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Ketamine is a cyclohexanone-derived general anesthetic and NMDA receptor antagonist with analgesic and hallucinogenic properties, used medically for anesthesia, depression, and pain management. Ketamine exists as its two enantiomers, S- (esketamine) and R- (arketamine), and has antidepressant action likely involving NMDA antagonism as well as other…
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effects used anesthesia nmda use depression receptor antidepressant pain anesthetic may esketamine doses drug also intravenous people recreational action liver
| Subject | Predicate | Object | Confidence | Src |
|---|---|---|---|---|
| Ketamine | 3D model (JSmol) | Interactive image | 1.00 | infobox |
| Ketamine | Addiction liability | Moderate–high | 1.00 | infobox |
| Ketamine | AHFS/Drugs.com | Monograph | 1.00 | infobox |
| Ketamine | ATC code | N01AX03 (WHO) | 1.00 | infobox |
| Ketamine | Bioavailability | Intravenous: 100% | 1.00 | infobox |
| Ketamine | Bioavailability | Intramuscular: 93% | 1.00 | infobox |
| Ketamine | Bioavailability | Epidural: 77% | 1.00 | infobox |
| Ketamine | Bioavailability | Intranasal: 45–50% | 1.00 | infobox |
| Ketamine | Bioavailability | Sublingual: 24–30% | 1.00 | infobox |
| Ketamine | Bioavailability | Rectal: 25–30% | 1.00 | infobox |
| Ketamine | Bioavailability | By mouth: 16–20% | 1.00 | infobox |
| Ketamine | CAS Number | 6740-88-1 Y 33643-46-8 (esketamine) 33643-49-1 (arketamine) | 1.00 | infobox |
| Ketamine | CAS Number | 33643-46-8 (esketamine) | 1.00 | infobox |
| Ketamine | CAS Number | 33643-49-1 (arketamine) | 1.00 | infobox |
| Ketamine | CAS Number | HCl: 1867-66-9 Y | 1.00 | infobox |
| Ketamine | ChEBI | CHEBI:6121 Y | 1.00 | infobox |
| Ketamine | ChEMBL | ChEMBL742 Y | 1.00 | infobox |
| Ketamine | ChemSpider | 3689 Y | 1.00 | infobox |
| Ketamine | Chirality | Esketamine (S(+)-isomer) | 1.00 | infobox |
| Ketamine | Chirality | Arketamine (R(−)-isomer) | 1.00 | infobox |
| Ketamine | CompTox Dashboard (EPA) | DTXSID8023187 | 1.00 | infobox |
| Ketamine | Drug class | NMDA receptor antagonist; general anesthetic; dissociative hallucinogen; analgesic; antidepressant | 1.00 | infobox |
| Ketamine | DrugBank | DB01221 Y | 1.00 | infobox |
| Ketamine | Duration of action | Intramuscular: 0.5–2 hours | 1.00 | infobox |
| Ketamine | Duration of action | Insufflation: 45–60 min | 1.00 | infobox |
| Ketamine | Duration of action | By mouth: 1–6+ hours | 1.00 | infobox |
| Ketamine | ECHA InfoCard | 100.027.095 | 1.00 | infobox |
| Ketamine | Elimination half-life | Ketamine: 2.5–3 hours | 1.00 | infobox |
| Ketamine | Elimination half-life | Norketamine: 12 hours | 1.00 | infobox |
| Ketamine | Excretion | Urine: 91% | 1.00 | infobox |
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