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Ketamine

Ketamine is a cyclohexanone-derived general anesthetic and NMDA receptor antagonist with analgesic and hallucinogenic properties, used medically for anesthesia, depression, and pain management. Ketamine exists as its two enantiomers, S- (esketamine) and R- (arketamine), and has antidepressant action likely involving NMDA antagonism as well as other…

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Key facts & relationships

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3D model (JSmol)
Interactive image
Addiction liability
Moderate–high
AHFS/Drugs.com
Monograph
ATC code
N01AX03 (WHO)
Bioavailability
Intravenous: 100% · Intramuscular: 93% · Epidural: 77% · Intranasal: 45–50% · Sublingual: 24–30%
CAS Number
6740-88-1 Y 33643-46-8 (esketamine) 33643-49-1 (arketamine) · 33643-46-8 (esketamine) · 33643-49-1 (arketamine) · HCl: 1867-66-9 Y

Topics to explore

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Overview

Medical uses

Contraindications

Adverse effects

Interactions

Pharmacology

Chemistry

History

Society and culture

Research

Veterinary uses

Advanced semantic analysis

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Map overview Semantic statistics

Ketamine

Nodes264
Edges263
Triples210
Avg. degree1.99
Density0.007576
Components1

How this topic connects Entity context

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Ketamine

Top relations

related to Legal status · 20
Ketamine → Act, August, Class, Cosmetics Act, Drug, February, Home Office, In, In Australia, In Canada, In December, India, October, Poisons Standard, Schedule, Schedule III, The, United Kingdom, United States Controlled Substances, While
related to history · 17
Ketamine → After, American, Calvin, CI-581, Domino, Edward, Following FDA, Hearing, It, Mrs, Parke-Davis, PCP, Stevens, The, These, Vietnam War, Wayne State University
related to Recreational use · 14
Ketamine → At, Due, England, John, K-hole, Lilly, Marcia Moore, Matthew Perry's October, Recreational, Several, The, They, Turner, Wales
related to Liver toxicity and urologic disease · 10
Ketamine → EGCG, Intravesical, It, Management, NSAIDs, Some, Studies, The, This, Urologic
has effect · 9
Ketamine → All, Also, At, Dizziness, Hallucinations, Laryngospasm, Psychotomimetic, The, Vomiting
Legal status · 8
Ketamine → AU: S8 (Controlled drug), BR: Class C1 (Other controlled substances), CA: Schedule I, DE: § 48 AMG/§ 1 MPAV (Prescription only), IN: Schedule X SE: Förteckning IV, UK: Class B (Class A if prepared as an injection), UN: Unscheduled (Rx only), US: Schedule III
related to Depression · 8
Ketamine → An, Anxiety Treatments, CANMAT, Esketamine, European Medicines Agency, Mood, The Canadian Network, United States
related to Structure · 8
Ketamine → However, In, Ketanest, NMDA, R-ketamine, S-ketamine, The, While S-ketamine
Bioavailability · 7
Ketamine → By mouth: 16–20%, Epidural: 77%, Intramuscular: 93%, Intranasal: 45–50%, Intravenous: 100%, Rectal: 25–30%, Sublingual: 24–30%
related to Anesthesia · 7
Ketamine → It, Ketofol, Protective, Psychotomimetic, The, Vietnam War, When

Important terminology Word statistics

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Important terminology

effects used anesthesia nmda use depression receptor antidepressant pain anesthetic may esketamine doses drug also intravenous people recreational action liver

Entity relationships Subject–Predicate–Object triples

SubjectPredicateObjectConfidenceSrc
Ketamine3D model (JSmol)Interactive image1.00infobox
KetamineAddiction liabilityModerate–high1.00infobox
KetamineAHFS/Drugs.comMonograph1.00infobox
KetamineATC codeN01AX03 (WHO)1.00infobox
KetamineBioavailabilityIntravenous: 100%1.00infobox
KetamineBioavailabilityIntramuscular: 93%1.00infobox
KetamineBioavailabilityEpidural: 77%1.00infobox
KetamineBioavailabilityIntranasal: 45–50%1.00infobox
KetamineBioavailabilitySublingual: 24–30%1.00infobox
KetamineBioavailabilityRectal: 25–30%1.00infobox
KetamineBioavailabilityBy mouth: 16–20%1.00infobox
KetamineCAS Number6740-88-1 Y 33643-46-8 (esketamine) 33643-49-1 (arketamine)1.00infobox
KetamineCAS Number33643-46-8 (esketamine)1.00infobox
KetamineCAS Number33643-49-1 (arketamine)1.00infobox
KetamineCAS NumberHCl: 1867-66-9 Y1.00infobox
KetamineChEBICHEBI:6121 Y1.00infobox
KetamineChEMBLChEMBL742 Y1.00infobox
KetamineChemSpider3689 Y1.00infobox
KetamineChiralityEsketamine (S(+)-isomer)1.00infobox
KetamineChiralityArketamine (R(−)-isomer)1.00infobox
KetamineCompTox Dashboard (EPA)DTXSID80231871.00infobox
KetamineDrug classNMDA receptor antagonist; general anesthetic; dissociative hallucinogen; analgesic; antidepressant1.00infobox
KetamineDrugBankDB01221 Y1.00infobox
KetamineDuration of actionIntramuscular: 0.5–2 hours1.00infobox
KetamineDuration of actionInsufflation: 45–60 min1.00infobox
KetamineDuration of actionBy mouth: 1–6+ hours1.00infobox
KetamineECHA InfoCard100.027.0951.00infobox
KetamineElimination half-lifeKetamine: 2.5–3 hours1.00infobox
KetamineElimination half-lifeNorketamine: 12 hours1.00infobox
KetamineExcretionUrine: 91%1.00infobox

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