AFAP1L2

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AFAP1L2 topic overview

The analysis highlights Function, Molecular structure and Clinical significance as prominent areas in the source structure around AFAP1L2.

Related topics: 52
Source areas: 6
Connected nodes: 58
Extracted relationships: 104
Concept neighborhoods: 19
Bridge connections: 58

What this topic covers Research coverage

Source areas are shown by the number of related topics found in each part of the analysis. Use smaller areas too: they can reveal specialized angles and content gaps.

Function · 21 topics

Molecular structure · 9 topics

Clinical significance · 8 topics

Overview · 7 topics

Interactions · 6 topics

Discovery · 1 topics

Smaller areas are not necessarily less important. They contain fewer connections in this analysis and can be useful for finding specialized angles or coverage gaps.

Key facts & relationships

High-confidence facts extracted from structured source data. Use them as anchors for further research.

Aliases: AFAP1L2, KIAA1914, XB130, CTB-1144G6.4, actin filament associated protein 1 like 2
Available structures: Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2COF
Band: 10q25.3 · 19|19 D2
Bgee: sural nerve · left lobe of thyroid gland · right lobe of thyroid gland · spleen · buccal mucosa cell
BioGPS: n/a
Chr.: Chromosome 10 (human) · Chromosome 19 (mouse)

Explore all related topics Closing gaps

Browse the complete topic structure, not only the most central items. Less prominent entities and concepts can reveal missing angles, specialized context and useful research gaps. Each item opens a new analysis centered on that subject.

Overview

Protein
Gene
Adaptor protein Signal transducing adaptor protein
Signal transduction
Gene expression
Thyroid
Spleen

Molecular structure

10q25.3 Chromosome 10 (human)
KDa Atomic mass unit
AFAP Actin filament-associated protein?action=edit&redlink=1
N-terminal N-terminus
Pleckstrin-homology domains Pleckstrin-homology domains?action=edit&redlink=1
C-terminal C-terminus
Leucine zipper
Translocation Protein translocation
Lamellipodia

Function

PI3K
Akt
SH2 domains SH2 domains?action=edit&redlink=1
Phosphorylating Phosphorylation
P21
P27Kip1 CDKN1B
GSK3β
Apoptosis
Caspase-8
Caspase-9
Cell death
Cytoskeletal
Motility
F-actin
Lamellipodium
Metastasis
MicroRNAs MicroRNA
MiR-33a MiR-33
Src Proto-oncogene tyrosine-protein kinase Src
Interleukin-8
AP-1 AP-1 transcription factor

Interactions

Clinical significance

Discovery

Toronto, Ontario

Advanced semantic analysis

Deeper signals for content research, entity SEO and topical coverage. The plain-language headings explain what each technical view is useful for.

How AFAP1L2 connects Entity context

The extracted context around AFAP1L2 shows recurring relationship patterns in the source. For example, AFAP1L2 → body of uterus, buccal mucosa cell, canal of the cervix, cerebellar hemisphere, decidua, external carotid artery, gastrula, left lobe of thyroid gland, left lung lobe, otolith organ, primary oocyte, right hemisphere of cerebellum, right lobe of thyroid gland, right uterine tube, sciatic nerve, secondary oocyte, spleen, sural nerve, utricle, zygote Another extracted example is AFAP1L2 → AFAP, AFAP's, Both, C-terminal, Despite XB130's, It, N-terminal, PI3K, Several, Src-containing, The, The C-terminal, The XB130, Two, XB130, XB130's. Use these groups to spot repeated connection types before inspecting the individual relationships.

Top relations

Bgee · 20

AFAP1L2 → body of uterus, buccal mucosa cell, canal of the cervix, cerebellar hemisphere, decidua, external carotid artery, gastrula, left lobe of thyroid gland, left lung lobe, otolith organ, primary oocyte, right hemisphere of cerebellum, right lobe of thyroid gland, right uterine tube, sciatic nerve, secondary oocyte, spleen, sural nerve, utricle, zygote

RNA expression pattern · 20

related to Molecular structure · 16

AFAP1L2 → AFAP, AFAP's, Both, C-terminal, Despite XB130's, It, N-terminal, PI3K, Several, Src-containing, The, The C-terminal, The XB130, Two, XB130, XB130's

Gene ontology · 15

AFAP1L2 → cytoplasm, cytosol, inflammatory response, plasma membrane, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of interleukin-8 production, positive regulation of protein tyrosine kinase activity, positive regulation of transcription, DNA-templated, protein tyrosine kinase activator activity, regulation of interleukin-6 production, regulation of mitotic cell cycle, regulation of signal transduction, SH2 domain binding, SH3 domain binding, signaling adaptor activity

related to Discovery · 9

AFAP1L2 → AFAP1, Canada, Laboratories Toronto, Latner Thoracic Surgery Research, Ontario, The, This, XB130, Xiaohui Bai

Band · 2

AFAP1L2 → 10q25.3, 19|19 D2

Chr. · 2

AFAP1L2 → Chromosome 10 (human), Chromosome 19 (mouse)

End · 2

AFAP1L2 → 114,404,756 bp, 57,008,228 bp

Aliases · 1

AFAP1L2 → AFAP1L2, KIAA1914, XB130, CTB-1144G6.4, actin filament associated protein 1 like 2

Available structures · 1

AFAP1L2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2COF

Important terminology

Use these terms to understand the vocabulary surrounding the topic, not as a checklist for keyword stuffing.

