataxia telangiectasia mutated
Ataxia telangiectasia and Rad3 related
DNA-dependent protein kinase DNA-dependent protein kinase?action=edit&redlink=1
Mammalian target of rapamycin

Mechanism

Function

Protein kinase B
PI3K-mTOR pathway PI3K/AKT/mTOR pathway
Insulin signaling pathway Insulin signal transduction pathway and regulation of blood glucose
Diabetes mellitus
Class IA PI3K Class IA PI 3-kinase?action=edit&redlink=1
Glioblastoma
EGFR Epidermal growth factor receptor
Cellular transformation
Cancer
Long-term potentiation
Hippocampal CA1 Hippocampal ca1 region
AMPA receptors AMPA receptor
Postsynaptic density
Glutamatergic
NMDA receptor
CaMKII
AMPA-R
GluR1
GSK3β
PSD-95
P70S6K
Insulin receptor substrate

Inhibition

Wortmannin
LY294002
Inhibitors of PI3Ks Phosphoinositide 3-kinase inhibitor
FDA Food and Drug Administration
Idelalisib
Copanlisib
Duvelisib

Advanced semantic analysis

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Map overview Semantic statistics

Nodes96

Edges95

Triples24

Avg. degree1.98

Density0.020833

Components1

How this topic connects Entity context

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Phosphoinositide 3-kinase

Top relations

AlphaFold · 2

Phosphoinositide 3-kinase → IPR000403, PF00454

Available protein structures: · 2

Phosphoinositide 3-kinase → IPR000403, PF00454

InterPro · 1

Phosphoinositide 3-kinase → IPR000403

OPM protein · 1

Phosphoinositide 3-kinase → 3ml9

OPM superfamily · 1

Phosphoinositide 3-kinase → 265

PDB · 1

Phosphoinositide 3-kinase → IPR000403 PF00454 (ECOD; PDBsum)

Pfam · 1

Phosphoinositide 3-kinase → PF00454

PROSITE · 1

Phosphoinositide 3-kinase → PDOC00710

SCOP2 · 1

Phosphoinositide 3-kinase → 3gmm / SCOPe / SUPFAM

SMART · 1

Phosphoinositide 3-kinase → SM00146

Important terminology Word statistics

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Important terminology

pi3ks pi3k class also kinase akt ptdins pathway protein p2 p3 ii iii regulatory subunit phosphatidylinositol cancer catalytic many ltp

Entity relationships Subject–Predicate–Object triples

Subject	Predicate	Object	Confidence	Src
Phosphoinositide 3-kinase	AlphaFold	IPR000403	1.00	infobox
Phosphoinositide 3-kinase	AlphaFold	PF00454	1.00	infobox
Phosphoinositide 3-kinase	Available protein structures:	IPR000403	1.00	infobox
Phosphoinositide 3-kinase	Available protein structures:	PF00454	1.00	infobox
Phosphoinositide 3-kinase	InterPro	IPR000403	1.00	infobox
Phosphoinositide 3-kinase	OPM protein	3ml9	1.00	infobox
Phosphoinositide 3-kinase	OPM superfamily	265	1.00	infobox
Phosphoinositide 3-kinase	PDB	IPR000403 PF00454 (ECOD; PDBsum)	1.00	infobox
Phosphoinositide 3-kinase	Pfam	PF00454	1.00	infobox
Phosphoinositide 3-kinase	PROSITE	PDOC00710	1.00	infobox
Phosphoinositide 3-kinase	SCOP2	3gmm / SCOPe / SUPFAM	1.00	infobox
Phosphoinositide 3-kinase	SMART	SM00146	1.00	infobox
Phosphoinositide 3-kinase	Symbol	PI3K	1.00	infobox

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