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AFAP1L2

Actin filament-associated protein 1-like 2 is a protein that in humans is encoded by the gene AFAP1L2 (previously KIAA1914 or XB130). The protein is a cytosolic adaptor protein and signal transduction mediator. AFAP1L2 regulates cell proliferation, cell survival, cell motility and gene expression. AFAP1L2 is highly similar to AFAP and is thus known as…

Function, Molecular structure & Clinical significance

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Aliases
AFAP1L2, KIAA1914, XB130, CTB-1144G6.4, actin filament associated protein 1 like 2
Available structures
Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2COF
Band
10q25.3 · 19|19 D2
Bgee
sural nerve · left lobe of thyroid gland · right lobe of thyroid gland · spleen · buccal mucosa cell
BioGPS
n/a
Chr.
Chromosome 10 (human) · Chromosome 19 (mouse)

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Molecular structure

Function

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Clinical significance

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Map overview Semantic statistics

AFAP1L2

Nodes59
Edges58
Triples104
Avg. degree1.97
Density0.033898
Components1

How this topic connects Entity context

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AFAP1L2

Top relations

Bgee · 20
AFAP1L2 → body of uterus, buccal mucosa cell, canal of the cervix, cerebellar hemisphere, decidua, external carotid artery, gastrula, left lobe of thyroid gland, left lung lobe, otolith organ, primary oocyte, right hemisphere of cerebellum, right lobe of thyroid gland, right uterine tube, sciatic nerve, secondary oocyte, spleen, sural nerve, utricle, zygote
RNA expression pattern · 20
AFAP1L2 → body of uterus, buccal mucosa cell, canal of the cervix, cerebellar hemisphere, decidua, external carotid artery, gastrula, left lobe of thyroid gland, left lung lobe, otolith organ, primary oocyte, right hemisphere of cerebellum, right lobe of thyroid gland, right uterine tube, sciatic nerve, secondary oocyte, spleen, sural nerve, utricle, zygote
related to Molecular structure · 16
AFAP1L2 → AFAP, AFAP's, Both, C-terminal, Despite XB130's, It, N-terminal, PI3K, Several, Src-containing, The, The C-terminal, The XB130, Two, XB130, XB130's
Gene ontology · 15
AFAP1L2 → cytoplasm, cytosol, inflammatory response, plasma membrane, positive regulation of epidermal growth factor receptor signaling pathway, positive regulation of interleukin-8 production, positive regulation of protein tyrosine kinase activity, positive regulation of transcription, DNA-templated, protein tyrosine kinase activator activity, regulation of interleukin-6 production, regulation of mitotic cell cycle, regulation of signal transduction, SH2 domain binding, SH3 domain binding, signaling adaptor activity
related to Discovery · 9
AFAP1L2 → AFAP1, Canada, Laboratories Toronto, Latner Thoracic Surgery Research, Ontario, The, This, XB130, Xiaohui Bai
Band · 2
AFAP1L2 → 10q25.3, 19|19 D2
Chr. · 2
AFAP1L2 → Chromosome 10 (human), Chromosome 19 (mouse)
End · 2
AFAP1L2 → 114,404,756 bp, 57,008,228 bp
Aliases · 1
AFAP1L2 → AFAP1L2, KIAA1914, XB130, CTB-1144G6.4, actin filament associated protein 1 like 2
Available structures · 1
AFAP1L2 → Available structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2COF

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Important terminology

xb130 protein gene cell human expression bp survival adaptor actin chr band molecular highly chromosome afap cancer 10 thyroid signal

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
AFAP1L2AliasesAFAP1L2, KIAA1914, XB130, CTB-1144G6.4, actin filament associated protein 1 like 21.00infobox
AFAP1L2Available structuresAvailable structuresPDBOrtholog search: PDBe RCSB List of PDB id codes2COF1.00infobox
AFAP1L2Band10q25.31.00infobox
AFAP1L2Band19|19 D21.00infobox
AFAP1L2Bgeesural nerve1.00infobox
AFAP1L2Bgeeleft lobe of thyroid gland1.00infobox
AFAP1L2Bgeeright lobe of thyroid gland1.00infobox
AFAP1L2Bgeespleen1.00infobox
AFAP1L2Bgeebuccal mucosa cell1.00infobox
AFAP1L2Bgeebody of uterus1.00infobox
AFAP1L2Bgeeright uterine tube1.00infobox
AFAP1L2Bgeecerebellar hemisphere1.00infobox
AFAP1L2Bgeeright hemisphere of cerebellum1.00infobox
AFAP1L2Bgeecanal of the cervix1.00infobox
AFAP1L2Bgeesecondary oocyte1.00infobox
AFAP1L2Bgeeprimary oocyte1.00infobox
AFAP1L2Bgeezygote1.00infobox
AFAP1L2Bgeeotolith organ1.00infobox
AFAP1L2Bgeeutricle1.00infobox
AFAP1L2Bgeesciatic nerve1.00infobox
AFAP1L2Bgeeexternal carotid artery1.00infobox
AFAP1L2Bgeedecidua1.00infobox
AFAP1L2Bgeeleft lung lobe1.00infobox
AFAP1L2Bgeegastrula1.00infobox
AFAP1L2BioGPSn/a1.00infobox
AFAP1L2Chr.Chromosome 10 (human)1.00infobox
AFAP1L2Chr.Chromosome 19 (mouse)1.00infobox
AFAP1L2DatabasesNCBI: entry; OMA: entry1.00infobox
AFAP1L2End114,404,756 bp1.00infobox
AFAP1L2End57,008,228 bp1.00infobox

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