Important terminology

xb130 protein gene cell human expression bp survival adaptor actin chr band molecular highly chromosome afap cancer 10 thyroid signal

AFAP1L2 relationships Subject–Predicate–Object triples

TTTA extracted 104 structured relationships around AFAP1L2. Examples in this analysis include AFAP1L2 → Aliases → AFAP1L2, KIAA1914, XB130, CTB-1144G6.4, actin filament associated protein 1 like 2 and AFAP1L2 → Available structures → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2COF. The table shows each extracted connection, where it came from and its confidence.

Subject	Predicate	Object	Confidence	Src
AFAP1L2	Aliases	AFAP1L2, KIAA1914, XB130, CTB-1144G6.4, actin filament associated protein 1 like 2	1.00	infobox
AFAP1L2	Available structures	Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2COF	1.00	infobox
AFAP1L2	Band	10q25.3	1.00	infobox
AFAP1L2	Band	19\|19 D2	1.00	infobox
AFAP1L2	Bgee	sural nerve	1.00	infobox
AFAP1L2	Bgee	left lobe of thyroid gland	1.00	infobox
AFAP1L2	Bgee	right lobe of thyroid gland	1.00	infobox
AFAP1L2	Bgee	spleen	1.00	infobox
AFAP1L2	Bgee	buccal mucosa cell	1.00	infobox
AFAP1L2	Bgee	body of uterus	1.00	infobox
AFAP1L2	Bgee	right uterine tube	1.00	infobox
AFAP1L2	Bgee	cerebellar hemisphere	1.00	infobox
AFAP1L2	Bgee	right hemisphere of cerebellum	1.00	infobox
AFAP1L2	Bgee	canal of the cervix	1.00	infobox
AFAP1L2	Bgee	secondary oocyte	1.00	infobox
AFAP1L2	Bgee	primary oocyte	1.00	infobox
AFAP1L2	Bgee	zygote	1.00	infobox
AFAP1L2	Bgee	otolith organ	1.00	infobox
AFAP1L2	Bgee	utricle	1.00	infobox
AFAP1L2	Bgee	sciatic nerve	1.00	infobox
AFAP1L2	Bgee	external carotid artery	1.00	infobox
AFAP1L2	Bgee	decidua	1.00	infobox
AFAP1L2	Bgee	left lung lobe	1.00	infobox
AFAP1L2	Bgee	gastrula	1.00	infobox
AFAP1L2	BioGPS	n/a	1.00	infobox
AFAP1L2	Chr.	Chromosome 10 (human)	1.00	infobox
AFAP1L2	Chr.	Chromosome 19 (mouse)	1.00	infobox
AFAP1L2	Databases	NCBI: entry; OMA: entry	1.00	infobox
AFAP1L2	End	114,404,756 bp	1.00	infobox
AFAP1L2	End	57,008,228 bp	1.00	infobox

Related concept clusters Concept neighborhoods

The concept neighborhoods around AFAP1L2 bring nearby vocabulary together. In this analysis, examples include Protein, Gene and Thus. Use the clusters to find adjacent concepts and terminology that may deserve separate research.

AFAP1L2
- Protein
- Gene
- Thus
- Molecular
- Associated
- Expressed
- Expression
- Filament
- Function
- Known
- Location
- Motility
afap1l2
- Protein
- Gene
- Thus
- Molecular
- Associated
- Expressed
- Expression
- Filament
- Function
- Known
- Location
- Motility
protein
- Molecular
- Adaptor
- Human
- Xb130
- Associated
- Filament
- Thus
- Afap
- Signal
- Function
- Known
- Location
gene
- Location
- Chromosome
- Bp
- Chr
- Afap1l2
- Molecular
- Human
- Function
- Motility
- Transduction
- Band
- Cycle
adaptor protein
- Signal
- Transduction
- Molecular
- Adaptor
- Protein
- Human
- Xb130
- Associated
- Filament
- Thus
- Afap
- Highly
gene expression
- Location
- Chromosome
- Bp
- Chr
- Afap1l2
- Function
- Molecular
- Survival
- Human
- Level
- Thyroid
- Motility
cell death
- Survival
- Cycle
- Proliferation
- Function
- Motility
- Akt
- Expression
- Gene
- Location
- Signaling
- Xb130
- Chromosome
signal transduction
- Transduction
- Molecular
- Interact
- Expressed
- Function
- Known
- Location
- Pi3k
- Signaling
- Tyrosine
- Band
- Chromosome

Connections between topic areas Semantic bridges

For AFAP1L2, one of the stronger structural bridges in this analysis connects AFAP1L2 with Function. Bridges highlight paths between different parts of the map and can reveal research angles that are easy to miss in a flat list.

Min side: 3

AFAP1L2 — Function · splits 37 ⟂ 22

AFAP1L2 — Molecular structure · splits 49 ⟂ 10

AFAP1L2 — Clinical significance · splits 50 ⟂ 9

AFAP1L2 — Overview · splits 51 ⟂ 8

AFAP1L2 — Interactions · splits 52 ⟂ 7

Map overview Semantic statistics

AFAP1L2

Nodes59

Edges58

Triples104

Avg. degree1.97

Density0.033898

Components1

Source & methodology

TTTA analyzes the structure around AFAP1L2 to surface related topics, entities, relationships, concept neighborhoods and bridge connections. Use the map to explore areas such as Function, Molecular structure & Clinical significance, including less central topics that may reveal useful research gaps. Automatically extracted connections are research leads rather than rewritten encyclopedia content.

Source: Wikipedia — AFAP1L2 · EN edition · Analysis: TopicsToTalkAbout